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M. Freund · SciRah

Researcher profile · Semantic Scholar

M. Freund

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M. Freund — researcher profile on SciRah

h-index: 32
Works: 72
Citations: 4,172

Most-cited papers

Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice.
C. Léon, B. Hechler, M. Freund, A. Eckly +6 more
1999Journal of Clinical Investigation478 citations Open access
Semantic Scholar
A revised model of platelet aggregation.
S. Kulkarni, Sacha M. Dopheide, Cindy L. Yap, C. Ravanat +7 more
2000Journal of Clinical Investigation374 citations Open access
Semantic Scholar
Mechanisms underlying FeCl3‐induced arterial thrombosis
A. Eckly, B. Hechler, M. Freund, M. Zerr +4 more
2011Journal of Thrombosis and Haemostasis246 citations Open access
Semantic Scholar
A Role of the Fast ATP-gated P2X1 Cation Channel in Thrombosis of Small Arteries In Vivo
B. Hechler, Nadège Lenain, P. Marchese, C. Vial +7 more
2003Journal of Experimental Medicine237 citations Open access
Semantic Scholar
Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.
C. Léon, A. Eckly, B. Hechler, B. Aleil +12 more
2007Blood205 citations Open access
Semantic Scholar
Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist.
A. Baurand, P. Raboisson, M. Freund, C. Léon +3 more
2001European Journal of Pharmacology170 citations
Semantic Scholar
Differential Involvement of the P2Y1 and P2Y12 Receptors in Platelet Procoagulant Activity
C. Léon, C. Ravanat, M. Freund, J. Cazenave +1 more
2003Arteriosclerosis, Thrombosis and Vascular Biology151 citations
Semantic Scholar
Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist.
C. Léon, M. Freund, C. Ravanat, A. Baurand +2 more
2001Circulation130 citations Open access
Semantic Scholar
Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation.
S. Moog, P. Mangin, Nadège Lenain, C. Strassel +9 more
2001Blood128 citations
Semantic Scholar
ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq.
P. Ohlmann, A. Eckly, M. Freund, J. Cazenave +2 more
2000Blood122 citations
Semantic Scholar
Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell-derived ADAM9.
E. Mammadova-Bach, P. Zigrino, Camille Brucker, Catherine Bourdon +6 more
2016JCI Insight116 citations Open access
Semantic Scholar
Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.
A. Eckly, C. Strassel, M. Freund, J. Cazenave +3 more
2009Blood116 citations
Semantic Scholar
Inhibition of localized thrombosis in P2Y1‐deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist
N. Lenain, M. Freund, C. Léon, J. Cazenave +1 more
2003Journal of Thrombosis and Haemostasis105 citations Open access
Semantic Scholar
Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization
B. Hechler, C. Nonne, A. Eckly, S. Magnenat +6 more
2010Journal of Thrombosis and Haemostasis102 citations Open access
Semantic Scholar
Signaling Role for Phospholipase Cγ2 in Platelet Glycoprotein Ibα Calcium Flux and Cytoskeletal Reorganization
P. Mangin, Yu-Ping Yuan, Isaac Goncalves, A. Eckly +5 more
2003Journal of Biological Chemistry99 citations Open access
Semantic Scholar
Major Contribution of the P2Y1 Receptor in Purinergic Regulation of TNF&agr;-Induced Vascular Inflammation
M. Zerr, B. Hechler, M. Freund, S. Magnenat +4 more
2011Circulation93 citations
Semantic Scholar
Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome
C. Strassel, A. Eckly, C. Léon, C. Petitjean +4 more
2009Haematologica80 citations Open access
Semantic Scholar
Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA.
P. Mangin, Yu-Ping Yuan, Isaac Goncalves, A. Eckly +5 more
2003Journal of Biological Chemistry79 citations
Semantic Scholar
Cross-reactivity of human molecular markers for detection of prethrombotic states in various animal species.
C. Ravanat, M. Freund, F. Dol, Y. Cadroy +8 more
1995Blood Coagulation and Fibrinolysis77 citations
Semantic Scholar
Reduced Atherosclerotic Lesions in P2Y1/Apolipoprotein E Double-Knockout Mice: The Contribution of Non–Hematopoietic-Derived P2Y1 Receptors
B. Hechler, M. Freund, C. Ravanat, S. Magnenat +2 more
2008Circulation76 citations
Semantic Scholar
The P2Y1 receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice
C. Léon, M. Freund, Olivier Latchoumanin, A. Farret +3 more
2005Purinergic Signalling Purinergic Signalling69 citations Open access
Semantic Scholar
Human epidermal Langerhans cells secrete a soluble receptor for IgG (Fc gamma RII/CD32) that inhibits the binding of immune complexes to Fc gamma R+ cells.
A. Astier, H. de la Salle, C. de la Salle, T. Bieber +6 more
1994Journal of Immunology58 citations
Semantic Scholar
A Novel Monoclonal Antibody against the Extracellular Domain of GPIbβ Modulates vWF Mediated Platelet Adhesion
C. Perrault, S. Moog, E. Rubinstein, M. Santer +8 more
2001Thrombosis and Haemostasis57 citations
Semantic Scholar
A Humanized Glycoprotein VI (GPVI) Mouse Model to Assess the Antithrombotic Efficacies of Anti-GPVI Agents
P. Mangin, Chao-Jun Tang, Catherine Bourdon, S. Loyau +4 more
2012Journal of Pharmacology and Experimental Therapeutics54 citations
Semantic Scholar
Inhibition by Recombinant Hirudins of Experimental Venous Thrombosis and Disseminated Intravascular Coagulation Induced by Tissue Factor in Rats
M. Freund, J. Cazenave, M. Courtney, E. Degryse +5 more
1990Thrombosis and Haemostasis52 citations
Semantic Scholar
Decreased Thrombotic Tendency in Mouse Models of the Bernard-Soulier Syndrome
C. Strassel, C. Nonne, A. Eckly, T. David +5 more
2007Arteriosclerosis, Thrombosis and Vascular Biology50 citations
Semantic Scholar
GPV Is a Marker of In Vivo Platelet Activation – Study in a Rat Thrombosis Model
C. Ravanat, M. Freund, P. Mangin, D. Azorsa +6 more
2000Thrombosis and Haemostasis48 citations
Semantic Scholar
Simultaneous determination of homologues of vitamin E and coenzyme Q and products of alpha-tocopherol oxidation.
Claude Leray, M. Andriamampandry, M. Freund, C. Gachet +1 more
1998Journal of Lipid Research43 citations
Semantic Scholar
A PLCγ2‐independent platelet collagen aggregation requiring functional association of GPVI and integrin α2β1
P. Mangin, C. Nonne, A. Eckly, P. Ohlmann +5 more
200342 citations
Semantic Scholar
Long-Chain n-3 Fatty Acids Specifically Affect Rat Coagulation Factors Dependent on Vitamin K: Relation to Peroxidative Stress
C. Leray, M. Wiesel, M. Freund, J. Cazenave +1 more
2001Arteriosclerosis, Thrombosis and Vascular Biology40 citations Open access
Semantic Scholar
P2Y1 gene deficiency protects from renal disease progression and capillary rarefaction during passive crescentic glomerulonephritis.
B. Hohenstein, S. Renk, K. Lang, C. Daniel +5 more
2007Journal of the American Society of Nephrology39 citations
Semantic Scholar
The purinergic P2Y1 receptor supports leptin secretion in adipose tissue.
M. Laplante, L. Monassier, M. Freund, P. Bousquet +1 more
2010Endocrinology38 citations Open access
Semantic Scholar
Competitive adsorption of human immunoglobulin G and albumin: consequences for structure and reactivity of the adsorbed layer.
E. Lutanie, J. Voegel, P. Schaaf, M. Freund +2 more
1992Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
Antithrombotic effects of (n-3) polyunsaturated fatty acids in rat models of arterial and venous thrombosis.
Margaret D. Andriamampandry, Claude Leray, M. Freund, J. Cazenave +1 more
1999Thrombosis Research30 citations
Semantic Scholar
Experimental Thrombosis on a Collagen Coated Arterioarterial Shunt in Rats: A Pharmacological Model to Study Antithrombotic Agents inhibiting Thrombin Formation and Platelet Deposition
M. Freund, F. Mantz, P. Nicolini, C. Gachet +4 more
1993Thrombosis and Haemostasis28 citations
Semantic Scholar
Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.
A. Aguilar, Josiane Weber, Julie Boscher, M. Freund +9 more
2019Blood Advances25 citations Open access
Semantic Scholar
A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1.
P. Mangin, C. Nonne, A. Eckly, P. Ohlmann +5 more
2003FEBS Letters25 citations
Semantic Scholar
The Antithrombotic Activity of EP224283, a Neutralizable Dual Factor Xa Inhibitor/Glycoprotein IIbIIIa Antagonist, Exceeds That of the Coadministered Parent Compounds
B. Hechler, M. Freund, Ghina Alamé, C. Leguay +4 more
2011Journal of Pharmacology and Experimental Therapeutics22 citations
Semantic Scholar
Functional properties of human platelets derived in vitro from CD34+ cells
V. D. Sacramento, L. Mallo, M. Freund, A. Eckly +5 more
2020Scientific Reports20 citations Open access
Semantic Scholar
Detection and quantification of secreted soluble FcγRIIA in human sera by an enzyme-linked immunosorbent assay
A. Astier, J. Moncuit, M. Freund, J. Cazenave +3 more
199320 citations
Semantic Scholar
Differential Involvement of the P 2 Y 1 and P 2 Y 12 Receptors in Platelet Procoagulant Activity
C. Léon, C. Ravanat, M. Freund, J. Cazenave +1 more
200319 citations
Semantic Scholar
Dual role of IL-21 in megakaryopoiesis and platelet homeostasis
Salima Benbarche, C. Strassel, C. Angénieux, L. Mallo +4 more
2017Haematologica18 citations Open access
Semantic Scholar
Quantitative image analysis of angiogenesis in rats implanted with a fibrin gel chamber.
S. Rohr, F. Toti, C. Brisson, A. Albert +3 more
1992Nouvelle revue francaise d'hematologie18 citations
Semantic Scholar
Diets enriched in (n-3) fatty acids affect rat coagulation factors dependent on vitamin K.
M. Andriamampandry, M. Freund, M. Wiesel, Sonia Rhinn +4 more
1998Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie15 citations
Semantic Scholar
Species Specific Immunoassays to Measure Blood Platelet and Coagulation Activation in the Rat
C. Ravanat, M. Freund, S. Schuhler, P. Grunert +2 more
1996Thrombosis and Haemostasis15 citations
Semantic Scholar
Rat platelets contain glycosylated and non-glycosylated forms of platelet factor 4. Identification and characterization by mass spectrometry.
C. Ravanat, Christian Gachet, Jean-Marc Herbert, Simone Schuhler +6 more
1994European Journal of Biochemistry13 citations Open access
Semantic Scholar
Loss of α4A- and β1-tubulin leads to severe platelet spherocytosis and strongly impairs hemostasis in mice.
Quentin Kimmerlin, S. Moog, A. Yakusheva, A. Eckly +5 more
2022Blood11 citations
Semantic Scholar
Diets rich in saturated n-9 and n-3 fatty acids differentially affect the fatty acid composition of phospholipids and function of rat platelets.
M. Andriamampandry, Claude Leray, Geneviève Gutbier, M. Freund +3 more
1996Platelets11 citations
Semantic Scholar
Human platelets labeled at two discrete biotin densities are functional in vitro and are detected in vivo in the murine circulation: A promising approach to monitor platelet survival in vivo in clinical research
C. Ravanat, A. Pongerard, M. Freund, V. Heim +6 more
2021Transfusion10 citations
Semantic Scholar
Key Role of the P2Y1 Receptor in Tissue Factor–Induced Thrombin-Dependent Acute Thromboembolism: Studies in P2Y1-Knockout Mice and Mice Treated With a P2Y1 Antagonist
C. Léon, M. Freund, C. Ravanat, A. Baurand +2 more
200110 citations
Semantic Scholar

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J. Cazenave×20
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F. Lanza×17
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A. Eckly×16
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P. Mangin — researcher profile on SciRah

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B. Hechler — researcher profile on SciRah

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C. Strassel — researcher profile on SciRah

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C. Nonne — researcher profile on SciRah

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P. Ohlmann — researcher profile on SciRah