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Lei L. Chen · SciRah

Researcher profile · Semantic Scholar

Lei L. Chen

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Lei L. Chen — researcher profile on SciRah

h-index: 17
Works: 27
Citations: 3,578

Most-cited papers

Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria.
Haesun Choi, C. Charnsangavej, S. Faria, H. Macapinlac +5 more
2007Journal of Clinical Oncology1,500 citations Open access
Semantic Scholar
We should desist using RECIST, at least in GIST.
R. Benjamin, Haesun Choi, H. Macapinlac, M. Burgess +4 more
2007Journal of Clinical Oncology570 citations
Semantic Scholar
A Missense Mutation in KIT Kinase Domain 1 Correlates with Imatinib Resistance in Gastrointestinal Stromal Tumors
Lei L. Chen, J. Trent, Elsie F. Wu, G. Fuller +17 more
2004Cancer Research349 citations Open access
Semantic Scholar
Surgical Resection of Gastrointestinal Stromal Tumors After Treatment with Imatinib
R. Andtbacka, C. Ng, C. Scaife, J. Cormier +10 more
2006Annals of Surgical Oncology280 citations
Semantic Scholar
Is there a role for surgery in patients with "unresectable" cKIT+ gastrointestinal stromal tumors treated with imatinib mesylate?
C. Scaife, K. Hunt, Shreyaskumar R. Patel, Robert S. Benjamin +8 more
2003American Journal of Surgery141 citations
Semantic Scholar
A two‐arm phase II study of temozolomide in patients with advanced gastrointestinal stromal tumors and other soft tissue sarcomas
J. Trent, J. Beach, M. A. Burgess, N. Papadopolous +3 more
2003Cancer124 citations Open access
Semantic Scholar
Extraosseous osteosarcoma: response to treatment and long-term outcome.
S. Ahmad, Shreyaskumar R. Patel, M. Ballo, Treneth P. Baker +11 more
2002Journal of Clinical Oncology110 citations
Semantic Scholar
Clinical, histopathologic, molecular and therapeutic findings in a large kindred with gastrointestinal stromal tumor
E. P. Kleinbaum, A. Lazar, E. Tamborini, J. Mcauliffe +8 more
2008International Journal of Cancer71 citations Open access
Semantic Scholar
Therapy-related acute myeloid leukemia with t(8;21) (q22;q22) shares many features with de novo acute myeloid leukemia with t(8;21)(q22;q22) but does not have a favorable outcome.
Steven A. Gustafson, P. Lin, Suipeng Chen, Lei L. Chen +4 more
2009American Journal of Clinical Pathology61 citations Open access
Semantic Scholar
Angiosarcoma of the breast
S. Vorburger, Y. Xing, K. Hunt, G. Lakin +10 more
2005Cancer57 citations Open access
Semantic Scholar
A mutation-created novel intra-exonic pre-mRNA splice site causes constitutive activation of KIT in human gastrointestinal stromal tumors
Lei L. Chen, M. Sabripour, Elsie F. Wu, V. Prieto +2 more
2005Oncogene57 citations
Semantic Scholar
Exploiting antitumor immunity to overcome relapse and improve remission duration
Lei L. Chen, Xinjian Chen, Haesun Choi, Hong-Xun Sang +25 more
2011Cancer Immunology and Immunotherapy50 citations Open access
Semantic Scholar
Imatinib resistance in gastrointestinal stromal tumors
Lei L. Chen, M. Sabripour, R. Andtbacka, Shreyaskumar R. Patel +6 more
2005Current Oncology Reports48 citations
Semantic Scholar
Acute myeloid leukemia harboring t(8;21)(q22;q22): a heterogeneous disease with poor outcome in a subset of patients unrelated to secondary cytogenetic aberrations
P. Lin, Lei L. Chen, R. Luthra, S. Konoplev +2 more
2008Modern Pathology42 citations
Semantic Scholar
Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression
Lei L. Chen, J. Holden, Haesun Choi, Jing Zhu +13 more
2008Modern Pathology40 citations Open access
Semantic Scholar
Gastrointestinal stromal tumors: overview of pathologic features, molecular biology, and therapy with imatinib mesylate.
J. Koh, J. Trent, Lei L. Chen, A. El-Naggar +3 more
2004Histology and Histopathology40 citations
Semantic Scholar
Response of gastrointestinal stromal tumors (GISTs) to imatinib by Choi criteria and response evaluation criteria in solid tumors (RECIST) as surrogates for survival and time to progression.
Robert S. Benjamin, Haesun Choi, H. Macapinlac, M. A. Burgess +4 more
2006Journal of Clinical Oncology18 citations
Semantic Scholar
Combining targeted therapy with immunotherapy (interferon-α)
Lei L. Chen, L. Gouw, M. Sabripour, W. Hwu +1 more
2012Oncoimmunology9 citations Open access
Semantic Scholar
Endostar plus pembrolizumab combined with a platinum-based dual chemotherapy regime for advanced pulmonary large-cell neuroendocrine carcinoma as a first-line treatment: A case report
Si-Jia Zhang, Yu Xiao, Lei L. Chen, Zhenyu Li +3 more
2022Open Life Sciences4 citations Open access
Semantic Scholar
SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions
Lei L. Chen, Jing Zhu, Jonathan A. Schumacher, Chong-Juan Wei +14 more
2017PLoS ONE3 citations Open access
Semantic Scholar
Combination of targeted therapy (imatinib) with immunotherapy (peginterferon {alpha}-2b) to overcome drug resistance and tumor stem cells in gastrointestinal stromal tumors (GIST).
Lei L. Chen, Xinjian Chen, L. Gouw, R. Andtbacka +6 more
20103 citations
Semantic Scholar
Loss of heterozygosity with acquisition of homozygous KIT-activating mutation promotes gastrointestinal stromal tumor progression.
Lei L. Chen, V. Prieto, M. Sabripour, Elsie F. Wu +3 more
2006Journal of Clinical Oncology1 citations
Semantic Scholar
Quantitative real time-PCR of CD133 mRNA: A potential surrogate angiogenic marker of response for patients with metastatic sarcoma.
E. Lin, Y. Li, J. Trent, Sunil M. Patel +5 more
2006Journal of Clinical Oncology1 citations
Semantic Scholar
Familial gastrointestinal stromal tumor with homo-/hemizygous kit exon 11 deletion: Genotypic, histopathologic, radiographic, and therapeutic findings.
E. P. Kleinbaum, Lei L. Chen, A. Lazar, Louise C. Strong +5 more
2006Journal of Clinical Oncology1 citations
Semantic Scholar
Outcomes of gastrointestinal stromal tumors (GIST) and other intra-abdominal sarcomas (IAS) in the era of imatinib therapy
D. Steinert, L. Blakely, Shreyaskumar R. Patel, M. Burgess +4 more
20041 citations
Semantic Scholar
KIT/Val654Ala receptor detected in one imatinib-resistant GIST patient [3] (multiple letters)
E. Tamborini, E. Gabanti, M. Lagonigro, T. Negri +5 more
20050 citations
Semantic Scholar
Differential sensitivity of rhabomyosarcoma cell line clones to EGF receptor inhibition with gefitinib.
Jason Salganick, Caroline O. Oyedeji, Shreyaskumar R. Patel, M. A. Burgess +3 more
2004Journal of Clinical Oncology0 citations
Semantic Scholar

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