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W. Xia · SciRah

Researcher profile · Semantic Scholar

W. Xia

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W. Xia — researcher profile on SciRah

h-index: 25
Works: 49
Citations: 3,646

Most-cited papers

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
W. Xia, R. Mullin, B. Keith, Lei-Hua Liu +5 more
2002Oncogene680 citations
Semantic Scholar
A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer
W. Xia, S. Bacus, P. Hegde, I. Husain +8 more
2006Proceedings of the National Academy of Sciences of the United States of America393 citations
Semantic Scholar
Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies.
N. Spector, W. Xia, H. Burris, H. Hurwitz +16 more
2005Journal of Clinical Oncology383 citations Open access
Semantic Scholar
Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells
W. Xia, Catherine Gérard, Lei-Hua Liu, N. Baudson +2 more
2005Oncogene268 citations Open access
Semantic Scholar
Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016
W. Xia, Lei-Hua Liu, P. Ho, N. Spector
2004Oncogene268 citations Open access
Semantic Scholar
Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers.
W. Xia, J. Bisi, J. Strum, Lei-Hua Liu +10 more
2006Cancer Research163 citations Open access
Semantic Scholar
Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers.
W. Xia, I. Husain, Lei-Hua Liu, S. Bacus +6 more
2007Cancer Research150 citations
Semantic Scholar
An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models
W. Xia, Emanual F. Iii Petricoin, Sumin Zhao, Lei-Hua Liu +9 more
2013Breast Cancer Research147 citations Open access
Semantic Scholar
Hyperphosphorylation of Heat Shock Transcription Factor 1 Is Correlated with Transcriptional Competence and Slow Dissociation of Active Factor Trimers*
W. Xia, R. Voellmy
1997Journal of Biological Chemistry147 citations Open access
Semantic Scholar
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells
N. Spector, Y. Yarden, Bradley L. Smith, L. Lyass +6 more
2007Proceedings of the National Academy of Sciences of the United States of America121 citations Open access
Semantic Scholar
Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors
Franklin L. Chen, W. Xia, N. Spector
2008Clinical Cancer Research119 citations Open access
Semantic Scholar
Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine.
W. Xia, Sydney A. Spector, L. Hardy, Sumin Zhao +3 more
2000Proceedings of the National Academy of Sciences of the United States of America76 citations Open access
Semantic Scholar
A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53
M. Kurokawa, Jiyeon Kim, J. Geradts, Kenkyo Matsuura +11 more
2013Science Signaling66 citations Open access
Semantic Scholar
HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors
N. Spector, W. Xia, I. El-Hariry, Y. Yarden +1 more
2007Breast Cancer Research65 citations Open access
Semantic Scholar
Transcriptional Activation of Heat Shock Factor HSF1 Probed by Phosphopeptide Analysis of Factor 32P-labeled in Vivo *
W. Xia, Yong-Le Guo, N. Vilaboa, Jian-Ru Zuo +1 more
1998Journal of Biological Chemistry56 citations Open access
Semantic Scholar
Resistance to ErbB2 Tyrosine Kinase Inhibitors in Breast Cancer Is Mediated by Calcium-Dependent Activation of RelA
W. Xia, S. Bacus, I. Husain, Lei-Hua Liu +7 more
2010Molecular Cancer Therapeutics55 citations Open access
Semantic Scholar
Azidothymidine and Interferon-α Induce Apoptosis in Herpesvirus-associated Lymphomas
Richard K. Lee, Jian-Ping Cai, V. Deyev, P. Gill +7 more
199955 citations
Semantic Scholar
Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors
W. Xia, Zu-Guo Liu, Rongrong Zong, Lei-Hua Liu +13 more
2011Molecular Cancer Therapeutics47 citations Open access
Semantic Scholar
Modulation of tolerance by mutant heat shock transcription factors.
W. Xia, N. Vilaboa, Jody L. Martin, Ruben Mestril +2 more
1999Cell stress & chaperones (Print)46 citations
Semantic Scholar
Sensitization of tumor cells to Fas killing through overexpression of heat‐shock transcription factor 1
W. Xia, R. Voellmy, N. Spector
2000Journal of Cellular Physiology36 citations
Semantic Scholar
Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells
Xiu-Rong Ren, Junping Wei, Gang-Jun Lei, Jiang-Bo Wang +12 more
2012Breast Cancer Research34 citations Open access
Semantic Scholar
Photo-Activated Psoralen Binds the ErbB2 Catalytic Kinase Domain, Blocking ErbB2 Signaling and Triggering Tumor Cell Apoptosis
W. Xia, David M. Gooden, Lei-Hua Liu, Sumin Zhao +5 more
2014PLoS ONE33 citations Open access
Semantic Scholar
Azidothymidine and interferon-alpha induce apoptosis in herpesvirus-associated lymphomas.
R. K. Lee, J.-P. Cai, V. Deyev, P. Gill +7 more
1999Cancer Research32 citations
Semantic Scholar
Adipose pyruvate carboxylase: amino acid sequence and domain structure deduced from cDNA sequencing.
Juan Zhang, W. Xia, Keith Brew, Fazal Ahmad
1993Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
An Adenoviral Vaccine Encoding Full-Length Inactivated Human HER2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy Without Oncogenicity
Z. Hartman, Junping Wei, T. Osada, O. Glass +14 more
2010Clinical Cancer Research28 citations Open access
Semantic Scholar
X-Ray Psoralen Activated Cancer Therapy (X-PACT)
M. Oldham, P. Yoon, Z. Fathi, W. F. Beyer +16 more
2016PLoS ONE25 citations Open access
Semantic Scholar
Luminescent Gold Nanoparticles with Controllable Hydrophobic Interactions.
Bing Tang, W. Xia, Weitian Cai, Jin-Bin Liu
2022Nano letters (Print)23 citations
Semantic Scholar
SYNERGISM FROM COMBINED IMMUNOLOGIC AND PHARMACOLOGIC INHIBITION OF HER2 IN VIVO
M. Morse, Junping Wei, Z. Hartman, W. Xia +13 more
2010International Journal of Cancer21 citations Open access
Semantic Scholar
Regulation of pyruvate carboxylase in 3T3-L1 cells.
Juan Zhang, W. Xia, Fazal Ahmad
1995Biochemical Journal20 citations Open access
Semantic Scholar
A ratiometric detection of heparin with high sensitivity based on aggregation-enhanced emission of gold nanoclusters triggered by silicon nanoparticles.
Fei Qu, W. Xia, Lian Xia, Jin-Mao You +1 more
2019Talanta: The International Journal of Pure and Applied Analytical Chemistry19 citations
Semantic Scholar
Tumor selective G 2 y M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL 22 , a benzazepine
W. Xia, S. Spector, L. Hardy, Sumin Zhao +3 more
20009 citations
Semantic Scholar
Biotin holocarboxylase synthetase: purification from rat liver cytosol and some properties.
W. Xia, J. Zhang, Farhan Jalees Ahmad
1994Biochemistry and molecular biology international8 citations
Semantic Scholar
Therapeutic Discovery Truncated ErbB 2 Expressed in Tumor Cell Nuclei Contributes to Acquired Therapeutic Resistance to ErbB 2 Kinase Inhibitors
W. Xia, Zuguo Liu, Rongrong Zong, Lei-Hua Liu +13 more
20115 citations
Semantic Scholar
Combining lapatinib (GW572016) with anti-erbB2 antibodies elicits synergistic apoptotic effects in erbB2 overexpressing breast cancer cells
N. Spector, Lei-Hua Liu, C. Gerard, P. N. Baudson +3 more
20054 citations
Semantic Scholar
Affinity chromatography of regulatory subunits of protein phosphatase-1.
Su-Min Zhao, W. Xia, Ernest Y. C. Lee
1996Archives of Biochemistry and Biophysics4 citations Open access
Semantic Scholar
Modulation of tumor growth and survival pathways in cancer patients treated with GW572016
N. Spector, W. Xia, H. Burris, H. Hurwitz +6 more
20043 citations
Semantic Scholar
Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells
Xiu-Rong Ren, Junping Wei, Gang-Jun Lei, Jiang-Bo Wang +12 more
2012Breast Cancer Research2 citations Open access
Semantic Scholar
Modulation of tumor growth and survival pathways in cancer patients treated with GW572016.
N. Spector, W. Xia, H. Burris, H. Hurwitz +6 more
2004Journal of Clinical Oncology2 citations
Semantic Scholar
Concurrent Exposure to Heat Shock and H7 Synergizes to Trigger Breast Cancer Cell Apoptosis while Sparing Normal Cells
W. Xia, L. Hardy, Lei-Hua Liu, Sumin Zhao +3 more
2003Breast Cancer Research and Treatment2 citations
Semantic Scholar
Induction of autophagy across multiple tumor types through irreversible HER tyrosine kinase blockade.
W. Gwin, Lei-Hua Liu, Sumin Zhao, W. Xia +1 more
20131 citations
Semantic Scholar
Abstract P4-08-03: The impact of the heregulin-HER receptor signaling axis on response to HER tyrosine kinase inhibitors.
W. Gwin, Lei-Hua Liu, Sheng-Li Zhao, W. Xia +1 more
20121 citations
Semantic Scholar
Metabolic screening of cancer cell metabolism
Bennett B. Chin, W. Xia, Diana Dai, D. Mcdougald +1 more
20101 citations
Semantic Scholar
Abstract P4-08-07: Novel insight into the tumor “flare” phenomenon and lapatinib resistance
Ja Piede, Sheng-Li Zhao, Lei-Hua Liu, H. Lyerly +4 more
20120 citations
Semantic Scholar
Rational Development of Targeted Cancer Therapies Using Biomarkers
S. Bacus, Y. Yarden, W. Xia, N. Spector
20060 citations Open access
Semantic Scholar
Autoresistance to ErbB2 kinase inhibitors: Elucidating mechanisms and identfying strategies to prevent its onset in breast cancer.
W. Xia, S. Bacus, P. Hedge, I. Husain +6 more
2006Journal of Clinical Oncology0 citations
Semantic Scholar
A pharmaceutical composition against cancer, the quinazolinamine a 4 in combination with paclitaxel, carboplatin or vinorelbine
K. Lackey, N. Spector, E. Wood, W. Xia
20020 citations
Semantic Scholar
carboplatin or vinorelbine A pharmaceutical combination comprising a 4-quinazolinamine and paclitaxel, for the treatment of cancer
E. Lackey, N. Spector, R. Wood, W. Xia
20020 citations
Semantic Scholar
A pharmaceutical composition against cancer, which contains a 4-quinazolinamine in combination with paclitaxel, carboplatin or vinorelbine
E. Lackey, N. Spector, R. Wood, W. Xia
20020 citations
Semantic Scholar
Herpesvirus-associated Lymphomas Induce Apoptosis in α Azidothymidine and Interferon-Updated Version
Richard K. Lee, Jian-ping Cai, V. Deyev, P. Gill +7 more
19990 citations
Semantic Scholar

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