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Le Shen · SciRah

Researcher profile · Semantic Scholar

Le Shen

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Le Shen — researcher profile on SciRah

h-index: 43
Works: 132
Citations: 11K

Most-cited papers

Tight Junction Pore and Leak Pathways: A Dynamic Duo
Le Shen, Christopher R. Weber, D. Raleigh, Yu Dan +1 more
2011Annual Review of Physiology824 citations Open access
Semantic Scholar
Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
A. Marchiando, Le Shen, W. V. Graham, Christopher R. Weber +7 more
2010Journal of Cell Biology456 citations Open access
Semantic Scholar
TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis
Li-Ping Su, S. Nalle, Le Shen, Emily S Turner +8 more
2013Gastroenterology360 citations Open access
Semantic Scholar
Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions
D. Raleigh, A. Marchiando, Y. Zhang, Le Shen +4 more
2010Molecular Biology of the Cell320 citations Open access
Semantic Scholar
Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity*
Christopher R. Weber, D. Raleigh, Li-Ping Su, Le Shen +3 more
2010Journal of Biological Chemistry275 citations Open access
Semantic Scholar
The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding
A. Marchiando, Le Shen, W. V. Graham, Karen L. Edelblum +5 more
2011Gastroenterology274 citations Open access
Semantic Scholar
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function
D. Raleigh, D. Boe, Dan Yu, Christopher R. Weber +7 more
2011Journal of Cell Biology245 citations Open access
Semantic Scholar
MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function
Dan Yu, A. Marchiando, Christopher R. Weber, D. Raleigh +3 more
2010Proceedings of the National Academy of Sciences of the United States of America238 citations Open access
Semantic Scholar
IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance
Pei-Yun Tsai, Bing-Kun Zhang, Wei-Qi He, Juan-Min Zha +10 more
2017Cell Host and Microbe233 citations Open access
Semantic Scholar
PKCη regulates occludin phosphorylation and epithelial tight junction integrity
Takuya Suzuki, Bertha C. Elias, A. Seth, Le Shen +5 more
2009Proceedings of the National Academy of Sciences of the United States of America227 citations Open access
Semantic Scholar
Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase 3 Expression
W. Kuo, Le Shen, L. Zuo, N. Shashikanth +8 more
2019Gastroenterology223 citations Open access
Semantic Scholar
Tight junctions on the move: molecular mechanisms for epithelial barrier regulation
Le Shen
2012Annals of the New York Academy of Sciences210 citations Open access
Semantic Scholar
The role of molecular remodeling in differential regulation of tight junction permeability
J. Turner, M. Buschmann, A. Sailer, I. Calvo +1 more
2014Seminars in Cell and Developmental Biology187 citations Open access
Semantic Scholar
Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux
M. Buschmann, Le Shen, Harsha E. Rajapakse, D. Raleigh +11 more
2013Molecular Biology of the Cell168 citations Open access
Semantic Scholar
Dynamic migration of γδ intraepithelial lymphocytes requires occludin
Karen L. Edelblum, Le Shen, Christopher R. Weber, A. Marchiando +6 more
2012Proceedings of the National Academy of Sciences of the United States of America160 citations Open access
Semantic Scholar
Mechanisms and Functional Implications of Intestinal Barrier Defects
Le Shen, Li-Ping Su, J. Turner
2009Digestive Diseases156 citations Open access
Semantic Scholar
Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells.
Yan-Fang Guan, A. Watson, A. Marchiando, Emily M. Bradford +3 more
2011American Journal of Physiology - Cell Physiology100 citations Open access
Semantic Scholar
The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo
M. Odenwald, Wang-Sun Choi, Wei-Ting Kuo, Gurminder Singh +5 more
2018Journal of Biological Chemistry98 citations Open access
Semantic Scholar
Occludin Deficiency Promotes Ethanol-Induced Disruption of Colonic Epithelial Junctions, Gut Barrier Dysfunction and Liver Damage in Mice
H. Mir, Avtar S. Meena, K. Chaudhry, P. Shukla +8 more
2015Biochimica et Biophysica Acta98 citations Open access
Semantic Scholar
Claudin-2-dependent paracellular channels are dynamically gated
Christopher R. Weber, Guo-Hua Liang, Yi-Tang Wang, Sudipto Das +4 more
2015eLife94 citations Open access
Semantic Scholar
Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer
Fei-Fei Pu, Feng-Xia Chen, Zhi-Cai Zhang, Deyao Shi +20 more
2020Genes and Diseases84 citations Open access
Semantic Scholar
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation
Alan T. Tang, K. R. Sullivan, Courtney C. Hong, Lauren M. Goddard +35 more
2019Science Translational Medicine71 citations Open access
Semantic Scholar
Retinoic Acid-induced Gene-1 (RIG-I) Associates with the Actin Cytoskeleton via Caspase Activation and Recruitment Domain-dependent Interactions*
A. Mukherjee, Stefanie Morosky, Le Shen, Christopher R. Weber +4 more
2009Journal of Biological Chemistry60 citations Open access
Semantic Scholar
Molecular determination of claudin-15 organization and channel selectivity
Priyanka Samanta, Yi-Tang Wang, Shadi Fuladi, Jinjing Zou +4 more
2018The Journal of General Physiology53 citations Open access
Semantic Scholar
Microtubules are required for efficient epithelial tight junction homeostasis and restoration.
Lila G. Glotfelty, A. Zahs, C. Iancu, Le Shen +1 more
2014American Journal of Physiology - Cell Physiology51 citations Open access
Semantic Scholar
Idiopathic pulmonary fibrosis is associated with tight junction protein alterations.
Jinjing Zou, Ye Li, Ji-Mian Yu, Linchang Dong +3 more
2020Biochimica et Biophysica Acta - Biomembranes48 citations Open access
Semantic Scholar
Novel murine models of cerebral cavernous malformations
Matthew R. Detter, R. Shenkar, Christian R Benavides, Catherine A. Neilson +11 more
2020Angiogenesis45 citations Open access
Semantic Scholar
Reversibly immortalized keratinocytes (iKera) facilitate re-epithelization and skin wound healing: Potential applications in cell-based skin tissue engineering
Jiamin Zhong, Hao Wang, Ke-Qin Yang, Hui-Feng Wang +19 more
2021Bioactive Materials44 citations Open access
Semantic Scholar
A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice
Wenli Dai, Brigitte Laforest, L. Tyan, Kaitlyn M. Shen +12 more
2019eLife40 citations Open access
Semantic Scholar
Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
J. Koskimäki, Dongdong Zhang, Yan Li, Laleh Saadat +25 more
2019Acta Neuropathologica Communications39 citations Open access
Semantic Scholar
AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling
R. Ferrarotto, Vasudha Mishra, Elad Herz, A. Yaacov +16 more
2022Cell Death and Disease37 citations Open access
Semantic Scholar
Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma
S. Polster, Anukriti Sharma, Ceylan Tanes, Alan T. Tang +22 more
2020Nature Communications36 citations Open access
Semantic Scholar
Overactivation of Intestinal SREBP2 in Mice Increases Serum Cholesterol
K. Ma, P. Malhotra, Vinay Soni, Omar Hedroug +9 more
2014PLoS ONE35 citations Open access
Semantic Scholar
Micro-Computed Tomography in Murine Models of Cerebral Cavernous Malformations as a Paradigm for Brain Disease
R. Girard, H. Zeineddine, Courtney P Orsbon, H. Tan +16 more
2016Journal of Neuroscience Methods34 citations Open access
Semantic Scholar
Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1
Qiong Lai, Guang-ying Yuan, Le Shen, Lu Zhang +7 more
2021Basic Research in Cardiology31 citations
Semantic Scholar
Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation
Shu Wei, Ye Li, S. Polster, Christopher R. Weber +2 more
2020International Journal of Molecular Sciences30 citations Open access
Semantic Scholar
Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways
Linjuan Huang, Ling Zhao, Jing Zhang, Fang He +12 more
2021Aging28 citations Open access
Semantic Scholar
miR-210-3p Promotes Lung Cancer Development and Progression by Modulating USF1 and PCGF3
Qian Chen, Hong-Yu Zhang, Jian-Yin Zhang, Le Shen +4 more
2021OncoTargets and Therapy28 citations Open access
Semantic Scholar
Phenotypic Characterization of Murine Models of Cerebral Cavernous Malformations
H. Zeineddine, R. Girard, Laleh Saadat, Le Shen +18 more
2018Laboratory Investigation28 citations Open access
Semantic Scholar
Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway.
A. Mykoniatis, Le Shen, M. Fedor-Chaiken, Jun Tang +7 more
2010American Journal of Physiology - Cell Physiology27 citations Open access
Semantic Scholar
ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction
Wenli Dai, Rangarajan D. Nadadur, J. Brennan, Heather L. Smith +18 more
2020Circulation Research26 citations Open access
Semantic Scholar
Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.
P. Bouyer, Xu Tang, Christopher R. Weber, Le Shen +2 more
2013American Journal of Physiology - Gastrointestinal and Liver Physiology25 citations Open access
Semantic Scholar
Lymphatic Endothelial Differentiation in Pulmonary Lymphangioleiomyomatosis Cells
Jennifer M. Davis, E. Hyjek, A. Husain, Le Shen +2 more
2013Journal of Histochemistry and Cytochemistry25 citations Open access
Semantic Scholar
Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma
E. Broner, Jonathan A. Trujillo, Michael Korzinkin, Tejaswini Subbannayya +13 more
2021Frontiers in Oncology23 citations Open access
Semantic Scholar
Oroxylin A, a natural compound, mitigates the negative effects of TNF&agr;-treated acute myelogenous leukemia cells
Hui Li, N. Lu, Xiao-Xuan Yu, Xiao Liu +7 more
2018Carcinogenesis21 citations Open access
Semantic Scholar
Molecular mechanism of claudin-15 strand flexibility: A computational study
Shadi Fuladi, Sarah L McGuinness, Le Shen, Christopher R. Weber +1 more
2021bioRxiv20 citations Open access
Semantic Scholar
Oroxylin A, a natural anticancer flavonoid compound, induces differentiation of t(8;21)-positive Kasumi-1 and primary acute myeloid leukemia cells
H. Hui, Xiaoxiao Zhang, Hui Li, Xiao Liu +5 more
2016Journal of Cancer Research and Clinical Oncology20 citations Open access
Semantic Scholar
Oroxylin A inhibits the generation of Tregs in non-small cell lung cancer
Le Shen, Lu-Lu Zhang, Hui Li, Xiao Liu +5 more
2017OncoTarget19 citations Open access
Semantic Scholar
Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides
Yuhong Zhao, Shijing Wang, Wenyi Fei, Yuqi Feng +4 more
2021International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation
Yi-Tang Wang, Ye Li, Jinjing Zou, S. Polster +7 more
2018The FASEB Journal18 citations Open access
Semantic Scholar

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