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I. Sevrioukova · SciRah

Researcher profile · Semantic Scholar

I. Sevrioukova

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I. Sevrioukova — researcher profile on SciRah

h-index: 32
Works: 120
Citations: 3,716

Most-cited papers

Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation
I. Sevrioukova
2011Antioxidants and Redox Signaling338 citations Open access
Semantic Scholar
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
I. Sevrioukova, T. Poulos
2010Proceedings of the National Academy of Sciences of the United States of America278 citations Open access
Semantic Scholar
Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor.
D. Ghezzi, I. Sevrioukova, F. Invernizzi, C. Lamperti +6 more
2010American Journal of Human Genetics216 citations Open access
Semantic Scholar
UNDERSTANDING THE MECHANISM OF CYTOCHROME P450 3A4: RECENT ADVANCES AND REMAINING PROBLEMS
I. Sevrioukova, T. Poulos
2012Dalton Transactions153 citations Open access
Semantic Scholar
Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.
C. Rinaldi, C. Grunseich, I. Sevrioukova, Alice B. Schindler +10 more
2012American Journal of Human Genetics142 citations Open access
Semantic Scholar
Structural and Mechanistic Insights into the Interaction of Cytochrome P4503A4 with Bromoergocryptine, a Type I Ligand*
I. Sevrioukova, T. Poulos
2011Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4
I. Sevrioukova, T. Poulos
2016Proceedings of the National Academy of Sciences of the United States of America105 citations Open access
Semantic Scholar
Photoreduction of the active site of the metalloprotein putidaredoxin by synchrotron radiation.
Mary C. Corbett, M. Latimer, T. Poulos, I. Sevrioukova +2 more
2007Acta Crystallographica Section D: Biological Crystallography91 citations
Semantic Scholar
Redox-dependent Changes in Molecular Properties of Mitochondrial Apoptosis-inducing Factor*
I. Y. Churbanova, I. Sevrioukova
2008Journal of Biological Chemistry89 citations Open access
Semantic Scholar
Dissecting cytochrome P450 3A4-ligand interactions using ritonavir analogues.
I. Sevrioukova, T. Poulos
2013Biochemistry86 citations Open access
Semantic Scholar
Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir
I. Sevrioukova, T. Poulos
2013Journal of Medicinal Chemistry69 citations Open access
Semantic Scholar
Redox-linked Conformational Dynamics in Apoptosis Inducing Factor
I. Sevrioukova
2009Journal of Molecular Biology68 citations Open access
Semantic Scholar
Interaction of human cytochrome P4503A4 with ritonavir analogs
I. Sevrioukova, T. Poulos
2012Archives of Biochemistry and Biophysics60 citations Open access
Semantic Scholar
Structure/Function Relations in AIFM1 Variants Associated with Neurodegenerative Disorders.
I. Sevrioukova
2016Journal of Molecular Biology57 citations Open access
Semantic Scholar
Structural Biology of Redox Partner Interactions in P450cam Monooxygenase: A Fresh Look at an Old System
I. Sevrioukova, T. Poulos
2010Archives of Biochemistry and Biophysics56 citations Open access
Semantic Scholar
Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4
Nicholas P Toupin, S. Steinke, S. Nadella, Ao Li +5 more
2021Journal of the American Chemical Society55 citations Open access
Semantic Scholar
High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4
I. Sevrioukova
2017Biochemistry51 citations Open access
Semantic Scholar
Anion-Dependent Stimulation of CYP3A4 Monooxygenase.
I. Sevrioukova, T. Poulos
2015Biochemistry51 citations Open access
Semantic Scholar
Heme Binding Biguanides Target Cytochrome P450 Dependent Cancer Cell Mitochondria
Zhi-Jun Guo, I. Sevrioukova, I. Denisov, Xia Zhang +33 more
2017Cell Chemical Biology37 citations Open access
Semantic Scholar
Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanism
I. Sevrioukova, T. Poulos
2014Current Topics in Medicinal Chemistry37 citations Open access
Semantic Scholar
Electron Transfer between Cytochrome P450cin and Its FMN-containing Redox Partner, Cindoxin*
N. Kimmich, Aditi Das, I. Sevrioukova, Y. Meharenna +2 more
2007Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Interaction of human drug-metabolizing CYP3A4 with small inhibitory molecules
I. Sevrioukova
2019Biochemistry34 citations Open access
Semantic Scholar
Crystal Structure of the Putidaredoxin Reductase·Putidaredoxin Electron Transfer Complex*
I. Sevrioukova, T. Poulos, I. Y. Churbanova
2010Journal of Biological Chemistry30 citations Open access
Semantic Scholar
Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6′,7′-Dihydroxybergamottin
I. Sevrioukova
2019International Journal of Molecular Sciences29 citations Open access
Semantic Scholar
Inhibition of human CYP3A4 by rationally designed ritonavir-like compounds: Impact and interplay of the side group functionalities
E. Samuels, I. Sevrioukova
2017Molecular Pharmaceutics26 citations Open access
Semantic Scholar
Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase
P. Mukherjee, Hui-Ying Li, I. Sevrioukova, G. Chreifi +4 more
2014Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Key Role of the Adenylate Moiety and Integrity of the Adenylate-Binding Site for the NAD(+)/H Binding to Mitochondrial Apoptosis-Inducing Factor.
L. Sorrentino, A. Calogero, V. Pandini, M. Vanoni +2 more
2015Biochemistry24 citations
Semantic Scholar
Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding
I. Sevrioukova
2023Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.
Zhi-Jun Guo, I. Sevrioukova, I. Denisov, Xia Zhang +33 more
2017Cell Chemical Biology22 citations Open access
Semantic Scholar
Redox reactions of the FAD-containing apoptosis-inducing factor (AIF) with quinoidal xenobiotics: a mechanistic study
Lina Misevičienė, Ž. Anusevičius, J. Šarlauskas, I. Sevrioukova +1 more
2011Archives of Biochemistry and Biophysics21 citations Open access
Semantic Scholar
Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity
Yu-Jie Chen, Jian Zhang, Pingping Zhu, Xian Tan +10 more
2019Drug Metabolism And Disposition19 citations Open access
Semantic Scholar
Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions
I. Sevrioukova, T. Poulos
2015Advances in Experimental Medicine and Biology17 citations
Semantic Scholar
Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase
J. Ducharme, I. Sevrioukova, C. Thibodeaux, K. Auclair
2021bioRxiv16 citations Open access
Semantic Scholar
Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength
E. Samuels, I. Sevrioukova
2021International Journal of Molecular Sciences15 citations Open access
Semantic Scholar
Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution
Shih-Wei Chuo, S. Liou, Lee-Ping Wang, R. Britt +3 more
2019Biochemistry15 citations Open access
Semantic Scholar
An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4
E. Samuels, I. Sevrioukova
2020Bioorganic & Medicinal Chemistry14 citations Open access
Semantic Scholar
Innovative C2-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4
A. Paquin, Y. Oufqir, I. Sevrioukova, C. Reyes-Moreno +1 more
2021European journal of medicinal chemistry12 citations Open access
Semantic Scholar
Production and characterization of a functional putidaredoxin reductase-putidaredoxin covalent complex.
I. Y. Churbanova, T. Poulos, I. Sevrioukova
2010Biochemistry12 citations
Semantic Scholar
Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP3A7
I. Sevrioukova
2021International Journal of Molecular Sciences11 citations Open access
Semantic Scholar
Human CYP3A4 bound to an inhibitor
E. Samuels, I. Sevrioukova
201910 citations
Semantic Scholar
Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High-Affinity Ligand Binding Site
I. Sevrioukova
2022International Journal of Molecular Sciences9 citations Open access
Semantic Scholar
Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency
V. Polić, I. Sevrioukova, K. Auclair
2018Archives of Biochemistry and Biophysics9 citations Open access
Semantic Scholar
Unexpected Differences between Two Closely Related Bacterial P450 Camphor Monooxygenases
V. Murarka, D. Batabyal, J. A. Amaya, I. Sevrioukova +1 more
2020Biochemistry8 citations Open access
Semantic Scholar
Structure-activity relationships of rationally designed ritonavir analogs: Impact of side-group stereochemistry, head-group spacing, and backbone composition on the interaction with CYP3A4
E. Samuels, I. Sevrioukova
2019Biochemistry8 citations Open access
Semantic Scholar
Interaction of CYP3A4 with the inhibitor cobicistat: Structural and mechanistic insights and comparison with ritonavir
I. Sevrioukova
2024Archives of Biochemistry and Biophysics7 citations Open access
Semantic Scholar
Mixed Ru(II)−Ir(III) Complexes as Photoactive Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4
Justin J Ahrens, Madeline Denison, Santana P Garcia, S. Gupta +4 more
2024Inorganic Chemistry7 citations Open access
Semantic Scholar
Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4
Madeline Denison, Justin J Ahrens, Marilyn N. Dunbar, Habon Warmahaye +5 more
2023Inorganic Chemistry7 citations Open access
Semantic Scholar
Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment
E. Samuels, I. Sevrioukova
2022International Journal of Molecular Sciences7 citations Open access
Semantic Scholar
Direct Synthesis of α-Thio Aromatic Acids from Aromatic Amino Acids
E. Samuels, I. Sevrioukova
2018Tetrahedron Letters7 citations Open access
Semantic Scholar
Ir(III)-Based Agents for Monitoring the Cytochrome P450 3A4 Active Site Occupancy
Madeline Denison, S. Steinke, A. Majeed, C. Turro +3 more
2022Inorganic Chemistry6 citations Open access
Semantic Scholar

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