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H. Lawrence · SciRah

Researcher profile · Semantic Scholar

H. Lawrence

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H. Lawrence — researcher profile on SciRah

h-index: 22
Works: 58
Citations: 4,088

Most-cited papers

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib
J. Sosman, Kevin B. Kim, L. Schuchter, R. Gonzalez +21 more
2012New England Journal of Medicine2,143 citations Open access
Semantic Scholar
Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells.
H. Lawrence, J. L. Christensen, Stephen Fong, Yu-Long Hu +4 more
2005Blood250 citations Open access
Semantic Scholar
marrow cells induces stem cell expansion gene in bone Hoxa 9 associated − Overexpression of the myeloid leukemia
U. Thorsteinsdóttir, A. Mamo, Evert J. Kroon, Lori Jerome +3 more
2001246 citations
Semantic Scholar
HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.
Neal Fischbach, S. Rozenfeld, Wei-Fang Shen, Stephen Fong +7 more
2005Blood157 citations Open access
Semantic Scholar
Analytical Performance of a Real-time PCR-based Assay for V600 Mutations in the BRAF Gene, Used as the Companion Diagnostic Test for the Novel BRAF Inhibitor Vemurafenib in Metastatic Melanoma
H. Halait, K. DeMartin, Sweta Shah, S. Soviero +5 more
2012Diagnostic molecular pathology (Print)155 citations
Semantic Scholar
Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes.
David J. Izon, Sofia Rozenfeld, Stephen Fong, L. Kömüves +2 more
1998Blood128 citations
Semantic Scholar
A Biopsy-based 17-gene Genomic Prostate Score as a Predictor of Metastases and Prostate Cancer Death in Surgically Treated Men with Clinically Localized Disease.
S. K. Van den Eeden, R. Lu, Nan Zhang, C. Quesenberry +7 more
2018European Urology127 citations
Semantic Scholar
Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells.
J. Bijl, A. Thompson, R. Ramírez-Solís, J. Krosl +3 more
2006Blood89 citations Open access
Semantic Scholar
Evidence that the Pim1 kinase gene is a direct target of HOXA9.
Yu-Long Hu, E. Passegué, Stephen Fong, C. Largman +1 more
2007Blood83 citations Open access
Semantic Scholar
A comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens
D. D. de Castro, B. Angulo, B. Gomez, D. Mair +7 more
2012British Journal of Cancer82 citations Open access
Semantic Scholar
Measuring stem cell frequency in epidermis: A quantitative in vivo functional assay for long-term repopulating cells
T. E. Schneider, C. Barland, A. Alex, M. Mancianti +4 more
2003Proceedings of the National Academy of Sciences of the United States of America75 citations Open access
Semantic Scholar
Patient-specific Meta-analysis of 2 Clinical Validation Studies to Predict Pathologic Outcomes in Prostate Cancer Using the 17-Gene Genomic Prostate Score.
T. Brand, Nan Zhang, M. Crager, T. Maddala +11 more
2016Urology66 citations Open access
Semantic Scholar
Comparison of Testing Methods for the Detection of BRAF V600E Mutations in Malignant Melanoma: Pre-Approval Validation Study of the Companion Diagnostic Test for Vemurafenib
F. López-Rios, B. Angulo, B. Gomez, D. Mair +7 more
2013PLoS ONE59 citations Open access
Semantic Scholar
Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects.
M. Magnusson, A. Brun, H. Lawrence, S. Karlsson
2007Experimental Hematology56 citations Open access
Semantic Scholar
The HOX-MEIS connection in AML
H. Lawrence, C. Largman
200547 citations Open access
Semantic Scholar
Transit-amplifying cell frequency and cell cycle kinetics are altered in aged epidermis.
A. Charruyer, C. Barland, Li-Li Yue, Heike Wessendorf +4 more
2009Journal of Investigative Dermatology46 citations Open access
Semantic Scholar
Analytic performance studies and clinical reproducibility of a real-time PCR assay for the detection of epidermal growth factor receptor gene mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer
P. O'Donnell, J. Ferguson, J. Shyu, Robert W. Current +14 more
2013BMC Cancer42 citations Open access
Semantic Scholar
Clinical Validation of a PCR Assay for the Detection of EGFR Mutations in Non–Small-Cell Lung Cancer: Retrospective Testing of Specimens from the EURTAC Trial
S. Benlloch, M. Botero, Jordi Beltran-Alamillo, C. Mayo +16 more
2014PLoS ONE39 citations Open access
Semantic Scholar
A guide for clinicians in the evaluation of emerging molecular diagnostics for newly diagnosed prostate cancer.
S. Canfield, A. Kibel, Michael J. Kemeter, P. Febbo +2 more
2014Reviews in urology31 citations
Semantic Scholar
Gene expression in normal-appearing tissue adjacent to prostate cancers are predictive of clinical outcome: evidence for a biologically meaningful field effect
C. Magi-Galluzzi, T. Maddala, S. Falzarano, D. Cherbavaz +6 more
2016OncoTarget27 citations Open access
Semantic Scholar
Association between a 17-gene genomic prostate score and multi-parametric prostate MRI in men with low and intermediate risk prostate cancer (PCa)
M. Leapman, A. Westphalen, N. Ameli, H. Lawrence +3 more
2015PLoS ONE25 citations Open access
Semantic Scholar
Rapid Adhesion to Collagen Isolates Murine Keratinocytes with Limited Long‐Term Repopulating Ability In Vivo Despite High Clonogenicity In Vitro
L. R. Strachan, Kenneth J. Scalapino, H. Lawrence, R. Ghadially
2008Stem Cells25 citations
Semantic Scholar
Concurrent acute myeloid leukemia with inv(16)(p13.1q22) and chronic lymphocytic leukemia: Molecular evidence of two separate diseases
Chuan-Yi M. Lu, J. Murata-Collins, En-Di Wang, Imran Siddiqi +1 more
2006American journal of hematology/oncology18 citations Open access
Semantic Scholar
Evidence that the Pim 1 kinase gene is a direct target of HOXA 9
Yu-Long Hu, E. Passegué, Stephen Fong, C. Largman +1 more
200711 citations
Semantic Scholar
PP 28 Analytical performance and workflow comparison study of three methods for detecting KRAS mutations in formalin-fixed paraffin-embedded tissue (FFPET) specimens of colorectal cancer (CRC)
D. D. de Castro, B. Angulo, B. Gomez, D. Mair +6 more
20118 citations
Semantic Scholar
Clinical utility of a 17-gene genomic prostate score (GPS) for treatment selection in men with newly diagnosed prostate cancer (PCa).
M. Dall'Era, B. Dénes, H. Lawrence, Athanasios C. Tsiatis +4 more
20157 citations
Semantic Scholar
Homeobox Gene Networks and the Regulation of Hematopoiesis
G. Sauvageau, R. Humphries, H. Lawrence, C. Largman
20027 citations
Semantic Scholar
Molecular testing for BRAF V600 mutations in the BRIM-2 trial of the BRAF inhibitor vemurafenib in metastatic melanoma.
K. Bloom, Steven M. Anderson, R. Schilling, Ju Ruey-Jiuan Lee +4 more
2011Journal of Clinical Oncology6 citations
Semantic Scholar
Activation of Stem-Cell Specific Genes by HOXA9 and HOXA10 Homeodomain Proteins in CD34+ Human Cord Blood Cells.
H. Lawrence, C. M. Ferrell, S. Dorsam, H. Ohta +4 more
20045 citations
Semantic Scholar
Retrospective EGFR mutation testing of clinical specimens from the EURTAC trial of erlotinib in non-small cell lung cancer (NSCLC) using a novel allele-specific PCR (AS-PCR) assay.
S. Benlloch, M. Taron, M. Botero, J. Bertran-Alamillo +15 more
20124 citations
Semantic Scholar
Performance of the 17-gene genomic prostate score test in men with prostate cancer (PCa) managed with active surveillance (AS): Results from the Canary Prostate Active Surveillance Study (PASS).
D. Lin, Ying-Ye Zheng, Jesse K. McKenney, Marshall D. Brown +16 more
2019Journal of Clinical Oncology3 citations
Semantic Scholar
A 17-gene genomic prostate score (GPS) as a predictor of biochemical (BCR) and clinical recurrence (CR) in men with surgically treated intermediate- and high-risk prostate cancer (PCa).
E. Klein, Nan Zhang, M. Crager, T. Maddala +7 more
20163 citations
Semantic Scholar
Evidence for a field effect in early prostate cancer (PCa): Gene expression profiles in normal-appearing prostate tissue (NT) adjacent to tumor (T) as predictors of clinical outcome.
E. Klein, S. Falzarano, Nan Zhang, D. Knezevic +7 more
20133 citations
Semantic Scholar
Simultaneous presence of major secondary chromosomal abnormalities in blast crisis of chronic myeloid leukemia.
Chuan-Yi M. Lu, En-Di Wang, H. Lawrence
2007Cancer Genetics and Cytogenetics3 citations
Semantic Scholar
LBA22A PROSPECTIVELY-DESIGNED STUDY TO DETERMINE THE ASSOCIATION OF A 17-GENE GENOMIC PROSTATE SCORE WITH RECURRENCE FOLLOWING SURGERY FOR LOCALISED PROSTATE CANCER (PCA)
J. Cullen, I. Rosner, T. Brand, Amina Ali +10 more
20142 citations Open access
Semantic Scholar
1403 POSTER DISCUSSION Molecular Testing for BRAF V600 Mutations in Clinical Trials of the BRAF Inhibitor Vemurafenib (RG7204/PLX4032) in Metastatic Melanoma – a Comparison With Sánger Sequencing
S. Anderson, K. Bloom, R. Schilling, Ju Ruey-Jiuan Lee +3 more
20112 citations
Semantic Scholar
Prediction of prostate cancer gleason score upgrading from biopsy to radical prostatectomy (RP) using a validated 17-gene panel assay.
J. Cullen, H. Lawrence, Yongmei Chen, R. Lu +4 more
2018Annals of Oncology1 citations Open access
Semantic Scholar
Association of risk of clinical recurrence (CR) and prostate cancer death (PCD) with a 17-gene genomic prostate score (GPS) value <20.
P. Febbo, M. Crager, E. Burke, H. Lawrence +2 more
20171 citations
Semantic Scholar
Influence of common comorbid conditions on a 17-gene assay for prediction of adverse pathology in clinically low-risk prostate cancer.
J. Cullen, I. Sesterhenn, H. Lawrence, Huai-Ching Kuo +5 more
20171 citations
Semantic Scholar
MP02-19 BIOMARKERS OF BIOCHEMICAL (BCR) AND CLINICAL RECURRENCE (CR) IN PROSTATE CANCER (PCA) FOLLOWING RADICAL PROSTATECTOMY (RP) – PERFORMANCE OF A 17-GENE GENOMIC PROSTATE SCORE (GPS) AND TESTS FOR PTEN LOSS.
C. Magi-Galluzzi, M. Bonham, Athanasios C. Tsiatis, S. Falzarano +6 more
20161 citations
Semantic Scholar
marrow cells induces stem cell expansion associatedHoxa9 gene in bone - Overexpression of the myeloid leukemia
G. Sauvageau, U. Thorsteinsdóttir, A. Mamo, Evert J. Kroon +3 more
20131 citations
Semantic Scholar
CO18. The analytic performance of the cobasR 4800 BRAF V600 Mutation Test in the detection of V600E mutations in malignant melanoma: assay reproducibility and effects of melanin
Barbara Kovach, R. Langland, R. Schilling, H. Halait +5 more
20111 citations
Semantic Scholar
The analytic performance of a TaqMelt PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue (FFPET) samples of colorectal carcinoma (CRC).
Jian-Li Cao, M. Velez, C. Hoeppner, S. Lee +3 more
2011Journal of Clinical Oncology1 citations
Semantic Scholar
p53 mutational status, but not immunohistochemical staining (IHC), is associated with a clinical response of the primary tumor in women receiving neoadjuvant docetaxel-capecitabine chemotherapy for locally advanced breast cancer.
J. Ross, C. Perou, N. Aki, N. Patten +6 more
20091 citations
Semantic Scholar
Stem cells and the Heisenberg uncertainty principle
H. Lawrence
20041 citations Open access
Semantic Scholar
TPO: tapping into the HOX clock
H. Lawrence
20031 citations
Semantic Scholar
MP67-10 A 17-GENE GENOMIC ASSAY AS A PREDICTOR OF OUTCOMES IN AFRICAN AMERICANS WITH PROSTATE CANCER
J. Cullen, J. Lynch, E. Klein, S. K. Van den Eeden +5 more
20200 citations Open access
Semantic Scholar
The relative contributions of the Genomic Prostate Score and comorbidity profile in predicting outcomes in surgically treated men with clinically low and intermediate-risk prostate cancer.
J. Cullen, Dudith Pierre-Victor, H. Lawrence, Huai-Ching Kuo +2 more
2019Journal of Clinical Oncology0 citations
Semantic Scholar
Validation of a 17-Gene Genomic Prostate Score (GPS) as a predictor of biochemical recurrence (BCR) in men with prostate cancer treated with radical prostatectomy (RP) in a community setting.
S. Vandeneeden, Nan Zhang, C. Quesenberry, J. Han +6 more
20170 citations
Semantic Scholar
Patient-specific meta-analysis (MA) of two validation studies to predict pathologic outcomes in prostate cancer (PCa) using a 17-gene genomic prostate score (GPS).
M. Cooperberg, T. Brand, J. Simko, I. Sesterhenn +9 more
20160 citations
Semantic Scholar

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