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L. Doughty · SciRah

Researcher profile · Semantic Scholar

L. Doughty

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L. Doughty — researcher profile on SciRah

h-index: 21
Works: 71
Citations: 2,027

Most-cited papers

Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox
K. Nguyen, L. Cousens, L. Doughty, Gary C. Pien +2 more
2000Nature Immunology233 citations
Semantic Scholar
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice.
Doreen E. Wesche-Soldato, C. Chung, Joanne L. Lomas-Neira, L. Doughty +2 more
2005Blood189 citations Open access
Semantic Scholar
Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.
A. Ayala, C. Chung, J. Lomas, G. Y. Song +7 more
2002American Journal of Pathology168 citations Open access
Semantic Scholar
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure
J. Carcillo, L. Doughty, Danny Kofos, R. Frye +3 more
2003Intensive Care Medicine145 citations
Semantic Scholar
ADMISSION ANGIOPOIETIN LEVELS IN CHILDREN WITH SEPTIC SHOCK
J. Giuliano, Patrick Lahni, K. Harmon, H. Wong +6 more
2007Shock138 citations Open access
Semantic Scholar
Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox.
K. Nguyen, L. Cousens, L. Doughty, Gary C. Pien +2 more
2000Nature Immunology120 citations
Semantic Scholar
The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure.
L. Doughty, J. Carcillo, S. Kaplan, J. Janosky
1998Chest119 citations
Semantic Scholar
Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure.
L. Doughty, S. Kaplan, J. Carcillo
1996Critical Care Medicine119 citations
Semantic Scholar
Procalcitonin is persistently increased among children with poor outcome from bacterial sepsis*
Yong Y. Han, L. Doughty, Danny Kofos, H. Sasser +1 more
2003Pediatric Critical Care Medicine84 citations
Semantic Scholar
Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome
J. Carcillo, B. Podd, R. Aneja, S. Weiss +5 more
2017Pediatric Critical Care Medicine76 citations Open access
Semantic Scholar
Differential Effects of Macrophage Inflammatory Chemokine-2 and Keratinocyte-Derived Chemokine on Hemorrhage-Induced Neutrophil Priming for Lung Inflammation: Assessment by Adoptive Cells Transfer in Mice
J. Lomas, C. Chung, P. Grutkoski, B. W. LeBlanc +6 more
2003Shock75 citations Open access
Semantic Scholar
A Role for IFN-αβ in Virus Infection-Induced Sensitization to Endotoxin1
L. Doughty, K. Nguyen, J. Durbin, C. Biron
2001Journal of Immunology75 citations Open access
Semantic Scholar
sFas and sFas Ligand and Pediatric Sepsis-Induced Multiple Organ Failure Syndrome
L. Doughty, R. Clark, S. Kaplan, H. Sasser +1 more
2002Pediatric Research64 citations
Semantic Scholar
The Tissue Factor and Plasminogen Activator Inhibitor Type-1 Response in Pediatric Sepsis-induced Multiple Organ Failure
Jerril W. Green, L. Doughty, S. Kaplan, H. Sasser +1 more
2002Thrombosis and Haemostasis59 citations
Semantic Scholar
Early Protocolized vs. Usual Care Rehabilitation for Pediatric Neurocritical Care Patients: A Randomized Controlled Trial
E. Fink, S. Beers, A. Houtrow, R. Richichi +13 more
2019Pediatric Critical Care Medicine50 citations Open access
Semantic Scholar
Acute Renal Replacement Therapy in Pediatrics
Rajit K. Basu, D. Wheeler, S. Goldstein, L. Doughty
2011International Journal of Nephrology43 citations Open access
Semantic Scholar
Association of Blood-Based Brain Injury Biomarker Concentrations With Outcomes After Pediatric Cardiac Arrest
E. Fink, P. Kochanek, A. Panigrahy, S. Beers +28 more
2022JAMA Network Open37 citations Open access
Semantic Scholar
Plasma concentrations of defensins and lactoferrin in children with severe sepsis
N. Thomas, Joseph A. Carcillo, L. Doughty, H. Sasser +1 more
2002The Pediatric Infectious Disease Journal34 citations
Semantic Scholar
A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin.
L. Doughty, K. Nguyen, J. Durbin, C. Biron
2001Journal of Immunology29 citations
Semantic Scholar
SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis
C. Chung, Yaping Chen, P. Grutkoski, L. Doughty +1 more
2007Apoptosis28 citations
Semantic Scholar
Plasma bactericidal/permeability‐increasing protein concentrations in critically ill children with the sepsis syndrome
H. Wong, L. Doughty, N. Wedel, M. White +3 more
1995The Pediatric Infectious Disease Journal23 citations
Semantic Scholar
ACTIVATION OF COMMON ANTIVIRAL PATHWAYS CAN POTENTIATE INFLAMMATORY RESPONSES TO SEPTIC SHOCK
L. Doughty, S. Carlton, B. Galen, I. Cooma-Ramberan +2 more
2006Shock21 citations
Semantic Scholar
Immunology and Infectious Disease
L. Doughty, P. Linden
2003Molecular and Cellular Biology of Critical Care Medicine14 citations
Semantic Scholar
The Accreditation Council for Graduate Medical Education proposed work hour regulations.
D. Goodman, M. Winkler, Richard T. Fiser, S. Abd-Allah +50 more
2011Pediatric Critical Care Medicine11 citations
Semantic Scholar
Use of Magnetic Resonance Imaging in Neuroprognostication After Pediatric Cardiac Arrest: Survey of Current Practices
J. Piantino, Christopher M. Ruzas, Craig A. Press, S. Subramanian +13 more
2022medRxiv10 citations Open access
Semantic Scholar
Serum biomarkers of regeneration and plasticity are associated with functional outcome in pediatric neurocritical illness: An exploratory study
Catherine Madurski, J. Jarvis, Sue R. Beers, Amy J. Houtrow +11 more
2021Neurocritical Care9 citations Open access
Semantic Scholar
Adaptive immune function in critical illness
L. Doughty
2016Current opinion in pediatrics8 citations
Semantic Scholar
Pathogen Associated Molecular Patterns, Pattern Recognition Receptorsand Pediatric Sepsis
L. Doughty
20118 citations Open access
Semantic Scholar
819: PILOT RCT OF EARLY VERSUS USUAL CARE REHABILITATION IN PEDIATRIC NEUROCRITICAL CARE
E. Fink, S. Beers, A. Houtrow, R. Richichi +16 more
20185 citations
Semantic Scholar
Life Threatening Tropical Infections
G. Botez, L. Doughty
2014Pediatric Critical Care Medicine5 citations
Semantic Scholar
Cytokine Help for Diagnosing Community-Acquired Pneumonia.
S. Conway, L. Doughty
2017Pediatric Critical Care Medicine4 citations
Semantic Scholar
Electrolyte Emergencies and Acute Renal Failure in Pediatric Critical Care
E. Galloway, L. Doughty
20074 citations
Semantic Scholar
A MOUSE MODEL OF PRIMING FOR ACUTE LUNG INJURY FOLLOWING SHOCK.: 244
A. Ayala, C. Chung, J. Lomas, P. Grutkoski +2 more
20014 citations Open access
Semantic Scholar
Anaesthesia for a child with Sotos' syndrome.
D. Jones, L. Doughty, K. Brown
1991Anaesthesia and Intensive Care3 citations Open access
Semantic Scholar
Modulation of the Immune Response in Critical Illness/Injury
L. Doughty
20032 citations Open access
Semantic Scholar
Soluble Fas Receptor (sFasR) in Pediatric Sepsis-Induced MOF
L. Doughty, R. Clark, J. Carcillo
19982 citations
Semantic Scholar
The Procoagulant and Anti-fibrinolytic state and the development of pediatric sepsis-induced persistent multiple organ failure
Jerril W. Green, L. Doughty, J. Carcillo
19982 citations
Semantic Scholar
Soluble Fas Receptor (sFasR) and Fas Ligand (FasL)in Sepsis-Induced Multiple Organ Failure ♦ 191
L. Doughty, R. Clark, J. Carcillo
1998Pediatric Research2 citations
Semantic Scholar
Cytochrome P450 Function in Pediatric Sepsis-Induced Multiple Organ Failure.♦ 179
L. Doughty, S. Kaplan, G. Burckhart, R. Frye +1 more
1997Pediatric Research2 citations
Semantic Scholar
O020 / #442: POST PEDIATRIC NEUROCRITICAL CARE RECOVERY: A WHOLE CHILD AND FAMILY PERSPECTIVE
J. Jarvis, A. Houtrow, A. Treble-Barna, S. Beers +5 more
20211 citations Open access
Semantic Scholar
ASTHMA CARE STANDARDIZATION IN A PEDIATRIC EMERGENCY DEPARTMENT: CHANGING TO DISCHARGE MEDICATIONS IN-HAND AND UNDERSTANDING EFFECTS ACROSS THE CARE CONTINUUM
E. M. Kurowski, A. Rinderknecht, Michelle C. Caruso, Jennifer Oehler +8 more
2016BMJ Quality & Safety1 citations
Semantic Scholar
dsRNA‐ACTIVATED PROTEIN KINASE (PKR) MEDIATES VIRAL PRIMING OF LETHALITY IN POLYMICROBIAL SEPSIS,: 89
L. Doughty, C. Chung, S. Carlton, P. Grutkoski +2 more
20021 citations Open access
Semantic Scholar
Mechanisms of viral potentiation of inflammation: Ifn&agr; modulation of the cytokine response to sepsis.: 104
L. Doughty, C. Chung, J. Lomas, K. Nguyen +2 more
20011 citations Open access
Semantic Scholar
DEFENSIN AND LACTOFERRIN, CIRCULATING ENDOGENOUS ANTIMICROBIALS, ARE INCREASED IN PEDIATRIC SEPSIS
N. Thomas, L. Doughty, R. Heine, L. Mortimer +1 more
19981 citations
Semantic Scholar
Abstract 317: Brain MRI And Spectroscopy Biomarkers Predict Outcome After Pediatric Cardiac Arrest In POCCA
E. Fink, P. Kochanek, S. Bluml, J. Wisnowski +29 more
2022Circulation0 citations
Semantic Scholar
Abstract 265: Social Determinants Of Health Impact Phenotype-based Outcome Prediction After Pediatric Arrest
E. Fink, P. Kochanek, A. Panigrahy, S. Beers +25 more
2022Circulation0 citations
Semantic Scholar
995: Pursuing or Forgoing Tracheostomy and Ventilation for Children With Severe Neurologic Impairment
W. Sveen, D. Benscoter, Adrienne P Borschuk, DonnaMaria E. Cortezzo +5 more
20200 citations
Semantic Scholar
Comparing Early Rehab Therapy With Usual Care for Children With Acute Brain Injuries
E. Fink, S. Beers, A. Houtrow, R. Richichi +14 more
20200 citations
Semantic Scholar
Using QI Methodology to Standardize Education for Families Considering Tracheostomy Placement and Permanent Mechanical Ventilation for Their Children: An Attempt at Full Disclosure (SA520)
R. Thienprayoon, L. Doughty, H. Sawnani, Mark J. Meyer +4 more
20170 citations Open access
Semantic Scholar
THU0556 Smoking and Increased Airway Obstruction Over Time in Patients with Pulmonary Sarcoidosis
M. Walker, L. Doughty, A. C. Janot, H. Grewal +3 more
20150 citations
Semantic Scholar

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J. Carcillo×14
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C. Chung×8
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A. Ayala×8
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E. Fink×8
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S. Beers — researcher profile on SciRah

A. Treble-Barna×7

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P. Kochanek — researcher profile on SciRah

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S. Kaplan — researcher profile on SciRah

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C. Biron — researcher profile on SciRah

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J. Lomas — researcher profile on SciRah

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H. Sasser — researcher profile on SciRah