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Helen L. Wu · SciRah

Researcher profile · Semantic Scholar

Helen L. Wu

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Helen L. Wu — researcher profile on SciRah

h-index: 16
Works: 38
Citations: 1,453

Most-cited papers

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection
G. Chew, T. Fujita, G. Webb, B. Burwitz +17 more
2016PLoS Pathogens312 citations Open access
Semantic Scholar
Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex-E
Scott G. Hansen, Helen L. Wu, B. Burwitz, Colette M. Hughes +24 more
2016Science296 citations Open access
Semantic Scholar
CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14
B. Patterson, H. Seethamraju, Kush Dhody, M. Corley +27 more
2020International Journal of Infectious Diseases134 citations Open access
Semantic Scholar
Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19
B. Patterson, H. Seethamraju, Kush Dhody, M. Corley +20 more
2020medRxiv107 citations Open access
Semantic Scholar
MR1 Restricted Mucosal-Associated Invariant T (MAIT) Cells Respond to Mycobacterial Vaccination and Infection in Nonhuman Primates
Justin M. Greene, P. Dash, Sobhan Roy, Curtis McMurtrey +30 more
2016Mucosal Immunology103 citations Open access
Semantic Scholar
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques
B. Burwitz, J. Wettengel, Martin Muck-Hausl, M. Ringelhan +24 more
2017Nature Communications75 citations Open access
Semantic Scholar
The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques
G. Webb, Jhomary S Molden, K. Busman-Sahay, S. Abdulhaqq +18 more
2020PLoS Pathogens60 citations Open access
Semantic Scholar
Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab
Nicholas Agresti, J. Lalezari, Phillip P. Amodeo, K. Mody +13 more
2021Journal of Translational Autoimmunity55 citations Open access
Semantic Scholar
TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells.
J. Chow, M. Ban, Helen L. Wu, Flang Nguyen +4 more
2010American Journal of Physiology - Gastrointestinal and Liver Physiology51 citations Open access
Semantic Scholar
The role of MHC-E in T cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques
Helen L. Wu, R. Wiseman, Colette M. Hughes, G. Webb +18 more
2017Journal of Immunology50 citations Open access
Semantic Scholar
MHC-E-restricted CD8+ T cells target Hepatitis B virus-infected human hepatocytes
B. Burwitz, Patrick K Hashiguchi, Mandana Mansouri, C. Meyer +10 more
2020Journal of Immunology27 citations Open access
Semantic Scholar
Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected anti-retroviral therapy-suppressed macaques
Helen L. Wu, K. Busman-Sahay, W. Weber, Courtney M. Waytashek +39 more
2023Immunity25 citations
Semantic Scholar
Cytomegalovirus Vaccine-induced Unconventional T cell Priming and Control of SIV Replication is Conserved Between Primate Species
Daniel Malouli, Roxanne M. Gilbride, Helen L. Wu, Joseph M. Hwang +29 more
2022Cell Host and Microbe24 citations Open access
Semantic Scholar
Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
B. Burwitz, Helen L. Wu, S. Abdulhaqq, C. Shriver-Munsch +25 more
2017Nature Communications23 citations Open access
Semantic Scholar
CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab
Xiao-lin Chang, Helen L. Wu, G. Webb, M. Tiwary +17 more
2021Frontiers in Immunology22 citations Open access
Semantic Scholar
Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
Xiao-lin Chang, G. Webb, Helen L. Wu, Justin M. Greene +29 more
2021Nature Communications21 citations Open access
Semantic Scholar
Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species
Xiao-lin Chang, J. Reed, G. Webb, Helen L. Wu +30 more
2022PLoS Pathogens15 citations Open access
Semantic Scholar
Viral opportunistic infections in Mauritian cynomolgus macaques undergoing allogeneic stem cell transplantation mirror human transplant infectious disease complications
Helen L. Wu, W. Weber, C. Shriver-Munsch, Tonya Swanson +25 more
2020Xenotransplantation13 citations Open access
Semantic Scholar
Identification and spontaneous immune targeting of an endogenous retrovirus K envelope protein in the Indian rhesus macaque model of human disease
Helen L. Wu, Enrique J. Léon, Lyle T Wallace, Francesca A. Nimiyongskul +7 more
2016Retrovirology10 citations Open access
Semantic Scholar
Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques
M. Chan, M. Tiwary, Helen L. Wu, N. Tailor +16 more
2022Journal of Virology7 citations Open access
Semantic Scholar
8th IAS Conference on HIV Pathogenesis, Treatment & Prevention 19–22 July 2015, Vancouver, Canada
Kelly A. Metcalf Pate, Christopher W. Pohlmeyer, Victoria Walker-Sperling, J. Foote +496 more
2015Journal of the International AIDS Society5 citations Open access
Semantic Scholar
FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques
Joanna Zikos, G. Webb, Helen L. Wu, Jason Reed +7 more
2024mAbs4 citations Open access
Semantic Scholar
Identification and Characterization of Antigen-Specific CD8+ T Cells Using Surface-Trapped TNF-α and Single-Cell Sequencing
S. Abdulhaqq, Abigail B. Ventura, J. Reed, A. Bashirova +16 more
2021Journal of Immunology4 citations Open access
Semantic Scholar
Terumo Spectra Optia leukapheresis of cynomolgus macaques for hematopoietic stem cell and T cell collection
Helen L. Wu, Justin M. Greene, Tonya Swanson, C. Shriver-Munsch +14 more
2020Journal of clinical apheresis4 citations Open access
Semantic Scholar
Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+ T Cells in Nonhuman Primates
S. Abdulhaqq, Helen L. Wu, John B. Schell, Katherine B. Hammond +9 more
2019Journal of Virology4 citations Open access
Semantic Scholar
Adeno-associated virus gene therapy-mediated CCR5 blockade suppresses virus replication long term in SHIV-infected macaques.
Helen L. Wu, G. Webb, S. Fuchs, Cleiton T. Pessoa +29 more
2026Science Translational Medicine2 citations
Semantic Scholar
Identification of Vancomycin Resistance in Methicillin-resistant Staphylococcus aureus in two macaque species and decolonization and long-term prevention of recolonization in Cynomolgus Macaques (Macaca fascicularis)
R. Bochart, K. Armantrout, Hugh B Crank, Rachael Tonelli +7 more
2023Frontiers in Immunology2 citations Open access
Semantic Scholar
Tertiary Mutations Stabilize CD8+ T Lymphocyte Escape-Associated Compensatory Mutations following Transmission of Simian Immunodeficiency Virus
B. Burwitz, Helen L. Wu, J. Reed, Katherine B. Hammond +11 more
2013Journal of Virology2 citations Open access
Semantic Scholar
A model of lymphocryptovirus-associated post-transplant lymphoproliferative disorder in immunosuppressed Mauritian cynomolgus macaques
Helen L. Wu, W. Weber, Courtney M. Waytashek, C. Boyle +25 more
2024PLoS Pathogens1 citations
Semantic Scholar
Characterization of the urinary DNA virome of hematopoietic stem cell transplant recipient and healthy cynomolgus macaques
H. Vogel, Tristan T Neal, Helen L. Wu, Kaitlyn A. Kukula +3 more
2026bioRxiv0 citations Open access
Semantic Scholar
An ER stress-responsive RNA rheostat for Programmable Gene and mRNA therapies
Roza Ogurlu, Eliya B Sanchez, Joshua A. Hull, Sophia Fergione +10 more
2026Cell Chemical Biology0 citations Open access
Semantic Scholar
IgM-and IgG-cleaving enzyme facilitates AAV gene transfer in AAV-seropositive macaques
Helen L. Wu, Z. Elmore, Mark A. Ochoa, Allyson J. McCullen +15 more
2026Frontiers in Immunology0 citations Open access
Semantic Scholar
An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation
Sebastian Benjamin, G. McElfresh, Maanasa Kaza, Gregory J. Boggy +23 more
2025Frontiers in Immunology0 citations Open access
Semantic Scholar
Sequence Analysis of microRNAs Encoded by Simian Lymphocryptoviruses
Yan Chen, Devin N. Fachko, Helen L. Wu, J. Sacha +1 more
2024Viruses0 citations Open access
Semantic Scholar
OP 2.1 CCR5 in HIV Prevention and Cure
Helen L. Wu, G. Webb, J. Sacha
2022Journal of virus eradication0 citations Open access
Semantic Scholar
Donor T cell chimerism correlates with viral reservoir clearance following allogeneic stem cell transplantation in fully cART-suppressed Mauritian cynomolgus macaques
Helen L. Wu, W. Weber, S. Abdulhaqq, C. Shriver-Munsch +21 more
20190 citations Open access
Semantic Scholar
MHC-E-Restricted CD8+ T Cell Responses Elicited by Rhesus Cytomegalovirus Vaccine Vectors
Helen L. Wu
20160 citations
Semantic Scholar
TGF- (cid:1) downregulates PTEN via activation of NF- (cid:2) B in pancreatic cancer cells
J. Chow, M. Ban, Helen L. Wu, Flang Nguyen +4 more
20100 citations
Semantic Scholar
164 NF-κB Mediates TGFβ-Induced PTEN Suppression in Human Pancreatic Cancer Cells via SMAD-Independent Signaling
J. Chow, M. Ban, Helen L. Wu, Heekyung Chung +1 more
20090 citations
Semantic Scholar

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