Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

H. Dirr · SciRah

Researcher profile · Semantic Scholar

H. Dirr

Share profile

H. Dirr — researcher profile on SciRah

h-index: 30
Works: 114
Citations: 2,992

Most-cited papers

X-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic function.
H. Dirr, P. Reinemer, R. Huber
1994European Journal of Biochemistry394 citations
Semantic Scholar
Conformational stability of pGEX‐expressed Schistosoma japonicum glutathione S‐transferase: A detoxification enzyme and fusion‐protein affinity tag
Warren Kaplan, J. Erhardt, N. Sluis-Cremer, H. Dirr +2 more
1997Protein Science145 citations Open access
Semantic Scholar
Analysis of the levels of conservation of the J domain among the various types of DnaJ-like proteins
Fritha Hennessy, M. Cheetham, H. Dirr, G. Blatch
2000Cell stress & chaperones (Print)82 citations Open access
Semantic Scholar
Refined crystal structure of porcine class Pi glutathione S-transferase (pGST P1-1) at 2.1 A resolution.
H. Dirr, P. Reinemer, R. Huber
1994Journal of Molecular Biology79 citations
Semantic Scholar
The hydrophobic lock‐and‐key intersubunit motif of glutathione transferase A1‐1: implications for catalysis, ligandin function and stability
Y. Sayed, Louise A. Wallace, H. Dirr
2000FEBS Letters60 citations Open access
Semantic Scholar
Formation of an unfolding intermediate state of soluble chloride intracellular channel protein CLIC1 at acidic pH.
S. Fanucchi, R. Adamson, H. Dirr
2008Biochemistry59 citations
Semantic Scholar
Role of the C-terminal helix 9 in the stability and ligandin function of class alpha glutathione transferase A1-1.
H. Dirr, Louise A. Wallace
1999Biochemistry59 citations
Semantic Scholar
Equilibrium folding of dimeric class mu glutathione transferases involves a stable monomeric intermediate.
Judith A. T. Hornby, Jiann‐Kae Luo, J. M. Stevens, Louise A. Wallace +3 more
2000Biochemistry57 citations
Semantic Scholar
Protease inhibition in African subtypes of HIV-1.
A. Velázquez-Campoy, S. Vega, Erin Fleming, Usman M. Bacha +3 more
2003AIDS Reviews56 citations
Semantic Scholar
Native dimer stabilizes the subunit tertiary structure of porcine class pi glutathione S-transferase.
J. Erhardt, H. Dirr
1995European Journal of Biochemistry54 citations Open access
Semantic Scholar
Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion
Tawanda Zininga, I. Achilonu, H. Hoppe, E. Prinsloo +2 more
2016Cell stress & chaperones (Print)51 citations Open access
Semantic Scholar
Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance
Previn Naicker, I. Achilonu, S. Fanucchi, M. Fernandes +4 more
2013Journal of Biomolecular Structure and Dynamics48 citations
Semantic Scholar
Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein
Tawanda Zininga, I. Achilonu, H. Hoppe, E. Prinsloo +2 more
2015PLoS ONE47 citations Open access
Semantic Scholar
Active-Site Mutations in the South African Human Immunodeficiency Virus Type 1 Subtype C Protease Have a Significant Impact on Clinical Inhibitor Binding: Kinetic and Thermodynamic Study
Salerwe Mosebi, L. Morris, H. Dirr, Y. Sayed
2008Journal of Virology46 citations Open access
Semantic Scholar
Polymyxin B inhibits the chaperone activity of Plasmodium falciparum Hsp70
Tawanda Zininga, O. Pooe, Pertunia B. Makhado, Lebogang Ramatsui +4 more
2017Cell stress & chaperones (Print)45 citations Open access
Semantic Scholar
Structural Dynamics of Soluble Chloride Intracellular Channel Protein CLIC1 Examined by Amide Hydrogen-Deuterium Exchange Mass Spectrometry (DXMS)
S. Stoychev, C. Nathaniel, S. Fanucchi, Melissa A. Brock +4 more
2009Biochemistry45 citations Open access
Semantic Scholar
Class sigma glutathione transferase unfolds via a dimeric and a monomeric intermediate: impact of subunit interface on conformational stability in the superfamily.
J. M. Stevens, Judith A. T. Hornby, R. Armstrong, H. Dirr
1998Biochemistry42 citations
Semantic Scholar
(−)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners
Tawanda Zininga, Lebogang Ramatsui, Pertunia B. Makhado, S. Makumire +4 more
2017Molecules41 citations Open access
Semantic Scholar
Thermodynamics of the ligandin function of human class Alpha glutathione transferase A1-1: energetics of organic anion ligand binding.
Y. Sayed, Judith A. T. Hornby, Marimar Lopez, H. Dirr
2002Biochemical Journal40 citations Open access
Semantic Scholar
Structural and biochemical characterization of Plasmodium falciparum Hsp70‐x reveals functional versatility of its C‐terminal EEVN motif
Blessing Mabate, Tawanda Zininga, Lebogang Ramatsui, S. Makumire +3 more
2018Proteins: Structure, Function, and Bioinformatics38 citations Open access
Semantic Scholar
Molecular recognition at the dimer interface of a class mu glutathione transferase: role of a hydrophobic interaction motif in dimer stability and protein function.
Judith A. T. Hornby, Simona G. Codreanu, R. Armstrong, H. Dirr
2002Biochemistry37 citations
Semantic Scholar
Characterization of bromosulphophthalein binding to human glutathione S-transferase A1-1: thermodynamics and inhibition kinetics.
Doris Kolobe, Y. Sayed, H. Dirr
2004Biochemical Journal36 citations Open access
Semantic Scholar
The role of an evolutionarily conserved cis-proline in the thioredoxin-like domain of human class Alpha glutathione transferase A1-1.
C. Nathaniel, Louise A. Wallace, J. Burke, H. Dirr
2003Biochemical Journal36 citations Open access
Semantic Scholar
Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.
D. Kuhnert, Y. Sayed, Salerwe Mosebi, M. Sayed +2 more
2005Journal of Molecular Biology35 citations Open access
Semantic Scholar
The in Vitro Phosphorylation of the Co-Chaperone mSTI1 by Cell Cycle Kinases Substantiates a Predicted Casein Kinase II-p34cdc2-NLS (CcN) Motif
V. Longshaw, H. Dirr, G. Blatch, Michael Lässle
2000Biological chemistry35 citations
Semantic Scholar
Probing the nature of the Co(III) ion in corrins: a comparison of the thermodynamics and kinetics of the ligand substitution reactions of aquacyanocobyrinic acid heptamethyl ester and stable yellow aquacyanocobyrinic acid heptamethyl ester.
S. M. Chemaly, M. Florczak, H. Dirr, H. Marques
2011Inorganic Chemistry31 citations
Semantic Scholar
A Conserved N-capping Motif Contributes Significantly to the Stabilization and Dynamics of the C-terminal Region of Class Alpha Glutathione S-Transferases*
H. Dirr, T. Little, D. Kuhnert, Y. Sayed
2005Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Porcine class pi glutathione S-transferase: anionic ligand binding and conformational analysis.
P. Bico, J. Erhardt, Warren Kaplan, H. Dirr
1995Biochimica et Biophysica Acta31 citations
Semantic Scholar
Residue 219 impacts on the dynamics of the C-terminal region in glutathione transferase A1-1: implications for stability and catalytic and ligandin functions.
Salerwe Mosebi, Y. Sayed, J. Burke, H. Dirr
2003Biochemistry30 citations
Semantic Scholar
Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1.
I. Achilonu, S. Fanucchi, M. Cross, M. Fernandes +1 more
2012Biochemistry29 citations
Semantic Scholar
A Lys-Trp cation-π interaction mediates the dimerization and function of the chloride intracellular channel protein 1 transmembrane domain.
Bradley Peter, Anton A. Polyansky, S. Fanucchi, H. Dirr
2014Biochemistry27 citations
Semantic Scholar
The intersubunit lock-and-key motif in human glutathione transferase A1-1: role of the key residues Met51 and Phe52 in function and dimer stability.
Carla S. Alves, D. Kuhnert, Y. Sayed, H. Dirr
2006Biochemical Journal27 citations Open access
Semantic Scholar
Domain-domain interface packing at conserved Trp-20 in class alpha glutathione transferase impacts on protein stability.
Louise A. Wallace, J. Burke, H. Dirr
2000Biochimica et Biophysica Acta27 citations
Semantic Scholar
Molecular dynamics and ligand docking of a hinge region variant of South African HIV-1 subtype C protease.
Jake Zondagh, Vijayakumar Balakrishnan, I. Achilonu, H. Dirr +1 more
2018Journal of Molecular Graphics and Modelling25 citations
Semantic Scholar
V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity
C. van Eeden, C. K. Wibmer, C. Scheepers, S. Richardson +23 more
2018Cell Reports25 citations Open access
Semantic Scholar
Double mutation at the subunit interface of glutathione transferase rGSTM1-1 results in a stable, folded monomer.
Lawrence C. Thompson, J. Walters, J. Burke, J. Parsons +2 more
2006Biochemistry25 citations
Semantic Scholar
Class Pi glutathione transferase unfolds via a dimeric and not monomeric intermediate: functional implications for an unstable monomer.
S. Gildenhuys, Louise A. Wallace, J. Burke, D. Balchin +2 more
2010Biochemistry24 citations
Semantic Scholar
A Single Amino Acid in the Hinge Loop Region of the FOXP Forkhead Domain is Significant for Dimerisation
K. Perumal, H. Dirr, S. Fanucchi
2015The Protein Journal23 citations
Semantic Scholar
Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1.
S. Gildenhuys, M. Dobreva, N. Kinsley, Y. Sayed +6 more
2010Biophysical Chemistry22 citations
Semantic Scholar
High yield purification of JNK1β1 and activation by in vitro reconstitution of the MEKK1→MKK4→JNK MAPK phosphorylation cascade.
Gavin R. Owen, I. Achilonu, H. Dirr
2013Protein Expression and Purification21 citations
Semantic Scholar
Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1.
D. Balchin, S. Fanucchi, I. Achilonu, R. Adamson +4 more
2010Biochimica et Biophysica Acta21 citations
Semantic Scholar
Influence of the dimer interface on glutathione transferase structure and dynamics revealed by amide H/D exchange mass spectrometry.
Simona G. Codreanu, Lawrence C. Thompson, D. Hachey, H. Dirr +1 more
2005Biochemistry21 citations
Semantic Scholar
Purification and characterisation of recombinant human eukaryotic elongation factor 1 gamma.
I. Achilonu, Thendo P Siganunu, H. Dirr
2014Protein Expression and Purification20 citations
Semantic Scholar
Molecular basis of inhibition of Schistosoma japonicum glutathione transferase by ellagic acid: insights into biophysical and structural studies.
B. Akumadu, R. Pandian, J. Olfsen, R. Worth +6 more
2020Molecular and biochemical parasitology (Print)19 citations
Semantic Scholar
Role of arginine 29 and glutamic acid 81 interactions in the conformational stability of human chloride intracellular channel 1.
D. Legg-E'Silva, I. Achilonu, S. Fanucchi, S. Stoychev +2 more
2012Biochemistry18 citations
Semantic Scholar
Characterization of the binding of 8-anilinonaphthalene sulphonate to rat class Mu GST M1-1
N. Kinsley, Y. Sayed, Salerwe Mosebi, R. Armstrong +1 more
2008Biophysical Chemistry17 citations Open access
Semantic Scholar
Membrane mimetics induce helix formation and oligomerization of the chloride intracellular channel protein 1 transmembrane domain.
Bradley Peter, N. Ngubane, S. Fanucchi, H. Dirr
2013Biochemistry16 citations
Semantic Scholar
The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function.
I. Achilonu, Samantha Gildenhuys, L. Fisher, J. Burke +4 more
2010Acta Crystallographica. Section F : Structural Biology and Crystallization Communications16 citations Open access
Semantic Scholar
Polymorphic Diversity: N-Phenylbenzamide as a Possible Polymorphophore
Caitlin F. Zipp, H. Dirr, M. Fernandes, H. Marques +1 more
201315 citations
Semantic Scholar
Effect of glutathione, glutathione sulphonate and S‐hexylglutathione on the conformational stability of class pi glutathione S‐transferase
J. Erhardt, H. Dirr
1996FEBS Letters15 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Y. Sayed×16
Invite
Y. Sayed — researcher profile on SciRah
I. Achilonu×13
Invite
I. Achilonu — researcher profile on SciRah
S. Fanucchi×11
Invite
S. Fanucchi — researcher profile on SciRah
J. Burke×8
Invite
J. Burke — researcher profile on SciRah

×7

Invite

M. Fernandes — researcher profile on SciRah

Louise A. Wallace×6

Invite

Louise A. Wallace — researcher profile on SciRah

R. Armstrong×6

Invite

R. Armstrong — researcher profile on SciRah

Tawanda Zininga×5

Invite

Tawanda Zininga — researcher profile on SciRah

Invite

A. Shonhai — researcher profile on SciRah

Invite

J. Erhardt — researcher profile on SciRah

Judith A. T. Hornby×4

Invite

Judith A. T. Hornby — researcher profile on SciRah

Salerwe Mosebi×4

Invite

Salerwe Mosebi — researcher profile on SciRah