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J. Crean · SciRah

Researcher profile · Semantic Scholar

J. Crean

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J. Crean — researcher profile on SciRah

h-index: 25
Works: 59
Citations: 1,962

Most-cited papers

Matrix Metalloproteinases in the Human Intervertebral Disc: Role in Disc Degeneration and Scoliosis
J. Crean, S. Roberts, D. Jaffray, S. Eisenstein +1 more
1997Spine223 citations
Semantic Scholar
The Role of p42/44 MAPK and Protein Kinase B in Connective Tissue Growth Factor Induced Extracellular Matrix Protein Production, Cell Migration, and Actin Cytoskeletal Rearrangement in Human Mesangial Cells*
J. Crean, D. Finlay, M. Murphy, C. Moss +3 more
2002Journal of Biological Chemistry161 citations Open access
Semantic Scholar
Changes in Collagen Cross‐Linking in Degenerative Disc Disease and Scoliosis
V. Duance, J. Crean, T. Sims, N. Avery +4 more
1998Spine156 citations
Semantic Scholar
Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro.
R. Kirwan, C. Fenerty, J. Crean, R. Wordinger +2 more
2005Molecular Vision146 citations
Semantic Scholar
Lipoxin A4 Redistributes Myosin IIA and Cdc42 in Macrophages: Implications for Phagocytosis of Apoptotic Leukocytes1
Keira Reville, J. Crean, Sharon Vivers, I. Dransfield +1 more
2006Journal of Immunology107 citations Open access
Semantic Scholar
Effect of Cyclical Mechanical Stretch and Exogenous Transforming Growth Factor-β1 on Matrix Metalloproteinase-2 Activity in Lamina Cribrosa Cells from the Human Optic Nerve Head
R. Kirwan, J. Crean, C. Fenerty, A. Clark +1 more
2004Journal of glaucoma103 citations
Semantic Scholar
Connective tissue growth factor is increased in pseudoexfoliation glaucoma.
J. Browne, S. Ho, R. Kane, N. Oliver +3 more
2011Investigative Ophthalmology and Visual Science102 citations
Semantic Scholar
CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy
Brian Rooney, Helen C. O'Donovan, Andrew Gaffney, Marie B. Browne +6 more
2011FEBS Letters76 citations Open access
Semantic Scholar
Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization
J. Crean, F. Furlong, D. Finlay, D. Mitchell +5 more
2004The FASEB Journal72 citations
Semantic Scholar
Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells*
Giorgio Oliviero, Gerard L. Brien, A. Waston, G. Streubel +8 more
2016Molecular & Cellular Proteomics69 citations Open access
Semantic Scholar
Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells.
K. Nyhan, Noel Faherty, Gregg Murray, Laurence Berubé Cooey +3 more
2010Biochimica et Biophysica Acta67 citations Open access
Semantic Scholar
Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells.
D. Wallace, A. Clark, K. Lipson, D. Andrews +2 more
2013Investigative Ophthalmology and Visual Science61 citations
Semantic Scholar
CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGF&bgr; type II receptor with implications for nephropathic cell phenotypes
Noel Faherty, S. Curran, Helen C. O'Donovan, F. Martin +3 more
2012Journal of Cell Science55 citations Open access
Semantic Scholar
Connective tissue growth factor: an attractive therapeutic target in fibrotic renal disease
H. Brady, J. Crean, C. Godson, D. Lappin
2001Expert opinion on therapeutic targets42 citations
Semantic Scholar
Metastasis Suppressor microRNA-335 Targets the Formin Family of Actin Nucleators
J. Lynch, M. Meehan, J. Crean, J. Copeland +2 more
2013PLoS ONE38 citations Open access
Semantic Scholar
Regulation and consequences of differential gene expression in diabetic kidney disease.
M. Murphy, J. Crean, D. Brazil, D. Sadlier +2 more
2008Biochemical Society Transactions38 citations
Semantic Scholar
Comparative analysis of DNA methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines
E. Brennan, M. Ehrich, D. Brazil, J. Crean +8 more
2009Epigenetics34 citations Open access
Semantic Scholar
Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.
H. Beaton, D. Andrews, Martin E. M. Parsons, M. Murphy +10 more
2016AJP - Renal Physiology32 citations
Semantic Scholar
Formation of hydrated PEG layers on magnetic iron oxide nanoflowers shows internal magnetisation dynamics and generates high in-vivo efficacy for MRI and magnetic hyperthermia
Eoin P. McKiernan, Cara Moloney, T. R. Chaudhuri, Shane Clerkin +4 more
2022Acta Biomaterialia31 citations Open access
Semantic Scholar
DNA methylation profiling in cell models of diabetic nephropathy
E. Brennan, M. Ehrich, Helen C. O'Donovan, D. Brazil +8 more
2010Epigenetics30 citations Open access
Semantic Scholar
Growth and differentiation of human induced pluripotent stem cell (hiPSC)-derived kidney organoids using fully synthetic peptide hydrogels
Niall J. Treacy, Shane Clerkin, Jessica L. Davis, Ciarán Kennedy +5 more
2022Bioactive Materials28 citations Open access
Semantic Scholar
Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B‐mediated phosphorylation and cytoplasmic translocation of p27Kip‐1
J. Crean, F. Furlong, D. Mitchell, E. Mcardle +2 more
2006The FASEB Journal28 citations
Semantic Scholar
Spatiotemporally Resolved Heat Dissipation in 3D Patterned Magnetically Responsive Hydrogels.
Patricia Monks, Jacek K. Wychowaniec, Eoin P. McKiernan, Shane Clerkin +5 more
2020Small27 citations Open access
Semantic Scholar
Growth and differentiation of human induced pluripotent stem cell (hiPSC) derived kidney organoids using fully synthetic peptide hydrogels
Niall J. Treacy, Shane Clerkin, Jessica L. Davis, Ciarán Kennedy +5 more
2022The FASEB Journal26 citations
Semantic Scholar
Emerging Transcriptional Mechanisms in the Regulation of Epithelial to Mesenchymal Transition and Cellular Plasticity in the Kidney
Letizia De Chiara, J. Crean
2016Journal of Clinical Medicine26 citations Open access
Semantic Scholar
Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose.
F. Furlong, J. Crean, Laura Thornton, R. O'Leary +2 more
2007AJP - Renal Physiology22 citations
Semantic Scholar
Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy
Michelle B. Hookham, Helen C. O'Donovan, Rachel H. Church, Annie Mercier-Zuber +9 more
2013The FEBS Journal21 citations Open access
Semantic Scholar
Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest
James D. Smith, M. Meehan, J. Crean, A. McCann
2011Cellular and Molecular Life Sciences21 citations Open access
Semantic Scholar
Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells.
Helen C. O'Donovan, Fionnuala B. Hickey, D. Brazil, D. Kavanagh +4 more
2012Biochemical Journal19 citations Open access
Semantic Scholar
Haplotype association analysis of genes within the WNT signalling pathways in diabetic nephropathy
D. Kavanagh, D. Savage, C. Patterson, A. McKnight +3 more
2013BMC Nephrology18 citations Open access
Semantic Scholar
TGFβ and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation
Noel Faherty, Helen C. O'Donovan, D. Kavanagh, S. Madden +5 more
2013BMC Genomics17 citations Open access
Semantic Scholar
Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids
Jessica L. Davis, Ciarán Kennedy, Shane Clerkin, Niall J. Treacy +10 more
2022Communications Biology16 citations Open access
Semantic Scholar
Bioinformatic Evaluation of Transcriptional Regulation of WNT Pathway Genes with reference to Diabetic Nephropathy
G. Mckay, D. Kavanagh, J. Crean, A. Maxwell
2015Journal of Diabetes Research13 citations Open access
Semantic Scholar
Association Analysis of Canonical Wnt Signalling Genes in Diabetic Nephropathy
D. Kavanagh, D. Savage, C. Patterson, A. McKnight +3 more
2011PLoS ONE13 citations Open access
Semantic Scholar
The Role of Mitochondria in Optic Atrophy With Autosomal Inheritance
Elin L Strachan, Delphi Mac White-Begg, J. Crean, Alison L. Reynolds +2 more
2021Frontiers in Neuroscience11 citations Open access
Semantic Scholar
Unravelling the transcriptional responses of TGF‐β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification
D. Andrews, Giorgio Oliviero, Letizia De Chiara, Ariane Watson +10 more
2019The FASEB Journal9 citations Open access
Semantic Scholar
TGFβ and CCN 2 / CTGF mediate actin related gene expression by differential E 2 F 1 / CREB activation
Noel Faherty, O. Helen, Donovan, D. Kavanagh +6 more
20133 citations
Semantic Scholar
TGFβ and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation
Noel Faherty, Helen C. O'Donovan, D. Kavanagh, Stephen Madden +5 more
2013BMC Genomics1 citations Open access
Semantic Scholar
Anti-Connective Tissue Growth Factor Antibody Therapy Combats Expression of Fibrotic Genes in Glaucoma
D. Wallace, A. Clark, N. Oliver, J. Crean +1 more
20121 citations
Semantic Scholar
Not All Radiolucent Images Are Pathological Lesions (Stafne Cyst). Report of Two Cases
W. Terro, J. Crean
20061 citations
Semantic Scholar
Gelatin Methacryloyl (GelMA) as a Suitable Three‐Dimensional Extracellular Environment for the Derivation of hiPSC‐Derived Kidney Organoids
Shane Clerkin, Jacek K. Wychowaniec, Krutika Singh, Jessica L. Davis +4 more
2022The FASEB Journal0 citations
Semantic Scholar
Integrated single cell RNA‐seq and ATAC‐seq of iPSC‐derived kidney organoids reveals the complexity of TGFβ signalling to chromatin during the origin of fibroblasts
Jessica L. Davis, Ciarán Kennedy, Shane Clerkin, Niall J. Treacy +9 more
2022The FASEB Journal0 citations
Semantic Scholar
Magnetic Hydrogels: Spatiotemporally Resolved Heat Dissipation in 3D Patterned Magnetically Responsive Hydrogels (Small 5/2021)
Patricia Monks, Jacek K. Wychowaniec, Eoin P. McKiernan, Shane Clerkin +5 more
20210 citations Open access
Semantic Scholar
Corrigendum: miR302 regulates SNAI1 expression to control mesangial cell plasticity
Letizia De Chiara, D. Andrews, Ariane Watson, Giorgio Oliviero +2 more
2017Scientific Reports0 citations Open access
Semantic Scholar
Mechanism and Treatment of Kidney Fibrosis Wnt 6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis
H. Beaton, D. Andrews, Martin E. M. Parsons, M. Murphy +10 more
20160 citations
Semantic Scholar
Mechanism and Treatment of Kidney Fibrosis Wnt 6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis X
H. Beaton, D. Andrews, Martin E. M. Parsons, M. Murphy +10 more
20160 citations
Semantic Scholar
miR-302 regulates retinal epithelial cell fate; New insights into TGFβ signalling reveal a role for for the polycomb protein EZH2.
D. Andrews, Noel Faherty, G. Oliverio, C. O'Brien +2 more
20140 citations
Semantic Scholar
Genetic association analysis of WNT signalling pathway genes in diabetic nephropathy.
G. Mckay, D. Kavanagh, D. Savage, C. Patterson +4 more
20130 citations
Semantic Scholar
The retinal pigmented epithelial cell and peripapillary atrophy: potential mediators of glaucomatous optic disc cupping?
E. Hughes, N. Docherty, J. Crean, A. Clark +2 more
20130 citations
Semantic Scholar
Connective Tissue Growth Factor Induction of Lysl Oxidase (LOX) Enzyme Expression in Human Trabecular Meshwork Cells is reduced by FG-3019
D. Wallace, A. Clark, N. Oliver, J. Crean +1 more
20130 citations
Semantic Scholar

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