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Jeffrey Y. W. Mak · SciRah

Researcher profile · Semantic Scholar

Jeffrey Y. W. Mak

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Jeffrey Y. W. Mak — researcher profile on SciRah

h-index: 28
Works: 77
Citations: 3,526

Most-cited papers

T-cell activation by transitory neo-antigens derived from distinct microbial pathways
A. Corbett, S. Eckle, R. Birkinshaw, Li-Gong Liu +14 more
2014Nature839 citations
Semantic Scholar
Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells
A. Keller, S. Eckle, Wei-Jun Xu, Li-Gong Liu +17 more
2017Nature Immunology221 citations
Semantic Scholar
MAIT cells protect against pulmonary Legionella longbeachae infection
Hui-Meng Wang, C. D'Souza, X. Lim, L. Kostenko +21 more
2018Nature Communications203 citations Open access
Semantic Scholar
Abstracts of ICI 2016 International Congress of Immunology, 21-26 August 2016, Melbourne, Australia.
S. Eckle, A. Keller, Wei-Jun Xu, Bronwyn S. Meehan +14 more
2016European Journal of Immunology187 citations Open access
Semantic Scholar
Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells
Jeffrey Y. W. Mak, Wei-Jun Xu, R. Reid, A. Corbett +7 more
2017Nature Communications146 citations Open access
Semantic Scholar
MAIT cells promote tumor initiation, growth and metastases via tumor MR1.
Ju-Ming Yan, Stacey Allen, E. McDonald, I. Das +9 more
2019Cancer Discovery135 citations
Semantic Scholar
Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells*
S. Eckle, A. Corbett, A. Keller, Zhen-Jun Chen +6 more
2015Journal of Biological Chemistry135 citations Open access
Semantic Scholar
IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection
Hui-Meng Wang, L. Kjer-Nielsen, M. Shi, C. D'Souza +21 more
2019Science immunology108 citations Open access
Semantic Scholar
A divergent transcriptional landscape underpins the development and functional branching of MAIT cells
Hui-Fern Koay, S. Su, D. Amann-Zalcenstein, S. Daley +27 more
2019Science immunology103 citations Open access
Semantic Scholar
Recipient mucosal-associated invariant T cells control GVHD within the colon
Antiopi Varelias, Mark D. Bunting, Kate L. Ormerod, M. Koyama +18 more
2018Journal of Clinical Investigation94 citations Open access
Semantic Scholar
MAIT cells regulate NK cell-mediated tumor immunity
Emma V. Petley, Hui-Fern Koay, M. Henderson, K. Sek +27 more
2021Nature Communications90 citations Open access
Semantic Scholar
The molecular basis underpinning the potency and specificity of MAIT cell antigens
W. Awad, G. Ler, Wei-Jun Xu, A. Keller +9 more
2020Nature Immunology76 citations Open access
Semantic Scholar
An overview on the identification of MAIT cell antigens
L. Kjer-Nielsen, A. Corbett, Zhen-Jun Chen, Li-Gong Liu +6 more
2018Immunology and Cell Biology76 citations Open access
Semantic Scholar
Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection
C. D'Souza, Troi J Pediongco, Hui-Meng Wang, J. Scheerlinck +17 more
2018Journal of Immunology68 citations
Semantic Scholar
Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1
Lauren J. Howson, W. Awad, A. von Borstel, Hui-Jing Lim +18 more
2020Science immunology67 citations Open access
Semantic Scholar
Sulfated bile acid is a host-derived ligand for MAIT cells
E. Ito, S. Inuki, Yoshihiro Izumi, Masatomo Takahashi +13 more
2024Science immunology63 citations Open access
Semantic Scholar
Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease
Yizhuo Wang, Rishika Abrol, Jeffrey Y. W. Mak, Kaustav Das Gupta +4 more
2022The FEBS Journal55 citations Open access
Semantic Scholar
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens
H. McWilliam, Jeffrey Y. W. Mak, W. Awad, Matthew Zorkau +16 more
2020Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli
Caroline Boulouis, Rong-Sia Wan, M. Y. Gulam, J. Teo +12 more
2020bioRxiv54 citations Open access
Semantic Scholar
Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection
Zhe Zhao, Hui-Meng Wang, M. Shi, T. Zhu +18 more
2021Nature Communications53 citations Open access
Semantic Scholar
Tuning Electrostatic and Hydrophobic Surfaces of Aromatic Rings to Enhance Membrane Association and Cell Uptake of Peptides
A. D. de Araujo, H. N. Hoang, Jun-Xian Lim, Jeffrey Y. W. Mak +1 more
2022Angewandte Chemie48 citations Open access
Semantic Scholar
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles
T. Kammann, C. Cai, T. Sekine, Elli Mouchtaridi +29 more
2024Science immunology42 citations Open access
Semantic Scholar
Artificially induced MAIT cells inhibit M. bovis BCG but not M. tuberculosis during in vivo pulmonary infection
Hui-Feng Yu, A. Yang, S. Derrick, Jeffrey Y. W. Mak +3 more
2020Scientific Reports42 citations Open access
Semantic Scholar
CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells
Michael N. T. Souter, W. Awad, Shi-Han Li, Troi J Pediongco +28 more
2022Journal of Experimental Medicine40 citations Open access
Semantic Scholar
CXCL16 Stimulates Antigen-Induced MAIT Cell Accumulation but Trafficking During Lung Infection Is CXCR6-Independent
Hui-Feng Yu, A. Yang, Li-Gong Liu, Jeffrey Y. W. Mak +2 more
2020Frontiers in Immunology35 citations Open access
Semantic Scholar
MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques
J. Juno, Kathleen M. Wragg, Thakshila H. Amarasena, Bronwyn S. Meehan +6 more
2019Journal of Immunology35 citations Open access
Semantic Scholar
Chemical Modulators of Mucosal Associated Invariant T Cells
Jeffrey Y. W. Mak, Li-Gong Liu, D. Fairlie
2021Accounts of Chemical Research32 citations Open access
Semantic Scholar
Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I–related protein 1 MR1
Carl J H Wang, W. Awad, Li-Gong Liu, Jeffrey Y. W. Mak +9 more
2022Journal of Biological Chemistry28 citations Open access
Semantic Scholar
MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells
Mitchell P McInerney, W. Awad, Michael N. T. Souter, Yang Kang +18 more
2024Proceedings of the National Academy of Sciences of the United States of America27 citations Open access
Semantic Scholar
Human MAIT cells respond to and suppress HIV-1
Chansavath Phetsouphanh, Prabhjeet Phalora, C. Hackstein, J. Thornhill +14 more
2021eLife26 citations Open access
Semantic Scholar
Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu
Caroline Boulouis, Elli Mouchtaridi, Thomas R. Müller, Jeffrey Y. W. Mak +7 more
2025Proceedings of the National Academy of Sciences of the United States of America25 citations Open access
Semantic Scholar
MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis
Yichao Zheng, Fei Han, Zhengyu Wu, Bing-Jie Wang +13 more
2024Science Advances25 citations Open access
Semantic Scholar
MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection.
Hui-Meng Wang, Michael N. T. Souter, Marcela de Lima Moreira, Shi-Han Li +15 more
2024Science immunology25 citations
Semantic Scholar
Cigarette smoke components modulate the MR1–MAIT axis
W. Awad, Jemma R Mayall, Weijun Xu, M. Johansen +21 more
2025Journal of Experimental Medicine24 citations Open access
Semantic Scholar
MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto
E. Leeansyah, Y. Hey, Rong-Sia Wan, J. Ng +9 more
2020iScience22 citations Open access
Semantic Scholar
HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates.
Jeffrey Y. W. Mak, Kai‐Chen Wu, Praveer K. Gupta, S. Barbero +9 more
2021Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells
Hui-Jing Lim, Jacinta Wubben, C. García, S. Cruz-Gomez +14 more
2022Journal of Cell Biology16 citations Open access
Semantic Scholar
The balance of interleukin‐12 and interleukin‐23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection
Hui-Meng Wang, Adam G. Nelson, Bing-Jie Wang, Zhe Zhao +15 more
2022Immunology and Cell Biology16 citations Open access
Semantic Scholar
Computer modelling and synthesis of deoxy and monohydroxy analogues of a ribitylaminouracil bacterial metabolite that potently activates human T cells.
G. Ler, Weijun Xu, Jeffrey Y. W. Mak, Li-Gong Liu +2 more
2019Chemistry16 citations
Semantic Scholar
MAIT cell-MR1 reactivity is highly conserved across multiple divergent species
M. Edmans, Timothy K. Connelley, S. Morgan, Troi J Pediongco +17 more
2024Journal of Biological Chemistry15 citations Open access
Semantic Scholar
PAR2 Modulators Derived from GB88.
Mei-Kwan Yau, Li-Gong Liu, J. Suen, Jun-Xian Lim +8 more
2016ACS Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling
Calvin Xu, Andreas Obers, Minyi Qin, Alice Brandli +13 more
2024Journal of Experimental Medicine14 citations Open access
Semantic Scholar
Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections
M. Edmans, T. Connelley, S. Jayaraman, C. Vrettou +10 more
2020bioRxiv14 citations Open access
Semantic Scholar
Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 Biosynthesis.
Jeffrey Y. W. Mak, Ryan J D Rivero, H. N. Hoang, X. Lim +6 more
2024Angewandte Chemie13 citations Open access
Semantic Scholar
Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages
T. Tran, Carmen D Mathmann, Marcela Gatica-Andrades, Rachel F Rollo +39 more
2022PLoS Pathogens13 citations Open access
Semantic Scholar
piCRISPR: Physically informed deep learning models for CRISPR/Cas9 off-target cleavage prediction
Florian Störtz, Jeffrey Y. W. Mak, P. Minary
2021bioRxiv12 citations Open access
Semantic Scholar
Thiazoles in Peptides and Peptidomimetics
Jeffrey Y. W. Mak, Weijun Xu, D. Fairlie
201511 citations Open access
Semantic Scholar
Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulation.
Jieru Deng, Yu-Ting Yan, Xiaoyue Zhang, Calum J. Walsh +28 more
2025Science9 citations Open access
Semantic Scholar
Mucosal-Associated Invariant T Cell Effector Function Is an Intrinsic Cell Property That Can Be Augmented by the Metabolic Cofactor α-Ketoglutarate
Lauren J. Howson, Jasmine Li, A. von Borstel, Adele Barugahare +6 more
2021Journal of Immunology9 citations Open access
Semantic Scholar
Differential location of NKT and MAIT cells within lymphoid tissue
D. Johnson, Z. Ruan, Emma V. Petley, Sapna Devi +11 more
2021Scientific Reports8 citations Open access
Semantic Scholar

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