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Lu-Chen Weng · SciRah

Researcher profile · Semantic Scholar

Lu-Chen Weng

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Lu-Chen Weng — researcher profile on SciRah

h-index: 41
Works: 126
Citations: 7,506

Most-cited papers

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
D. Taliun, Daniel N. Harris, M. D. Kessler, Jedidiah Carlson +185 more
2019Nature2,049 citations Open access
Semantic Scholar
Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study
L. Staerk, Bi-Qi Wang, S. Preis, M. Larson +9 more
2018British medical journal332 citations Open access
Semantic Scholar
Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations
M. H. Kowalski, Huijun Qian, Zi-Yi Hou, Jonathan D. Rosen +74 more
2019bioRxiv244 citations Open access
Semantic Scholar
Frequency of Cardiac Rhythm Abnormalities in a Half Million Adults
S. Khurshid, Seung-Ho-An Choi, Lu-Chen Weng, Elizabeth Y. Wang +4 more
2018Circulation: Arrhythmia and Electrophysiology231 citations Open access
Semantic Scholar
Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation
Lu-Chen Weng, S. Preis, Olivia L. Hulme, M. Larson +10 more
2017Circulation220 citations Open access
Semantic Scholar
Association between titin loss-of-function variants and early-onset atrial fibrillation
S. Choi, Lu-Chen Weng, C. Roselli, Hong-Huang Lin +46 more
2018Journal of the American Medical Association (JAMA)203 citations Open access
Semantic Scholar
Deep learning enables genetic analysis of the human thoracic aorta
J. Pirruccello, M. Chaffin, E. Chou, Stephen J. Fleming +26 more
2020Nature Genetics195 citations Open access
Semantic Scholar
Clonal hematopoiesis and risk of chronic liver disease
Wai-Hay J. Wong, C. Emdin, A. Bick, S. Zekavat +435 more
2023Nature174 citations Open access
Semantic Scholar
Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
S. Jurgens, Seung-Ho-An Choi, Valerie N. Morrill, M. Chaffin +66 more
2022Nature Genetics146 citations Open access
Semantic Scholar
Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery
K. Aragam, M. Chaffin, R. Levinson, G. McDermott +19 more
2018Circulation141 citations Open access
Semantic Scholar
Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention.
Nicholas A. Marston, J. Pirruccello, G. Melloni, S. Koyama +12 more
2022JAMA cardiology134 citations Open access
Semantic Scholar
Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease
K. Aragam, Amanda Dobbyn, R. Judy, M. Chaffin +24 more
2020Journal of the American College of Cardiology124 citations Open access
Semantic Scholar
Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results from a National Biobank
Seung-Ho-An Choi, S. Jurgens, Lu-Chen Weng, J. Pirruccello +8 more
2019Circulation Research112 citations Open access
Semantic Scholar
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
I. Ntalla, Lu-Chen Weng, James H. Cartwright, A. Hall +183 more
2020Nature Communications99 citations Open access
Semantic Scholar
Heritability of Atrial Fibrillation
Lu-Chen Weng, Seung-Ho-An Choi, D. Klarin, J. G. Smith +11 more
2017Circulation: Cardiovascular Genetics91 citations Open access
Semantic Scholar
Accelerometer-derived physical activity and risk of atrial fibrillation.
S. Khurshid, Lu-Chen Weng, M. Al-Alusi, Jennifer L. Halford +6 more
2021European Heart Journal89 citations Open access
Semantic Scholar
Development and Validation of a Prediction Model for Atrial Fibrillation Using Electronic Health Records.
Olivia L. Hulme, S. Khurshid, Lu-Chen Weng, Christopher D. Anderson +8 more
2019JACC Clinical Electrophysiology88 citations Open access
Semantic Scholar
Genetics of myocardial interstitial fibrosis in the human heart and association with disease
V. Nauffal, Paolo Di Achille, M. Klarqvist, J. Cunningham +14 more
2021Nature Genetics78 citations Open access
Semantic Scholar
Initial Precipitants and Recurrence of Atrial Fibrillation
Elizabeth Y. Wang, Olivia L. Hulme, S. Khurshid, Lu-Chen Weng +10 more
2020Circulation: Arrhythmia and Electrophysiology71 citations Open access
Semantic Scholar
Stroke as the Initial Manifestation of Atrial Fibrillation: the Framingham Heart Study
S. Lubitz, Xiao-Yan Yin, D. McManus, Lu-Chen Weng +8 more
2017Stroke66 citations Open access
Semantic Scholar
Genetic Variants Associated with Circulating Parathyroid Hormone.
C. Robinson-Cohen, P. Lutsey, M. Kleber, C. Nielson +45 more
2017Journal of the American Society of Nephrology58 citations Open access
Semantic Scholar
Rare coding variant analysis for human diseases across biobanks and ancestries
S. Jurgens, Xin Wang, Seung-Ho-An Choi, Lu-Chen Weng +21 more
2024Nature Genetics56 citations Open access
Semantic Scholar
Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole-genome sequencing studies
Xi-Hao Li, Corbin Quick, Hufeng Zhou, Sheila M. Gaynor +420 more
2022Nature Genetics55 citations Open access
Semantic Scholar
Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience
S. Jurgens, Joel T. Rämö, D. Kramarenko, L. Wijdeveld +54 more
2024Nature Genetics54 citations Open access
Semantic Scholar
Wearable accelerometer-derived physical activity and incident disease
S. Khurshid, Lu-Chen Weng, V. Nauffal, J. Pirruccello +5 more
2022npj Digital Medicine54 citations Open access
Semantic Scholar
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
William J. Young, N. Lahrouchi, A. Isaacs, T. Duong +162 more
2022Nature Communications53 citations Open access
Semantic Scholar
Predictors of Oral Anticoagulant Non-prescription in Patients with Atrial Fibrillation and Elevated Stroke Risk
S. Lubitz, S. Khurshid, Lu-Chen Weng, G. Doros +7 more
2018American Heart Journal52 citations Open access
Semantic Scholar
Fifteen Genetic Loci Associated with the Electrocardiographic P-wave
I. Christophersen, Jared W. Magnani, Xiao-Yan Yin, J. Barnard +48 more
2017Circulation: Cardiovascular Genetics51 citations Open access
Semantic Scholar
Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: A Mendelian randomization study
Lu-Chen Weng, Nicholas S. Roetker, P. Lutsey, Á. Alonso +6 more
2018PLoS ONE46 citations Open access
Semantic Scholar
LMNA Variants and Risk of Adult-Onset Cardiac Disease
J. Lazarte, S. Jurgens, Seung-Ho-An Choi, S. Khurshid +9 more
2022Journal of the American College of Cardiology44 citations Open access
Semantic Scholar
Monogenic and Polygenic Contributions to QTc Prolongation in the Population
V. Nauffal, Valerie N. Morrill, S. Jurgens, S. Choi +34 more
2021medRxiv42 citations Open access
Semantic Scholar
Clinical Application of a Novel Genetic Risk Score for Ischemic Stroke in Patients with Cardiometabolic Disease
Nicholas A. Marston, Parth N. Patel, Frederick K. Kamanu, F. Nordio +24 more
2020Circulation42 citations Open access
Semantic Scholar
Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass
S. Khurshid, J. Lazarte, J. Pirruccello, Lu-Chen Weng +12 more
2022Nature Communications36 citations Open access
Semantic Scholar
Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms
S. Lubitz, O. Parsons, Christopher D. Anderson, E. Benjamin +9 more
2017Stroke35 citations Open access
Semantic Scholar
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk
S. Choi, S. Jurgens, Ling Xiao, M. Hill +496 more
2025Nature Genetics29 citations Open access
Semantic Scholar
Predictive Accuracy of a Clinical and Genetic Risk Model for Atrial Fibrillation
S. Khurshid, N. Mars, C. Haggerty, Qiuxi Huang +12 more
2021Circulation Genomic and Precision Medicine29 citations Open access
Semantic Scholar
Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study
P. D. de Vries, M. Sabater-Lleal, D. Chasman, S. Trompet +82 more
2017PLoS ONE29 citations Open access
Semantic Scholar
Clinical and Genetic Atrial Fibrillation Risk and Discrimination of Cardioembolic from Non-Cardioembolic Stroke
Lu-Chen Weng, S. Khurshid, Sophia Gunn, L. Trinquart +6 more
2023Stroke28 citations Open access
Semantic Scholar
Genetic Determinants of Electrocardiographic P-wave Duration and Relation to Atrial Fibrillation
Lu-Chen Weng, A. Hall, Seung-Ho-An Choi, S. Jurgens +56 more
2020Circulation Genomic and Precision Medicine28 citations Open access
Semantic Scholar
Electronic physician notifications to improve guideline-based anticoagulation in atrial fibrillation: a randomized controlled trial
J. Ashburner, S. Atlas, S. Khurshid, Lu-Chen Weng +5 more
2018Journal of general internal medicine27 citations Open access
Semantic Scholar
Unsupervised deep learning of electrocardiograms enables scalable human disease profiling
S. Friedman, S. Khurshid, R. Venn, Xin Wang +15 more
2025npj Digital Medicine26 citations Open access
Semantic Scholar
Targeted sequencing to identify novel genetic risk factors for deep vein thrombosis: a study of 734 genes
H. D. de Haan, A. van Hylckama Vlieg, L. Lotta, M. M. Gorski +38 more
2018Journal of Thrombosis and Haemostasis23 citations Open access
Semantic Scholar
Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval
Hong-Huang Lin, J. van Setten, A. Smith, Nathan A. Bihlmeyer +97 more
2018Circulation Genomic and Precision Medicine22 citations Open access
Semantic Scholar
The impact of common and rare genetic variants on bradyarrhythmia development
Lu-Chen Weng, Joel T. Rämö, S. Jurgens, S. Khurshid +103 more
2025Nature Genetics20 citations Open access
Semantic Scholar
Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals.
J. Pirruccello, Hong-Huang Lin, S. Khurshid, M. Nekoui +7 more
2022Journal of the American Medical Association (JAMA)20 citations Open access
Semantic Scholar
The AORTA Gene score for detection and risk stratification of ascending aortic dilation.
J. Pirruccello, S. Khurshid, Hong-Huang Lin, Lu-Chen Weng +8 more
2024European Heart Journal19 citations Open access
Semantic Scholar
Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The Atherosclerosis Risk in Communities (ARIC) Study
J. Pankow, Wei-Hong Tang, N. Pankratz, W. Guan +4 more
2017Arteriosclerosis, Thrombosis and Vascular Biology19 citations Open access
Semantic Scholar
Machine Learning to Understand Genetic and Clinical Factors Associated with the Pulse Waveform Dicrotic Notch
J. Cunningham, Paolo Di Achille, Valerie N. Morrill, Lu-Chen Weng +10 more
2021medRxiv18 citations Open access
Semantic Scholar
Novel risk modeling approach of atrial fibrillation with restricted mean survival times: application in the Framingham Heart Study community-based cohort
L. Staerk, S. Preis, Hong-Huang Lin, J. Casas +7 more
2020Circulation. Cardiovascular Quality and Outcomes18 citations Open access
Semantic Scholar
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium
Lu-Chen Weng, K. Lunetta, M. Müller-Nurasyid, A. Smith +66 more
2017Scientific Reports16 citations Open access
Semantic Scholar

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