Hong-Zhen Hu

Most-cited papers

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch
L. Oetjen, M. Mack, Jing Feng, T. M. Whelan +24 more
2017Cell958 citations Open access
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Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility
N. Spencer, Hong-Zhen Hu
2020Nature reviews: Gastroenterology & hepatology517 citations Open access
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Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling
Yong Zhou, Ching-On Wong, Kwang-jin Cho, Dharini van der Hoeven +9 more
2015Science295 citations Open access
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A Basophil-Neuronal Axis Promotes Itch
Fang Wang, A. Trier, Fengxian Li, Seonyoung Kim +20 more
2020Cell226 citations
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Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling
Nicole Rose Wong, Jayaram Mohan, B. Kopecky, Shuchi Guo +26 more
2021bioRxiv209 citations Open access
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Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch
Jing Feng, Jia-Lie Luo, Pu Yang, Junhui Du +2 more
2018Science180 citations Open access
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Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection
Wen Zhang, Mengze Lyu, N. Bessman, Zi-Li Xie +13 more
2022Cell159 citations Open access
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Sensory TRP channels contribute differentially to skin inflammation and persistent itch
Jing Feng, Pu Yang, M. Mack, D. Dryn +9 more
2017Nature Communications137 citations Open access
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TRPV1 activity and substance P release are required for corneal cold nociception
Feng-Xian Li, Weishan Yang, Hao-Wu Jiang, Chang-Xiong J. Guo +3 more
2019Nature Communications116 citations Open access
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IL-33 Signaling in Sensory Neurons Promotes Dry Skin Itch
A. Trier, M. Mack, Avery Fredman, Masato Tamari +19 more
2021Journal of Allergy and Clinical Immunology107 citations Open access
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Transient receptor potential vanilloid 4–expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch
Jia-Lie Luo, Jing Feng, Guang Yu, Pu Yang +18 more
2017Journal of Allergy and Clinical Immunology106 citations Open access
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TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells
Jia-Lie Luo, Ai-Hua Qian, L. Oetjen, Wei-Hua Yu +12 more
2018Immunity88 citations Open access
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A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain
Xueming Hu, Lixia Du, Shenbin Liu, Z. Lan +14 more
2023Journal of Clinical Investigation84 citations Open access
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Optogenetic Induction of Colonic Motility in Mice
T. Hibberd, Jing Feng, Jia-Lie Luo, Pu Yang +5 more
2018Gastroenterology77 citations Open access
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Piezo2 Channels Expressed by Colon-innervating TRPV1-lineage Neurons Mediate Visceral Mechanical Hypersensitivity
Zi-Li Xie, Jing Feng, T. Hibberd, B. Chen +8 more
2022Neuron76 citations Open access
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TRP Channels as Drug Targets to Relieve Itch
Zi-Li Xie, Hong-Zhen Hu
2018Pharmaceuticals76 citations Open access
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Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.
Shi-Jin Yin, Jia-Lie Luo, Ai-Hua Qian, Junhui Du +8 more
2013Journal of Clinical Investigation73 citations Open access
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The mechanosensitive TRPV4 is required for crystal-induced inflammation ------ TRPV4 mediates crystal-induced inflammation
Z. Lan, Lvyi Chen, Jing Feng, Zi-Li Xie +16 more
2021Annals of the Rheumatic Diseases72 citations Open access
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Gating of human TRPV3 in a lipid bilayer
Z. Deng, Grigory Maksaev, M. Rau, Zi-Li Xie +3 more
2020Nature Structural & Molecular Biology70 citations Open access
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Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle
N. Spencer, T. Hibberd, L. Travis, L. Wiklendt +7 more
2018Journal of Neuroscience70 citations Open access
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Sustained elevated adenosine via ADORA2B promotes chronic pain through neuro-immune interaction
Xia Hu, Morayo G. Adebiyi, Jia-Lie Luo, Kai-Qi Sun +18 more
2016Cell Reports69 citations Open access
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Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain
Jia-Lie Luo, A. Bavencoffe, Pu Yang, Jing Feng +9 more
2018Journal of Neuroscience65 citations Open access
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Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes
Jia-Lie Luo, R. Stewart, Rebecca Berdeaux, Hong-Zhen Hu
2012Journal of Investigative Dermatology55 citations Open access
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Erratum to: Molecular and cellular mechanisms that initiate pain and itch
Jia-Lie Luo, Jing Feng, Shenbin Liu, E. Walters +1 more
2015Cellular and Molecular Life Sciences51 citations Open access
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Polymodal TRPV1 and TRPV4 Sensors Colocalize but Do Not Functionally Interact in a Subpopulation of Mouse Retinal Ganglion Cells
Monika Lakk, Derek Young, Jackson M. Baumann, Andrew O. Jo +2 more
2018Frontiers in Cellular Neuroscience46 citations Open access
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Scaffolding by A-Kinase Anchoring Protein Enhances Functional Coupling between Adenylyl Cyclase and TRPV1 Channel*
R. Éfendiev, A. Bavencoffe, Hong-Zhen Hu, M. Zhu +1 more
2012Journal of Biological Chemistry45 citations Open access
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Neurogenic and myogenic patterns of electrical activity in isolated intact mouse colon
T. Hibberd, Marcello Costa, L. Travis, S. H. Brookes +4 more
2017Neurogastroenterology and Motility44 citations
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Thermally activated TRPV3 channels.
Jia-Lie Luo, Hong-Zhen Hu
2014Current topics in membranes44 citations
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Cryo-EM structure of a proton-activated chloride channel TMEM206
Z. Deng, Yong-Hui Zhao, Jing Feng, Jingying Zhang +5 more
2020Science Advances39 citations Open access
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Cell-based calcium assay for medium to high throughput screening of TRP channel functions using FlexStation 3.
Jia-Lie Luo, Ying-Min Zhu, M. Zhu, Hong-Zhen Hu
2011Journal of Visualized Experiments38 citations Open access
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Molecular and Cellular Mechanisms that Initiate Pain and Itch
Jia-Lie Luo, Jing Feng, Shenbin Liu, E. Walters +1 more
2015Cellular and Molecular Life Sciences37 citations Open access
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Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain‐ and itch‐related behaviours
Shenbin Liu, Jing Feng, Jia-Lie Luo, Pu Yang +2 more
2016British Journal of Pharmacology34 citations Open access
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Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle
Jing Feng, Yong-Hui Zhao, Zi-Li Xie, Kai-Kai Zang +14 more
2022Science Translational Medicine31 citations Open access
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Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel
William R. Arnold, Lauren N. Carnevale, Zi-Li Xie, Javier L. Baylon +3 more
2020Nature Communications29 citations Open access
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CaMKII Is Essential for the Function of the Enteric Nervous System
N. Gao, Jia-Lie Luo, K. Uray, Ai-Hua Qian +6 more
2012PLoS ONE29 citations Open access
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Versatile cell ablation tools and their applications to study loss of cell functions
Feng-Ming Liu, S. Dai, D. Feng, Xiao Peng +14 more
2019Cellular and Molecular Life Sciences28 citations Open access
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Structural and functional analysis of human pannexin 2 channel
Zhihui He, Yong-Hui Zhao, M. Rau, James A. J. Fitzpatrick +3 more
2023Nature Communications27 citations Open access
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Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice
Vivian Gonzalez-Perez, P. L. Martinez-Espinosa, M. Sala-Rabanal, N. Bharadwaj +7 more
2020Proceedings of the National Academy of Sciences of the United States of America27 citations Open access
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Identification and characterization of two ankyrin-B isoforms in mammalian heart.
H. Wu, Gokay Yamankurt, Jia-Lie Luo, Janani Subramaniam +3 more
2015Cardiovascular Research26 citations Open access
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Parathyroid Hormone-Related Peptide Elicits Peripheral TRPV1-dependent Mechanical Hypersensitivity
A. Shepherd, Aaron D. Mickle, S. Kadunganattil, Hong-Zhen Hu +1 more
2018Frontiers in Cellular Neuroscience24 citations Open access
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Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome
Nathaniel W. York, H. Parker, Zi-Li Xie, David Tyus +7 more
2020JCI Insight23 citations Open access
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Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain
Zi-Li Xie, Jing Feng, T. Cai, Ronald McCarthy +12 more
2022JCI Insight22 citations Open access
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Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain
Jia-Lie Luo, E. Walters, S. Carlton, Hong-Zhen Hu
2013Current Neuropharmacology22 citations Open access
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A novel player in the field: Merkel disk in touch, itch, and pain
Jing Feng, Hong-Zhen Hu
2019Experimental Dermatology21 citations Open access
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Enteric Nervous System Structure and Neurochemistry Related to Function and Neuropathology
Hong-Zhen Hu, N. Spencer
201821 citations
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The antimicrobial peptide hBD2 promotes itch through Toll-like receptor 4 signaling in mice
Jing Feng, Jia-Lie Luo, M. Mack, Pu Yang +8 more
2017Journal of Allergy and Clinical Immunology21 citations Open access
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Potentiation of High Voltage–Activated Calcium Channels by 4-Aminopyridine Depends on Subunit Composition
Li Li, De-Pei Li, Shao-Rui Chen, Jinjun Chen +2 more
2014Molecular Pharmacology21 citations Open access
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Synaptic activation of putative sensory neurons by hexamethonium-sensitive nerve pathways in mouse colon.
T. Hibberd, L. Travis, L. Wiklendt, Marcello Costa +4 more
2018American Journal of Physiology - Gastrointestinal and Liver Physiology20 citations
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MrgprA3-expressing pruriceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel
Ping Lu, Yong-Hui Zhao, Zi-Li Xie, Huan Zhou +5 more
2022bioRxiv19 citations Open access
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Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KV1.3 Channels
Shujuan Shi, Qian-Ru Zhao, Caihua Ke, Si-Ru Long +6 more
2021Frontiers in Pharmacology18 citations Open access
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