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J. Cieśla · SciRah

Researcher profile · Semantic Scholar

J. Cieśla

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J. Cieśla — researcher profile on SciRah

h-index: 15
Works: 68
Citations: 821

Most-cited papers

Phosphorylation of basic amino acid residues in proteins: important but easily missed.
J. Cieśla, T. Frączyk, W. Rode
2011Acta Biochimica Polonica206 citations Open access
Semantic Scholar
Metabolic enzymes that bind RNA: yet another level of cellular regulatory network?
J. Cieśla
2006Acta Biochimica Polonica110 citations Open access
Semantic Scholar
Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.
Rogerio R. Sotelo-Mundo, J. Cieśla, J. M. Dzik, Wojciech Rode +4 more
1999Biochemistry42 citations
Semantic Scholar
Mechanism of inhibition of mammalian tumor and other thymidylate synthases by N4-hydroxy-dCMP, N4-hydroxy-5-fluoro-dCMP, and related analogues.
W. Rode, Z. Zieliński, Jolanta M. Dzik, Tadeusz Kulikowski +4 more
1990Biochemistry42 citations
Semantic Scholar
Isolation and expression of rat thymidylate synthase cDNA: phylogenetic comparison with human and mouse thymidylate synthases.
J. Cieśla, Karen X. B. Weiner, Russell S. Weiner, J. Reston +2 more
1995Biochimica et Biophysica Acta36 citations
Semantic Scholar
Thiophosphorylation of free amino acids and enzyme protein by thiophosphoramidate ions.
T. Ruman, Karolina Długopolska, Agata Jurkiewicz, Dagmara Rut +5 more
2010Bioorganic chemistry (Print)29 citations
Semantic Scholar
Phosphorylation of thymidylate synthase from various sources by human protein kinase CK2 and its catalytic subunits.
T. Frączyk, K. Kubiński, M. Masłyk, J. Cieśla +3 more
2010Bioorganic chemistry (Print)21 citations
Semantic Scholar
Trichinella spiralis thymidylate synthase: cDNA cloning and sequencing, and developmental pattern of mRNA expression
Magdalena Dabrowska, Elżbieta Jagielska, J. Cieśla, A. Plucienniczak +4 more
2004Parasitology21 citations
Semantic Scholar
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Krzysztof Felczak, Agnieszka Miazga, J. Poznański, Maria Bretner +6 more
2000Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells
A. Antosiewicz, A. Jarmuła, D. Przybylska, G. Mosieniak +4 more
2017Journal of Biomolecular Structure and Dynamics17 citations
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Interaction of 5-fluoro-4-thio-2'-deoxyuridine 5'-phosphate with mammalian tumour thymidylate synthase: role of the pyrimidine N(3)-H dissociation.
J. Dzik, T. Kulikowski, Z. Zieliński, J. Cieśla +2 more
1987Biochemical and Biophysical Research Communications - BBRC17 citations
Semantic Scholar
Chromosomal Location and Structural Organization of the Human Deoxycytidylate Deaminase Gene (*)
Karen X. B. Weiner, J. Cieśla, Anita B. Jaffe, Roy Ketring +2 more
1995Journal of Biological Chemistry16 citations Open access
Semantic Scholar
Properties of phosphorylated thymidylate synthase.
T. Frączyk, T. Ruman, P. Wilk, P. Palmowski +12 more
2015Biochimica et Biophysica Acta15 citations Open access
Semantic Scholar
Quartz crystal microbalance with dissipation and microscale thermophoresis as tools for investigation of protein complex formation between thymidylate synthesis cycle enzymes.
A. Antosiewicz, Elżbieta Senkara, J. Cieśla
2015Biosensors & bioelectronics15 citations
Semantic Scholar
Developmental arrest in Caenorhabditis elegans dauer larvae causes high expression of enzymes involved in thymidylate biosynthesis, similar to that found in Trichinella muscle larvae
P. Wińska, Barbara Gołos, J. Cieśla, Z. Zieliński +3 more
2005Parasitology15 citations
Semantic Scholar
Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells
P. Wińska, Katarzyna Skierka, E. Lukowska-Chojnacka, M. Koronkiewicz +2 more
2018Anticancer Research13 citations Open access
Semantic Scholar
The effect of Arg209 to Lys mutation in mouse thymidylate synthase.
J. Cieśla, B. Gołos, E. Wałajtys-Rode, Elżbieta Jagielska +2 more
2002Acta Biochimica Polonica12 citations Open access
Semantic Scholar
Interaction of 2-thio-5-fluoro-dUMP and 4-thio-5-fluoro-dUMP with mammalian normal and tumour and helminthic thymidylate synthases: influence of C(4)-substituents on specificity for enzyme inactivation.
Jolanta M. Dzik, Z. Zieliński, J. Cieśla, Maria Bretner +4 more
1993Biochemical and Biophysical Research Communications - BBRC12 citations
Semantic Scholar
Simultaneous Inhibition of Protein Kinase CK2 and Dihydrofolate Reductase Results in Synergistic Effect on Acute Lymphoblastic Leukemia Cells
P. Wińska, Łukasz Widło, Katarzyna Skierka, Alicja Krzyśko +4 more
2019Anticancer Research11 citations Open access
Semantic Scholar
Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification.
J. Cieśla, T. Frączyk, Z. Zieliński, J. Sikora +1 more
2006Acta Biochimica Polonica11 citations Open access
Semantic Scholar
Mouse thymidylate synthase does not show the inactive conformation, observed for the human enzyme
A. Dowierciał, A. Jarmuła, P. Wilk, W. Rypniewski +4 more
2017Structural Chemistry10 citations Open access
Semantic Scholar
Crystal structure of phosphoramide-phosphorylated thymidylate synthase reveals pSer127, reflecting probably pHis to pSer phosphotransfer.
P. Wilk, A. Jarmuła, T. Ruman, K. Banaszak +4 more
2014Bioorganic chemistry (Print)9 citations
Semantic Scholar
Trichinella spiralis infection enhances protein kinase C phosphorylation in guinea pig alveolar macrophages
J. M. Dzik, Z. Zieliński, J. Cieśla, E. Wałajtys-Rode
2010Parasite immunology (Print)9 citations
Semantic Scholar
Interactions of 2'-fluoro-substituted dUMP analogues with thymidylate synthase.
P. Ziemkowski, K. Felczak, J. Poznański, T. Kulikowski +3 more
2007Biochemical and Biophysical Research Communications - BBRC9 citations
Semantic Scholar
Segmental motions of rat thymidylate synthase leading to half-the-sites behavior.
Monika Świniarska, A. Leś, W. Rode, J. Cieśla +3 more
2010Biopolymers8 citations
Semantic Scholar
Thymidylate synthases from Hymenolepis diminuta and regenerating rat liver: purification, properties, and inhibition by substrate and cofactor analogues.
J. Cieśla, Barbara Gołos, Jolanta M. Dzik, Krzysztof Pawełczak +7 more
1995Biochimica et Biophysica Acta8 citations
Semantic Scholar
Purification and properties of mouse thymus thymidylate synthase. Comparison of the enzyme from mammalian normal and tumour tissues.
W. Rode, J. Cieśla, Z. Zieliński, Barbara Kedzierska
1986International Journal of Biochemistry8 citations
Semantic Scholar
Human dihydrofolate reductase is a substrate of protein kinase CK2α.
Katarzyna Skierka, Paweł Wilamowski, M. Wielechowska, D. Cysewski +4 more
2019Biochemical and Biophysical Research Communications - BBRC7 citations
Semantic Scholar
Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.
A. Jarmuła, P. Wilk, P. Maj, J. Ludwiczak +10 more
2017Journal of Molecular Graphics and Modelling7 citations
Semantic Scholar
Interaction of Thymidylate Synthase with the 5-Thiophosphates, 5-Dithiophosphates, 5-H-Phosphonates and 5-S-Thiosulfates of 2-Deoxyuridine, Thymidine and 5-Fluoro-2-Deoxyuridine
Barbara Gołos, J. M. Dzik, Z. Kazimierczuk, J. Cieśla +6 more
2001Biological chemistry7 citations
Semantic Scholar
Single tryptophan Y160W mutant of homooligomeric E. coli purine nucleoside phosphorylase implies that dimers forming the hexamer are functionally not equivalent
M. Narczyk, Łukasz Mioduszewski, Aleksandra Oksiejuk, M. Winiewska-Szajewska +4 more
2021Scientific Reports6 citations Open access
Semantic Scholar
Interaction of the 5'-phosphates of the anti-HIV agents, 3'-azido-3'-deoxythymidine and 3'-azido-2',3'-dideoxyuridine, with thymidylate synthase.
J. Dzik, Maria Bretner, T. Kulikowski, J. Cieśla +3 more
1988Biochemical and Biophysical Research Communications - BBRC6 citations
Semantic Scholar
Immunofluorescent localization of thymidylate synthase in the development of Trichinella spiralis and Caenorhabditis elegans.
B. Gołos, Magdalena Dabrowska, E. Wałajtys-Rode, Z. Zieliński +5 more
2012Molecular and biochemical parasitology (Print)5 citations
Semantic Scholar
Binding and repression of translation of the cognate mRNA by Trichinella spiralis thymidylate synthase differ from the corresponding interactions of the human enzyme.
J. Cieśla, Elżbieta Jagielska, T. Skopiński, Magdalena Dabrowska +2 more
2005Biochemical Journal5 citations Open access
Semantic Scholar
A QM-MD simulation approach to the analysis of FRET processes in (bio)molecular systems. A case study: complexes of E. coli purine nucleoside phosphorylase and its mutants with formycin A
M. Sobieraj, K. A. Krzyśko, A. Jarmuła, M. Kalinowski +5 more
2015Journal of Molecular Modeling4 citations Open access
Semantic Scholar
Tyrosine nitration affects thymidylate synthase properties.
Elżbieta Dąbrowska-Maś, T. Frączyk, T. Ruman, Karolina Radziszewska +13 more
2012Organic and biomolecular chemistry4 citations
Semantic Scholar
Thymidylate Synthase Heterogeneity Assessed by Monoclonal Antibodies
B. Gołos, E. Wałajtys-Rode, A. Porębska, J. Cieśla +3 more
20024 citations
Semantic Scholar
Crystal structures of thymidylate synthase from nematodes, Trichinella spiralis and Caenorhabditis elegans, as a potential template for species-specific drug design
A. Dowierciał, P. Wilk, W. Rypniewski, T. Frączyk +5 more
20133 citations Open access
Semantic Scholar
Unusual Developmental Pattern of Expression of Enzymes Involved in DNA Biosynthesis in Trichinella spiralis and Trichinella pseudospiralis
Magdalena Dabrowska, B. Gołos, E. Wałajtys-Rode, P. Wińska +4 more
20103 citations
Semantic Scholar
Thymidylate synthase activity in the development of Hymenolepis diminuta.
J. Cieśla, Z. Zieliński, B. Machnicka, W. Rode
1987Acta Biochimica Polonica3 citations
Semantic Scholar
Regulation of oxidative decarboxylation of branched-chain 2-oxo acids in rat liver mitochondria.
J. Cieśla, Elżbieta Waa̵jtys-Rode
1986International Journal of Biochemistry3 citations
Semantic Scholar
Advanced Spectroscopy and APBS Modeling for Determination of the Role of His190 and Trp103 in Mouse Thymidylate Synthase Interaction with Selected dUMP Analogues
M. Prokopowicz, A. Jarmuła, Yannick Casamayou-Boucau, Fiona Gordon +7 more
2021International Journal of Molecular Sciences2 citations Open access
Semantic Scholar
Towards understanding the E. coli PNP binding mechanism and FRET absence between E. coli PNP and formycin A.
M. Prokopowicz, B. Greń, J. Cieśla, B. Kierdaszuk
2017Biophysical Chemistry2 citations
Semantic Scholar
[Primary forms of extralymphatic non-Hodgkin's lymphoma].
Z. Rusinowska, A. Kozaczka, J. Wojnar, I. Lalowicz +6 more
1996Polski tygodnik lekarski2 citations
Semantic Scholar
Phosphorylation of Thymidylate Synthase and Dihydrofolate Reductase in Cancer Cells and the Effect of CK2α Silencing
P. Wińska, A. Sobiepanek, K. Pawlak, M. Staniszewska +1 more
2023International Journal of Molecular Sciences1 citations Open access
Semantic Scholar
Overproduction in bacteria of mouse thymidylate synthase forms with point mutations in N4-hydroxy-dCMP binding site
J. Cieśla, P. Mitkowski, A. Gojdź, A. Jarmuła +1 more
20161 citations
Semantic Scholar
Acanthosis nigricans as a para neoplastic syndrome
M. Krawczyk, J. Cieśla, Aleksandra Kołodziej Jaskuła
20091 citations
Semantic Scholar
THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX
R. Sotelo-Mundo, J. Cieśla, J. Dzik, W. Rode +4 more
19991 citations
Semantic Scholar
Synthesis and antimetabolic properties of 4,5-substituted pyrimidine 2'-deoxynucleosides and their 5'-monophosphates.
T. Kulikowski, M. Bretner, J. Dzik, Z. Zieliński +4 more
1987Nucleic Acids Symposium Series1 citations
Semantic Scholar
A synergistic effect of phosphate, pH and Phe159 substitution on the formycin A association to the E. coli purine nucleoside phosphorylase.
M. Prokopowicz, J. Cieśla, B. Kierdaszuk
2018Biochimie0 citations
Semantic Scholar

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