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C. Hose · SciRah

Researcher profile · Semantic Scholar

C. Hose

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C. Hose — researcher profile on SciRah

h-index: 23
Works: 53
Citations: 5,327

Most-cited papers

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
A. Monks, D. Scudiero, P. Skehan, R. Shoemaker +10 more
1991Journal of the National Cancer Institute3,160 citations
Semantic Scholar
Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen.
Jin‐Gu Lee, K. Paull, M. Álvarez, C. Hose +4 more
1994Molecular Pharmacology361 citations
Semantic Scholar
Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen.
Manuel Alvarez, K. Paull, A. Monks, C. Hose +5 more
1995Journal of Clinical Investigation224 citations Open access
Semantic Scholar
Cediranib for metastatic alveolar soft part sarcoma.
S. Kummar, Deborah H. Allen, A. Monks, Eric C. Polley +10 more
2013Journal of Clinical Oncology214 citations Open access
Semantic Scholar
The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network.
C. P. Webb, C. Hose, S. Koochekpour, M. Jeffers +4 more
2000Cancer Research173 citations
Semantic Scholar
Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells.
F. J. Sharom, Xiaohong Yu, P. Lu, Rong-Hua Liu +8 more
1999Biochemical Pharmacology112 citations
Semantic Scholar
DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells
V. Trapani, V. Patel, C. Leong, H. Ciolino +6 more
2003British Journal of Cancer98 citations Open access
Semantic Scholar
Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells.
A. Loaiza-Pérez, S. Kenney, J. Boswell, M. Hollingshead +7 more
2004Molecular Cancer Therapeutics94 citations Open access
Semantic Scholar
Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole.
A. Loaiza-Pérez, V. Trapani, C. Hose, Sheo S. Singh +4 more
2002Molecular Pharmacology94 citations
Semantic Scholar
Identification of CBX3 and ABCA5 as Putative Biomarkers for Tumor Stem Cells in Osteosarcoma
V. Saini, C. Hose, A. Monks, K. Nagashima +11 more
2012PLoS ONE87 citations Open access
Semantic Scholar
UCN-01 Enhances the In Vitro Toxicity of Clinical Agents in Human Tumor Cell Lines
A. Monks, E. Harris, A. Vaigro-Wolff, C. Hose +2 more
2000Investigational new drugs74 citations
Semantic Scholar
Genotoxic profiling of MCF-7 breast cancer cell line elucidates gene expression modifications underlying toxicity of the anticancer drug 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole.
A. Monks, E. Harris, C. Hose, J. Connelly +1 more
2003Molecular Pharmacology59 citations
Semantic Scholar
The NCI Transcriptional Pharmacodynamics Workbench: a tool to examine dynamic expression profiling of therapeutic response in the NCI-60 cell line panel
A. Monks, Yingdong Zhao, C. Hose, Hossein A. Hamed +18 more
2018Cancer Research56 citations Open access
Semantic Scholar
FLUORINATED 2-(4-AMINO-3-METHYLPHENYL)BENZOTHIAZOLES INDUCE CYP1A1 EXPRESSION, BECOME METABOLIZED, AND BIND TO MACROMOLECULES IN SENSITIVE HUMAN CANCER CELLS
E. Brantley, V. Trapani, M. Alley, C. Hose +4 more
2004Drug Metabolism And Disposition55 citations
Semantic Scholar
Drug-Induced Expression of Nonsteroidal Anti-Inflammatory Drug-Activated Gene/Macrophage Inhibitory Cytokine-1/Prostate-Derived Factor, a Putative Tumor Suppressor, Inhibits Tumor Growth
Jeanelle M. Martinez, Tina M. Sali, R. Okazaki, C. Anna +6 more
2006Journal of Pharmacology and Experimental Therapeutics53 citations
Semantic Scholar
Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity.
C. Hose, M. Hollingshead, E. Sausville, A. Monks
2003Molecular Cancer Therapeutics48 citations
Semantic Scholar
The Experimental Antitumor Agents Phortress and Doxorubicin are Equiactive Against Human-Derived Breast Carcinoma Xenograft Models
I. Fichtner, A. Monks, C. Hose, M. Stevens +1 more
2004Breast Cancer Research and Treatment42 citations
Semantic Scholar
Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery.
E. Stone, Francesca Citossi, Rajinder Singh, Balvinder Kaur +10 more
2015Bioorganic & Medicinal Chemistry41 citations Open access
Semantic Scholar
Clinical Reversal of Multidrug Resistance
S. Bates, Wyndham H. Wilson, A. Fojo, M. Álvarez +7 more
1996The Oncologist39 citations Open access
Semantic Scholar
The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-κB activity in drug-sensitive MCF-7 cells
E. Brantley, V. Patel, S. Stinson, V. Trapani +6 more
2005Anti-Cancer Drugs36 citations
Semantic Scholar
Resistance to paclitaxel mediated by P-glycoprotein can be modulated by changes in the schedule of administration
Zhi-Rong Zhan, S. Scala, A. Monks, C. Hose +2 more
1997Cancer Chemotherapy and Pharmacology35 citations
Semantic Scholar
Sensitivity of renal cell carcinoma to aminoflavone: role of CYP1A1.
A. Loaiza-Pérez, Susan Kenney, J. Boswell, M. Hollingshead +6 more
2004Journal of Urology30 citations
Semantic Scholar
Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts
A. Monks, C. Hose, P. Pezzoli, S. Kondapaka +5 more
2009Anti-Cancer Drugs27 citations
Semantic Scholar
Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment
J. Krushkal, Ying-Dong Zhao, C. Hose, A. Monks +2 more
2016Clinical Epigenetics23 citations Open access
Semantic Scholar
Correction: Identification of CBX3 and ABCA5 as Putative Biomarkers for Tumor Stem Cells in Osteosarcoma
V. Saini, C. Hose, A. Monks, K. Nagashima +11 more
2012PLoS ONE17 citations Open access
Semantic Scholar
Transcriptional Profiling Identifies Altered Intracellular Labile Iron Homeostasis as a Contributing Factor to the Toxicity of Adaphostin: Decreased Vascular Endothelial Growth Factor Secretion Is Independent of Hypoxia-Inducible Factor-1 Regulation
C. Hose, G. Kaur, E. Sausville, A. Monks
2005Clinical Cancer Research17 citations Open access
Semantic Scholar
Clinical reversal of multidrug resistance.
S. Bates, Wyndham H. Wilson, A. Fojo, Manuel Alvarez +7 more
1996Stem Cells12 citations Open access
Semantic Scholar
ATR inhibition reverses the resistance of homologous recombination deficient MGMTlow/MMRproficient cancer cells to temozolomide
Lara H. el Touny, C. Hose, J. Connelly, E. Harris +11 more
2021OncoTarget11 citations Open access
Semantic Scholar
Development of Antiproliferative Phenylmaleimides that Activate the Unfolded Protein Response
Ulrike Muus, C. Hose, Wei Yao, T. Kosakowska-Cholody +7 more
2010Bioorganic & Medicinal Chemistry9 citations Open access
Semantic Scholar
Longitudinal Transcriptional Response of Glycosylation-Related Genes, Regulators, and Targets in Cancer Cell Lines Treated With 11 Antitumor Agents
J. Krushkal, Ying-Dong Zhao, C. Hose, A. Monks +2 more
2017Cancer Informatics8 citations Open access
Semantic Scholar
Identification of pharmacodynamic biomarkers and common molecular mechanisms of response to genotoxic agents in cancer cell lines
Dong-Joon Min, Ying-Dong Zhao, A. Monks, Alida Palmisano +4 more
2019Cancer Chemotherapy and Pharmacology7 citations Open access
Semantic Scholar
Human tumor cell lines in vitro provide a relevant model for topotecan-induced transcriptional changes in analogous xenografts
A. Monks, M. Hollingshead, H. Stotler, Raymond Divellbiss +1 more
20076 citations
Semantic Scholar
Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment
J. Krushkal, Ying-Dong Zhao, C. Hose, A. Monks +2 more
2016Clinical Epigenetics1 citations Open access
Semantic Scholar
Defining a set of genes dysregulated in response to the HDAC inhibitor PXD101 (belinostat)
R. Shoemaker, C. Hose, P. Pezzoli, G. Vansant +3 more
20071 citations
Semantic Scholar
Abstract 5776: Advancing a screening platform with panels of patient-derived organoid models for drug discovery and development
A. Rapisarda, Eric M. Jones, C. Hose, E. Harris +18 more
2023Cancer Research0 citations
Semantic Scholar
Abstract 3079: Development of an automated platform for screening patient-derived organoid models
S. Paul, C. Hose, Eric M. Jones, E. Harris +16 more
2022Cancer Research0 citations
Semantic Scholar
Abstract 3091: Patient-derived organoid drug responses corroborate known target-drug interactions for selected anticancer agents
C. Hose, E. Harris, J. Connelly, Petreena S. Campbell +10 more
2022Cancer Research0 citations
Semantic Scholar
Abstract 3913: Evaluation of patient-derived cell lines and cancer organoids for the prediction of drug responses in patient-derived xenograft models
Petreena S. Campbell, C. Hose, Lara H. el Touny, E. Harris +29 more
2020Clinical Trials0 citations
Semantic Scholar
Abstract 270: Temozolomide resistant MGMT negative/MMR proficient cancer cells rely on ATR signaling and homologous recombination for DNA repair and survival
Lara H. el Touny, E. Harris, C. Hose, J. Connelly +6 more
2019Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract A116: Temozolomide-resistant MGMT/MSI double-negative cancer cells rely on ATR signaling and homologous recombination for DNA repair and survival
Lara H. el Touny, E. Harris, C. Hose, J. Connelly +8 more
20180 citations
Semantic Scholar
Abstract A117: Modeling ATM loss of function via CRISPR-Cas9 as a predictive tool for therapeutic responses in cancer cells
Lara H. el Touny, J. Connelly, C. Hose, A. Monks +7 more
20180 citations
Semantic Scholar
Abstract 1557: Longitudinal expression response of glycosylation related genes, regulators, and targets in cancer cell lines treated with eleven anti-tumor agents
J. Krushkal, Ying-Dong Zhao, C. Hose, A. Monks +2 more
20170 citations
Semantic Scholar
Abstract 5178: Determinants of response to temozolomide in an exceptionally sensitive patient derived model
Lara H. el Touny, J. Connelly, C. Hose, A. Monks +16 more
20160 citations
Semantic Scholar
450 Precise gene editing of mutant NRAS using CRISPR to determine sensitivity to trametinib
C. Hose, Nicole Fer, Mark W. Burkett, J. Connelly +10 more
20140 citations
Semantic Scholar
171 Antagonistic interaction between gemcitabine and erlotinib is influenced by EGR1 (early growth response 1) transcription factor expression
C. Hose, Y. Zhao, E. Polley, J. Fang +6 more
20140 citations
Semantic Scholar
Abstract 2361: Identification and analysis of gene fusion and splice variant events in the NCI sarcoma cell line panel
K. Wrzeszczynski, E. Polley, C. Hose, A. Monks +1 more
20140 citations
Semantic Scholar
Abstract 5663: Confirmation of peroxiredoxin II as a driver gene for doxorubicin sensitivity identified from drug-induced expression profiling of the NCI-60 cell lines using Reverse Engineering (REFS) network models
A. Monks, C. Hose, B. Hayete, Karl Runge +5 more
20120 citations
Semantic Scholar
Abstract 2853: Sunitinib induces anti-angiogenic splice-variant VEGF165b through induction of CLK1 and CLK4 kinases in prostate cell line DU-145
A. Monks, C. Hose, J. Doroshow
20110 citations
Semantic Scholar
Author ' s personal copy Development of antiproliferative phenylmaleimides that activate the unfolded protein response
Ulrike Muus, C. Hose, Wei Yao, T. Kosakowska-Cholody +7 more
20100 citations
Semantic Scholar
Drug-induced expression of NAG-1/MIC-1/PDF, a putative tumor suppressor, inhibits tumor growth
Jeanelle M. Martinez, Tina M. Sali, R. Okazaki, C. Anna +6 more
20060 citations
Semantic Scholar

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