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N. Dumaz · SciRah

Researcher profile · Semantic Scholar

N. Dumaz

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N. Dumaz — researcher profile on SciRah

h-index: 23
Works: 66
Citations: 2,916

Most-cited papers

Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
N. Dumaz, D. W. Meek
1999EMBO Journal498 citations Open access
Semantic Scholar
Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways
N. Dumaz, R. Marais
2005The FEBS Journal319 citations Open access
Semantic Scholar
In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.
N. Dumaz, R. Hayward, Jan Martin, Lesley M Ogilvie +5 more
2006Cancer Research288 citations
Semantic Scholar
Protein Kinase A Blocks Raf-1 Activity by Stimulating 14-3-3 Binding and Blocking Raf-1 Interaction with Ras*
N. Dumaz, R. Marais
2003Journal of Biological Chemistry260 citations Open access
Semantic Scholar
Protein kinase CK1 is a p53‐threonine 18 kinase which requires prior phosphorylation of serine 15
N. Dumaz, D. Milne, D. W. Meek
1999FEBS Letters150 citations Open access
Semantic Scholar
Skin Tumors Induced by Sorafenib; Paradoxic RAS–RAF Pathway Activation and Oncogenic Mutations of HRAS, TP53, and TGFBR1
J. Arnault, C. Mateus, B. Escudier, G. Tomasic +17 more
2011Clinical Cancer Research133 citations Open access
Semantic Scholar
ERK and PDE4 cooperate to induce RAF isoform switching in melanoma
Amélie Marquette, J. André, M. Bagot, A. Bensussan +1 more
2011Nature Structural &Molecular Biology100 citations
Semantic Scholar
Cyclic AMP Blocks Cell Growth through Raf-1-Dependent and Raf-1-Independent Mechanisms
N. Dumaz, Y. Light, R. Marais
2002Molecular and Cellular Biology84 citations Open access
Semantic Scholar
c-Kit mutants require hypoxia-inducible factor 1α to transform melanocytes
G. Monsel, N. Ortonne, M. Bagot, A. Bensussan +1 more
2010Oncogene80 citations Open access
Semantic Scholar
Atypical BRAF and NRAS Mutations in Mucosal Melanoma
N. Dumaz, F. Jouenne, J. Delyon, S. Mourah +2 more
2019Cancers79 citations Open access
Semantic Scholar
PARKIN Inactivation Links Parkinson's Disease to Melanoma.
Hui-Han Hu, C. Kannengiesser, S. Lesage, J. André +20 more
2016Journal of the National Cancer Institute74 citations
Semantic Scholar
Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes
N. Dumaz, A. Duthu, J. Ehrhart, C. Drougard +5 more
1997Molecular Carcinogenesis71 citations
Semantic Scholar
The role of RICTOR downstream of receptor tyrosine kinase in cancers
A. Jebali, N. Dumaz
2018Molecular Cancer62 citations Open access
Semantic Scholar
TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation
Andrelou F. Vallarelli, P. Rachakonda, J. André, Barbara Heidenreich +4 more
2016OncoTarget62 citations Open access
Semantic Scholar
Oncogene abnormalities in a series of primary melanomas of the sinonasal tract: NRAS mutations and cyclin D1 amplification are more frequent than KIT or BRAF mutations.
M. Chraybi, I. A. Alsamad, C. Copie-Bergman, M. Baia +3 more
2013Human Pathology60 citations Open access
Semantic Scholar
STAT3 Mediates Nilotinib Response in KIT-Altered Melanoma: A Phase II Multicenter Trial of the French Skin Cancer Network.
J. Delyon, S. Chevret, T. Jouary, S. Dalac +21 more
2018Journal of Investigative Dermatology57 citations Open access
Semantic Scholar
Quantitative detection of ultraviolet-specific p53 mutations in normal skin from Japanese patients.
A. Ouhtit, M. Ueda, H. Nakazawa, M. Ichihashi +3 more
1997Cancer Epidemiology, Biomarkers and Prevention42 citations
Semantic Scholar
Targeted therapies in melanoma beyond BRAF: targeting NRAS-mutated and KIT-mutated melanoma.
J. Delyon, C. Lebbé, N. Dumaz
2019Current Opinion in Oncology37 citations
Semantic Scholar
RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma
F. Laugier, A. Finet-Benyair, J. André, P. Rachakonda +3 more
2015OncoTarget36 citations Open access
Semantic Scholar
PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma
J. Delyon, A. Servy, F. Laugier, J. André +6 more
2017Oncogene34 citations
Semantic Scholar
Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles
A. Eisenhardt, Adrian Sprenger, M. Röring, Ricarda Herr +14 more
2016OncoTarget32 citations Open access
Semantic Scholar
Mechanism of RAF isoform switching induced by oncogenic RAS in melanoma
N. Dumaz
2011Small GTPases31 citations Open access
Semantic Scholar
Recent discoveries in the genetics of melanoma and their therapeutic implications
Amélie Marquette, M. Bagot, A. Bensussan, N. Dumaz
2007Archivum Immunologiae et Therapiae Experimentalis24 citations Open access
Semantic Scholar
Mutations causing acrodysostosis‐2 facilitate activation of phosphodiesterase 4D3
C. Briet, A. Pereda, C. Le Stunff, E. Motte +4 more
2017Human Molecular Genetics21 citations Open access
Semantic Scholar
A Large French Case-Control Study Emphasizes the Role of Rare Mc1R Variants in Melanoma Risk
Hui-Han Hu, M. Benfodda, N. Dumaz, S. Gazal +10 more
2014BioMed Research International20 citations Open access
Semantic Scholar
Inhibition of the Proprotein Convertases Represses the Invasiveness of Human Primary Melanoma Cells with Altered p53, CDKN2A and N-Ras Genes
C. Lalou, N. Scamuffa, S. Mourah, F. Plassa +6 more
2010PLoS ONE19 citations Open access
Semantic Scholar
Raf phosphorylation: one step forward and two steps back.
N. Dumaz, R. Marais
2005Molecules and Cells18 citations Open access
Semantic Scholar
TERT Expression Induces Resistance to BRAF and MEK Inhibitors in BRAF-Mutated Melanoma In Vitro
J. Delyon, A. Vallet, Mélanie Bernard-Cacciarella, I. Kuzniak +6 more
2023Cancers16 citations Open access
Semantic Scholar
Modulation of signaling through GPCR-cAMP-PKA pathways by PDE4 depends on stimulus intensity: Possible implications for the pathogenesis of acrodysostosis without hormone resistance.
E. Motte, C. Le Stunff, C. Briet, N. Dumaz +1 more
2017Molecular and Cellular Endocrinology16 citations
Semantic Scholar
RICTOR Affects Melanoma Tumorigenesis and Its Resistance to Targeted Therapy
A. Jebali, M. Battistella, C. Lebbé, N. Dumaz
2021Biomedicines15 citations Open access
Semantic Scholar
A targeted genomic alteration analysis predicts survival of melanoma patients under BRAF inhibitors
B. Louveau, J. Delyon, C. R. de Moura, M. Battistella +12 more
2019OncoTarget15 citations Open access
Semantic Scholar
Baseline Genomic Features in BRAFV600-Mutated Metastatic Melanoma Patients Treated with BRAF Inhibitor + MEK Inhibitor in Routine Care
B. Louveau, F. Jouenne, Coralie Reger de Moura, A. Sadoux +9 more
2019Cancers13 citations Open access
Semantic Scholar
Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2
E. Ezine, C. Lebbé, N. Dumaz
2023Clinical and Translational Medicine12 citations Open access
Semantic Scholar
Validation of a preclinical model for assessment of drug efficacy in melanoma
J. Delyon, M. Varna, J. Feugeas, A. Sadoux +8 more
2016OncoTarget12 citations Open access
Semantic Scholar
Novel treatment strategy for NRAS-mutated melanoma through a selective inhibitor of CD147/VEGFR-2 interaction
Alexandra Landras, Coralie Reger de Moura, B. Villoutreix, M. Battistella +6 more
2022Oncogene11 citations
Semantic Scholar
Mechanisms of resistance and predictive biomarkers of response to targeted therapies and immunotherapies in metastatic melanoma.
S. Mourah, B. Louveau, N. Dumaz
2019Current Opinion in Oncology11 citations
Semantic Scholar
Driver KIT mutations in melanoma cluster in four hotspots
N. Dumaz, J. André, A. Sadoux, F. Laugier +3 more
2015Melanoma research11 citations
Semantic Scholar
Hypoxia and MITF regulate KIT oncogenic properties in melanocytes
F. Laugier, J. Delyon, J. André, A. Bensussan +1 more
2016Oncogene10 citations
Semantic Scholar
The soluble form of CD160 acts as a tumor mediator of immune escape in melanoma
Marie-Léa Gauci, J. Giustiniani, C. Lepelletier, C. Garbar +6 more
2022Cancer Immunology and Immunotherapy9 citations Open access
Semantic Scholar
Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma
A. Yurchenko, O. Pop, M. Ighilahriz, Ismael Padioleau +28 more
2022Clinical Cancer Research9 citations Open access
Semantic Scholar
Phase II multicentric uncontrolled national trial assessing the efficacy of nilotinib in the treatment of advanced melanomas with c-KIT mutation or amplification.
C. Lebbé, S. Chevret, T. Jouary, S. Dalac +16 more
20149 citations
Semantic Scholar
Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1
Coralie Reger de Moura, B. Louveau, F. Jouenne, P. Vilquin +7 more
2024Oncogene8 citations
Semantic Scholar
FGF2 Induces Resistance to Nilotinib through MAPK Pathway Activation in KIT Mutated Melanoma
P. Têtu, J. Delyon, J. André, Coralie Reger de Moura +6 more
2020Cancers8 citations Open access
Semantic Scholar
New perspectives on targeting RAF, MEK and ERK in melanoma
N. Dumaz, C. Lebbé
2020Current Opinion in Oncology8 citations
Semantic Scholar
PDE4D drives rewiring of the MAPK pathway in BRAF-mutated melanoma resistant to MAPK inhibitors
J. Delyon, Selma Becherirat, A. Roger, Mélanie Bernard-Cacciarella +5 more
2024Cell Communication and Signaling7 citations Open access
Semantic Scholar
A Melanoma-Tailored Next-Generation Sequencing Panel Coupled with a Comprehensive Analysis to Improve Routine Melanoma Genotyping
B. Louveau, F. Jouenne, P. Têtu, A. Sadoux +13 more
2020Targeted oncology7 citations
Semantic Scholar
Genetic variation at KIT locus may predispose to melanoma
A. Bourillon, Hui-Han Hu, G. Hetet, J. Lacapere +11 more
2013Pigment Cell & Melanoma Research6 citations
Semantic Scholar
Mitogen-activated protein kinase blockade in melanoma: intermittent versus continuous therapy, from preclinical to clinical data
P. Têtu, L. Vercellino, Coralie Reger de Moura, B. Baroudjian +3 more
2020Current Opinion in Oncology4 citations
Semantic Scholar
A new KIT mutation (N505I) in acral melanoma confers constitutive signaling, favors tumorigenic properties, and is sensitive to imatinib.
M. Allégra, D. Giacchero, C. Ségalen, N. Dumaz +7 more
2014Journal of Investigative Dermatology3 citations Open access
Semantic Scholar
Combined PDE4+MEK inhibition shows antiproliferative effects in NRASQ61 mutated melanoma preclinical models
B. Louveau, Coralie Reger de Moura, F. Jouenne, A. Sadoux +7 more
2023Melanoma research2 citations
Semantic Scholar

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S. Mourah×20
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S. Mourah — researcher profile on SciRah
C. Lebbé×17
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C. Lebbé — researcher profile on SciRah
J. Delyon×12
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J. André×11
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A. Bensussan — researcher profile on SciRah

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M. Battistella — researcher profile on SciRah

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B. Louveau — researcher profile on SciRah

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A. Sadoux — researcher profile on SciRah

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M. Bagot — researcher profile on SciRah

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