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N. Dzamko · SciRah

Researcher profile · Semantic Scholar

N. Dzamko

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N. Dzamko — researcher profile on SciRah

h-index: 28
Works: 64
Citations: 2,391

Most-cited papers

Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology
N. Dzamko, Amanda M. Gysbers, G. Perera, Anita Y. Bahar +4 more
2016Acta Neuropathologica237 citations Open access
Semantic Scholar
Inflammation is genetically implicated in Parkinson's disease.
N. Dzamko, C. Geczy, G. Halliday
2015Neuroscience193 citations
Semantic Scholar
Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease
J. Galper, N. Dean, Russell Pickford, S. Lewis +3 more
2022Brain : a journal of neurology142 citations Open access
Semantic Scholar
Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s disease
F. Atashrazm, Deborah A. Hammond, G. Perera, C. Dobson-Stone +7 more
2018Scientific Reports111 citations Open access
Semantic Scholar
Inhibitor treatment of peripheral mononuclear cells from Parkinson’s disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker
G. Perera, M. Ranola, D. Rowe, G. Halliday +1 more
2016Scientific Reports111 citations Open access
Semantic Scholar
Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells
Jianqun Gao, G. Perera, Megha Bhadbhade, G. Halliday +1 more
2019Journal of Biological Chemistry97 citations Open access
Semantic Scholar
Parkinson’s progression prediction using machine learning and serum cytokines
Diba Ahmadi Rastegar, Nicholas Ho, G. Halliday, N. Dzamko
2019npj Parkinson's Disease94 citations Open access
Semantic Scholar
Increased peripheral inflammation in asymptomatic leucine‐rich repeat kinase 2 mutation carriers
N. Dzamko, D. Rowe, Glenda M. Halliday
2016Movement Disorders92 citations
Semantic Scholar
LRRK2‐mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients
F. Atashrazm, Deborah A. Hammond, G. Perera, M. Bolliger +6 more
2018Movement Disorders91 citations
Semantic Scholar
Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis
N. Dzamko, Jin-Xia Zhou, Yue Huang, G. Halliday
2014Frontiers in Molecular Neuroscience88 citations Open access
Semantic Scholar
A blood-based marker of mitochondrial DNA damage in Parkinson’s disease
Rui Qi, E. Sammler, Claudia P. Gonzalez-Hunt, Ivana Barraza +25 more
2023Science Translational Medicine75 citations Open access
Semantic Scholar
LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives
F. Atashrazm, N. Dzamko
2016Clinical Pharmacology : Advances and Applications60 citations Open access
Semantic Scholar
Leucine Rich Repeat Kinase 2 and Innate Immunity
Diba Ahmadi Rastegar, N. Dzamko
2020Frontiers in Neuroscience53 citations Open access
Semantic Scholar
LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies
N. Dzamko, Amanda M. Gysbers, R. Bandopadhyay, M. Bolliger +10 more
2017Movement Disorders52 citations Open access
Semantic Scholar
Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers
Zhao Ye, G. Perera, J. Takahashi‐Fujigasaki, D. Mash +8 more
2017Brain : a journal of neurology48 citations Open access
Semantic Scholar
Measurement of LRRK2 and Ser910/935 Phosphorylated LRRK2 in Peripheral Blood Mononuclear Cells from Idiopathic Parkinson's Disease Patients
N. Dzamko, Germaine Chua, Madelaine B. Rañola, D. Rowe +1 more
2013Journal of Parkinson's Disease48 citations Open access
Semantic Scholar
Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain
Yu-Hong Fu, Ying He, Katherine Phan, S. Bhatia +5 more
2022Acta Neuropathologica Communications47 citations Open access
Semantic Scholar
An emerging role for LRRK2 in the immune system.
N. Dzamko, G. Halliday
2012Biochemical Society Transactions47 citations Open access
Semantic Scholar
Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages
Diba Ahmadi Rastegar, Laura P. Hughes, G. Perera, Shikara Keshiya +5 more
2022npj Parkinson's Disease46 citations Open access
Semantic Scholar
LRRK2 and the Immune System.
N. Dzamko
2017Advances in neurobiology46 citations
Semantic Scholar
Recent Developments in LRRK2-Targeted Therapy for Parkinson’s Disease
Zhao Ye, N. Dzamko
2019Drugs45 citations
Semantic Scholar
Evaluation of plasma levels of NFL, GFAP, UCHL1 and tau as Parkinson's disease biomarkers using multiplexed single molecule counting
P. Youssef, Laura P. Hughes, W. Kim, Glenda M. Halliday +3 more
2023Scientific Reports43 citations Open access
Semantic Scholar
Cytokine activity in Parkinson’s disease
N. Dzamko
2023Neuronal Signaling41 citations Open access
Semantic Scholar
Evaluation of strategies for measuring lysosomal glucocerebrosidase activity
Daniel Ysselstein, Tiffany J. Young, M. Nguyen, S. Padmanabhan +3 more
2021Movement Disorders41 citations Open access
Semantic Scholar
Multiple pathways of lipid dysregulation in amyotrophic lateral sclerosis
Katherine Phan, Ying He, S. Bhatia, Russell Pickford +9 more
2022Brain Communications32 citations Open access
Semantic Scholar
Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation.
Lenka Munoz, Madeline E. Kavanagh, A. Phoa, Benjamin Heng +5 more
2015European journal of medicinal chemistry32 citations Open access
Semantic Scholar
Comparison of Different Platform Immunoassays for the Measurement of Plasma Alpha-Synuclein in Parkinson’s Disease Patients
P. Youssef, W. Kim, G. Halliday, S. Lewis +1 more
2021Journal of Parkinson's Disease31 citations Open access
Semantic Scholar
Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia
Katherine Phan, Ying He, Yu-Hong Fu, N. Dzamko +10 more
2021Communications Medicine29 citations Open access
Semantic Scholar
WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson’s Disease Monocytes
R. Wallings, Laura P. Hughes, Hannah A. Staley, Z. Simon +7 more
2022Frontiers in Cellular Neuroscience25 citations Open access
Semantic Scholar
LRRK2 and Lipid Pathways: Implications for Parkinson’s Disease
J. Galper, W. Kim, N. Dzamko
2022Biomolecules25 citations Open access
Semantic Scholar
Cytokines and Gaucher Biomarkers in Glucocerebrosidase Carriers with and Without Parkinson Disease
J. Galper, M. Balwani, S. Fahn, C. Waters +4 more
2021Movement Disorders24 citations Open access
Semantic Scholar
Glucocerebrosidase Activity is Reduced in Cryopreserved Parkinson’s Disease Patient Monocytes and Inversely Correlates with Motor Severity
Laura P. Hughes, Marília Pereira, Deborah A. Hammond, John B. J. Kwok +3 more
2021Journal of Parkinson's Disease23 citations Open access
Semantic Scholar
Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model
Fiona Weiss, Laura P. Hughes, Yu-Hong Fu, Cedric Bardy +2 more
2024Translational Neurodegeneration22 citations Open access
Semantic Scholar
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease
C. Matrone, N. Dzamko, P. Madsen, M. Nyegaard +7 more
2016PLoS ONE22 citations Open access
Semantic Scholar
A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells
Y. Naaldijk, B. Fernández, Rachel Fasiczka, Elena Fdez +20 more
2023bioRxiv21 citations Open access
Semantic Scholar
A protective role of ABCA5 in response to elevated sphingomyelin levels in Parkinson’s disease
Yu-Hong Fu, Russell Pickford, J. Galper, Katherine Phan +6 more
2024npj Parkinson's Disease18 citations Open access
Semantic Scholar
Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice
Ye Zhao, Shikara Keshiya, F. Atashrazm, Jianqun Gao +5 more
2018Neurobiology of Disease18 citations Open access
Semantic Scholar
A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology
Jessica Chedid, A. Labrador-Garrido, Siying Zhong, Jianqun Gao +5 more
2022Journal of Biological Chemistry16 citations Open access
Semantic Scholar
LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation.
Ye Zhao, Shikara Keshiya, G. Perera, Lauren Schramko +2 more
2020Neurobiology of Disease16 citations Open access
Semantic Scholar
Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation.
Matthieu Drouyer, M. Bolliger, Evy Lobbestael, C. Van den Haute +16 more
2021Neurobiology of Disease14 citations Open access
Semantic Scholar
Human endogenous retrovirus K in astrocytes is altered in Parkinson’s disease
Yu-Hong Fu, Gabrielle L Adler, P. Youssef, Katherine Phan +3 more
2025Movement Disorders12 citations Open access
Semantic Scholar
Sex-specific lipid dysregulation in the Abca7 knockout mouse brain
Yu-Hong Fu, Ying He, Katherine Phan, Russell Pickford +4 more
2022Brain Communications12 citations Open access
Semantic Scholar
Prediction of motor and non-motor Parkinson’s disease symptoms using serum lipidomics and machine learning: a 2-year study
J. Galper, Giorgia Mori, Gordon McDonald, Diba Ahmadi Rastegar +5 more
2024npj Parkinson's Disease11 citations Open access
Semantic Scholar
Dopamine and cortical neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction
Jessica Chedid, Yan Li, A. Labrador-Garrido, Dad Abu-Bonsrah +14 more
2025npj Parkinson's Disease8 citations Open access
Semantic Scholar
Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations
A. Labrador-Garrido, Siying Zhong, Laura P. Hughes, Shikara Keshiya +3 more
2023Frontiers in Cellular Neuroscience8 citations Open access
Semantic Scholar
Dysregulation of Monounsaturated Fatty Acids is Related to α‐Synuclein in Multiple System Atrophy
Finula I Isik, Yu-Hong Fu, Russell Pickford, Qi Cheng +5 more
2025Movement Disorders7 citations Open access
Semantic Scholar
Leucine-rich repeat kinase 2 biomarkers for Parkinson’s disease
N. Dzamko
2025Biochemical Journal6 citations
Semantic Scholar
Single-Molecule Fingerprinting Reveals Different Growth Mechanisms in Seed Amplification Assays for Different Polymorphs of α-Synuclein Fibrils
Derrick Lau, Yuan Tang, Vijaya Kenche, Thomas Copie +8 more
2024bioRxiv5 citations Open access
Semantic Scholar
Flow Cytometry Measurement of Glucocerebrosidase Activity in Human Monocytes.
Laura P. Hughes, G. Halliday, N. Dzamko
2020Bio-protocol4 citations Open access
Semantic Scholar
Unlocking the secrets of LRRK2 function with selective kinase inhibitors
N. Dzamko, G. Halliday
20134 citations Open access
Semantic Scholar

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