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Christian Orrenius · SciRah

Researcher profile · Semantic Scholar

Christian Orrenius

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Christian Orrenius — researcher profile on SciRah

h-index: 17
Works: 39
Citations: 1,939

Most-cited papers

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.
P. Magnaghi, R. D'Alessio, B. Valsasina, N. Avanzi +20 more
2013Nature Chemical Biology373 citations
Semantic Scholar
Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone).
G. Bellomo, F. Mirabelli, D. Dimonte, P. Richelmi +3 more
1987Biochemical Pharmacology267 citations
Semantic Scholar
Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor.
M. Menichincheri, E. Ardini, P. Magnaghi, N. Avanzi +25 more
2016Journal of Medicinal Chemistry262 citations Open access
Semantic Scholar
Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat.
Jing’an Lu, K. Crimin, J. Goodwin, P. Crivori +8 more
2004Journal of Medicinal Chemistry157 citations
Semantic Scholar
CHIRAL RECOGNITION OF ALCOHOL ENANTIOMERS IN ACYL TRANSFER REACTIONS CATALYSED BY CANDIDA ANTARCTICA LIPASE B
Christian Orrenius, Fredrik Hbffner, D. Rotticci, Niklas Öhrner +2 more
1998103 citations
Semantic Scholar
Molecular recognition of sec-alcohol enantiomers by Candida antarctica lipase B
D. Rotticci, Fredrik Hæffner, Christian Orrenius, T. Norin +1 more
199894 citations
Semantic Scholar
Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.
P. Polucci, P. Magnaghi, M. Angiolini, D. Asa +22 more
2013Journal of Medicinal Chemistry87 citations Open access
Semantic Scholar
The Candida antarctica lipase B catalysed kinetic resolution of seudenol in non-aqueous media of controlled water activity
Christian Orrenius, T. Norin, K. Hult, G. Carrea
199576 citations
Semantic Scholar
Kinetic resolutions of amine and thiol analogues of secondary alcohols catalyzed by the Candida antarctica lipase B
Niklas Öhrner, Christian Orrenius, A. Mattson, T. Norin +1 more
199673 citations
Semantic Scholar
Afatinib Is a New Therapeutic Approach in Chordoma with a Unique Ability to Target EGFR and Brachyury
P. Magnaghi, B. Salom, L. Cozzi, N. Amboldi +14 more
2017Molecular Cancer Therapeutics67 citations
Semantic Scholar
Preparation of a Novel Cross-Linked Polymer for Second-Order Nonlinear Optics
M. Trollsås, Christian Orrenius, F. Sahlén, U. Gedde +7 more
199657 citations
Semantic Scholar
Candida antarctica lipase B catalysed kinetic resolutions: Substrate structure requirements for the preparation of enantiomerically enriched secondary alcanols
Christian Orrenius, Niklas Öhrner, D. Rotticci, A. Mattson +2 more
199556 citations
Semantic Scholar
Enantiomerically enriched bifunctional sec-alcohols prepared by Candida antarctica lipase B catalysis. Evidence of non-steric interactions
D. Rotticci, Christian Orrenius, K. Hult, T. Norin
199751 citations
Semantic Scholar
Model based on GRID-derived descriptors for estimating CYP3A4 enzyme stability of potential drug candidates
P. Crivori, I. Zamora, Bill Speed, Christian Orrenius +1 more
2004J. Comput. Aided Mol. Des.39 citations
Semantic Scholar
Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases.
F. Casuscelli, E. Ardini, N. Avanzi, E. Casale +15 more
2013Bioorganic & Medicinal Chemistry34 citations Open access
Semantic Scholar
Linear and Nonlinear Methods in Modeling the Aqueous Solubility of Organic Compounds
C. Catana, Hua Gao, Christian Orrenius, P. Stouten
2005Journal of Chemical Information and Modeling31 citations
Semantic Scholar
Preparation of 1-pyridinylethanols of high enantiomeric purity by lipase catalysed transesterifications
Christian Orrenius, A. Mattson, T. Norin, Niklas Öhrner +1 more
199425 citations
Semantic Scholar
Kinetic resolution of chiral auxiliaries with C-2-symmetry by lipase-catalyzed alcoholysis and aminolysis
A. Mattson, Christian Orrenius, Niklas Öhrner, C. Unelius +2 more
199617 citations Open access
Semantic Scholar
The generation of purinome-targeted libraries as a means to diversify ATP-mimetic chemical classes for lead finding
E. Felder, Alessandra Badari, T. Disingrini, S. Mantegani +4 more
2012Molecular diversity15 citations
Semantic Scholar
Simple conformation space search protocols for the evaluation of enantioselectivity of lipases.
Christian Orrenius, Caroline van Heusden, J. Vanruiten, P. L. Antoine Overbeeke +3 more
1998Protein Engineering15 citations
Semantic Scholar
Second-harmonic generation in a novel crosslinked pyroelectric liquid crystal polymer (PLCP)
D. Hermann, P. Rudquist, S. Lagerwall, L. Komitov +8 more
199813 citations
Semantic Scholar
ENANTIOSELECTIVE PREPARATION OF THE STEREOISOMERS OF 4-METHYLHEPTAN-3-OL USING CANDIDA ANTARCTICA LIPASE B
C. Unelius, J. Sandell, Christian Orrenius
19988 citations
Semantic Scholar
Stereoselective synthesis of 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as PIM kinase inhibitors inspired from marine alkaloids.
F. Casuscelli, E. Ardini, N. Avanzi, Alessandra Badari +13 more
2022Chirality5 citations
Semantic Scholar
Correction to Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor.
M. Menichincheri, E. Ardini, P. Magnaghi, N. Avanzi +25 more
2019Journal of Medicinal Chemistry5 citations
Semantic Scholar
Molecular Dynamics Simulations of p97 Including Covalent, Allosteric and ATP-Competitive Inhibitors
S. Rendine, Christian Orrenius, F. Dapiaggi, S. Pieraccini +6 more
2019Acta Chimica Slovenica2 citations Open access
Semantic Scholar
Molecular Dynamics Simulations of p97 Including Covalent, Allosteric and ATP-competitive Inhibitors.
S. Rendine, Christian Orrenius, F. Dapiaggi, S. Pieraccini +6 more
2019Acta Chimica Slovenica2 citations Open access
Semantic Scholar
Enantioselective Preparation of the Stereoisomers of 4‐Methylheptan‐3‐ol Using Candida antarctica Lipase B.
C. Unelius, J. Sandell, Christian Orrenius
20102 citations
Semantic Scholar
Linear and Nonlinear Methods in Modeling the Aqueous Solubility of Organic Compounds.
C. Catana, Hua Gao, Christian Orrenius, P. Stouten
20052 citations
Semantic Scholar
Phospholipid transphosphatidylation catalysed by cabbage phospholipase D in emulsion systems
Christian Orrenius, M. Norin, A. Persson, K. Hult +3 more
19932 citations Open access
Semantic Scholar
Identification of Unprecedented ATP-competitive Choline Kinase Inhibitors.
F. Quartieri, M. Nesi, N. Avanzi, D. Borghi +17 more
2021Bioorganic & Medicinal Chemistry Letters1 citations Open access
Semantic Scholar
Kinetic Resolution of Chiral Auxiliaries with C2‐Symmetry by Lipase‐ Catalyzed Alcoholysis and Aminolysis.
A. Mattson, Christian Orrenius, N. Oehrner, C. Unelius +2 more
19971 citations
Semantic Scholar
Candida antarctica Lipase B Catalyzed Kinetic Resolutions: Substrate Structure Requirements for the Preparation of Enantiomerically Enriched Secondary Alkanols.
Christian Orrenius, N. Oehrner, D. Rotticci, A. Mattson +2 more
19951 citations
Semantic Scholar
Correcting CFTR mRNA splicing defects with the plant cytokine kinetin and its analogues.
V. Rimoldi, G. Soldà, Anita Capalbo, Elena Saba +13 more
2025Journal of Cystic Fibrosis0 citations Open access
Semantic Scholar
Abstract 4790: Identification and characterization of ATP-mimetic choline kinase inhibitors
P. Gnocchi, F. Quartieri, Alessandra Badari, R. Bosotti +16 more
2019Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Crystal structure of the ALK kinase domain in complex with Cmpd 17
R. Bossi, G. Canevari, M. Fasolini, M. Menichincheri +25 more
20160 citations
Semantic Scholar
Crystal structure of the ALK kinase domain in complex with Entrectinib
R. Bossi, G. Canevari, M. Fasolini, M. Menichincheri +25 more
20160 citations
Semantic Scholar
The generation of purinome-targeted libraries as a means to diversify ATP-mimetic chemical classes for lead finding
E. Felder, Alessandra Badari, T. Disingrini, S. Mantegani +4 more
2012Molecular diversity0 citations
Semantic Scholar
Enantiomerically Enriched Bifunctional sec‐Alcohols Prepared by Candida antarctica Lipase B Catalysis. Evidence of Non‐Steric Interactions.
D. Rotticci, Christian Orrenius, K. Hult, T. Norin
19970 citations
Semantic Scholar
Preparation of 1-Pyridinylethanols of High Enantiomeric Purity by Lipase-Catalyzed Transesterifications.
Christian Orrenius, A. Mattson, T. Norin, N. Oehrner +1 more
19940 citations
Semantic Scholar

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