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R. Shenkar · SciRah

Researcher profile · Semantic Scholar

R. Shenkar

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R. Shenkar — researcher profile on SciRah

h-index: 50
Works: 158
Citations: 7,451

Most-cited papers

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling
Zi-Nan Zhou, Alan T. Tang, Weng-Yew Wong, Sharika Bamezai +12 more
2016Nature302 citations Open access
Semantic Scholar
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
Alan T. Tang, Jaesung P. Choi, Jonathan J. Kotzin, Yiqing Yang +26 more
2017Nature290 citations Open access
Semantic Scholar
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism
Aileen A. Ren, D. Snellings, Sophie Y. Su, Courtney C. Hong +24 more
2021Nature181 citations Open access
Semantic Scholar
Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis.
David A. McDonald, Chang-Bin Shi, R. Shenkar, C. Gallione +7 more
2014Human Molecular Genetics133 citations Open access
Semantic Scholar
Evaluation of Iron Content in Human Cerebral Cavernous Malformation using Quantitative Susceptibility Mapping
H. Tan, Tian Liu, Ying Wu, J. Thacker +8 more
2014Investigative Radiology98 citations Open access
Semantic Scholar
RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations
R. Shenkar, Chang-Bin Shi, C. Austin, Thomas Moore +13 more
2016Stroke97 citations Open access
Semantic Scholar
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations
M. Lopez-Ramirez, Gregory Fonseca, H. Zeineddine, R. Girard +10 more
2017Journal of Experimental Medicine90 citations Open access
Semantic Scholar
Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.
S. Polster, Agnieszka Stadnik, Amy L. Akers, Ying Cao +21 more
2018Neurosurgery75 citations Open access
Semantic Scholar
Vascular Permeability in Cerebral Cavernous Malformations
A. Mikati, O. Khanna, Lingjiao Zhang, R. Girard +10 more
2015Journal of Cerebral Blood Flow and Metabolism72 citations Open access
Semantic Scholar
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation
Alan T. Tang, K. R. Sullivan, Courtney C. Hong, Lauren M. Goddard +35 more
2019Science Translational Medicine71 citations Open access
Semantic Scholar
Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth
R. Girard, H. Zeineddine, J. Koskimäki, M. Fam +13 more
2018Circulation Research64 citations Open access
Semantic Scholar
Vascular Permeability and Iron Deposition Biomarkers in Longitudinal Follow-up of Cerebral Cavernous Malformations
R. Girard, M. Fam, H. Zeineddine, H. Tan +10 more
2016Journal of Neurosurgery59 citations Open access
Semantic Scholar
Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease
R. Shenkar, Amy Peiper, Heidy Pardo, Thomas Moore +15 more
2019Stroke56 citations Open access
Semantic Scholar
Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation.
M. Lopez-Ramirez, Ch Lai, S. Soliman, Preston Hale +17 more
2021Journal of Clinical Investigation53 citations Open access
Semantic Scholar
Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations
R. Girard, H. Zeineddine, M. Fam, A. Mayampurath +12 more
2017Translational Stroke Research50 citations Open access
Semantic Scholar
Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease.
R. Girard, O. Khanna, R. Shenkar, Lingjiao Zhang +11 more
2016Biomarkers in Medicine50 citations Open access
Semantic Scholar
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican
Courtney C. Hong, Alan T. Tang, Matthew R. Detter, Jaesung P. Choi +26 more
2020Journal of Experimental Medicine48 citations Open access
Semantic Scholar
Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes.
J. Koskimäki, R. Girard, Yan Li, Laleh Saadat +25 more
2019JCI Insight48 citations Open access
Semantic Scholar
B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models
Chang-Bin Shi, R. Shenkar, H. Zeineddine, R. Girard +13 more
2016Journal of Neuroimmune Pharmacology48 citations Open access
Semantic Scholar
Novel murine models of cerebral cavernous malformations
Matthew R. Detter, R. Shenkar, Christian R Benavides, Catherine A. Neilson +11 more
2020Angiogenesis45 citations Open access
Semantic Scholar
Biomarkers of cavernous angioma with symptomatic hemorrhage.
S. Lyne, R. Girard, J. Koskimäki, H. Zeineddine +18 more
2019JCI Insight44 citations Open access
Semantic Scholar
Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH)
S. Polster, Ying Cao, T. Carroll, Kelly D. Flemming +16 more
2019Neurosurgery41 citations Open access
Semantic Scholar
Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models.
Wen-Qing Li, R. Shenkar, Mathew R. Detter, Thomas Moore +12 more
2021Journal of Clinical Investigation39 citations Open access
Semantic Scholar
Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
J. Koskimäki, Dongdong Zhang, Yan Li, Laleh Saadat +25 more
2019Acta Neuropathologica Communications39 citations Open access
Semantic Scholar
A Brain Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease
L. Mckerracher, R. Shenkar, Matthew Abbinanti, Ying Cao +12 more
2019Translational Stroke Research37 citations Open access
Semantic Scholar
Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma
S. Polster, Anukriti Sharma, Ceylan Tanes, Alan T. Tang +22 more
2020Nature Communications36 citations Open access
Semantic Scholar
Micro-Computed Tomography in Murine Models of Cerebral Cavernous Malformations as a Paradigm for Brain Disease
R. Girard, H. Zeineddine, Courtney P Orsbon, H. Tan +16 more
2016Journal of Neuroscience Methods34 citations Open access
Semantic Scholar
Quantitative Susceptibility Mapping as a Monitoring Biomarker in Cerebral Cavernous Malformations with Recent Hemorrhage
H. Zeineddine, R. Girard, Ying Cao, Nicholas Hobson +12 more
2017Journal of Magnetic Resonance Imaging33 citations Open access
Semantic Scholar
Immune complex formation and in situ B-cell clonal expansion in human cerebral cavernous malformations.
Chang-Bin Shi, R. Shenkar, A. Kinloch, Scott G. Henderson +4 more
2014Journal of Neuroimmunology32 citations
Semantic Scholar
Phenotypic Characterization of Murine Models of Cerebral Cavernous Malformations
H. Zeineddine, R. Girard, Laleh Saadat, Le Shen +18 more
2018Laboratory Investigation28 citations Open access
Semantic Scholar
A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH).
R. Girard, Yan Li, Agnieszka Stadnik, R. Shenkar +17 more
2021Neurosurgery26 citations Open access
Semantic Scholar
Corrigendum: Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling
Zi-Nan Zhou, Alan T. Tang, Weng-Yew Wong, Sharika Bamezai +12 more
2016Nature21 citations Open access
Semantic Scholar
Subclinical imaging changes in cerebral cavernous angiomas during prospective surveillance
J. Carrión-Penagos, H. Zeineddine, S. Polster, R. Girard +10 more
2020Journal of Neurosurgery20 citations Open access
Semantic Scholar
The mTORC1 inhibitor Rapamycin inhibits growth of cerebral cavernous malformation in adult mice
Lun Li, Aileen A. Ren, Siqi Gao, YouRong S. Su +13 more
2023Stroke17 citations Open access
Semantic Scholar
Perfusion and Permeability MRI Predicts Future Cavernous Angioma Hemorrhage and Growth
J. Y. Sone, Nicholas Hobson, Abhinav Srinath, Sharbel Romanos +14 more
2021Journal of Magnetic Resonance Imaging17 citations Open access
Semantic Scholar
Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma
Abhinav Srinath, Bing-Qing Xie, Ying Li, J. Y. Sone +28 more
2023Communications Medicine16 citations Open access
Semantic Scholar
Safety and efficacy of atorvastatin for rebleeding in cerebral cavernous malformations (AT CASH EPOC): a phase 1/2a, randomised placebo-controlled trial
I. Awad, Roberto J. Alcazar-Felix, Agnieszka Stadnik, Serena Kinkade +18 more
2025Lancet Neurology14 citations Open access
Semantic Scholar
Propranolol as therapy for cerebral cavernous malformations: a cautionary note
R. Shenkar, Thomas Moore, Christian R Benavides, R. Lightle +9 more
2022Journal of Translational Medicine14 citations Open access
Semantic Scholar
Rapamycin in Cerebral Cavernous Malformations: What Doses to Test in Mice and Humans.
Matthew J. Hagan, R. Shenkar, Abhinav Srinath, Sharbel Romanos +5 more
2022ACS Pharmacology & Translational Science14 citations Open access
Semantic Scholar
Phantom Validation of Quantitative Susceptibility and Dynamic Contrast-Enhanced Permeability MR Sequences Across Instruments and Sites
Nicholas Hobson, S. Polster, Ying Cao, Kelly D. Flemming +19 more
2019Journal of Magnetic Resonance Imaging14 citations Open access
Semantic Scholar
Transcriptomic signatures of individual cell types in cerebral cavernous malformation
Ying Li, R. Girard, Abhinav Srinath, Diana Vera Cruz +17 more
2024Cell Communication and Signaling13 citations Open access
Semantic Scholar
Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation
Ying Li, Abhinav Srinath, Roberto J. Alcazar-Felix, Stephanie Hage +6 more
2023Brain Science13 citations Open access
Semantic Scholar
Multidisciplinary coordinated care of hereditary hemorrhagic telangiectasia (Osler–Weber–Rendu disease)
Yasmine Alkhalid, Zeena Darji, R. Shenkar, M. Clancy +2 more
2023Vascular Medicine13 citations
Semantic Scholar
Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation
J. Koskimäki, S. Polster, Yan Li, Sharbel Romanos +16 more
2020GeroScience12 citations Open access
Semantic Scholar
Trial Readiness of Cavernous Malformations with Symptomatic Hemorrhage. Part II: Biomarkers and Trial Modeling
Stephanie Hage, Serena Kinkade, R. Girard, Kelly D. Flemming +28 more
2023Stroke11 citations Open access
Semantic Scholar
Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism.
Wen-Qing Li, R. Shenkar, Matthew R. Detter, Thomas Moore +12 more
2020Journal of Clinical Investigation11 citations Open access
Semantic Scholar
EXCEPTIONAL AGGRESSIVENESS OF CEREBRAL CAVERNOUS MALFORMATION DISEASE ASSOCIATED WITH PDCD10 MUTATIONS
R. Shenkar, Chang-Bin Shi, T. Rebeiz, Rebecca A. Stockton +13 more
2014Genetics in Medicine11 citations Open access
Semantic Scholar
Trial Readiness of Cavernous Malformations with Symptomatic Hemorrhage. Part I: Event Rates and Clinical Outcome
Kelly D. Flemming, Helen Kim, Stephanie Hage, J. Mandrekar +28 more
2023Stroke10 citations Open access
Semantic Scholar
Antibodies in Cerebral Cavernous Malformations React with Cytoskeleton Autoantigens in the Lesional Milieu
Dongdong Zhang, A. Kinloch, Abhinav Srinath, R. Shenkar +11 more
2020Journal of Autoimmunity10 citations Open access
Semantic Scholar
Except for robust outliers, rapamycin increases lesion burden in a murine model of cerebral cavernous malformations
Roberto J. Alcazar-Felix, R. Shenkar, Christian R Benavides, Akash Bindal +17 more
2024Translational Stroke Research8 citations Open access
Semantic Scholar

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