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V. Guagnano · SciRah

Researcher profile · Semantic Scholar

V. Guagnano

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V. Guagnano — researcher profile on SciRah

h-index: 16
Works: 48
Citations: 1,967

Most-cited papers

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.
P. Furet, V. Guagnano, R. A. Fairhurst, Patricia Imbach‐Weese +9 more
2013Bioorganic & Medicinal Chemistry Letters445 citations Open access
Semantic Scholar
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
V. Guagnano, P. Furet, C. Spanka, V. Bordas +13 more
2011Journal of Medicinal Chemistry437 citations Open access
Semantic Scholar
FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.
V. Guagnano, A. Kauffmann, Simon Wöhrle, C. Stamm +20 more
2012Cancer Discovery324 citations
Semantic Scholar
Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23‐mediated hypophosphatemic rickets
Simon Wöhrle, Christine Henninger, O. Bonny, A. Thuery +7 more
2013Journal of Bone and Mineral Research147 citations Open access
Semantic Scholar
Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth.
Fred Harbinski, V. Craig, Sneha Sanghavi, D. Jeffery +20 more
2012Cancer Discovery104 citations Open access
Semantic Scholar
Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument.
P. Furet, K. Masuya, J. Kallen, Thérèse Stachyra-Valat +9 more
2016Bioorganic & Medicinal Chemistry Letters72 citations
Semantic Scholar
Entry into a new class of protein kinase inhibitors by pseudo ring design.
P. Furet, G. Caravatti, V. Guagnano, M. Lang +2 more
2008Bioorganic & Medicinal Chemistry Letters59 citations Open access
Semantic Scholar
Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design.
P. Furet, P. Imbach, Maria Noorani, J. Koeppler +7 more
2004Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
Fibroblast Growth Factor Receptors as Novel Therapeutic Targets in SNF5-Deleted Malignant Rhabdoid Tumors
Simon Wöhrle, A. Weiss, Moriko Ito, A. Kauffmann +14 more
2013PLoS ONE53 citations Open access
Semantic Scholar
Synthesis and biological evaluation of highly potent analogues of epothilones B and D.
K. Altmann, G. Bold, G. Caravatti, A. Flörsheimer +2 more
2000Bioorganic & Medicinal Chemistry Letters52 citations
Semantic Scholar
The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition
P. Furet, V. Bordas, Mickaël Le Douget, Bahaâ Salem +13 more
2022ChemMedChem41 citations
Semantic Scholar
Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents.
P. Furet, G. Bold, Thomas J. Meyer, J. Roesel +1 more
2006Journal of Medicinal Chemistry25 citations
Semantic Scholar
Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes
J. Kallen, A. Izaac, Suzanne Chau, E. Wirth +13 more
2019ChemMedChem24 citations
Semantic Scholar
In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor.
Andrea Vaupel, Philipp Holzer, S. Ferretti, V. Guagnano +11 more
2018Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Novel beta-lactam derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
P. Imbach, M. Lang, C. García-echeverría, V. Guagnano +5 more
2007Bioorganic & Medicinal Chemistry Letters19 citations
Semantic Scholar
BET bromodomain inhibitors regulate keratinocyte plasticity
Gabi Schutzius, Christian Kolter, S. Bergling, F. Tortelli +47 more
2021Nature Chemical Biology16 citations
Semantic Scholar
Corrigendum to “Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation” [Bioorg. Med. Chem. Lett. 23 (2013) 3741–3748]
P. Furet, V. Guagnano, R. A. Fairhurst, Patricia Imbach‐Weese +9 more
201311 citations Open access
Semantic Scholar
Abstract 1239: NVP-HDM201: Biochemical and biophysical profile of a novel highly potent and selective PPI inhibitor of p53-Mdm2
Thérèse Stachyra-Valat, Frederic Baysang, Anne-Cécile D’Alessandro, Erdmann Dirk +12 more
201610 citations
Semantic Scholar
Epothilones and Their Analogs – Potential New Weapons in the Fight Against Cancer
K. Altmann, G. Bold, G. Caravatti, N. End +4 more
2000Chimia (Basel)9 citations Open access
Semantic Scholar
3-Nitro-5,6-dihydro-4H-pyran, a latent-CHO equivalent : a new synthesis of aldehydes
R. Menicagli, C. Malanga, V. Guagnano
19929 citations
Semantic Scholar
Abstract 4855: Discovery of NVP-HDM201 - First disclosure of a Next-Generation Mdm2 inhibitor with superior characteristics
Philipp Holzer, P. Chène, S. Ferretti, P. Furet +14 more
20168 citations
Semantic Scholar
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
R. A. Fairhurst, T. Marsilje, Stefan Stutz, A. Boos +12 more
2016Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
One-pot synthesis of 2-alkyltetrahydropyran-3-ones from 3-nitro-5,6-dihydro-4H-pyran and grignard reagents
R. Menicagli, V. Guagnano, S. Samaritani
19956 citations
Semantic Scholar
Abstract 1225: NVP-HDM201: cellular and in vivo profile of a novel highly potent and selective PPI inhibitor of p53-Mdm2
S. Jeay, P. Chène, S. Ferretti, P. Furet +17 more
20165 citations
Semantic Scholar
1-Ethoxy-2-nitroethylene and Aluminum Derivatives: A Useful Choice for the Synthesis of Polyunsaturated Nitro Compounds.
R. Menicagli, V. Guagnano, C. Malanga
19935 citations
Semantic Scholar
Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.
R. A. Fairhurst, G. Caravatti, V. Guagnano, R. Aichholz +7 more
2016Bioorganic & Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Front Cover: The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition (ChemMedChem 19/2022)
P. Furet, V. Bordas, Mickaël Le Douget, Bahaâ Salem +13 more
2022ChemMedChem1 citations
Semantic Scholar
Abstract 1922: 2-Aminothiazoles as potent and selective PI3Kalpha inhibitors: Discovery of NVP-BYL719 and structural basis for the isoform selectivity
G. Caravatti, V. Guagnano, R. A. Fairhurst, P. Imbach +10 more
20121 citations
Semantic Scholar
Abstract B246: NVP-BGJ398: A potent and selective inhibitor of the fibroblast growth factor receptor family.
V. Guagnano, Diana Graus Porta, V. Bordas, Mickaël Le Douget +12 more
20111 citations
Semantic Scholar
Front Cover: Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes (ChemMedChem 14/2019)
J. Kallen, A. Izaac, Suzanne Chau, E. Wirth +13 more
2019ChemMedChem0 citations Open access
Semantic Scholar
Fibroblast growth factor receptors as novel therapeutic targets in malignant rhabdoid tumors
Simon Woehrle, A. Weiss, Moriko Ito, A. Kauffmann +13 more
20130 citations
Semantic Scholar
Abstract 854: Patient stratification strategies for NVP-BGJ398, a selective pan-FGFR inhibitor in phase I clinical trials
Diana Graus Porta, V. Guagnano, C. Stamm, Simon Woehrle +16 more
20120 citations
Semantic Scholar
Abstract C193: FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a novel orally bioavailable, selective, and potent FGFR inhibitor.
Diana Graus Porta, V. Guagnano, Yao Yao, A. Kauffmann +15 more
20110 citations
Semantic Scholar
N-oxide 3- (2,6-dichloro-3,5-dimethoxyphenyl) -1- {6- [4- (4-piperazin-ethyl-1-yl) -phenylamino] -pyrimidin-4-yl } -1-methyl-urea
R. Aichholz, F. Blasco, V. Bordas, P. Graus +1 more
20100 citations
Semantic Scholar
Thiazole derivatives used as inhibitors of PI 3 kinase
G. Caravatti, R. A. Fairhurst, P. Furet, V. Guagnano +1 more
20080 citations
Semantic Scholar
Phenylacetamides appropries en tant qu'inhibiteurs de proteines kinases
G. Bold, Pascal Furet, V. Guagnano, C. Mccarthy +1 more
20060 citations
Semantic Scholar
Fenilacetaminas suitable as inhibitors of kinase protein.
G. Bold, P. Furet, V. Guagnano, C. Mccarthy +1 more
20060 citations
Semantic Scholar
Compounds and compositions containing diarylamine, and their use as c-kit receptor modulators
D. Chianelli, P. Furet, V. Guagnano, D. Karanewsky +8 more
20060 citations
Semantic Scholar
Non-covalent inhibitors of the 20S proteasome
C. García-echeverría, P. Imbach, J. Roesel, P. Fuerst +5 more
20030 citations Open access
Semantic Scholar
Diarylharnstoffderivate suitable for treatment of protein kinase dependent diseases
A. Floersheimer, P. Furet, P. Manley, G. Bold +3 more
20030 citations
Semantic Scholar
Diaril urea derivatives useful for the treatment of dependent diseases of protein kinase.
G. Bold, E. Boss, A. Floersheimer, P. Furet +3 more
20030 citations
Semantic Scholar
Derivatives acid 2 - ((n- (2-amino-3- (heteroaryl or aryl) propionyl) aminoacyl) amino) alkylboronic.
P. Furet, V. Guagnano, P. Imbach, M. Lang
20020 citations
Semantic Scholar
Synthesis and Biological Evaluation of Highly Potent Analogues of Epothilones B and D.
K. Altmann, G. Bold, G. Caravatti, A. Floersheimer +2 more
20010 citations
Semantic Scholar
Regioselective Ni(II)‐Assisted Alkylation of 2‐Methoxy‐5,6‐diyhdro‐2H‐pyran: A New Route to 2‐n.Alkyl‐5,6‐dihydro‐2H‐pyrans.
V. Guagnano, L. Lardicci, C. Malanga, R. Menicagli
19980 citations
Semantic Scholar
Synthesis and Chromatographic Evolution of Structurally Rigid Naproxen Analogs and Trans-3,4-Disubstituted-2,6-Piperidinediones
V. Guagnano
19980 citations
Semantic Scholar
One-Pot Synthesis of 2-Alkyltetrahydropyran-3-ones from 3-Nitro-5,6- dihydro-4H-pyran and Grignard Reagents.
R. Menicagli, V. Guagnano, S. Samaritani
19960 citations
Semantic Scholar
Tandem Inter (4 + 2)/Intra (3 + 2) Cycloadditions. Part 6. The Bridged Mode.
S. Denmark, A. Stolle, J. Dixon, V. Guagnano
19950 citations
Semantic Scholar
3-Nitro-5,6-dihydro-4H-pyran, a Latent-CHO Equivalent: A New Synthesis of Aldehydes.
R. Menicagli, C. Malanga, V. Guagnano
19920 citations
Semantic Scholar

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