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J. Hechtman · SciRah

Researcher profile · Semantic Scholar

J. Hechtman

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J. Hechtman — researcher profile on SciRah

h-index: 57
Works: 195
Citations: 24K

Most-cited papers

Clinical sequencing defines the genomic landscape of metastatic colorectal cancer
R. Yaeger, W. Chatila, Marla D Lipsyc, J. Hechtman +25 more
2018Cancer Cell804 citations Open access
Semantic Scholar
Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade
W. Abida, M. Cheng, J. Armenia, S. Middha +27 more
2019JAMA Oncology600 citations Open access
Semantic Scholar
Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.
Alicia J. Latham, P. Srinivasan, Y. Kemel, J. Shia +40 more
2019Journal of Clinical Oncology518 citations Open access
Semantic Scholar
NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls
James P. Solomon, I. Linkov, Andrea Rosado, Kerry A. Mullaney +10 more
2019Modern Pathology498 citations Open access
Semantic Scholar
Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response
Rajarsi Mandal, R. Samstein, Ken-Wing Lee, J. Havel +20 more
2019Science490 citations Open access
Semantic Scholar
ESMO recommendations on the standard methods to detect NTRK fusions in daily practice and clinical research.
C. Marchiò, M. Scaltriti, M. Ladanyi, A. Iafrate +8 more
2019Annals of Oncology350 citations Open access
Semantic Scholar
ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper
A. Dasari, V. Morris, C. J. Allegra, C. Atreya +39 more
2020Nature Reviews Clinical Oncology348 citations Open access
Semantic Scholar
First-line pembrolizumab and trastuzumab in HER2-positive esophagogastric cancer
Y. Janjigian, S. Maron, W. Chatila, Brittanie M Millang +21 more
2020The Lancet Oncology268 citations Open access
Semantic Scholar
Identifying patients with NTRK fusion cancer
James P. Solomon, R. Benayed, J. Hechtman, M. Ladanyi
2019Annals of Oncology244 citations Open access
Semantic Scholar
NTRK Fusions Define a Novel Uterine Sarcoma Subtype with Features of Fibrosarcoma
S. Chiang, P. Cotzia, D. Hyman, A. Drilon +13 more
2018American Journal of Surgical Pathology211 citations Open access
Semantic Scholar
Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation
E. Cocco, A. Schram, Amanda Kulick, S. Misale +25 more
2019Nature Medicine193 citations Open access
Semantic Scholar
Detection of NTRK fusions: Merits and Limitations of Current Diagnostic Platforms
James P. Solomon, J. Hechtman
2019Cancer Research161 citations Open access
Semantic Scholar
Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma
T. Boerner, E. Drill, L. Pak, B. Nguyen +28 more
2021Hepatology152 citations Open access
Semantic Scholar
TRK Fusions are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations
E. Rosen, D. Goldman, J. Hechtman, R. Benayed +12 more
2019Clinical Cancer Research137 citations Open access
Semantic Scholar
Colorectal carcinomas containing hypermethylated MLH1 promoter and wild type BRAF/KRAS are enriched for targetable kinase fusions
E. Cocco, J. Benhamida, S. Middha, A. Zehir +16 more
2019Cancer Research130 citations Open access
Semantic Scholar
NTRK insights: best practices for pathologists
J. Hechtman
2021Modern Pathology111 citations Open access
Semantic Scholar
Majority of B2M-Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High
S. Middha, R. Yaeger, J. Shia, Z. Stadler +11 more
2019JCO Precision Oncology109 citations Open access
Semantic Scholar
DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma
Monika Vyas, J. Hechtman, Yan-Ming Zhang, R. Benayed +5 more
2019Modern Pathology108 citations Open access
Semantic Scholar
Overcoming MET-dependent resistance to selective RET inhibition in patients with RET fusion-positive lung cancer by combining selpercatinib with crizotinib
E. Rosen, M. Johnson, S. Clifford, Romel Somwar +24 more
2020Clinical Cancer Research104 citations Open access
Semantic Scholar
Retained Mismatch Repair Protein Expression Occurs in Approximately 6% of Microsatellite Instability-High Cancers and is Associated with Missense Mutations in Mismatch Repair Genes.
J. Hechtman, Satshil Rana, S. Middha, Z. Stadler +7 more
2019Modern Pathology99 citations Open access
Semantic Scholar
RET fusions in a small subset of advanced colorectal cancers at risk of being neglected
F. Pietrantonio, F. Di Nicolantonio, A. Schrock, J.-W. Lee +32 more
2018Annals of Oncology96 citations Open access
Semantic Scholar
Tumour response to TRK inhibition in a patient with pancreatic adenocarcinoma harbouring an NTRK gene fusion
E. O'Reilly, J. Hechtman
2019Annals of Oncology89 citations Open access
Semantic Scholar
Current Management of Appendiceal Neoplasms.
Richard S. Hoehn, Caroline J. Rieser, M. H. Choudry, N. Melnitchouk +2 more
2021American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting87 citations Open access
Semantic Scholar
Clinical and molecular predictors of response to immune checkpoint inhibitors in patients with advanced esophagogastric cancer
M. Greally, Joanne F. Chou, W. Chatila, Matthew L Margolis +15 more
2019Clinical Cancer Research84 citations Open access
Semantic Scholar
Carcinomas assemble a filamentous CXCL12–keratin-19 coating that suppresses T cell–mediated immune attack
Zhi-Kai Wang, Philip Moresco, Ran Yan, Jiayun Li +9 more
2022Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
Semantic Scholar
A Performance Comparison of Commonly Used Assays to Detect RET Fusions
Soo-Ryum Yang, U. Aypar, E. Rosen, Douglas A. Mata +10 more
2020Clinical Cancer Research74 citations Open access
Semantic Scholar
Lineage reversion drives WNT independence in intestinal cancer
Teng Han, Sukanya Goswami, Yang Hu, Fan-Ying Tang +10 more
2020bioRxiv68 citations Open access
Semantic Scholar
Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers
W. Chatila, H. Walch, J. Hechtman, Sydney M. Moyer +24 more
2023Nature Communications52 citations Open access
Semantic Scholar
Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies
Justin Taylor, D. Pavlick, A. Yoshimi, C. Marcelus +23 more
2018Journal of Clinical Investigation51 citations Open access
Semantic Scholar
First-line pembrolizumab (P), trastuzumab (T), capecitabine (C) and oxaliplatin (O) in HER2-positive metastatic esophagogastric adenocarcinoma (mEGA).
Y. Janjigian, Joanne F. Chou, M. Simmons, Parisa Momtaz +16 more
2019Journal of Clinical Oncology46 citations
Semantic Scholar
TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors
E. Cocco, J. E. Lee, S. Kannan, A. Schram +30 more
2020Cancer Discovery45 citations Open access
Semantic Scholar
Reliable Clinical MLH1 Promoter Hypermethylation Assessment using a High-Throughput Genome-Wide Methylation Array Platform.
J. Benhamida, J. Hechtman, K. Nafa, Liliana B. Villafania +8 more
2019Journal of Molecular Diagnostics43 citations Open access
Semantic Scholar
Germline SDHA mutations in children and adults with cancer
Marianne Dubard Gault, D. Mandelker, D. DeLair, Carolyn Stewart +34 more
2018Cold Spring Harbor molecular case studies42 citations Open access
Semantic Scholar
Genomic Characterization of ERBB2-Driven Biliary Cancer and a Case of Response to Ado-Trastuzumab Emtansine.
S. Mondaca, P. Razavi, Chong-Rui Xu, M. Offin +9 more
2019JCO Precision Oncology39 citations Open access
Semantic Scholar
Microsatellite instability and mismatch repair deficiency define a distinct subset of lung cancers characterized by smoking exposure, high tumor mutational burden and recurrent somatic MLH1 inactivation
Soo-Ryum Yang, E. Gedvilaite, R. Ptashkin, Jason C. Chang +15 more
2023Journal of Thoracic Oncology38 citations
Semantic Scholar
Characterization and Clinical Outcomes of DNA Mismatch Repair Deficient (MMR-D) Small Bowel Adenocarcinoma
Alicia J. Latham, J. Shia, Zalak Patel, D. Reidy-Lagunes +21 more
2020Clinical Cancer Research34 citations Open access
Semantic Scholar
V211D mutation in MEK1 causes resistance to MEK inhibitors in colon cancer
Yijun Gao, Ann Maria, Na Na, Arnaud Da Cruz Paula +12 more
2019Cancer Discovery34 citations Open access
Semantic Scholar
Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
S. Maron, W. Chatila, H. Walch, Joanne F. Chou +30 more
2023Clinical Cancer Research32 citations Open access
Semantic Scholar
Enrichment of kinase fusions in ESR1 wild-type, metastatic breast cancer revealed by a systematic analysis of 4854 patients
D. Ross, B. Liu, A. Schram, P. Razavi +11 more
2020Annals of Oncology30 citations Open access
Semantic Scholar
Larotrectinib Demonstrates CNS Efficacy in TRK Fusion-Positive Solid Tumors
E. Rosen, A. Schram, R. Young, Mark Schreyer +5 more
2019JCO Precision Oncology28 citations Open access
Semantic Scholar
Rates of TP53 Mutation are Significantly Elevated in African American Patients with Gastric Cancer
E. van Beek, Jonathan M. Hernandez, D. Goldman, Jeremy L. Davis +14 more
2018Annals of Surgical Oncology25 citations Open access
Semantic Scholar
Prevalence of Germline Alterations on Targeted Tumor-Normal Sequencing of Esophagogastric Cancer
G. Ku, Y. Kemel, S. Maron, Joanne F. Chou +22 more
2021JAMA Network Open23 citations Open access
Semantic Scholar
SWI/SNF COMPLEX-DEFICIENT UNDIFFERENTIATED CARCINOMA OF THE PANCREAS: CLINICOPATHOLOGIC AND GENOMIC ANALYSIS
A. Yavas, Kerem Ozcan, N. Adsay, S. Balci +19 more
2024Modern Pathology22 citations Open access
Semantic Scholar
EGFR Amplification in Metastatic Colorectal Cancer.
G. Randon, R. Yaeger, J. Hechtman, P. Manca +22 more
2021Journal of the National Cancer Institute22 citations Open access
Semantic Scholar
ARAF protein kinase activates RAS by antagonizing its binding to the RASGAP NF1
Wenjing Su, Radha Mukherjee, R. Yaeger, Jieun Son +23 more
2022Molecules and Cells21 citations Open access
Semantic Scholar
Molecular Epidemiology of IDH2 Hotspot Mutations in Cancer and Immunohistochemical Detection of R172K, R172G and R172M Variants
S. Dogan, D. Frosina, Jerica A. Geronimo, Enmily Hernandez +6 more
2020Human Pathology21 citations Open access
Semantic Scholar
Performance of DAXX Immunohistochemistry as a Screen for DAXX Mutations in Pancreatic Neuroendocrine Tumors
J. Hechtman, D. Klimstra, G. Nanjangud, D. Frosina +2 more
2019Pancreas19 citations Open access
Semantic Scholar
First-line pembrolizumab (P), trastuzumab (T), capecitabine (C) and oxaliplatin (O) in HER2-positive metastatic esophagogastric adenocarcinoma
Y. Janjigian, S. Maron, Joanne F. Chou, A. Gabler +15 more
2019Annals of Oncology19 citations Open access
Semantic Scholar
Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways
S. Sihag, S. Nussenzweig, H. Walch, M. Hsu +17 more
2021Clinical Cancer Research18 citations Open access
Semantic Scholar
Phase II study of trastuzumab with modified docetaxel, cisplatin, and 5 fluorouracil in metastatic HER2-positive gastric cancer
S. Mondaca, Matthew L Margolis, F. Sánchez-Vega, P. Jonsson +18 more
2018Gastric Cancer18 citations Open access
Semantic Scholar

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