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H. Marrakchi · SciRah

Researcher profile · Semantic Scholar

H. Marrakchi

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H. Marrakchi — researcher profile on SciRah

h-index: 20
Works: 40
Citations: 2,362

Most-cited papers

Mycolic acids: structures, biosynthesis, and beyond.
H. Marrakchi, M. Lanéelle, M. Daffé
2014Chemistry and Biology565 citations Open access
Semantic Scholar
InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II.
H. Marrakchi, G. Lanéelle, A. Quémard
2000Microbiology248 citations Open access
Semantic Scholar
MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II.
H. Marrakchi, Stéphanie Ducasse, G. Labesse, H. Montrozier +5 more
2002Microbiology130 citations Open access
Semantic Scholar
Mechanistic diversity and regulation of Type II fatty acid synthesis.
H. Marrakchi, Y.-M. Zhang, C. Rock
2002Biochemical Society Transactions129 citations
Semantic Scholar
A New Mechanism for Anaerobic Unsaturated Fatty Acid Formation inStreptococcus pneumoniae *
H. Marrakchi, Keum-Hwa Choi, C. Rock
2002Journal of Biological Chemistry122 citations Open access
Semantic Scholar
The FabR (YijC) Transcription Factor Regulates Unsaturated Fatty Acid Biosynthesis in Escherichia coli *
Yong-Mei Zhang, H. Marrakchi, C. Rock
2002Journal of Biological Chemistry112 citations Open access
Semantic Scholar
Unraveling the Structure of the Mycobacterial Envelope
M. Daffé, H. Marrakchi
2019Microbiology spectrum111 citations Open access
Semantic Scholar
The Pks13/FadD32 Crosstalk for the Biosynthesis of Mycolic Acids in Mycobacterium tuberculosis*
Sabine Gavalda, Mathieu Léger, B. van der Rest, Alexandre Stella +7 more
2009Journal of Biological Chemistry111 citations Open access
Semantic Scholar
Mycobacterial Lipomannan Induces Granuloma Macrophage Fusion via a TLR2-Dependent, ADAM9- and β1 Integrin-Mediated Pathway1
M. Puissegur, G. Lay, M. Gilleron, Laure Botella +9 more
2007Journal of Immunology111 citations Open access
Semantic Scholar
Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).
H. Marrakchi, W. Dewolf, C. Quinn, J. West +8 more
2003Biochemical Journal105 citations Open access
Semantic Scholar
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase Published, JLR Papers in Press, November 4, 2002. DOI 10.1194/jlr.R200016-JLR200
Yong-Mei Zhang, H. Marrakchi, S. White, C. Rock
2003Journal of Lipid Research101 citations Open access
Semantic Scholar
The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis.
Mathieu Léger, Sabine Gavalda, V. Guillet, B. van der Rest +6 more
2009Chemistry and Biology87 citations Open access
Semantic Scholar
In Vitro Inhibition of the Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Reductase MabA by Isoniazid
S. Ducasse-Cabanot, M. Cohen-Gonsaud, H. Marrakchi, M. Nguyen +5 more
2004Antimicrobial Agents and Chemotherapy58 citations Open access
Semantic Scholar
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.
Roxane Simeone, Mathieu Léger, P. Constant, W. Malaga +4 more
2010The FEBS Journal53 citations Open access
Semantic Scholar
4 A Comprehensive Overview of Mycolic Acid Structure and Biosynthesis
H. Marrakchi, F. Bardou, M. Lanéelle, M. Daffé
200834 citations
Semantic Scholar
Assay Development for Identifying Inhibitors of the Mycobacterial FadD32 Activity
Ségolène Galandrin, V. Guillet, Rajendra Rane, Mathieu Léger +7 more
2013Journal of biomolecular screening33 citations Open access
Semantic Scholar
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis
Roxane Simeone, Mathieu Léger, P. Constant, W. Malaga +4 more
201031 citations Open access
Semantic Scholar
Mycolic Acids: From Chemistry to Biology
M. Daffé, A. Quémard, H. Marrakchi
2019Biogenesis of Fatty Acids, Lipids and Membranes30 citations
Semantic Scholar
Characterization of the Mycobacterial Acyl-CoA Carboxylase Holo Complexes Reveals Their Functional Expansion into Amino Acid Catabolism
M. Ehebauer, Michael Zimmermann, A. Jakobi, Elke E. E. Noens +9 more
2015PLoS Pathogens24 citations Open access
Semantic Scholar
Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria*
V. Guillet, Ségolène Galandrin, L. Maveyraud, S. Ladevèze +6 more
2016Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA.
Melina Chebaiki, E. Delfourne, R. Tamhaev, S. Danoun +14 more
2023European journal of medicinal chemistry20 citations Open access
Semantic Scholar
The protein kinase PknB negatively regulates biosynthesis and trafficking of mycolic acids in mycobacteria[S]
Nguyen-Hung Le, M. Locard-Paulet, Alexandre Stella, Nicolas Tomas +4 more
2020Journal of Lipid Research17 citations Open access
Semantic Scholar
Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis*
Nguyen-Hung Le, V. Molle, N. Eynard, M. Miras +11 more
2016Journal of Biological Chemistry16 citations Open access
Semantic Scholar
A novel mycolic acid species defines two novel genera of the Actinobacteria, Hoyosella and Amycolicicoccus.
M. Lanéelle, Anne Launay, Lucie Spina, H. Marrakchi +6 more
2012Microbiology16 citations Open access
Semantic Scholar
Structural elucidation and genomic scrutiny of the C60-C100 mycolic acids of Segniliparus rotundus.
M. Lanéelle, N. Eynard, Lucie Spina, A. Lemassu +5 more
2013Microbiology15 citations Open access
Semantic Scholar
Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex
N. Pinotsis, Anna Krüger, Nicolas Tomas, Spyros D Chatziefthymiou +6 more
2023bioRxiv13 citations Open access
Semantic Scholar
The nonenzymatic activation of isoniazid by MnIII-pyrophosphate in the presence of NADH produces the inhibition of the enoyl-ACP reductase InhA from Mycobacterium tuberculosis
M. Nguyen, A. Quémard, H. Marrakchi, J. Bernadou +1 more
20018 citations
Semantic Scholar
Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis.
Nguyen-Hung Le, P. Constant, S. Tranier, V. Nahoum +6 more
2022Bioorganic & Medicinal Chemistry7 citations Open access
Semantic Scholar
LysX2 is a Mycobacterium tuberculosis membrane protein with an extracytoplasmic MprF-like domain
Francesca Boldrin, Laura Cioetto Mazzabò, M. Lanéelle, L. Rindi +9 more
2022BMC Microbiology6 citations Open access
Semantic Scholar
In vitro determination of antiviral activity of MS8209, a new amphotericin B derivative, against primary isolates of HIV1.
M. Magierowska‐Jung, D. Cefaï, H. Marrakchi, F. Chièze +3 more
1996Research in Virology6 citations
Semantic Scholar
Telacebec Interferes with Virulence Lipid Biosynthesis Protein Expression and Sensitizes to Other Antibiotics
Zhiyu Zhou, R. Wattiez, Patricia Constant, H. Marrakchi +4 more
2023Microorganisms5 citations Open access
Semantic Scholar
[Efficacy of intra-lesional glucantime in the treatment of zoonotic cutaneous leishmaniasis in basic health care conditions].
M. K. Chahed, A. Ben Salah, H. Louzir, H. Marrakchi +6 more
1999Les Archives de l'Institut Pasteur de Tunis5 citations
Semantic Scholar
HadBD dehydratase from Mycobacterium tuberculosis fatty acid synthase type II: A singular structure for a unique function
P. Bories, Julie Rima, S. Tranier, J. Marcoux +11 more
2024Protein Science4 citations Open access
Semantic Scholar
[Spontaneous course of lesions of Leishmania major cutaneous leishmaniasis in Tunisia].
H. Zakraoui, A. Ben Salah, A. Ftaiti, H. Marrakchi +6 more
1995Annales de dermatologie et de vénéréologie4 citations
Semantic Scholar
Bioinformatic Mining and Structure-Activity Profiling of Baeyer-Villiger Monooxygenases from Mycobacterium tuberculosis
Nicolas Tomas, Dimitri Leonelli, M. Campoy, S. Marthey +12 more
2022Msphere3 citations Open access
Semantic Scholar
Genome Mining and Chemistry-Driven Discovery of a Cell Wall Lipopeptide Signature for Mycobacterium avium subsp. paratuberculosis Ancestral Lineage.
J. Bannantine, G. Etienne, A. Lemassu, T. Cochard +6 more
2025ACS Infectious Diseases1 citations Open access
Semantic Scholar
Integrin-Mediated Pathway 1 b TLR2-Dependent, ADAM9- and Granuloma Macrophage Fusion via a Mycobacterial Lipomannan Induces
M. Puissegur, G. Lay, M. Gilleron, Laure Botella +9 more
20071 citations
Semantic Scholar
Deciphering the anti-Mycobacterium tuberculosis activity of bioinspired lipidic alkynylcarbinols.
Jon Bouvet, Chérine Mehalla, Maria Vieira de Brito, Léa B. Masson +13 more
2025European journal of medicinal chemistry0 citations Open access
Semantic Scholar
The Rv1619 protein of Mycobacterium tuberculosis increases resistance to beta-defensins
Roberta Provvedi, B. Santiago, L. Rindi, Francesca Boldrin +4 more
20120 citations
Semantic Scholar
Mycobacterial Lipomannan Induces Granuloma Macrophage
P. Barbry, G. Puzo, F. Altare, Marí +10 more
20070 citations
Semantic Scholar

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