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B. Cuiffo · SciRah

Researcher profile · Semantic Scholar

B. Cuiffo

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B. Cuiffo — researcher profile on SciRah

h-index: 11
Works: 47
Citations: 1,743

Most-cited papers

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
Y. J. Kim, Y. Yi, E. Sapp, Yu-Mei Wang +5 more
2001Proceedings of the National Academy of Sciences of the United States of America427 citations Open access
Semantic Scholar
Huntingtin Is Present in the Nucleus, Interacts with the Transcriptional Corepressor C-terminal Binding Protein, and Represses Transcription*
K. Kegel, A. Meloni, Y. Yi, Y. J. Kim +9 more
2002Journal of Biological Chemistry318 citations Open access
Semantic Scholar
Huntingtin Bodies Sequester Vesicle-Associated Proteins by a Polyproline-Dependent Interaction
Zheng-Hong Qin, Yu-Mei Wang, E. Sapp, B. Cuiffo +5 more
2004Journal of Neuroscience183 citations Open access
Semantic Scholar
Huntingtin Associates with Acidic Phospholipids at the Plasma Membrane*
K. Kegel, E. Sapp, Jennifer Yoder, B. Cuiffo +9 more
2005Journal of Biological Chemistry167 citations Open access
Semantic Scholar
MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis.
B. Cuiffo, Antoine Campagne, G. Bell, Antonio Lembo +15 more
2014Cell Stem Cell165 citations Open access
Semantic Scholar
Mesenchymal stem cells in tumor development
B. Cuiffo, A. E. Karnoub
2012Cell Adhesion & Migration146 citations Open access
Semantic Scholar
Palmitoylation of oncogenic NRAS is essential for leukemogenesis.
B. Cuiffo, R. Ren
2007Blood101 citations Open access
Semantic Scholar
Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.
Y. J. Kim, E. Sapp, B. Cuiffo, Lindsay Sobin +6 more
2006Neurobiology of Disease85 citations Open access
Semantic Scholar
Pentraxin-3 is a PI3K signaling target that promotes stem cell–like traits in basal-like breast cancers
Clémence Thomas, W. Henry, B. Cuiffo, A. Collmann +10 more
2017Science Signaling50 citations Open access
Semantic Scholar
Microenvironmental Regulation of Long Noncoding RNA LINC01133 Promotes Cancer Stem Cell‐Like Phenotypic Traits in Triple‐Negative Breast Cancers
Zhen-Bo Tu, J. Schmöllerl, B. Cuiffo, A. E. Karnoub
2019Stem Cells48 citations Open access
Semantic Scholar
Silencing FOXP2 in breast cancer cells promotes cancer stem cell traits and metastasis
B. Cuiffo, A. E. Karnoub
2016Molecular & Cellular Oncology23 citations Open access
Semantic Scholar
GM-1111 reduces radiation-induced oral mucositis in mice by targeting pattern recognition receptor-mediated inflammatory signaling
A. Pulsipher, J. Savage, T. Kennedy, K. Gupta +3 more
2021PLoS ONE11 citations Open access
Semantic Scholar
Self-delivering RNAi immunotherapeutic PH-762 silences PD-1 to generate local and abscopal antitumor efficacy
B. Cuiffo, M. Maxwell, D. Yan, Ramdane Guemiri +6 more
2024Frontiers in Immunology8 citations Open access
Semantic Scholar
Abstract 5113: INTASYL self-delivering RNAi therapeutic dual targeting PD-1 and CTLA-4 provides synergistic antitumor efficacy in the treatment of murine colon cancer in vivo
B. Cuiffo, Andrew Boone, D. Yan, M. Maxwell +3 more
2023Cancer Research2 citations
Semantic Scholar
Models of hematopoietic malignancies: chronic myeloid leukemia
B. Cuiffo, R. Ren
20062 citations
Semantic Scholar
NEUROBIOLOGY OF DISEASE Neuroprotective Function of the PGE 2 EP 2 Receptor in Cerebral Ischemia
F. Kawasaki, Bei-Yan Zou, Xia Xu, R. Ordway +18 more
20032 citations
Semantic Scholar
474 Intratumoral CTLA-4-targeting INTASYL™ self-delivering RNAi enhances tumor control in combination with systemic anti-PD-1 antibody therapy in vivo suggesting a strategy to mitigate irSAEs
B. Cuiffo, D. Yan, Andrew Boone, B. Rivest +2 more
2023Regular and Young Investigator Award Abstracts1 citations Open access
Semantic Scholar
Abstract 4237: Local administration of BRD4-targeting self-delivering RNAi (PH-894) provides abscopal efficacy toward untreated distal tumors and potentiates the efficacy of systemic anti-PD-1 antibody therapy
B. Cuiffo, M. Maxwell, D. Yan, Shenghua Zhou +4 more
2022Cancer Research1 citations
Semantic Scholar
537 Local immunotherapy with INTASYL™ self-delivering RNAi targeting CTLA-4 provides robust tumor control in vivo
B. Cuiffo, M. Maxwell, D. Yan, B. Rivest +4 more
2022Regular and Young Investigator Award Abstracts1 citations Open access
Semantic Scholar
198 Combination intratumoral treatment with INTASYL™ self-delivering RNAi targeting TIGIT and PD-1/PD-L1 improves tumor control compared to monotherapy in a CT26 model of murine colorectal cancer
B. Cuiffo, M. Maxwell, D. Yan, A. Jedinák +2 more
2020Journal for ImmunoTherapy of Cancer1 citations Open access
Semantic Scholar
Abstract P1-07-02: Mesenchymal stem cell regulated microRNAs converge on the speech gene FOXP2 and regulate breast cancer metastasis
B. Cuiffo, Antoine Campagne, G. Bell, Antonio Lembo +13 more
20151 citations
Semantic Scholar
Abstract C107: INTASYL™ self-delivering RNAi therapeutic targeting BRD4 elicits on-target apoptosis of human tumor cells
Andrew Boone, D. Yan, M. Maxwell, B. Rivest +2 more
2023Molecular Cancer Therapeutics0 citations
Semantic Scholar
Abstract C109: INTASYL™ PH-894 self-delivering RNAi targeting BRD4 enhances the antigenicity of melanoma cells through MART-1 upregulation
B. Rivest, M. Maxwell, Andrew Boone, B. Cuiffo +2 more
2023Molecular Cancer Therapeutics0 citations
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Abstract 1846: Intratumoral mPH-762, a self-delivering RNAi therapeutic (INTASYL™) targeting mouse PD-1, generates systemic tumor-specific memory CD8 T cells, providing a mechanism for abscopal efficacy toward untreated tumors in a murine hepatocarcinoma model
B. Cuiffo, Andrew Boone, D. Yan, M. Maxwell +3 more
2023Cancer Research0 citations
Semantic Scholar
788 A phase 1b study to evaluate the safety, tolerability, pharmacokinetics and anti-tumor activity of neoadjuvant use of PH-762 administered intratumorally in subjects with advanced melanoma
S. Fricker, C. Robert, François-Xavier Danloss, É. Routier +2 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
493 PH-804, an INTASYL self-delivering RNAi compound that targets TIGIT enhances NK cell cytotoxicity to tumor cells
M. Maxwell, D. Yan, B. Rivest, Andrew Boone +4 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
INTRATUMORAL PH 109 INTASYL ™ SELFDELIVERING RNAI TARGETING CONNECTIVE TISSUE GROWTH FACTOR PROVIDES EFFICACY IN VIVO IN A MOUSE MODEL OF METASTATIC BREAST CANCER
B. Cuiffo, M. Maxwell, D. Yan, Andrew Boone +4 more
20220 citations
Semantic Scholar
P01.03 RNAi mediated PD-1 knockdown induces a TCF-1 positive population in activated human CD8 T cells with stem-like associated marker profile
AS Herbstritt, M. Maxwell, Dong Yan, B. Cuiffo +4 more
2022Poster Presentations0 citations Open access
Semantic Scholar
1402 PH 894: an INTASYL self-delivering siRNA targeting BRD4 has dual functions to sensitize tumor cell killing and activate CD8 T cells
Sheng-Hua Zhou, B. Cuiffo, M. Maxwell, D. Yan +4 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
1431 Intratumoral PH 109 INTASYL™ selfdelivering RNAi targeting connective tissue growth factor provides efficacy in vivo in a mouse model of metastatic breast cancer
B. Cuiffo, M. Maxwell, D. Yan, Andrew Boone +4 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
TARGETING KINASE ALPHA AND ZETA BY TO OPTIMIZE
M. Maxwell, Dong Yan, B. Cuiffo, J. Cardia +2 more
20220 citations
Semantic Scholar
P01.03 Targeting diaclyglycerol kinase alpha and zeta by self delivering RNAi to optimize tlymphocytes for adoptive therapy of solid tumors
AS Herbstritt, M. Maxwell, D. Yan, B. Cuiffo +3 more
2021Journal for ImmunoTherapy of Cancer0 citations Open access
Semantic Scholar
TARGETING KINASE ALPHA AND ZETA BY TO OPTIMIZE
M. Maxwell, Dong Yan, B. Cuiffo, J. Cardia +2 more
20210 citations
Semantic Scholar
Abstract 1739: Intratumoral INTASYL™ self-delivering RNAi targeting PD-1 provides in vivo tumor control and mechanistic modulation of tumor microenvironment analogous to that of systemic anti-PD-1 antibody
B. Cuiffo, M. Maxwell, D. Yan, J. Cardia +1 more
2021Immunology0 citations
Semantic Scholar
TARGETING KINASE ALPHA AND ZETA BY TO OPTIMIZE
M. Maxwell, Dong Yan, B. Cuiffo, J. Cardia +2 more
20210 citations
Semantic Scholar
INTASYL self-delivering RNAi therapy specifically dual-targeting BRD4 and PD-1 to elicit complete tumor responses and evidence of synergy in a subcutaneous Hepa1-6 model of murine hepatoma in C57BL/6N mice.
B. Cuiffo, M. Maxwell, D. Yan, B. Rivest +2 more
20210 citations
Semantic Scholar
Abstract P109: Targeting BRD4 in T cells with self-delivering RNAi PH-894 for immunotherapy
M. Maxwell, D. Ujiie, B. Cuiffo, B. Rivest +5 more
2021Poster Presentations - Proffered Abstracts0 citations
Semantic Scholar
1792P Dual targeting PD-1 and BRD4 with INTASYL self-delivering RNAi elicits persistent anti-tumor immunity in-vivo following complete resolution of tumors
B. Cuiffo, M. Maxwell, D. Yan, B. Rivest +2 more
2021Annals of Oncology0 citations Open access
Semantic Scholar
Abstract 585: Colitis in tumor-bearing mice undergoing checkpoint inhibitor therapy
Caitlin S. L. Parello, B. Cuiffo, K. Reardon, A. Fusco +3 more
2020Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 1499: Recolonizing microbiota may impact tumor response to PD-1 inhibition following antibiotic and radiotherapy treatment in a bioluminescent orthotopic model of murine lung cancer
B. Cuiffo, Caitlin S. L. Parello, Chelsea Ritchie, Nicholas Rivelli +9 more
2019Immunology0 citations
Semantic Scholar
Abstract 511: An assessment of pre-conditioning regimens for optimal hCD34+ hematopoietic stem cell humanization of NSGTMmice
Caitlin S. L. Parello, B. Cuiffo, Alexandra Kury, K. Reardon +9 more
2019Immunology0 citations
Semantic Scholar
Abstract 1146: Early PD-1 inhibition abrogates PBMC engraftment in a triple-humanized (tumor/PBMC/MSC) bioluminescent orthotopic model of pancreatic cancer
B. Cuiffo, Caitlin S. L. Parello, Chelsea Ritchie, Alexandra Kury +3 more
2018Tumor Biology0 citations
Semantic Scholar
Abstract 2683: The gastrointestinal microbiome and its composition are critical for antitumor efficacy of immune checkpoint inhibition by anti-PD-L1
B. Cuiffo, Caitlin S. L. Parello, Chelsea Ritchie, Katie Pedrick +6 more
20170 citations
Semantic Scholar
Abstract 633: Gene-expression characterization of bioluminescent PDX in orthotopic and ectopic models of pancreatic cancer and metastatic triple-negative breast cancer
B. Cuiffo, O. Déas, I. Rankin, Gregory D. Lyng +6 more
20160 citations
Semantic Scholar
Abstract A9: Bioluminescent orthotopic PDX models of primary pancreatic cancer and residual/metastatic breast cancer predict efficacy of standard of care and experimental treatments
B. Cuiffo, O. Déas, Gregory D. Lyng, S. Cairo +3 more
20150 citations
Semantic Scholar
Abstract 173: Tumor proximal mesenchymal stem cells initiate a pro-metastatic microRNA regulatory network which acts via convergent targeting of the speech-associated transcriptional repressor FOXP2
B. Cuiffo, Antoine Campagne, G. Bell, Evan C. Lien +4 more
20140 citations
Semantic Scholar
Dominant Negative Effect of Palmitoylation-Deficient NRAS In Suppression of BCR/ABL Leukemogenesis
B. Cuiffo, R. Ren
20100 citations
Semantic Scholar

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