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R. Frye · SciRah

Researcher profile · Semantic Scholar

R. Frye

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R. Frye — researcher profile on SciRah

h-index: 42
Works: 157
Citations: 5,598

Most-cited papers

Effect of St John's Wort on imatinib mesylate pharmacokinetics
R. Frye, S. M. Fitzgerald, T. Lagattuta, M. Hruska +1 more
2004Clinical pharmacology and therapy242 citations
Semantic Scholar
Liver disease selectively modulates cytochrome P450–mediated metabolism
R. Frye, N. Zgheib, G. Matzke, D. Chaves‐Gnecco +3 more
2006Clinical pharmacology and therapy237 citations
Semantic Scholar
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.
Bernard J. Komoroski, Shi-Min Zhang, H. Cai, J. Hutzler +7 more
2004Drug Metabolism And Disposition197 citations
Semantic Scholar
Effects of high fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects
MyPhuong T. Le, R. Frye, C. Rivard, Jing Cheng +4 more
2011Metabolism: Clinical and Experimental167 citations Open access
Semantic Scholar
ESRD impairs nonrenal clearance of fexofenadine but not midazolam.
T. Nolin, R. Frye, P. Le, Hooman Sadr +4 more
2009Journal of the American Society of Nephrology140 citations Open access
Semantic Scholar
Pharmacokinetics of α-mangostin in rats after intravenous and oral application.
Li Li, I. Brunner, A. Han, M. Hamburger +3 more
2011Molecular Nutrition & Food Research101 citations
Semantic Scholar
Effects of Herbal Supplements on Drug Glucuronidation. Review of Clinical, Animal, and In Vitro Studies
Mohamed-Eslam F. Mohamed, R. Frye
2010Planta Medica99 citations Open access
Semantic Scholar
Probing the world of cytochrome P450 enzymes.
R. Frye
2004Molecular Interventions77 citations
Semantic Scholar
Pharmacometabolomics Reveals Racial Differences in Response to Atenolol Treatment
W. R. Wikoff, R. Frye, Hongjie Zhu, Yan Gong +8 more
2013PLoS ONE75 citations Open access
Semantic Scholar
A Sensitive and Specific Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Intracellular and Extracellular Uric Acid
Kyung Mee Kim, G. Henderson, Xiao-Sen Ouyang, R. Frye +3 more
2009Journal of chromatography. B, Analytical technologies in the biomedical and life sciences70 citations Open access
Semantic Scholar
Pharmacogenomics Competencies in Pharmacy Practice: A Blueprint for Change
Mary W. Roederer, Grace M. Kuo, D. Kisor, R. Frye +3 more
2016Journal of the American Pharmacists Association68 citations Open access
Semantic Scholar
Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography–mass spectrometry
Kyung Mee Kim, G. Henderson, R. Frye, C. Galloway +5 more
2008Journal of chromatography. B, Analytical technologies in the biomedical and life sciences62 citations Open access
Semantic Scholar
The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity
Marina Kawaguchi‐Suzuki, R. Frye, Hao-Jie Zhu, B. Brinda +3 more
2014Drug Metabolism And Disposition58 citations Open access
Semantic Scholar
Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity
Mohamed-Eslam F. Mohamed, Tiffany Tseng, R. Frye
2010Xenobiotica; the fate of foreign compounds in biological systems56 citations
Semantic Scholar
The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.
M. Hruska, J. Amico, T. Langaee, R. Ferrell +2 more
2005British Journal of Clinical Pharmacology56 citations Open access
Semantic Scholar
Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis.
M. Joy, Mary K. La, Jinzhao Wang, Arlene S. Bridges +8 more
2012British Journal of Clinical Pharmacology55 citations Open access
Semantic Scholar
Inhibitory Effects of Commonly Used Herbal Extracts on UDP-Glucuronosyltransferase 1A4, 1A6, and 1A9 Enzyme Activities
Mohamed-Eslam F. Mohamed, R. Frye
2011Drug Metabolism And Disposition51 citations Open access
Semantic Scholar
Validation of incorporating flurbiprofen into the Pittsburgh cocktail
N. Zgheib, R. Frye, T. Tracy, M. Romkes +1 more
2006Clinical pharmacology and therapy51 citations
Semantic Scholar
Early Atorvastatin Reduces Hemorrhage after Acute Cerebral Ischemia in Diabetic Rats
H. Elewa, A. Kozák, A. El-Remessy, R. Frye +3 more
2009Journal of Pharmacology and Experimental Therapeutics50 citations Open access
Semantic Scholar
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
S. Poloyac, M. Tortorici, Danielle I. Przychodzin, R. B. Reynolds +3 more
2004Drug Metabolism And Disposition49 citations
Semantic Scholar
Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study
K. Flaherty, C. Lathia, R. Frye, L. Schuchter +3 more
2011Cancer Chemotherapy and Pharmacology47 citations
Semantic Scholar
Cytochrome P-450 activity is differentially altered in severely injured patients
B. Harbrecht, R. Frye, M. Zenati, R. Branch +1 more
2005Critical Care Medicine43 citations
Semantic Scholar
Inhibition of Intestinal and Hepatic Glucuronidation of Mycophenolic Acid by Ginkgo biloba Extract and Flavonoids
Mohamed-Eslam F. Mohamed, R. Frye
2010Drug Metabolism And Disposition42 citations
Semantic Scholar
A summer research training program to foster PharmD students' interest in research.
Julie Johnson, Mariellen J. Moore, Jaekyu Shin, R. Frye
2008American Journal of Pharmaceutical Education40 citations Open access
Semantic Scholar
Pharmacokinetic Properties of Pure Xanthones in Comparison to a Mangosteen Fruit Extract in Rats
Li Li, A. Han, A. Kinghorn, R. Frye +2 more
2013Planta Medica39 citations
Semantic Scholar
Pyrosequencing method for genotyping cytochrome P450 CYP2C8 and CYP2C9 enzymes.
M. Hruska, R. Frye, T. Langaee
2004Clinical Chemistry35 citations Open access
Semantic Scholar
Association of Branched and Aromatic Amino Acids Levels with Metabolic Syndrome and Impaired Fasting Glucose in Hypertensive Patients
Liming Weng, E. Quinlivan, Yan Gong, A. L. Beitelshees +8 more
2015Metabolic Syndrome and Related Disorders34 citations Open access
Semantic Scholar
Effect of Cytochrome P450 3A5 Genotype on Atorvastatin Pharmacokinetics and Its Interaction with Clarithromycin
Jaekyu Shin, D. Pauly, M. Pacanowski, T. Langaee +2 more
2011Pharmacotherapy33 citations Open access
Semantic Scholar
Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction
C. Haas, D. Brazeau, D. Cloen, B. M. Booker +4 more
2005European Journal of Clinical Pharmacology33 citations
Semantic Scholar
Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity.
N. Zgheib, R. Frye, T. Tracy, M. Romkes +1 more
2007British Journal of Clinical Pharmacology29 citations Open access
Semantic Scholar
A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis
Marina Kawaguchi‐Suzuki, Kenneth Cusi, F. Bril, Yan Gong +2 more
2018Frontiers in Pharmacology28 citations Open access
Semantic Scholar
A GENETIC RESPONSE SCORE FOR HYDROCHLOROTHIAZIDE USE: INSIGHTS FROM GENOMICS AND METABOLOMICS INTEGRATION
Mohamed H. Shahin, Yan Gong, Caitrin W. McDonough, D. Rotroff +12 more
2016HYPERTENSION28 citations Open access
Semantic Scholar
Simplified method for determination of clarithromycin in human plasma using protein precipitation in a 96-well format and liquid chromatography-tandem mass spectrometry
Jaekyu Shin, D. Pauly, Julie A. Johnson, R. Frye
2008Journal of chromatography. B, Analytical technologies in the biomedical and life sciences27 citations Open access
Semantic Scholar
Vancomycin Disposition following Intraperitoneal Administration in Children Receiving Peritoneal Dialysis
D. Blowey, B. Warady, S. Abdel-Rahman, R. Frye +1 more
2007Peritoneal Dialysis International27 citations Open access
Semantic Scholar
Pharmacokinetics of Intraperitoneal Cefepime in Automated Peritoneal Dialysis
Rowland J. Elwell, R. Frye, G. Bailie
2005Peritoneal Dialysis International27 citations Open access
Semantic Scholar
Effect of Conjugated Equine Estrogens on Oxidative Metabolism in Middle‐aged and Elderly Postmenopausal Women
M. O'Connell, R. Frye, G. Matzke, J. S. St. Peter +4 more
2006Journal of clinical pharmacology25 citations
Semantic Scholar
Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype‐Derived Activity Scores
Cameron D. Thomas, Scott A. Mosley, Sarah Kim, K. Lingineni +21 more
2020CPT: Pharmacometrics & Systems Pharmacology24 citations Open access
Semantic Scholar
Is a Diabetes-Linked Amino Acid Signature associated with Beta Blocker-Induced Impaired Fasting Glucose?
R. Cooper-DeHoff, W. Hou, Liming Weng, R. Baillie +14 more
2014Circulation: Cardiovascular Genetics24 citations Open access
Semantic Scholar
Current clinical evidence on pioglitazone pharmacogenomics
Marina Kawaguchi‐Suzuki, R. Frye
2013Frontiers in Pharmacology24 citations Open access
Semantic Scholar
The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.
A. Albassam, R. Frye, J. S. Markowitz
2017Chemico-Biological Interactions22 citations
Semantic Scholar
Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol
Liming Weng, Yan Gong, J. Culver, S. Gardell +13 more
2016Metabolomics21 citations Open access
Semantic Scholar
Pharmacokinetics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats.
K. Woelkart, R. Frye, H. Derendorf, R. Bauer +1 more
2009Planta Medica21 citations
Semantic Scholar
Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics
Mohamed H. Shahin, Yan Gong, R. Frye, D. Rotroff +12 more
2017Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease20 citations Open access
Semantic Scholar
Early thrombin formation capacity in trauma patients and association with venous thromboembolism.
Stacy A. Voils, S. Lemon, J. Jordan, P. Riley +1 more
2016Thrombosis Research20 citations
Semantic Scholar
Plasma Coenzyme Q10 Predicts Lipid-lowering Response to High-Dose Atorvastatin
M. Pacanowski, R. Frye, Osatohanmen Enogieru, R. Schofield +1 more
2008Journal of Clinical Lipidology20 citations Open access
Semantic Scholar
Effect of Age and Postoperative Time on Cytochrome P450 Enzyme Activity Following Liver Transplantation
Shanshan Liu, R. Frye, R. A. Branch, R. Venkataramanan +2 more
2005Journal of clinical pharmacology19 citations
Semantic Scholar
Intensive Care Unit Delirium in Surgical Patients Is Associated with Upregulation in Tryptophan Metabolism
Stacy A. Voils, Bethany R. Shoulders, Sonal Singh, L. Solberg +2 more
2020Pharmacotherapy17 citations
Semantic Scholar
Relative bioavailability of silybin A and silybin B from two multi-constituent dietary supplement formulations containing milk thistle extract: A single dose study
Wen-Yi Li, Guo Yu, Renee M. Hogan, R. Mohandas +3 more
2017Clinical Therapeutics17 citations Open access
Semantic Scholar
Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations.
C. Sampath, Karin G. Haug, Sophia Thanei, M. Hamburger +3 more
2012Planta Medica17 citations
Semantic Scholar
Metabolomic association between venous thromboembolism in critically ill trauma patients and kynurenine pathway of tryptophan metabolism.
Stacy A. Voils, Mohamed H. Shahin, T. Garrett, R. Frye
2018Thrombosis Research15 citations
Semantic Scholar

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