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L. Borthwick · SciRah

Researcher profile · Semantic Scholar

L. Borthwick

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L. Borthwick — researcher profile on SciRah

h-index: 35
Works: 102
Citations: 4,494

Most-cited papers

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
D. Choy, Kevin M. Hart, L. Borthwick, A. Shikotra +21 more
2015Science Translational Medicine449 citations Open access
Semantic Scholar
Cytokine mediated tissue fibrosis
L. Borthwick, T. Wynn, A. Fisher
2012Biochimica et Biophysica Acta375 citations Open access
Semantic Scholar
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation
T. Fabre, Alexander M. S. Barron, S. Christensen, S. Asano +16 more
2023Science immunology327 citations Open access
Semantic Scholar
The IL-1 cytokine family and its role in inflammation and fibrosis in the lung
L. Borthwick
2016Seminars in Immunopathology284 citations Open access
Semantic Scholar
Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis
K. Vannella, T. Ramalingam, L. Borthwick, L. Barron +9 more
2016Science Translational Medicine182 citations Open access
Semantic Scholar
IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts
M. Suwara, N. Green, L. Borthwick, J. Mann +7 more
2013Mucosal Immunology176 citations Open access
Semantic Scholar
Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation
L. Borthwick, S. Parker, Kathrine A. Brougham, G. Johnson +6 more
2009Thorax142 citations Open access
Semantic Scholar
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis
L. Borthwick, L. Barron, Kevin M. Hart, K. Vannella +7 more
2015Mucosal Immunology135 citations Open access
Semantic Scholar
Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β
Kevin M. Hart, T. Fabre, J. Sciurba, Richard L. Gieseck +12 more
2017Science Translational Medicine132 citations Open access
Semantic Scholar
International consensus on the definition and classification of fibrosis of the knee joint.
N. Kalson, L. Borthwick, Derek A. Mann, D. J. Deehan +15 more
2016The Bone & Joint Journal130 citations Open access
Semantic Scholar
The Role of Epithelial Damage in the Pulmonary Immune Response
Rachel A. Burgoyne, A. Fisher, L. Borthwick
2021Cells119 citations Open access
Semantic Scholar
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
A. John, Rebecca H. Graves, Tao K. Pun, G. Vitulli +33 more
2020Nature Communications116 citations Open access
Semantic Scholar
Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanism.
Marta Gorowiec, L. Borthwick, S. Parker, J. Kirby +2 more
2012Free Radical Biology & Medicine115 citations
Semantic Scholar
Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis
K. Vannella, L. Barron, L. Borthwick, Kristen N. Kindrachuk +7 more
2014PLoS Pathogens107 citations Open access
Semantic Scholar
Fibrosis is a common outcome following total knee arthroplasty
Nicole Abdul, D. Dixon, A. Walker, J. Horabin +6 more
2015Scientific Reports93 citations Open access
Semantic Scholar
A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision‐Cut Liver Slices
Hannah L. Paish, Lee H. Reed, Helen Brown, Mark C. Bryan +20 more
2019Hepatology92 citations Open access
Semantic Scholar
The circadian clock protein REVERBα inhibits pulmonary fibrosis development
Peter S. Cunningham, P. Meijer, Alicja Nazgiewicz, S. Anderson +20 more
2019Proceedings of the National Academy of Sciences of the United States of America87 citations Open access
Semantic Scholar
Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation
L. Barron, A. Smith, K. El Kasmi, Joseph E. Qualls +6 more
2013PLoS ONE85 citations Open access
Semantic Scholar
Epigenetic reprogramming in liver fibrosis and cancer
C. Wilson, D. Mann, L. Borthwick
2017Advanced Drug Delivery Reviews81 citations Open access
Semantic Scholar
Inflammation and Epithelial to Mesenchymal Transition in Lung Transplant Recipients: Role in Dysregulated Epithelial Wound Repair
L. Borthwick, E. McIlroy, Marta Gorowiec, M. Brodlie +6 more
2010American Journal of Transplantation73 citations Open access
Semantic Scholar
Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways
L. Borthwick, A. Gardner, A. De Soyza, D. Mann +1 more
2012Cancer Microenvironment68 citations Open access
Semantic Scholar
A Mammalian Target of Rapamycin‐Perilipin 3 (mTORC1‐Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis
M. García-Macía, A. Santos-Ledo, J. Leslie, Hannah L. Paish +13 more
2021Hepatology64 citations Open access
Semantic Scholar
The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion
A. Andreasson, L. Borthwick, C. Gillespie, K. Jiwa +10 more
2017The Journal of Heart and Lung Transplantation63 citations Open access
Semantic Scholar
Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion
A. Andreasson, D. Karamanou, C. Gillespie, F. Özalp +13 more
2016European Journal of Cardio-Thoracic Surgery61 citations Open access
Semantic Scholar
The formation of the cAMP/protein kinase A-dependent annexin 2-S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function.
L. Borthwick, J. Mcgaw, Gregory E. Conner, Christopher J. Taylor +4 more
2007Molecular Biology of the Cell58 citations Open access
Semantic Scholar
Acidic chitinase primes the protective immune response to gastrointestinal nematodes
K. Vannella, T. Ramalingam, Kevin M. Hart, Rafael de Queiroz Prado +13 more
2016Nature Immunology57 citations Open access
Semantic Scholar
Mechanistic differences between phenotypes of chronic lung allograft dysfunction after lung transplantation
Monika Suwara, B. Vanaudenaerde, S. Verleden, R. Vos +9 more
2014Transplant International53 citations Open access
Semantic Scholar
Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway
L. Borthwick, S. Sunny, V. Oliphant, J. Perry +7 more
2010European Respiratory Journal50 citations Open access
Semantic Scholar
The annexin 2-S100A10 complex and its association with TRPV6 is regulated by cAMP/PKA/CnA in airway and gut epithelia.
L. Borthwick, A. Neal, Lynsey Hobson, V. Gerke +2 more
2008Cell Calcium45 citations
Semantic Scholar
Inhibition of RelA-Ser536 Phosphorylation by a Competing Peptide Reduces Mouse Liver Fibrosis Without Blocking the Innate Immune Response
A. Moles, A. M. Sánchez, P. Banks, Lindsay B. Murphy +10 more
2013Hepatology44 citations Open access
Semantic Scholar
Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2
Hannah L. Paish, N. Kalson, Graham R. Smith, A. M. Del Carpio Pons +8 more
2017American Journal of Pathology41 citations Open access
Semantic Scholar
Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis
J. Calver, N. Parmar, Gemma Harris, R. Lithgo +11 more
2023bioRxiv40 citations Open access
Semantic Scholar
Lung epithelial wound healing in health and disease
A. Gardner, L. Borthwick, A. Fisher
2010Expert Review of Respiratory Medicine40 citations Open access
Semantic Scholar
The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.
A. Gardner, A. Fisher, C. Richter, G. Johnson +6 more
2012American Journal of Pathology36 citations Open access
Semantic Scholar
Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis
D. Bartis, L. Crowley, Vijay K. D'Souza, L. Borthwick +7 more
2016BMC Pulmonary Medicine35 citations Open access
Semantic Scholar
c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis
J. Leslie, M. G. Macia, S. Luli, Julie C. Worrell +38 more
2020Nature Metabolism34 citations Open access
Semantic Scholar
A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty
D. Dixon, J. Coates, A. M. Del Carpio Pons, J. Horabin +8 more
2015Scientific Reports32 citations Open access
Semantic Scholar
TNFα/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction
V. Badalyan, Kezia A. Addo, Robert W. Thompson, L. Borthwick +5 more
2014Journal of Allergy and Clinical Immunology32 citations Open access
Semantic Scholar
Chronic, Active Inflammation in Patients With Failed Total Knee Replacements Undergoing Revision Surgery
Hannah L. Paish, T. Baldock, C. Gillespie, A. M. Del Carpio Pons +4 more
2019Journal of Orthopaedic Research28 citations Open access
Semantic Scholar
Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells
Jinheng Lin, M. Taggart, L. Borthwick, A. Fisher +4 more
2021Scientific Reports21 citations Open access
Semantic Scholar
Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse
A. Leitch, T. Abdelghany, A. Charlton, Justina Grigalyte +8 more
2020Ecotoxicology and Environmental Safety21 citations Open access
Semantic Scholar
Defective formation of PKA/CnA-dependent annexin 2-S100A10/CFTR complex in DeltaF508 cystic fibrosis cells.
L. Borthwick, C. Riemen, C. Goddard, W. Colledge +3 more
2008Cellular Signalling21 citations
Semantic Scholar
Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy
F. Oakley, Lucy M. Gee, N. Sheerin, L. Borthwick
2019Current opinion in pharmacology (Print)17 citations Open access
Semantic Scholar
Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?
Marco Y. W. Zaki, S. F. Alhasan, R. Shukla, M. McCain +21 more
2022Liver Cancer16 citations Open access
Semantic Scholar
Anti–Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct–Ligated Mice
Lucy M. Gee, B. Barron-Millar, J. Leslie, C. Richardson +30 more
2022American Journal of Pathology16 citations Open access
Semantic Scholar
Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?
L. Borthwick, P. Botha, B. Verdon, M. Brodlie +5 more
2011PLoS ONE16 citations Open access
Semantic Scholar
Airway Epithelial Cell Senescence in the Lung Allograft
S. Parker, M. R. Goriwiec, L. Borthwick, G. Johnson +5 more
2008American Journal of Transplantation16 citations Open access
Semantic Scholar
Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection
Guo-Parke Hong, D. Linden, A. Mousnier, I. Scott +6 more
2022Frontiers in Medicine13 citations Open access
Semantic Scholar
Transcriptional analysis identifies potential novel biomarkers associated with successful ex‐vivo perfusion of human donor lungs
J. Ferdinand, M. Morrison, A. Andreasson, C. Charlton +5 more
2021Clinical Transplantation13 citations Open access
Semantic Scholar
Liver: Osteopontin and HMGB1: novel regulators of HSC activation
L. Borthwick, D. Mann
2016Nature Reviews Gastroenterology &Hepatology13 citations Open access
Semantic Scholar

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A. Fisher×20
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A. Fisher — researcher profile on SciRah
D. Mann×12
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D. Mann — researcher profile on SciRah
T. Wynn×10
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T. Wynn — researcher profile on SciRah
F. Oakley×8
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F. Oakley — researcher profile on SciRah

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Kevin M. Hart — researcher profile on SciRah

T. Ramalingam×7

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T. Ramalingam — researcher profile on SciRah

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K. Vannella — researcher profile on SciRah

Robert W. Thompson×6

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Robert W. Thompson — researcher profile on SciRah

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L. Barron — researcher profile on SciRah

Hannah L. Paish×6

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Hannah L. Paish — researcher profile on SciRah

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Sandra White — researcher profile on SciRah

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