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Christopher A. Bristow · SciRah

Researcher profile · Semantic Scholar

Christopher A. Bristow

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Christopher A. Bristow — researcher profile on SciRah

h-index: 46
Works: 118
Citations: 33K

Most-cited papers

Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma
M. Ceccarelli, F. Barthel, T. Malta, Thais S. Sabedot +202 more
2016Cell1,978 citations Open access
Semantic Scholar
Integrated genomic and molecular characterization of cervical cancer
R. Burk, Zi-Gui Chen, C. Saller, Katherine Tarvin +297 more
2017Nature1,275 citations Open access
Semantic Scholar
An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Jennifer R. Molina, Yu-Ting Sun, M. Protopopova, S. Gera +62 more
2018Nature Medicine842 citations Open access
Semantic Scholar
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.
A. G. Robertson, Juliann Shih, C. Yau, E. Gibb +37 more
2018Cancer Cell664 citations Open access
Semantic Scholar
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T cell Therapy
T. Cascone, Jodi A. McKenzie, Rina M Mbofung, Simone Punt +33 more
2018Cell Metabolism560 citations Open access
Semantic Scholar
A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Yi-Qun Zhang, P. Ng, M. Kucherlapati, Feng-Ju Chen +38 more
2017Cancer Cell557 citations Open access
Semantic Scholar
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy
J. Hsu, Tajhal Dayaram, A. Tovy, E. De Braekeleer +16 more
2018Cell Stem Cell375 citations Open access
Semantic Scholar
Complex I Inhibitor of Oxidative Phosphorylation in Advanced Solid Tumors and Acute Myeloid Leukemia: Phase I Trials
T. Yap, N. Daver, Mikhila Mahendra, Ji-Xiang Zhang +45 more
2023Nature Medicine359 citations Open access
Semantic Scholar
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
A. G. Robertson, Juliann Shih, C. Yau, E. Gibb +166 more
2017Cancer Cell287 citations Open access
Semantic Scholar
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
Julien Dilly, Megan T. Hoffman, Laleh Abbassi, Zi-Yue Li +51 more
2024Cancer Discovery227 citations
Semantic Scholar
Abstract GS5-05: Resistance to neoadjuvant chemotherapy in triple negative breast cancer mediated by a reversible drug-tolerant state
G. Echeverria, Zhong-Qi Ge, S. Seth, Sabrina Jeter-Jones +20 more
2019General Session Abstracts139 citations
Semantic Scholar
Resistance to neoadjuvant chemotherapy in triple negative breast cancer mediated by a reversible drug-tolerant state
G. Echeverria, Zhong-Qi Ge, S. Seth, Xiaomei Zhang +26 more
2019Science Translational Medicine136 citations Open access
Semantic Scholar
Oxidative Phosphorylation is a Metabolic Vulnerability in Chemotherapy Resistant Triple Negative Breast Cancer
K. Evans, E. Yuca, Stephen S Scott, Ming Zhao +22 more
2021Cancer Research130 citations Open access
Semantic Scholar
In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.
A. Carugo, G. Genovese, S. Seth, L. Nezi +32 more
2016Cell Reports126 citations Open access
Semantic Scholar
Oncogenic KRAS recruits an expansive transcriptional network through mutant p53 to drive pancreatic cancer metastasis
Michael P. Kim, Xin-Qun Li, Jenying Deng, Yun Zhang +18 more
2021Cancer Discovery116 citations Open access
Semantic Scholar
High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
G. Echeverria, E. Powell, S. Seth, Zhong-Qi Ge +17 more
2018Nature Communications111 citations Open access
Semantic Scholar
Telomere dysfunction drives aberrant hematopoietic differentiation and Myelodysplastic Syndrome
S. Colla, D. Ong, Y. Ogoti, M. Marchesini +38 more
2015Cancer Cell99 citations Open access
Semantic Scholar
ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
Roxsan Manshouri, É. Coyaud, S. Kundu, D. Peng +15 more
2019Nature Communications89 citations Open access
Semantic Scholar
PRKCI promotes immune suppression in ovarian cancer
Sharmistha Sarkar, Christopher A. Bristow, P. Dey, Kunal Rai +18 more
2017Genes & Development86 citations Open access
Semantic Scholar
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties
M. Soth, K. Le, M. D. Di Francesco, M. Hamilton +43 more
2020Journal of Medicinal Chemistry83 citations Open access
Semantic Scholar
A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases
Yi-Qun Zhang, Li-Xing Yang, M. Kucherlapati, Feng-Ju Chen +21 more
2018Cell Reports77 citations Open access
Semantic Scholar
Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib
Yu-Ting Sun, B. Meyers, B. Czako, P. Leonard +41 more
2020Cancer Research65 citations Open access
Semantic Scholar
Molecular Landscape of ERBB2/ERBB3 Mutated Colorectal Cancer
J. Loree, Ann M. Bailey, Amber M. Johnson, Yao Yu +11 more
2018Journal of the National Cancer Institute64 citations Open access
Semantic Scholar
YAP1 Oncogene is a Context-specific Driver for Pancreatic Ductal Adenocarcinoma
Bo Tu, Jun Yao, S. Ferri-Borgogno, Jun Zhao +20 more
2018bioRxiv61 citations Open access
Semantic Scholar
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
V. Giuliani, Meredith A. Miller, Chiu-Yi Liu, Stella R. Hartono +34 more
2021Nature Communications60 citations Open access
Semantic Scholar
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance
Venu Thatikonda, Hengyu Lyu, Sabine Jurado, K. Kostyrko +34 more
2024Nature Cancer56 citations Open access
Semantic Scholar
Global impact of somatic structural variation on the DNA methylome of human cancers
Yi-Qun Zhang, Li-Xing Yang, M. Kucherlapati, Angela Hadjipanayis +19 more
2019Genome Biology56 citations Open access
Semantic Scholar
PAF promotes stemness and radioresistance of glioma stem cells
D. Ong, Bao-Li Hu, Yan Ho, C. Sauvé +19 more
2017Proceedings of the National Academy of Sciences of the United States of America51 citations Open access
Semantic Scholar
Modeling of Patient Derived Xenografts in Colorectal Cancer
A. Katsiampoura, K. Raghav, Zhi-Qin Jiang, D. Menter +15 more
2017Molecular Cancer Therapeutics51 citations Open access
Semantic Scholar
Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.
Yu-Ting Sun, Madhavi Bandi, Timothy E. Lofton, Melinda G. Smith +34 more
2019Cell Reports50 citations Open access
Semantic Scholar
4-1BB agonist focuses CD8+ tumor-infiltrating T-cell growth into a distinct repertoire capable of tumor recognition in pancreatic cancer
Donastas Sakellariou-Thompson, M. Forget, C. Creasy, V. Bernard +19 more
2017Clinical Cancer Research50 citations Open access
Semantic Scholar
A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis
E. Powell, Jiansu Shao, Hector Picon, Christopher A. Bristow +16 more
2018npj Breast Cancer48 citations Open access
Semantic Scholar
ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism
D. Peng, S. Kundu, Jared J. Fradette, L. Diao +14 more
2019Science Translational Medicine47 citations Open access
Semantic Scholar
Loss of ARID1A promotes epithelial-mesenchymal transition and sensitizes pancreatic tumors to proteotoxic stress
Hideo Tomihara, F. Carbone, L. Perelli, Justin K. Huang +18 more
2020Cancer Research46 citations Open access
Semantic Scholar
Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing.
Li-Xing Yang, Mi-sook Lee, Hengyu Lu, D. Oh +13 more
2016American Journal of Human Genetics45 citations Open access
Semantic Scholar
Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition
Liang Yan, Bo Tu, Jun Yao, Jing Gong +13 more
2021Cancer Research42 citations Open access
Semantic Scholar
Sequential administration of XPO1 and ATR inhibitors enhances therapeutic response in TP53-mutated colorectal cancer
A. Inoue, Frederick S. Robinson, R. Minelli, Hideo Tomihara +31 more
2021Gastroenterology38 citations Open access
Semantic Scholar
The Stromal Microenvironment Modulates Mitochondrial Oxidative Phosphorylation in Chronic Lymphocytic Leukemia Cells
Hima V. Vangapandu, M. Ayres, Christopher A. Bristow, W. Wierda +4 more
2017Neoplasia38 citations Open access
Semantic Scholar
Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer
L. Perelli, F. Carbone, Li Zhang, Justin K. Huang +40 more
2023Nature Cancer30 citations Open access
Semantic Scholar
Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer
J. Konen, B. L. Rodriguez, Jared J. Fradette, Laura Gibson +8 more
2019Cancers28 citations Open access
Semantic Scholar
Easy NanoString nCounter data analysis with the NanoTube
C. Class, C. Lukan, Christopher A. Bristow, K. Do
2022Bioinform.26 citations Open access
Semantic Scholar
A functional genomic approach to actionable gene fusions for precision oncology
Jun Li, Hengyu Lu, P. Ng, A. Pantazi +33 more
2022Science Advances24 citations Open access
Semantic Scholar
Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance
Venu Thatikonda, Hengyu Lu, S. Jurado, K. Kostyrko +24 more
2023bioRxiv22 citations Open access
Semantic Scholar
Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers
Sherille D. Bradley, A. Talukder, Ivy P. Lai, Rebecca K Davis +28 more
2020Nature Communications22 citations Open access
Semantic Scholar
Predictive signatures inform the effective repurposing of Decitabine to treat K-RAS-dependent Pancreatic Ductal Adenocarcinoma.
Carla Mottini, Hideo Tomihara, D. Carrella, A. Lamolinara +20 more
2019Cancer Research22 citations Open access
Semantic Scholar
Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer
A. Padhye, J. Konen, B. L. Rodriguez, Jared J. Fradette +12 more
2021JCI Insight18 citations Open access
Semantic Scholar
Combined inhibition of DDR1 and CDK4/6 induces synergistic effects in ER-positive, HER2 negative breast cancer with PIK3CA/AKT1 mutations
M. Shariati, K. Evans, Xiao-Feng Zheng, Christopher A. Bristow +9 more
2021Oncogene18 citations Open access
Semantic Scholar
Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions
Eiru Kim, L. Novak, Chen-Chu Lin, Medina Colic +4 more
2021bioRxiv15 citations Open access
Semantic Scholar
Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways
Federica Invrea, Simona Punzi, Consalvo Petti, R. Minelli +13 more
2021Cancers12 citations Open access
Semantic Scholar
BRCA1 identified as a modulator of temozolomide resistance in P53 wild-type GBM using a high-throughput shRNA-based synthetic lethality screening.
Jie Ding, Shaofang Wu, Chen Zhang, A. Garyali +8 more
2019American Journal of Cancer Research11 citations
Semantic Scholar

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