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W. Béguelin · SciRah

Researcher profile · Semantic Scholar

W. Béguelin

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W. Béguelin — researcher profile on SciRah

h-index: 32
Works: 97
Citations: 4,528

Most-cited papers

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
W. Béguelin, R. Popovic, Matt Teater, Yan-Wen Jiang +29 more
2013Cancer Cell819 citations Open access
Semantic Scholar
Loss of BAP1 function leads to EZH2-dependent transformation
Lindsay M. LaFave, W. Béguelin, R. Koche, Matt Teater +27 more
2015Nature Medicine336 citations Open access
Semantic Scholar
Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition.
Daisuke Ennishi, K. Takata, W. Béguelin, Gerben Duns +22 more
2019Cancer Discovery256 citations Open access
Semantic Scholar
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis
W. Béguelin, Matt Teater, M. Gearhart, María Teresa Calvo Fernández +15 more
2016Cancer Cell215 citations Open access
Semantic Scholar
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture
Nevin Yusufova, A. Kloetgen, Matt Teater, Adewola Osunsade +25 more
2020Nature214 citations Open access
Semantic Scholar
EMERGING DRUG PROFILE
N. Gulati, W. Béguelin, L. Giulino-Roth
2018Leukemia and Lymphoma166 citations Open access
Semantic Scholar
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
W. Béguelin, M. Rivas, M. T. Calvo Fernandez, Matt Teater +7 more
2017Nature Communications163 citations Open access
Semantic Scholar
TNFα acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-κB-dependent pathways
M. Rivas, Romina P. Carnevale, Cecilia J. Proietti, C. Rosemblit +8 more
2008152 citations
Semantic Scholar
TET2 deficiency causes germinal center hyperplasia, impairs plasma cell differentiation and promotes B-cell lymphomagenesis
Pilar M. Dominguez, H. Ghamlouch, Wojciech Rosikiewicz, Parveen Kumar +30 more
2018Cancer Discovery148 citations Open access
Semantic Scholar
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.
Mariano G. Cárdenas, Wenbo Yu, W. Béguelin, Matt Teater +21 more
2016Journal of Clinical Investigation139 citations Open access
Semantic Scholar
Hematopoietic Stem Cell Origin of BRAFV600E Mutations in Hairy Cell Leukemia
Stephen S. Chung, Eunhee Kim, Jae H. Park, Young Rock Chung +18 more
2014Science Translational Medicine129 citations Open access
Semantic Scholar
Multi-tiered reorganization of the genome during B-cell affinity maturation anchored by a germinal center specific locus control region
Karen L. Bunting, T. D. Soong, Rajat Singh, Yan-Wen Jiang +8 more
2016Immunity128 citations Open access
Semantic Scholar
MUTANT EZH2 INDUCES A PRE-MALIGNANT LYMPHOMA NICHE BY REPROGRAMMING THE IMMUNE RESPONSE
W. Béguelin, Matt Teater, Cem Meydan, Kenneth B. Hoehn +16 more
2020Cancer Cell127 citations Open access
Semantic Scholar
Progesterone Receptor Induces ErbB-2 Nuclear Translocation To Promote Breast Cancer Growth via a Novel Transcriptional Effect: ErbB-2 Function as a Coactivator of Stat3
W. Béguelin, M. D. Díaz Flaqué, Cecilia J. Proietti, F. Cayrol +7 more
2010Molecular and Cellular Biology113 citations Open access
Semantic Scholar
TBL1XR1 MUTATIONS DRIVE EXTRANODAL LYMPHOMA BY INDUCING A PRO-TUMORIGENIC MEMORY FATE
Leandro Venturutti, Matt Teater, Andrew J Zhai, A. Chadburn +22 more
2020Cell103 citations Open access
Semantic Scholar
p42/p44 MAPK-mediated Stat3Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth.
M. Tkach, C. Rosemblit, M. Rivas, Cecilia J. Proietti +9 more
2013Endocrine-Related Cancer85 citations Open access
Semantic Scholar
TNF alpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappa B-dependent pathways.
M. Rivas, Romina P. Carnevale, Cecilia J. Proietti, C. Rosemblit +8 more
2008Experimental Cell Research84 citations
Semantic Scholar
IL10 receptor is a novel therapeutic target in DLBCLs
W. Béguelin, S. Sawh, N. Chambwe, F. Chan +10 more
2015Leukemia77 citations Open access
Semantic Scholar
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
A. Pastore, Federico Gaiti, Sydney X. Lu, Ryan Brand +19 more
2019Nature Communications76 citations Open access
Semantic Scholar
EZH2 INHIBITION ENHANCES T-CELL IMMUNOTHERAPIES BY INDUCING LYMPHOMA IMMUNOGENICITY AND IMPROVING T-CELL FUNCTION
Yusuke Isshiki, Xi Chen, Matt Teater, Ioannis Karagiannidis +21 more
2024Cancer Cell72 citations Open access
Semantic Scholar
EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models
P. Porazzi, Siena Nason, Ziqi Yang, A. Carturan +26 more
2025Cancer Cell66 citations Open access
Semantic Scholar
Intravital three-photon microscopy allows visualization over the entire depth of mouse lymph nodes
K. Choe, Yusaku Hontani, Tian-Yu Wang, Eric Hebert +6 more
2022Nature Immunology66 citations Open access
Semantic Scholar
Activation of Stat3 by Heregulin/ErbB-2 through the Co-Option of Progesterone Receptor Signaling Drives Breast Cancer Growth
Cecilia J. Proietti, C. Rosemblit, W. Béguelin, M. Rivas +4 more
2008Molecular and Cellular Biology64 citations Open access
Semantic Scholar
Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma
E. Oricchio, Natalya Katanayeva, M. Donaldson, Stephanie Sungalee +15 more
2017Science Translational Medicine60 citations Open access
Semantic Scholar
Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance
R. Cordo Russo, W. Béguelin, M. D. Díaz Flaqué, Cecilia J. Proietti +9 more
2014Oncogene54 citations Open access
Semantic Scholar
Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation
M. Salatino, W. Béguelin, M. G. Peters, Romina P. Carnevale +7 more
2006Oncogene53 citations Open access
Semantic Scholar
Ex vivo synthetic immune tissues with T cell signals for differentiating antigen-specific, high affinity germinal center B cells
Alberto Purwada, Shivem B. Shah, W. Béguelin, A. August +2 more
2018Biomaterials51 citations Open access
Semantic Scholar
Targeting Stat3 Induces Senescence in Tumor Cells and Elicits Prophylactic and Therapeutic Immune Responses against Breast Cancer Growth Mediated by NK Cells and CD4+ T Cells
M. Tkach, L. Coria, C. Rosemblit, M. Rivas +8 more
2012Journal of Immunology51 citations Open access
Semantic Scholar
Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer
R. Schillaci, P. Guzmán, F. Cayrol, W. Béguelin +9 more
2012BMC Cancer47 citations Open access
Semantic Scholar
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation
M. Rivas, Cem Meydan, Christopher R. Chin, Matt F. Challman +17 more
2021Nature Immunology37 citations Open access
Semantic Scholar
Transactivation of ErbB-2 induced by tumor necrosis factor α promotes NF-κB activation and breast cancer cell proliferation
M. Rivas, M. Tkach, W. Béguelin, Cecilia J. Proietti +4 more
2010Breast Cancer Research and Treatment37 citations
Semantic Scholar
Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy
M. D. Díaz Flaqué, N. Galigniana, W. Béguelin, Rocío Vicario +14 more
2013Breast Cancer Research36 citations Open access
Semantic Scholar
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment
Jie Li, Christopher R. Chin, Hsia-Yuan Ying, Cem Meydan +20 more
2024Nature Communications30 citations Open access
Semantic Scholar
Modular Immune Organoids with Integrin Ligand Specificity Differentially Regulate Ex Vivo B Cell Activation.
Alberto Purwada, Shivem B. Shah, W. Béguelin, A. Melnick +1 more
2017ACS Biomaterials Science & Engineering30 citations
Semantic Scholar
Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer.
Cecilia J. Proietti, W. Béguelin, M. C. D. Flaqué, F. Cayrol +5 more
2011Steroids30 citations
Semantic Scholar
Epigenetic, Metabolic, and Immune Crosstalk in Germinal-Center-Derived B-Cell Lymphomas: Unveiling New Vulnerabilities for Rational Combination Therapies
I. Serganova, Sanjukta Chakraborty, S. Yamshon, Yusuke Isshiki +4 more
2022Frontiers in Cell and Developmental Biology28 citations Open access
Semantic Scholar
An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities
R. Flümann, T. Rehkämper, P. Nieper, P. Pfeiffer +34 more
2020Blood Cancer Discovery28 citations Open access
Semantic Scholar
Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma
K. Takata, Lauren Chong, Daisuke Ennishi, T. Aoki +32 more
2020Journal of Clinical Investigation23 citations Open access
Semantic Scholar
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility
Vianne R. Gao, Rui Yang, Arnav Das, Ren-He Luo +20 more
2024Nature Communications18 citations Open access
Semantic Scholar
Epigenetic Mechanisms in Leukemias and Lymphomas.
C. Duy, W. Béguelin, A. Melnick
2020Cold Spring Harbor Perspectives in Medicine18 citations Open access
Semantic Scholar
An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas
Leandro Venturutti, M. Rivas, Benedikt W. Pelzer, R. Flümann +20 more
2022Cancer Discovery16 citations Open access
Semantic Scholar
Synergistic antitumor effect of combined EZH2 and DOT1L inhibition in B-cell lymphoma.
Van T M Nguyen, H. Namba, Hayley Porter, Daria Shlyueva +5 more
2025Blood14 citations Open access
Semantic Scholar
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility
Vianne R. Gao, Rui Yang, Arnav Das, Ren-He Luo +20 more
2023bioRxiv14 citations Open access
Semantic Scholar
Biology as vulnerability in follicular lymphoma: genetics, epigenetics, and immunogenetics.
F. Araujo-Ayala, W. Béguelin
2025Blood10 citations Open access
Semantic Scholar
p 42 / p 44 MAPK-mediated Stat 3 Ser 727 phosphorylation is required for progestin-induced full activation of Stat 3 and breast cancer growth
M. Tkach, C. Rosemblit, A. Rivas, Cecilia J. Proietti +8 more
20139 citations
Semantic Scholar
Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status"
Lindsay M. LaFave, W. Béguelin, R. Koche, Matt Teater +27 more
2016Nature Medicine8 citations
Semantic Scholar
Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms
Sara E. DiNapoli, Raúl Martinez-McFaline, Hao Shen, A. Doane +13 more
2022Frontiers in Cell and Developmental Biology6 citations Open access
Semantic Scholar
Consensus recommendations from the 2024 International Follicular Lymphoma Scientific Workshop
R. Merryman, Sarah C. Rutherford, S. Ansell, Philippe Armand +21 more
2025Blood Advances4 citations Open access
Semantic Scholar
Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma
Ofir Griess, Noa Furth, Nofar Harpaz, Nicoletta Di Bernardo +9 more
2024bioRxiv4 citations Open access
Semantic Scholar
Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas
Jie Li, Christopher R. Chin, Hsia-Yuan Ying, Cem Meydan +13 more
2023bioRxiv4 citations Open access
Semantic Scholar

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