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E. Janssen · SciRah

Researcher profile · Semantic Scholar

E. Janssen

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E. Janssen — researcher profile on SciRah

h-index: 28
Works: 67
Citations: 3,910

Most-cited papers

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
Caroline Junqueira, Â. Crespo, S. Ranjbar, Luna B. de Lacerda +28 more
2022Nature513 citations Open access
Semantic Scholar
Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series.
P. Nigrovic, M. Mannion, Femke H. M. Prince, A. Zeft +16 more
2011Arthritis & Rheumatism459 citations
Semantic Scholar
Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children.
Pui Y. Lee, M. Day-Lewis, L. Henderson, K. Friedman +25 more
2020Journal of Clinical Investigation343 citations Open access
Semantic Scholar
Dominant gain-of-function STAT1 mutations in FOXP3WT IPEX-like Syndrome
G. Uzel, E. Sampaio, M. Lawrence, Amy P. Hsu +19 more
2013Journal of Allergy and Clinical Immunology299 citations Open access
Semantic Scholar
Regulatory T Cell Deficiency and Immune dysregulation, Polyendocrinopathy, Enteropathy, X-Linked-Like Disorder Due to Loss of Function Mutations in LRBA
L. Charbonnier, E. Janssen, J. Chou, T. Ohsumi +11 more
2014Journal of Allergy and Clinical Immunology232 citations Open access
Semantic Scholar
Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food anaphylaxis
L. Bartnikas, M. Gurish, O. Burton, S. Leisten +9 more
2013Journal of Allergy and Clinical Immunology173 citations Open access
Semantic Scholar
LAB: A new membrane-associated adaptor molecule in B cell activation
E. Janssen, Minghua Zhu, Weijia Zhang, S. Koonpaew +1 more
2003Nature Immunology164 citations
Semantic Scholar
DOCK8 functions as an adaptor that links Toll-like receptor–MyD88 signaling to B cell activation
H. Jabara, Douglas R. McDonald, E. Janssen, M. Massaad +27 more
2012Nature Immunology145 citations Open access
Semantic Scholar
Minimal Requirement of Tyrosine Residues of Linker for Activation of T Cells in TCR Signaling and Thymocyte Development1
Minghua Zhu, E. Janssen, Weiguo Zhang
2003Journal of Immunology117 citations
Semantic Scholar
SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release
Caroline Junqueira, Â. Crespo, S. Ranjbar, Mercedes Lewandrowski +26 more
2021Research Square115 citations Open access
Semantic Scholar
Pleiotropic defects in TCR signaling in a Vav‐1‐null Jurkat T‐cell line
You-Jia Cao, E. Janssen, Andrew W. Duncan, A. Altman +2 more
2002EMBO Journal111 citations Open access
Semantic Scholar
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
E. Janssen, Mira Tohmé, M. Hedayat, Marion Leick +15 more
2016Journal of Clinical Investigation103 citations Open access
Semantic Scholar
DOCK8 Functions as an Adaptor that Links TLR–MyD88 Signaling to B Cell Activation
H. Jabara, Douglas R. McDonald, E. Janssen, M. Massaad +31 more
2012101 citations
Semantic Scholar
DOCK8 deficient patients have a breakdown in peripheral B cell tolerance and defective regulatory T cells
E. Janssen, H. Morbach, Sumana Ullas, Jason M. Bannock +11 more
2014Journal of Allergy and Clinical Immunology94 citations Open access
Semantic Scholar
Molecular Cloning of a Novel Gene Encoding a Membrane-associated Adaptor Protein (LAX) in Lymphocyte Signaling*
Minghua Zhu, E. Janssen, K. Leung, Weiguo Zhang
2002Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
M. Massaad, Jia Zhou, D. Tsuchimoto, J. Chou +24 more
2016Journal of Clinical Investigation75 citations Open access
Semantic Scholar
Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis.
L. Henderson, Kacie J. Hoyt, Pui Lee, D. Rao +24 more
2020JCI Insight64 citations Open access
Semantic Scholar
Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency
S. Pai, H. D. de Boer, M. Massaad, T. Chatila +9 more
2014Journal of Allergy and Clinical Immunology55 citations Open access
Semantic Scholar
Linker for Activation of B Cells: A Functional Equivalent of a Mutant Linker for Activation of T Cells Deficient in Phospholipase C-γ1 Binding1
E. Janssen, Minghua Zhu, B. Craven, Weiguo Zhang
2004Journal of Immunology54 citations Open access
Semantic Scholar
Next Generation Sequencing Reveals Restriction and Clonotypic Expansion of Regulatory T Cells in Juvenile Idiopathic Arthritis
Lauren A. Henderson, Stefano Volpi, Francesco Frugoni, E. Janssen +15 more
2016Arthritis & Rheumatology51 citations Open access
Semantic Scholar
Primary immunodeficiencies caused by mutations in actin regulatory proteins
E. Janssen, R. Geha
2018Immunological Reviews47 citations
Semantic Scholar
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
A. Biswas, D. Shouval, Alexandra E. Griffith, J. Goettel +13 more
2018Nature Communications47 citations Open access
Semantic Scholar
The Importance of Three Membrane-distal Tyrosines in the Adaptor Protein NTAL/LAB*
S. Koonpaew, E. Janssen, Minghua Zhu, Weiguo Zhang
2004Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis
Amélie M. Julé, Kacie J. Hoyt, Kevin Wei, M. Gutierrez-Arcelus +21 more
2021JCI Insight42 citations Open access
Semantic Scholar
DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.
E. Janssen, Sudha Kumari, Mira Tohmé, Sumana Ullas +8 more
2017JCI Insight41 citations Open access
Semantic Scholar
Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis
E. Janssen, E. Tsitsikov, W. Al-Herz, G. Lefranc +6 more
2013Clinical Immunology37 citations Open access
Semantic Scholar
Defining a new immune deficiency syndrome: MAN2B2-CDG
Jan Verheijen, Sun-Nie Y. Wong, J. Rowe, K. Raymond +19 more
2019Journal of Allergy and Clinical Immunology35 citations Open access
Semantic Scholar
Adaptor proteins in lymphocyte activation.
E. Janssen, Weiguo Zhang
2003Current Opinion in Immunology32 citations
Semantic Scholar
Pulmonary manifestations of immune dysregulation in CTLA‐4 haploinsufficiency and LRBA deficiency
K. Krone, Abbey J. Winant, S. Vargas, Craig D. Platt +6 more
2020Pediatric Pulmonology21 citations Open access
Semantic Scholar
Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor κB kinase alpha (IKKα)
Wayne Bainter, V. Lougaris, Jacqueline G. Wallace, Y. Badran +25 more
2021Science immunology18 citations Open access
Semantic Scholar
DOCK8 is essential for LFA-1 dependent positioning of T follicular helper cells in germinal centers.
E. Janssen, Mira Tohmé, Jordan Butts, S. Giguère +10 more
2020JCI Insight17 citations Open access
Semantic Scholar
TRIF signaling is essential for TLR4-driven IgE class switching
E. Janssen, Esra Ozcan, Kyriaki Liadaki, H. Jabara +6 more
2014Journal of Immunology17 citations Open access
Semantic Scholar
Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis
Amélie M. Julé, K. Lam, M. Taylor, Kacie J. Hoyt +24 more
2023Frontiers in Immunology16 citations Open access
Semantic Scholar
Immune dysregulation caused by homozygous mutations in CBLB
E. Janssen, Zachary Peters, M. Alosaimi, Emma M. Smith +17 more
2022Journal of Clinical Investigation15 citations Open access
Semantic Scholar
An Evidence-Based Guideline Improves Outcomes for Patients with Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome
M. Taylor, Kacie J. Hoyt, Joseph Han, L. Benson +27 more
2022Journal of Rheumatology15 citations Open access
Semantic Scholar
Treg cell dysfunction and cutaneous exposure to S. aureus underlie eczema in DOCK8 deficiency.
Hazel Wilkie, Mrinmoy Das, Tyler Pelovitz, Wayne Bainter +27 more
2024Journal of Allergy and Clinical Immunology14 citations Open access
Semantic Scholar
Heterozygosity for TACI A144E causes haploinsufficiency and pneumococcal susceptibility in mice
H. Jabara, J. Lee, E. Janssen, Sumana Ullas +11 more
2016Journal of Allergy and Clinical Immunology14 citations Open access
Semantic Scholar
The Immunologic Features of Patients with Early-Onset and Polyautoimmunity
Kacie J. Hoyt, T. Chatila, L. Notarangelo, Melissa M. Hazen +2 more
2019Clinical Immunology13 citations Open access
Semantic Scholar
SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release
Caroline Junqueira, Â. Crespo, S. Ranjbar, Jacob Ingber +25 more
2021medRxiv9 citations Open access
Semantic Scholar
DOCK8 expression in Treg cells maintains their stability and limits contact hypersensitivity
H. Wilkie, E. Janssen, J. Leyva-Castillo, R. Geha
2020Journal of Investigative Dermatology9 citations Open access
Semantic Scholar
Genetic diagnosis of immune dysregulation can lead to targeted therapy for interstitial lung disease: A case series and single center approach
Holly Wobma, R. Perkins, L. Bartnikas, F. Dedeoğlu +10 more
2022Pediatric Pulmonology8 citations Open access
Semantic Scholar
Cytotoxic T Lymphocyte Antigen 4 Haploinsufficiency Presenting As Refractory Celiac-Like Disease: Case Report
L. Collen, C. Salgado, B. Bao, E. Janssen +6 more
2022Frontiers in Immunology7 citations Open access
Semantic Scholar
DOCK8 deficient patients have a breakdown in peripheral B cell tolerance and defective regulatory T cells
E. Janssen, H. Morbach, Sumana Ullas, M. Jason +14 more
20146 citations
Semantic Scholar
Dominant gain-of-function STAT1 mutations in FOXP3 WT IPEX-like Syndrome
G. Uzel, E. Sampaio, M. Lawrence, Amy P. Hsu +20 more
20136 citations
Semantic Scholar
Case Report: Insulin hypersensitivity in youth with type 1 diabetes
Einas H. Alkhatib, Jody B. Grundman, Anna M. Adamusiak, M. Bellin +8 more
2023Frontiers in Endocrinology5 citations Open access
Semantic Scholar
A homozygous truncating mutation of FGL2 is associated with immune dysregulation.
E. Janssen, Mohammad F Alosaimi, A. Alazami, A. Alsuliman +10 more
2022Journal of Allergy and Clinical Immunology5 citations
Semantic Scholar
Macabre Th2 skewing in DOCK8 deficiency.
E. Janssen, H. Wilkie, R. Geha
2021Journal of Allergy and Clinical Immunology5 citations
Semantic Scholar
Cytoskeletal tension actively sustains the migratory T‐cell synaptic contact
Sudha Kumari, M. Mak, Y. Poh, Mira Tohmé +6 more
2020EMBO Journal4 citations Open access
Semantic Scholar
Hearsay in the Smiley Face: Analyzing the Use of Emojis as Evidence
E. Janssen
20184 citations
Semantic Scholar
Autoantibody signatures in children with celiac disease, juvenile idiopathic arthritis, and polyautoimmunity
Nan Du, Denis Chang, Madison Wong, Jay R. Thiagarajah +4 more
2025JPGN Reports3 citations Open access
Semantic Scholar

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