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S. Iwata · SciRah

Researcher profile · Semantic Scholar

S. Iwata

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S. Iwata — researcher profile on SciRah

h-index: 36
Works: 85
Citations: 5,662

Most-cited papers

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.
K. Hirota, M. Matsui, S. Iwata, A. Nishiyama +2 more
1997Proceedings of the National Academy of Sciences of the United States of America872 citations Open access
Semantic Scholar
Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression*
A. Nishiyama, M. Matsui, S. Iwata, Kiichi Hirota +6 more
1999Journal of Biological Chemistry766 citations Open access
Semantic Scholar
Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects.
N. Otsuki, N. Dang, Emi Kumagai, A. Kondo +2 more
2010Journal of Ethnopharmacology444 citations
Semantic Scholar
Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide.
H. Nakamura, M. Matsuda, K. Furuke, Y. Kitaoka +6 more
1994Immunology Letters261 citations
Semantic Scholar
Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis.
N. Sato, S. Iwata, Kazuhiro Nakamura, Toshiyuki Hori +2 more
1995Journal of Immunology215 citations Open access
Semantic Scholar
Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.
T. Sasada, S. Iwata, N. Sato, Y. Kitaoka +6 more
1996Journal of Clinical Investigation212 citations Open access
Semantic Scholar
Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes
M. Minegishi, K. Tachibana, Toshiyasu Sato, S. Iwata +2 more
1996Journal of Experimental Medicine170 citations Open access
Semantic Scholar
Tyrosine Phosphorylation of Crk-associated Substrates by Focal Adhesion Kinase
K. Tachibana, T. Urano, Hiroo Fujita, Yoshiyuki Ohashi +4 more
1997Journal of Biological Chemistry161 citations Open access
Semantic Scholar
CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: enhancement of plasma cell differentiation by CD27 signaling.
S. Jacquot, T. Kobata, S. Iwata, Chika Morimoto +1 more
1997Journal of Immunology157 citations
Semantic Scholar
CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1.
K. Ohnuma, T. Yamochi, M. Uchiyama, K. Nishibashi +6 more
2004Proceedings of the National Academy of Sciences of the United States of America134 citations Open access
Semantic Scholar
Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state.
S. Iwata, Toshiyuki Hori, N. Sato, Kiichi Hirota +4 more
1997Journal of Immunology124 citations Open access
Semantic Scholar
CD26/dipeptidyl peptidase IV differentially regulates the chemotaxis of T cells and monocytes toward RANTES: possible mechanism for the switch from innate to acquired immune response.
S. Iwata, N. Yamaguchi, Y. Munakata, Hideto Ikushima +4 more
1999International Immunology109 citations Open access
Semantic Scholar
Thiol-mediated redox regulation of lymphocyte proliferation. Possible involvement of adult T cell leukemia-derived factor and glutathione in transferrin receptor expression.
S. Iwata, Toshiyuki Hori, N. Sato, Y. Ueda-Taniguchi +4 more
1994Journal of Immunology107 citations
Semantic Scholar
Inhibition of Middle East Respiratory Syndrome Coronavirus Infection by Anti-CD26 Monoclonal Antibody
K. Ohnuma, B. Haagmans, R. Hatano, V. S. Raj +5 more
2013Journal of Virology95 citations Open access
Semantic Scholar
Cd26/Dipeptidyl Peptidase IV in Context
S. Iwata, C. Morimoto
1999Journal of Experimental Medicine90 citations Open access
Semantic Scholar
CD26 Mediates Dissociation of Tollip and IRAK-1 from Caveolin-1 and Induces Upregulation of CD86 on Antigen-Presenting Cells
K. Ohnuma, T. Yamochi, M. Uchiyama, K. Nishibashi +6 more
2005Molecular and Cellular Biology80 citations Open access
Semantic Scholar
Soluble CD26/dipeptidyl peptidase IV enhances transendothelial migration via its interaction with mannose 6-phosphate/insulin-like growth factor II receptor.
Hideto Ikushima, Y. Munakata, S. Iwata, K. Ohnuma +3 more
2002Cellular Immunology79 citations Open access
Semantic Scholar
Identification of cancer stem cell markers in human malignant mesothelioma cells.
Farhana Ishrat Ghani, Hiroto Yamazaki, S. Iwata, Toshihiro Okamoto +8 more
2011Biochemical and Biophysical Research Communications - BBRC78 citations
Semantic Scholar
Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation
S. Iwata, Yuya Sato, M. Asada, M. Takagi +8 more
1999Oncogene76 citations Open access
Semantic Scholar
Soluble CD26/Dipeptidyl Peptidase IV Induces T Cell Proliferation Through CD86 Up-Regulation on APCs1
K. Ohnuma, Y. Munakata, T. Ishii, S. Iwata +5 more
2001Journal of Immunology68 citations Open access
Semantic Scholar
SS-A/Ro52, an Autoantigen Involved in CD28-Mediated IL-2 Production 1
T. Ishii, K. Ohnuma, Akikazu Murakami, N. Takasawa +6 more
2003Journal of Immunology63 citations Open access
Semantic Scholar
Heterogeneity of the breakpoint in the ABL gene in cases with BCR/ABL transcript lacking ABL exon a2.
S. Iwata, Shuki Mizutani, Shinpei Nakazawa, J.-I. Yata
1994Leukemia61 citations
Semantic Scholar
Anti-CD26 Monoclonal Antibody–Mediated G1-S Arrest of Human Renal Clear Cell Carcinoma Caki-2 Is Associated with Retinoblastoma Substrate Dephosphorylation, Cyclin-Dependent Kinase 2 Reduction, p27kip1 Enhancement, and Disruption of Binding to the Extracellular Matrix
T. Inamoto, T. Yamochi, K. Ohnuma, S. Iwata +6 more
2006Clinical Cancer Research58 citations Open access
Semantic Scholar
Soluble CD26/Dipeptidyl Peptidase IV Enhances the Transcription of IL-6 and TNF-α in THP-1 Cells and Monocytes
T. Ikeda, Emi Kumagai, S. Iwata, Akio Yamakawa
2013PLoS ONE57 citations Open access
Semantic Scholar
CD90 and CD110 correlate with cancer stem cell potentials in human T-acute lymphoblastic leukemia cells.
Hiroto Yamazaki, H. Nishida, S. Iwata, N. Dang +1 more
2009Biochemical and Biophysical Research Communications - BBRC54 citations
Semantic Scholar
Impact of the Integrin Signaling Adaptor Protein NEDD9 on Prognosis and Metastatic Behavior of Human Lung Cancer
S. Kondo, S. Iwata, Taketo Yamada, Y. Inoue +13 more
2012Clinical Cancer Research53 citations Open access
Semantic Scholar
CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells.
H. Nishida, Hiroto Yamazaki, Taketo Yamada, S. Iwata +5 more
2009Biochemical and Biophysical Research Communications - BBRC52 citations
Semantic Scholar
Histamine H1‐receptor antagonists with immunomodulating activities: potential use for modulating T helper type 1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases
Toshihiro Okamoto, S. Iwata, K. Ohnuma, Nam H. Dang +1 more
2009Clinical and Experimental Immunology52 citations Open access
Semantic Scholar
Regulation of cancer stem cell properties by CD9 in human B-acute lymphoblastic leukemia.
Hiroto Yamazaki, C. W. Xu, Motohiko Naito, H. Nishida +6 more
2011Biochemical and Biophysical Research Communications - BBRC51 citations
Semantic Scholar
Dissociation between cell cycle arrest and apoptosis can occur in Li-Fraumeni cells heterozygous for p53 gene mutations
D. Delia, K. Goi, S. Mizutani, Takayuki Yamada +8 more
1997Oncogene50 citations Open access
Semantic Scholar
The tetraspanin CD9 is preferentially expressed on the human CD4+CD45RA+ naive T cell population and is involved in T cell activation
H. Kobayashi, O. Hosono, S. Iwata, H. Kawasaki +4 more
2004Clinical and Experimental Immunology45 citations Open access
Semantic Scholar
Regulation of Pulmonary Graft-versus-Host Disease by IL-26+CD26+CD4 T Lymphocytes
K. Ohnuma, R. Hatano, T. Aune, Haruna Otsuka +4 more
2015Journal of Immunology44 citations Open access
Semantic Scholar
Nedd9 Protein, a Cas-L Homologue, Is Upregulated After Transient Global Ischemia in Rats: Possible Involvement of Nedd9 in the Differentiation of Neurons After Ischemia
Takahiro Sasaki, S. Iwata, H. Okano, Y. Urasaki +5 more
2005Stroke40 citations Open access
Semantic Scholar
Association of CD26 with CD45RA outside lipid rafts attenuates cord blood T-cell activation.
Seiji Kobayashi, K. Ohnuma, M. Uchiyama, K. Iino +3 more
2004Blood40 citations Open access
Semantic Scholar
CD9 Negatively Regulates CD26 Expression and Inhibits CD26-Mediated Enhancement of Invasive Potential of Malignant Mesothelioma Cells
Toshihiro Okamoto, S. Iwata, Hiroto Yamazaki, R. Hatano +4 more
2014PLoS ONE36 citations Open access
Semantic Scholar
Characterization of cancer stem cell properties of CD24 and CD26-positive human malignant mesothelioma cells.
Hiroto Yamazaki, Motohiko Naito, Farhana Ishrat Ghani, N. Dang +2 more
2012Biochemical and Biophysical Research Communications - BBRC36 citations
Semantic Scholar
Distinctive signaling pathways through CD82 and β1 integrins in human T cells
S. Iwata, H. Kobayashi, R. Miyake‐Nishijima, Takahiro Sasaki +6 more
2002European Journal of Immunology35 citations Open access
Semantic Scholar
p53 activity and chemotherapy
D. Delia, S. Mizutani, G. Lamorte, K. Goi +2 more
1996Nature Medicine35 citations
Semantic Scholar
A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1: role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein.
T. Shimizu, Y. Miyakawa, S. Iwata, Akiko Kuribara +4 more
2004Experimental Hematology33 citations Open access
Semantic Scholar
Ebastine inhibits T cell migration, production of Th2‐type cytokines and proinflammatory cytokines
M. Nori, S. Iwata, Y. Munakata, H. Kobayashi +8 more
2003Clinical and Experimental Allergy33 citations Open access
Semantic Scholar
G1/S cell cycle arrest provoked in human T cells by antibody to CD26
K. Ohnuma, T. Ishii, S. Iwata, O. Hosono +6 more
2002Immunology33 citations
Semantic Scholar
CD26-mediated regulation of periostin expression contributes to migration and invasion of malignant pleural mesothelioma cells.
E. Komiya, K. Ohnuma, Hiroto Yamazaki, R. Hatano +5 more
2014Biochemical and Biophysical Research Communications - BBRC27 citations
Semantic Scholar
CD26 Expression on T-Anaplastic Large Cell Lymphoma (ALCL) Line Karpas 299 is associated with increased expression of Versican and MT1-MMP and enhanced adhesion
P. Havre, L. Dang, K. Ohnuma, S. Iwata +2 more
2013BMC Cancer27 citations Open access
Semantic Scholar
Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma
Junpei Yamamoto, K. Ohnuma, R. Hatano, Toshihiro Okamoto +8 more
2014British Journal of Cancer25 citations Open access
Semantic Scholar
The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans.
Mutsumi Hashimoto-Okada, T. Kitawaki, N. Kadowaki, S. Iwata +3 more
2009International Immunology25 citations Open access
Semantic Scholar
Crk-associated substrate lymphocyte type regulates transforming growth factor-β signaling by inhibiting Smad6 and Smad7
S. Inamoto, S. Iwata, T. Inamoto, S. Nomura +7 more
2007Oncogene25 citations Open access
Semantic Scholar
CD26-Mediated Induction of EGR2 and IL-10 as Potential Regulatory Mechanism for CD26 Costimulatory Pathway
R. Hatano, K. Ohnuma, Haruna Otsuka, E. Komiya +5 more
2015Journal of Immunology24 citations Open access
Semantic Scholar
Roxithromycin specifically inhibits development of collagen induced arthritis and production of proinflammatory cytokines by human T cells and macrophages.
Y. Urasaki, M. Nori, S. Iwata, Takahiro Sasaki +6 more
2005Journal of Rheumatology23 citations
Semantic Scholar
HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L)
S. Iwata, A. Souta-Kuribara, Akio Yamakawa, Takahiro Sasaki +8 more
2005Oncogene22 citations
Semantic Scholar
VLA-4-mediated signaling.
C. Morimoto, S. Iwata, K. Tachibana
1998Current Topics in Microbiology and Immunology21 citations
Semantic Scholar

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C. Morimoto×29
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C. Morimoto — researcher profile on SciRah
N. Dang×23
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N. Dang — researcher profile on SciRah
K. Ohnuma×16
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K. Ohnuma — researcher profile on SciRah
Hirotoshi Tanaka×10
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H. Kawasaki — researcher profile on SciRah

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O. Hosono — researcher profile on SciRah

Hiroto Yamazaki×9

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Hiroto Yamazaki — researcher profile on SciRah

Toshihiro Okamoto×6

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Toshihiro Okamoto — researcher profile on SciRah

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T. Yamochi — researcher profile on SciRah

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M. Uchiyama — researcher profile on SciRah

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R. Hatano — researcher profile on SciRah

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