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Y. Sasaki · SciRah

Researcher profile · Semantic Scholar

Y. Sasaki

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Y. Sasaki — researcher profile on SciRah

h-index: 47
Works: 100
Citations: 12K

Most-cited papers

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
T. Araki, Y. Sasaki, J. Milbrandt
2004Science1,113 citations
Semantic Scholar
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.
Javier R Revollo, A. Körner, K. Mills, A. Satoh +9 more
2007Cell Metabolism959 citations Open access
Semantic Scholar
Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice
K. Mills, Shohei Yoshida, L. R. Stein, Alessia Grozio +8 more
2016Cell Metabolism849 citations Open access
Semantic Scholar
SARM1 activation triggers axon degeneration locally via NAD+ destruction
J. Gerdts, E. Brace, Y. Sasaki, A. Diantonio +1 more
2015Science560 citations Open access
Semantic Scholar
The SARM1 Toll/Interleukin-1 Receptor (TIR) Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration
Kow Essuman, Daniel W. Summers, Y. Sasaki, X. Mao +2 more
2017Neuron544 citations Open access
Semantic Scholar
Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia.
K. Ohsawa, Y. Imai, H. Kanazawa, Y. Sasaki +1 more
2000Journal of Cell Science420 citations
Semantic Scholar
TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death
Lingwei Wan, Kow Essuman, Ryan G. Anderson, Y. Sasaki +7 more
2019Science377 citations Open access
Semantic Scholar
Microglia/macrophage‐specific protein Iba1 binds to fimbrin and enhances its actin‐bundling activity
K. Ohsawa, Y. Imai, Y. Sasaki, S. Kohsaka
2004Journal of Neurochemistry368 citations
Semantic Scholar
Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice
Mitsukuni Yoshida, A. Satoh, Jonathan B. Lin, K. Mills +5 more
2019Cell Metabolism358 citations Open access
Semantic Scholar
Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions
J. Gerdts, Daniel W. Summers, Y. Sasaki, A. Diantonio +1 more
2013Journal of Neuroscience356 citations Open access
Semantic Scholar
Iba1 is an actin-cross-linking protein in macrophages/microglia.
Y. Sasaki, K. Ohsawa, H. Kanazawa, S. Kohsaka +1 more
2001Biochemical and Biophysical Research Communications - BBRC354 citations
Semantic Scholar
A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration
B. R. Miller, Craig A. Press, Richard W. Daniels, Y. Sasaki +2 more
2009Nature Neuroscience311 citations Open access
Semantic Scholar
Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy
Y. Sasaki, T. Araki, J. Milbrandt
2006Journal of Neuroscience297 citations Open access
Semantic Scholar
SARM1 is a Metabolic Sensor Activated by an Increased NMN/NAD+ Ratio to Trigger Axon Degeneration
Matthew D. Figley, W. Gu, J. Nanson, Yun Shi +21 more
2021Neuron291 citations Open access
Semantic Scholar
Aberrant Schwann Cell Lipid Metabolism Linked to Mitochondrial Deficits Leads to Axon Degeneration and Neuropathy
Andreu Viader, Y. Sasaki, Sungsu Kim, Amy Strickland +4 more
2013Neuron265 citations Open access
Semantic Scholar
Slc12a8 is a nicotinamide mononucleotide transporter
Alessia Grozio, K. Mills, Jun Yoshino, Santina Bruzzone +7 more
2019Nature Metabolism254 citations Open access
Semantic Scholar
Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide
Y. Sasaki, B. Vohra, F. Lund, J. Milbrandt
2009Journal of Neuroscience237 citations Open access
Semantic Scholar
Selective expression of Gi/o‐coupled ATP receptor P2Y12 in microglia in rat brain
Y. Sasaki, Masato Hoshi, C. Akazawa, Yasuko Nakamura +3 more
2003Glia235 citations
Semantic Scholar
TIR Domain Proteins Are an Ancient Family of NAD+ Consuming Enzymes
Kow Essuman, Daniel W. Summers, Y. Sasaki, X. Mao +3 more
2018Current Biology223 citations Open access
Semantic Scholar
SCG10 is a JNK target in the axonal degeneration pathway
J. Shin, B. R. Miller, E. Babetto, Yongcheol Cho +6 more
2012Proceedings of the National Academy of Sciences of the United States of America191 citations Open access
Semantic Scholar
NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion
Y. Sasaki, T. Nakagawa, X. Mao, A. Diantonio +1 more
2016eLife186 citations Open access
Semantic Scholar
Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration
A. Misko, Y. Sasaki, E. Tuck, J. Milbrandt +1 more
2012Journal of Neuroscience186 citations Open access
Semantic Scholar
Macrophage/Microglia-specific Protein Iba1 Enhances Membrane Ruffling and Rac Activation via Phospholipase C-γ-dependent Pathway*
H. Kanazawa, K. Ohsawa, Y. Sasaki, S. Kohsaka +1 more
2002Journal of Biological Chemistry170 citations Open access
Semantic Scholar
Western Diet Induces Paneth Cell Defects through Microbiome Alterations and Farnesoid X Receptor and Type I Interferon Activation
Ta-Chiang Liu, Justin T. Kern, Umang Jain, Naomi M. Sonnek +13 more
2021Cell Host and Microbe154 citations Open access
Semantic Scholar
Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo
Y. Sasaki, B. Vohra, R. Baloh, J. Milbrandt
2009Journal of Neuroscience153 citations Open access
Semantic Scholar
MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2
Lauren J Walker, Daniel W. Summers, Y. Sasaki, E. Brace +2 more
2017eLife146 citations Open access
Semantic Scholar
An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma
Amit D. Gujar, Son Le, Diane D. Mao, D. Dadey +12 more
2016Proceedings of the National Academy of Sciences of the United States of America127 citations Open access
Semantic Scholar
Structural basis of SARM1 activation, substrate recognition and inhibition by small molecules
Yun Shi, P. Kerry, J. Nanson, T. Bosanac +21 more
2022Molecules and Cells120 citations Open access
Semantic Scholar
APP cleavage dependent and independent axonal degeneration programs share a common Nmnat1-sensitive pathway
B. Vohra, Y. Sasaki, B. R. Miller, Jufang Chang +2 more
2010Journal of Neuroscience102 citations Open access
Semantic Scholar
cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons
Y. Sasaki, T. Engber, R. Hughes, Matthew D. Figley +6 more
2020Experimental Neurology98 citations Open access
Semantic Scholar
Assembly and maintenance of nodes of Ranvier rely on distinct sources of proteins and targeting mechanisms
Yanqing Zhang, Yoko Bekku, Yulia Dzhashiashvili, Stephen T. Armenti +4 more
2012Neuron92 citations Open access
Semantic Scholar
Adipose tissue NAD+ biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice
Shintaro Yamaguchi, Michael P. Franczyk, M. Chondronikola, Nathan Qi +10 more
2019Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
The AMPK β2 Subunit Is Required for Energy Homeostasis during Metabolic Stress
B. Dasgupta, Jeong-sun Ju, Y. Sasaki, Xiao-Na Liu +4 more
2012Molecular and Cellular Biology75 citations Open access
Semantic Scholar
Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients
A. J. Bloom, X. Mao, Amy Strickland, Y. Sasaki +2 more
2022Molecular Neurodegeneration74 citations Open access
Semantic Scholar
A Model of Toxic Neuropathy in Drosophila Reveals a Role for MORN4 in Promoting Axonal Degeneration
Martha R. C. Bhattacharya, J. Gerdts, Sarah A. Naylor, Emily X Royse +4 more
2012Journal of Neuroscience73 citations Open access
Semantic Scholar
Axonal Degeneration Is Blocked by Nicotinamide Mononucleotide Adenylyltransferase (Nmnat) Protein Transduction into Transected Axons*
Y. Sasaki, J. Milbrandt
2010Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Image-based Screening Identifies Novel Roles for IκB Kinase and Glycogen Synthase Kinase 3 in Axonal Degeneration*
J. Gerdts, Y. Sasaki, B. Vohra, J. Marasa +1 more
2011Journal of Biological Chemistry69 citations Open access
Semantic Scholar
The Upregulated Expression of Sonic Hedgehog in Motor Neurons after Rat Facial Nerve Axotomy
C. Akazawa, H. Tsuzuki, Yasuko Nakamura, Y. Sasaki +4 more
2004Journal of Neuroscience66 citations Open access
Semantic Scholar
SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration
Y. Sasaki, Hiroki Kakita, S. Kubota, A. Séne +9 more
2020bioRxiv65 citations Open access
Semantic Scholar
Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.
Yan-Li Zhu, Li-Hong Zhang, Y. Sasaki, J. Milbrandt +1 more
2013Investigative Ophthalmology and Visual Science65 citations Open access
Semantic Scholar
Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death
P. Verghese, Y. Sasaki, Dong-Han M. Yang, Floy R. Stewart +7 more
2011Proceedings of the National Academy of Sciences of the United States of America64 citations Open access
Semantic Scholar
Live imaging reveals the cellular events downstream of SARM1 activation
Kwang Woo Ko, Laura DeVault, Y. Sasaki, J. Milbrandt +1 more
2021bioRxiv59 citations Open access
Semantic Scholar
Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity
Sungsu Kim, Jason C. Maynard, Y. Sasaki, Amy Strickland +4 more
2016Journal of Neuroscience57 citations Open access
Semantic Scholar
Multiple domain interfaces mediate SARM1 autoinhibition
Chen Shen, M. Vohra, Pengfei Zhang, X. Mao +6 more
2021Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion
Ryo Terao, Tae Jun Lee, Jason J. Colasanti, Charles W. Pfeifer +9 more
2024Cell Reports55 citations Open access
Semantic Scholar
Mechanisms of Nucleotide Trafficking during siRNA Delivery to Endothelial Cells using Perfluorocarbon Nanoemulsions
Megan M. Kaneda, Y. Sasaki, G. Lanza, J. Milbrandt +1 more
2010Biomaterials55 citations Open access
Semantic Scholar
A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model
Yurie Sato-Yamada, Amy Strickland, Y. Sasaki, Joseph Bloom +2 more
2022Journal of Clinical Investigation53 citations Open access
Semantic Scholar
NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism.
Lane C. Porter, Michael P. Franczyk, T. Pietka, Shintaro Yamaguchi +5 more
2018American Journal of Physiology. Endocrinology and Metabolism44 citations Open access
Semantic Scholar
Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity
Yanchun Pan, T. Daito, Y. Sasaki, Y. Chung +6 more
2016Scientific Reports43 citations Open access
Semantic Scholar
Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss
Tong Wu, Jian Zhu, Amy Strickland, Kwang Woo Ko +9 more
2021bioRxiv40 citations Open access
Semantic Scholar

Frequent co-authors

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J. Milbrandt×36
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J. Milbrandt — researcher profile on SciRah
A. Diantonio×19
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A. Diantonio — researcher profile on SciRah
X. Mao×7
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X. Mao — researcher profile on SciRah
S. Kohsaka×6
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S. Kohsaka — researcher profile on SciRah

×5

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R. Apte — researcher profile on SciRah

Amy Strickland×5

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Amy Strickland — researcher profile on SciRah

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K. Mills — researcher profile on SciRah

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S. Imai — researcher profile on SciRah

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Jun Yoshino — researcher profile on SciRah

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J. Gerdts — researcher profile on SciRah

Daniel W. Summers×4

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Daniel W. Summers — researcher profile on SciRah

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K. Ohsawa — researcher profile on SciRah