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M. Protopopova · SciRah

Researcher profile · Semantic Scholar

M. Protopopova

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M. Protopopova — researcher profile on SciRah

h-index: 17
Works: 47
Citations: 3,445

Most-cited papers

An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Jennifer R. Molina, Yu-Ting Sun, M. Protopopova, S. Gera +62 more
2018Nature Medicine842 citations Open access
Semantic Scholar
Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors
N. Issaeva, P. Bozko, M. Enge, M. Protopopova +4 more
2004Nature Medicine813 citations
Semantic Scholar
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients.
D. Carrasco, G. Tonon, Yongsheng Huang, Yunyu Zhang +16 more
2006Cancer Cell422 citations
Semantic Scholar
The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis
D. Carrasco, K. Sukhdeo, M. Protopopova, Raktim Sinha +13 more
2007Cancer Cell421 citations Open access
Semantic Scholar
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer
A. Kimmelman, A. Hezel, Andrew J. Aguirre, Hong-Wu Zheng +25 more
2008Proceedings of the National Academy of Sciences of the United States of America164 citations Open access
Semantic Scholar
Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
Jacob Falck, C. Lukas, M. Protopopova, J. Lukas +2 more
2001Oncogene134 citations
Semantic Scholar
Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy.
B. Cho, Z. Zeng, H. Mu, Zhi-Qiang Wang +11 more
2015Blood115 citations Open access
Semantic Scholar
915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons
I. Belyaev, L. Hillert, M. Protopopova, Christoffer Tamm +4 more
2005Bioelectromagnetics104 citations
Semantic Scholar
Hypoxia-activated prodrug TH-302 targets hypoxic bone marrow niches in pre-clinical leukemia models
J. Benito, M. Ramirez, N. Millward, Juliana Vélez +20 more
2015Clinical Cancer Research70 citations Open access
Semantic Scholar
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans.
D. Carrasco, T. Fenton, K. Sukhdeo, M. Protopopova +11 more
2006Cancer Cell62 citations Open access
Semantic Scholar
Dolaflexin: A Novel Antibody–Drug Conjugate Platform Featuring High Drug Loading and a Controlled Bystander Effect
Aleksandr V. Yurkovetskiy, Natalya D. Bodyak, M. Yin, Joshua D Thomas +19 more
2021Molecular Cancer Therapeutics48 citations
Semantic Scholar
Dose – response for radiation-induced apoptosis, residual 53BP1 foci and DNA-loop relaxation in human lymphocytes
J. Torudd, M. Protopopova, R. Sarimov, J. Nygren +5 more
2005International Journal of Radiation Biology48 citations
Semantic Scholar
EBV‐encoded EBNA‐5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF‐expressing cells
E. Kashuba, K. Mattsson, K. Pokrovskaja, C. Kiss +4 more
2003International Journal of Cancer41 citations Open access
Semantic Scholar
p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core.
S. Zotchev, M. Protopopova, G. Selivanova
2000Nucleic Acids Research38 citations Open access
Semantic Scholar
Abstract 3503: XMT-2056, a HER2-targeted Immunosynthen STING-agonist antibody-drug conjugate, binds a novel epitope of HER2 and shows increased anti-tumor activity in combination with trastuzumab and pertuzumab
Jeremy R. Duvall, R. Bukhalid, N. Cetinbas, Kalli C. Catcott +24 more
2022Cancer Research22 citations
Semantic Scholar
Abstract 6706: Systemic administration of STING agonist antibody-drug conjugates elicit potent anti-tumor immune responses with minimal induction of circulating cytokines
R. Bukhalid, Jeremy R. Duvall, N. Cetinbas, Kalli C. Catcott +24 more
2020Immunology20 citations
Semantic Scholar
Abstract 1738: XMT-2056, a well-tolerated, Immunosynthen-based STING-agonist antibody-drug conjugate which induces anti-tumor immune activity
Jeremy R. Duvall, R. Bukhalid, N. Cetinbas, Kalli C. Catcott +25 more
2021Immunology17 citations
Semantic Scholar
Abstract 4380: IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities
M. Protopopova, Madhavi Bandi, Jennifer P Bardenhagen, Christopher A. Bristow +22 more
201510 citations
Semantic Scholar
Abstract 2114: Tumor cell-targeted STING-agonist antibody-drug conjugates achieve potent anti-tumor activity by delivering STING agonist specifically to tumor cells andFcγRI-expressing subset of myeloid cells
N. Cetinbas, Kalli C. Catcott, Travis Monnell, Jahna Soomer-James +13 more
2022Cancer Research7 citations
Semantic Scholar
Abstract 754: Unique pharmacologic properties of Dolaflexin-based ADCs—a controlled bystander effect
Susan M. Clardy, A. Yurkovetskiy, M. Yin, D. Gumerov +11 more
2018Experimental and Molecular Therapeutics6 citations
Semantic Scholar
Inhibition of p53 Activity In Vitro and In Living Cells by a Synthetic Peptide Derived from its Core Domain
M. Protopopova, G. Selivanova
2003Cell Cycle6 citations Open access
Semantic Scholar
Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors
M. D. Di Francesco, J. Marszalek, Timothy J. McAfoos, C. Carroll +19 more
2018Cancer Chemistry5 citations
Semantic Scholar
Comprehensive Genome-Wide Profile of Regional Gains and Losses in Multiple Myeloma Using Array-CGH: The 1q21 Amplification and Potential Role of the BCL-9 Gene in Multiple Myeloma Pathogenesis.
R. Carrasco, G. Tonon, Cameron W. Brennan, A. Protopopov +15 more
20045 citations
Semantic Scholar
Abstract A65: IACS-10759: A novel OXPHOS inhibitor that selectively kills tumors with metabolic vulnerabilities
M. Protopopova, Madhavi Bandi, Yu-Ting Sun, Jennifer P Bardenhagen +23 more
20164 citations
Semantic Scholar
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans (DOI: 10.1016/j.ccr.2006.03.028)
D. Carrasco, T. Fenton, K. Sukhdeo, M. Protopopova +11 more
20064 citations Open access
Semantic Scholar
Targeted Overexpression of the Transcription Factor XBP-1 in B Cells Promotes Plasma Cell and Lymphoplasmacytic Neoplasms in Transgenic Mice.
R. Carrasco, K. Sukhdeo, M. Protopopova, M. German +3 more
20054 citations
Semantic Scholar
Abstract 232: An antibody-drug conjugate carrying a microtubule inhibitor and a DNA alkylator exerts both mechanisms of action on tumor cells
Jeremy R. Duvall, M. Damelin, M. Kozytska, B. Nehilla +8 more
2019Experimental and Molecular Therapeutics3 citations
Semantic Scholar
Development of a Novel DNA Mono-alkylator Platform for Antibody Drug Conjugates.
Joshua D Thomas, Aleksandr V. Yurkovetskiy, M. Yin, Natalya D. Bodyak +16 more
2024Molecular Cancer Therapeutics2 citations
Semantic Scholar
MA09.10 A NaPi2b Antibody-Drug Conjugate Induces Durable Complete Tumor Regressions in Patient-Derived Xenograft Models of NSCLC
D. Bergstrom, Natalya D. Bodyak, A. Yurkovetskiy, Laura L Poling +8 more
20172 citations Open access
Semantic Scholar
Abstract LB-A15: IACS-010759 is a novel inhibitor of oxidative phosphorylation that selectively targets AML cells by inducing a metabolic catastrophe
Jennifer R. Molina, M. Protopopova, Madhavi Bandi, Jennifer P Bardenhagen +24 more
20152 citations
Semantic Scholar
Novel Nanomolar Potency Mitochondrial Complex I Inhibitor Iacs-1131 Selectively Kills Oxphos-Dependent AML Cells
Polina R Matre, M. Protopopova, N. Feng, J. Greer +10 more
20142 citations
Semantic Scholar
785 STING-agonist ADCs targeting tumor-associated antigens coordinate immune-mediated killing of antigen-negative cancer cells
Phonphimon Wongthida, Kalli C. Catcott, K. Lancaster, Keith W Bentley +16 more
2021Journal for ImmunoTherapy of Cancer1 citations Open access
Semantic Scholar
Abstract PR01: IACS-010759 a novel inhibitor of oxidative phosphorylation advancing into first-in-human studies to exploit metabolic vulnerabilities
P. Jones, M. D. Di Francesco, Jennifer Molina, M. Protopopova +18 more
20171 citations
Semantic Scholar
Abstract 335: Title: IACS-010759 is a novel clinical candidate that targets AML cells by inducing a metabolic catastrophe through inhibition of oxidative phosphorylation
Jennifer R. Molina, M. Protopopova, Madhavi Bandi, Jennifer P Bardenhagen +26 more
20161 citations
Semantic Scholar
Cho B-S, Zeng Z, Mu H, et al. Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy. Blood. 2015;126(2):222-232.
B. Cho, Z. Zeng, H. Mu, Zhi-Qiang Wang +11 more
2015Blood1 citations Open access
Semantic Scholar
Pronounced Anti-Leukemia Activity in Vivo of the Novel Peptidic CXCR4 Antagonist LY2510924 As a Single Agent and in Combination with Chemotherapy
B. Cho, Z. Zeng, H. Mu, Zhi-Qiang Wang +9 more
20141 citations
Semantic Scholar
Abstract 2831: Collateral lethality: A new target for personalized oncology
Yu-Hsi Lin, N. Hammoudi, Nikunj Satani, Jeffrey J. Ackroyd +10 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors
Jennifer R. Molina, Madhavi Bandi, Jennifer P Bardenhagen, Christopher A. Bristow +32 more
20170 citations
Semantic Scholar
A prospective randomized clinical trial on accuracy of plastic periodontal probes compared to conventional metal probes around dental implants
M. Protopopova
20170 citations
Semantic Scholar
Abstract 2670: Combination of anti-HER2 ADC XMT-1522 and checkpoint inhibitor pembrolizumab for treatment of NSCLC in preclinical models
Natalya D. Bodyak, M. Protopopova, Qingxiu Zhang, A. Yurkovetskiy +6 more
20170 citations
Semantic Scholar
Abstract 3837: Passenger deletion of ENO1 as a collateral lethality target in cancer
Yu-Hsi Lin, Nikunj Satani, N. Hammoudi, J. Marszalek +7 more
20160 citations
Semantic Scholar
Abstract 4455: Relapsed/refractory AML responds robustly to IACS-10759, a novel OXPHOS inhibitor
M. Protopopova, Madhavi Bandi, Jennifer P Bardenhagen, C. Bristow +22 more
20150 citations
Semantic Scholar
Abstract 4768: Novel peptidic CXCR4 antagonist LY2510924 disrupts the SDF-1α/CXCR4 axis resulting in anti-AML efficacyin vivo
B. Cho, Z. Zeng, H. Mu, T. McQueen +7 more
20140 citations
Semantic Scholar
Abstract 949: Identification of OXPHOS inhibitors which selectively kill tumors with specific metabolic vulnerabilities
J. Marszalek, Madhavi Bandi, Jennifer P Bardenhagen, Christopher A. Bristow +22 more
20140 citations
Semantic Scholar
Affect Chromatin Conformation and 53BP1Foci in Human Lymphocytes From Hypersensitive and Healthy Persons
I. Belyaev, L. Hillert, M. Protopopova, Christoffer Tamm +4 more
20050 citations
Semantic Scholar
Abstracts of theses from the Nordic countries
M. Protopopova
20050 citations Open access
Semantic Scholar
Modulation of activity of the tumour suppressor p53 by small molecules and damaged DNA
M. Protopopova
20040 citations
Semantic Scholar

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