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C. Schnell · SciRah

Researcher profile · Semantic Scholar

C. Schnell

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C. Schnell — researcher profile on SciRah

h-index: 36
Works: 89
Citations: 9,802

Most-cited papers

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response
Hui Gao, Joshua M. Korn, S. Ferretti, J. Monahan +60 more
2015Nature Medicine1,267 citations
Semantic Scholar
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
S. Maira, F. Stauffer, Joseph Brueggen, P. Furet +13 more
2008Molecular Cancer Therapeutics1,169 citations
Semantic Scholar
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.
J. Wood, G. Bold, E. Buchdunger, R. Cozens +22 more
2000Cancer Research870 citations
Semantic Scholar
Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
S. Maira, S. Pecchi, A. Huang, M. Burger +21 more
2011Molecular Cancer Therapeutics525 citations Open access
Semantic Scholar
Structure-based design of aliskiren, a novel orally effective renin inhibitor.
J. Wood, J. Maibaum, J. Rahuel, M. Grütter +18 more
2003Biochemical and Biophysical Research Communications - BBRC500 citations
Semantic Scholar
Characterization of the Novel and Specific PI3Kα Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials
C. Fritsch, A. Huang, C. Chatenay‐Rivauday, C. Schnell +24 more
2014Molecular Cancer Therapeutics450 citations Open access
Semantic Scholar
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
V. Guagnano, P. Furet, C. Spanka, V. Bordas +13 more
2011Journal of Medicinal Chemistry437 citations Open access
Semantic Scholar
LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
M. Herzig, C. Kolly, E. Persohn, D. Theil +17 more
2011Human Molecular Genetics361 citations Open access
Semantic Scholar
Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation.
H. Echchannaoui, K. Frei, C. Schnell, S. Leib +2 more
2002Journal of Infectious Diseases352 citations Open access
Semantic Scholar
Cell-Demanded Liberation of VEGF121 From Fibrin Implants Induces Local and Controlled Blood Vessel Growth
M. Ehrbar, V. Djonov, C. Schnell, S. Tschanz +6 more
2004Circulation Research351 citations Open access
Semantic Scholar
Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
S. Brachmann, Irmgard Hofmann, C. Schnell, C. Fritsch +5 more
2009Proceedings of the National Academy of Sciences of the United States of America335 citations Open access
Semantic Scholar
Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization.
K. Lamontagne, A. Littlewood-Evans, C. Schnell, T. O'Reilly +10 more
2006Cancer Research303 citations Open access
Semantic Scholar
mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor
H. Lane, J. Wood, P. Mcsheehy, P. Allegrini +8 more
2009Clinical Cancer Research246 citations Open access
Semantic Scholar
Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging.
C. Schnell, F. Stauffer, P. Allegrini, T. O'Reilly +7 more
2008Cancer Research188 citations Open access
Semantic Scholar
The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesis.
M. Ehrbar, S. Zeisberger, G. Raeber, J. Hubbell +2 more
2008Biomaterials144 citations Open access
Semantic Scholar
Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis.
P. Manley, G. Bold, J. Brüggen, G. Fendrich +9 more
2004Biochimica et Biophysica Acta137 citations
Semantic Scholar
Deprivation of parenting disrupts development of homeostatic and reward systems in marmoset monkey offspring.
C. Pryce, A. Dettling, M. Spengler, C. Schnell +1 more
2004Biological Psychiatry131 citations
Semantic Scholar
The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis
G. Martiny-Baron, Philipp Holzer, E. Billy, C. Schnell +6 more
2010Angiogenesis127 citations Open access
Semantic Scholar
Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro.
J. Tille, J. Wood, S. J. Mandriota, C. Schnell +5 more
2001Journal of Pharmacology and Experimental Therapeutics127 citations
Semantic Scholar
Targeting PI3K/mTOR Overcomes Resistance to HER2-Targeted Therapy Independent of Feedback Activation of AKT
N. O'Brien, K. McDonald, L. Tong, E. von Euw +9 more
2014Clinical Cancer Research120 citations Open access
Semantic Scholar
PI3K inhibitors for cancer treatment: where do we stand?
S. Maira, F. Stauffer, C. Schnell, C. García-echeverría
2009Biochemical Society Transactions120 citations
Semantic Scholar
Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors
Romina Marone, Dominik Erhart, A. C. Mertz, Thomas Bohnacker +7 more
2009Molecular Cancer Research116 citations Open access
Semantic Scholar
Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors.
P. Manley, P. Furet, G. Bold, J. Brüggen +12 more
2002Journal of Medicinal Chemistry100 citations Open access
Semantic Scholar
PTK 787 / ZK 222584 , a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases , Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration
J. Wood, G. Bold, E. Buchdunger, R. Cozens +23 more
200099 citations
Semantic Scholar
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
A. Weiss, E. Lorthiois, Louise Barys, Kim S. Beyer +35 more
2022Cancer Discovery98 citations Open access
Semantic Scholar
The Antitumor and Antiangiogenic Activity of Vascular Endothelial Growth Factor Receptor Inhibition Is Potentiated by ErbB1 Blockade
P. Sini, L. Wyder, C. Schnell, T. O'Reilly +4 more
2005Clinical Cancer Research91 citations Open access
Semantic Scholar
Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor
L. Wyder, T. Suply, Bérangère Ricoux, E. Billy +9 more
2011Angiogenesis85 citations
Semantic Scholar
Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets.
J. Maibaum, Stefan Stutz, R. Göschke, P. Rigollier +10 more
2007Journal of Medicinal Chemistry81 citations Open access
Semantic Scholar
Autonomic arousal in an appetitive context in primates: a behavioural and neural analysis
K. Braesicke, J. Parkinson, Y. Reekie, M. Man +5 more
2005European Journal of Neuroscience78 citations
Semantic Scholar
Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions
T. Seabrook, A. Littlewood-Evans, V. Brinkmann, B. Pöllinger +2 more
2010Journal of Neuroinflammation77 citations Open access
Semantic Scholar
Patupilone Induced Vascular Disruption in Orthotopic Rodent Tumor Models Detected by Magnetic Resonance Imaging and Interstitial Fluid Pressure
S. Ferretti, P. Allegrini, T. O'Reilly, C. Schnell +4 more
2005Clinical Cancer Research67 citations Open access
Semantic Scholar
PTK787/ZK222584, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, reduces uptake of the contrast agent GdDOTA by murine orthotopic B16/BL6 melanoma tumours and inhibits their growth in vivo
M. Rudin, P. Mcsheehy, P. Allegrini, M. Rausch +8 more
2005NMR in Biomedicine64 citations Open access
Semantic Scholar
Identification and characterization of NVP-BKM 120 , an orally available pan class I PI 3-Kinase inhibitor
S. Maira, S. Pecchi, A. Huang, M. Burger +21 more
201148 citations
Semantic Scholar
Inhibition of multiple vascular endothelial growth factor receptors (VEGFR) blocks lymph node metastases but inhibition of VEGFR-2 is sufficient to sensitize tumor cells to platinum-based chemotherapeutics.
P. Sini, Ivana Samaržija, F. Baffert, A. Littlewood-Evans +9 more
2008Cancer Research44 citations Open access
Semantic Scholar
Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin.
R. Göschke, Stefan Stutz, V. Rasetti, N. Cohen +12 more
2007Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis.
G. Bold, C. Schnell, P. Furet, P. Mcsheehy +16 more
2016Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Behavioral and cardiophysiological responses of common marmosets (Callithrix jacchus) to social and environmental changes
P. Gerber, C. Schnell, G. Anzenberger
2002Primates36 citations
Semantic Scholar
Behavioral and physiological effects of an infant-neglect manipulation in a bi-parental, twinning primate: impact is dependent on familial factors.
A. Dettling, C. Schnell, Claudia Maier, J. Feldon +1 more
2007Psychoneuroendocrinology33 citations
Semantic Scholar
Abstract 4498: Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials
Voliva Charles, S. Pecchi, M. Burger, Tobi E. Nagel +13 more
201032 citations
Semantic Scholar
mTOR Inhibitor RAD 001 ( Everolimus ) Has Antiangiogenic / Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor
H. Lane, J. Wood, P. Mcsheehy, P. Allegrini +8 more
200923 citations
Semantic Scholar
The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.
Y. Yamaguchi, K. Menear, N. Cohen, R. Mah +4 more
2009Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Abstract 3748: NVP-BYL719, a novel PI3Kalpha selective inhibitor with all the characteristics required for clinical development as an anti-cancer agent
C. Fritsch, C. Schnell, C. Chatenay‐Rivauday, Daniel A. Guthy +8 more
201218 citations
Semantic Scholar
Characterization of a new potent, in vivo neutralizing monoclonal antibody to human vascular endothelial growth factor
J. Schlaeppi, G. Siemeister, K. Weindel, C. Schnell +1 more
1999Journal of Cancer Research and Clinical Oncology18 citations Open access
Semantic Scholar
Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition.
B. Herkert, A. Kauffmann, S. Mollé, C. Schnell +17 more
2016Cancer Research17 citations
Semantic Scholar
Everolimus and PTK/ZK show synergistic growth inhibition in the orthotopic BL16/BL6 murine melanoma model
T. O'Reilly, H. Lane, J. Wood, C. Schnell +3 more
2010Cancer Chemotherapy and Pharmacology17 citations
Semantic Scholar
Prenatal Dexamethasone Exposure Does Not Alter Blood Pressure and Nephron Number in the Young Adult Marmoset Monkey
C. Bramlage, C. Schlumbohm, C. Pryce, Serkan Mirza +10 more
2009HYPERTENSION17 citations Open access
Semantic Scholar
Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.
R. A. Fairhurst, M. Gerspacher, Patricia Imbach‐Weese, R. Mah +13 more
2015Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Preclinical and Preliminary Clinical Activity of NVP-BKM120, an Oral Pan-Class I PI3K Inhibitor, in the Brain
M. Maira, C. Schnell, P. Lollini, C. Chouaid +6 more
201215 citations Open access
Semantic Scholar
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
R. A. Fairhurst, P. Furet, Patricia Imbach‐Weese, F. Stauffer +18 more
2022Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Abstract 4497: NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials, shows significant antitumor activity in xenograft and primary tumor models
M. Maira, D. Menezes, S. Pecchi, K. Shoemaker +9 more
201013 citations
Semantic Scholar

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