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J. Nakae · SciRah

Researcher profile · Semantic Scholar

J. Nakae

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J. Nakae — researcher profile on SciRah

h-index: 39
Works: 109
Citations: 9,068

Most-cited papers

The forkhead transcription factor Foxo1 regulates adipocyte differentiation.
J. Nakae, T. Kitamura, Y. Kitamura, W. Biggs +2 more
2003Developmental Cell752 citations Open access
Semantic Scholar
Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
Nirmala Hariharan, Y. Maejima, J. Nakae, J. Paik +2 more
2010Circulation Research676 citations Open access
Semantic Scholar
Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
J. Nakae, William H. Iii Biggs, T. Kitamura, W. Cavenee +3 more
2002Nature Genetics661 citations
Semantic Scholar
Distinct and overlapping functions of insulin and IGF-I receptors.
J. Nakae, Y. Kido, D. Accili
2001Endocrine reviews546 citations Open access
Semantic Scholar
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.
T. Kitamura, J. Nakae, Y. Kitamura, Y. Kido +5 more
2002Journal of Clinical Investigation541 citations Open access
Semantic Scholar
Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway*
J. Nakae, B. Park, D. Accili
1999Journal of Biological Chemistry497 citations Open access
Semantic Scholar
Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity*
A. Tsuchida, T. Yamauchi, Yusuke Ito, Yusuke Hada +16 more
2004Journal of Biological Chemistry483 citations Open access
Semantic Scholar
Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle.
N. Shimizu, N. Yoshikawa, Naoki Ito, T. Maruyama +11 more
2011Cell Metabolism476 citations Open access
Semantic Scholar
Differential regulation of gene expression by insulin and IGF‐1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR
J. Nakae, Valarie A. Barr, D. Accili
2000EMBO Journal296 citations Open access
Semantic Scholar
The Insulin Receptor and Its Cellular Targets
Y. Kido, J. Nakae, D. Accili
2001225 citations Open access
Semantic Scholar
Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice.
J. Altomonte, Anja Richter, S. Harbaran, Jenny Suriawinata +5 more
2003American Journal of Physiology. Endocrinology and Metabolism220 citations
Semantic Scholar
Regulation of insulin-like growth factor–dependent myoblast differentiation by Foxo forkhead transcription factors
M. Hribal, J. Nakae, T. Kitamura, J. Shutter +1 more
2003Journal of Cell Biology219 citations Open access
Semantic Scholar
Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure
J. Nakae, Yong-Heng Cao, Miyo Oki, Y. Orba +6 more
2008Diabetes193 citations Open access
Semantic Scholar
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
S. Xuan, T. Kitamura, J. Nakae, K. Politi +8 more
2002Journal of Clinical Investigation193 citations Open access
Semantic Scholar
The FoxO transcription factors and metabolic regulation
J. Nakae, Miyo Oki, Yong-Heng Cao
2008FEBS Letters190 citations Open access
Semantic Scholar
Analysis of the steroidogenic acute regulatory protein (StAR) gene in Japanese patients with congenital lipoid adrenal hyperplasia.
J. Nakae, T. Tajima, T. Sugawara, F. Arakane +14 more
1997Human Molecular Genetics184 citations
Semantic Scholar
Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner.
Yoshinaga Kawano, J. Nakae, N. Watanabe, Tetsuhiro Kikuchi +6 more
2016Cell Metabolism183 citations Open access
Semantic Scholar
Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency.
T. Tajima, K. Fujieda, Naoya Kouda, J. Nakae +1 more
2001Journal of Clinical Endocrinology and Metabolism178 citations Open access
Semantic Scholar
Transgenic rescue of insulin receptor-deficient mice.
H. Okamoto, J. Nakae, T. Kitamura, Byung-Chul Park +2 more
2004Journal of Clinical Investigation160 citations Open access
Semantic Scholar
Spontaneous puberty in 46,XX subjects with congenital lipoid adrenal hyperplasia. Ovarian steroidogenesis is spared to some extent despite inactivating mutations in the steroidogenic acute regulatory protein (StAR) gene.
K. Fujieda, T. Tajima, J. Nakae, S. Sageshima +4 more
1997Journal of Clinical Investigation148 citations Open access
Semantic Scholar
Clinical review 125: The insulin receptor and its cellular targets.
Y. Kido, J. Nakae, D. Accili
2001Journal of Clinical Endocrinology and Metabolism137 citations
Semantic Scholar
The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity.
J. Nakae, Yong-Heng Cao, H. Daitoku, A. Fukamizu +3 more
2006Journal of Clinical Investigation133 citations Open access
Semantic Scholar
Sporadic heterozygous frameshift mutation of HESX1 causing pituitary and optic nerve hypoplasia and combined pituitary hormone deficiency in a Japanese patient.
T. Tajima, Tsukasa Hattorri, Takeo Nakajima, Kouji Okuhara +4 more
2003Journal of Clinical Endocrinology and Metabolism127 citations
Semantic Scholar
Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice
T. Uebi, Yumi Itoh, O. Hatano, A. Kumagai +27 more
2012PLoS ONE77 citations Open access
Semantic Scholar
Hydrochlorothiazide effectively reduces urinary calcium excretion in two Japanese patients with gain-of-function mutations of the calcium-sensing receptor gene.
Kohei Sato, Y. Hasegawa, J. Nakae, K. Nanao +4 more
2002Journal of Clinical Endocrinology and Metabolism75 citations Open access
Semantic Scholar
Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and β-Cell Compensation to Insulin Resistance*
Y. Kido, J. Nakae, M. Hribal, S. Xuan +2 more
2002Journal of Biological Chemistry73 citations Open access
Semantic Scholar
PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake.
Kristy Iskandar, Yong-Heng Cao, Y. Hayashi, M. Nakata +10 more
2010American Journal of Physiology. Endocrinology and Metabolism71 citations
Semantic Scholar
Long-term effect of recombinant human insulin-like growth factor I on metabolic and growth control in a patient with leprechaunism.
J. Nakae, Mikiko Kato, M. Murashita, N. Shinohara +2 more
1998Journal of Clinical Endocrinology and Metabolism71 citations Open access
Semantic Scholar
Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR
M. Tomizawa, Amit Kumar, Valérie Perrot, J. Nakae +2 more
2000Journal of Biological Chemistry69 citations Open access
Semantic Scholar
Truncation at the C-terminus of the DAX-1 protein impairs its biological actions in patients with X-linked adrenal hypoplasia congenita.
J. Nakae, T. Tajima, S. Kusuda, N. Kohda +7 more
1996Journal of Clinical Endocrinology and Metabolism64 citations Open access
Semantic Scholar
Interaction of FoxO1 and TSC2 Induces Insulin Resistance through Activation of the Mammalian Target of Rapamycin/p70 S6K Pathway*
Yong-Heng Cao, Y. Kamioka, N. Yokoi, Toshiyuki Kobayashi +4 more
2006Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts.
H. Takemori, Yoshiko Katoh Hashimoto, J. Nakae, E. Olson +1 more
2009Endocrine journal59 citations Open access
Semantic Scholar
Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance
Yoshinaga Kawano, J. Nakae, N. Watanabe, S. Fujisaka +9 more
2012Diabetes58 citations Open access
Semantic Scholar
Molecular pathogenesis of lipoid adrenal hyperplasia and adrenal hypoplasia congenita.
K. Fujieda, K. Okuhara, S. Abe, T. Tajima +2 more
2003Journal of Steroid Biochemistry and Molecular Biology55 citations
Semantic Scholar
Tissue-Specific Metabolic Regulation of FOXO-Binding Protein: FOXO Does Not Act Alone
N. Kodani, J. Nakae
2020Cells54 citations Open access
Semantic Scholar
Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance.
Hye-jin Kim, Masaki Kobayashi, Tsutomu Sasaki, Osamu Kikuchi +8 more
2012Endocrinology48 citations
Semantic Scholar
Compound heterozygous mutations in the gamma subunit gene of ENaC (1627delG and 1570-1G-->A) in one sporadic Japanese patient with a systemic form of pseudohypoaldosteronism type 1.
Masanori Adachi, Katsuhiko Tachibana, Y. Asakura, Syuji Abe +3 more
2001Journal of Clinical Endocrinology and Metabolism43 citations
Semantic Scholar
Genetics of type 2 diabetes: insight from targeted mouse mutants.
D. Accili, Y. Kido, J. Nakae, D. Lauro +1 more
2001Current molecular medicine42 citations
Semantic Scholar
Mosaic analysis of insulin receptor function.
T. Kitamura, Y. Kitamura, J. Nakae, A. Giordano +4 more
2004Journal of Clinical Investigation39 citations Open access
Semantic Scholar
Novel repressor regulates insulin sensitivity through interaction with Foxo1
J. Nakae, Yong-Heng Cao, F. Hakuno, H. Takemori +8 more
2012EMBO Journal37 citations Open access
Semantic Scholar
The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase–leukotriene B4 axis
T. Hosooka, Yusei Hosokawa, Kaku Matsugi, M. Shinohara +20 more
2020Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
Semantic Scholar
PDK1-Foxo1 in Agouti-Related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure
Yong-Heng Cao, M. Nakata, Shiki Okamoto, Eisuke Takano +14 more
2011PLoS ONE33 citations Open access
Semantic Scholar
Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity.
Yasuhide Fukatsu, T. Noguchi, T. Hosooka, Takeshi Ogura +16 more
2009Endocrinology30 citations
Semantic Scholar
Two heterozygous mutations of CLDN16 in a Japanese patient with FHHNC
T. Tajima, J. Nakae, K. Fujieda
2003Pediatric nephrology (Berlin, West)30 citations
Semantic Scholar
Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes
R. Furuhata, Y. Kabe, Ayaka Kanai, Y. Sugiura +12 more
2020Communications Biology27 citations Open access
Semantic Scholar
Three Novel AVPR2 Mutations in Three Japanese Families with X-Linked Nephrogenic Diabetes Insipidus
T. Tajima, J. Nakae, Y. Takekoshi, Yutaka Takahashi +3 more
1996Pediatric Research26 citations
Semantic Scholar
Two novel mutations of thiazide-sensitive Na-Cl cotrans porter (TSC) gene in two sporadic Japanese patients with Gitelman syndrome.
T. Tajima, Yuichi Kobayashi, S. Abe, Michiko Takahashi +7 more
2002Endocrine journal25 citations Open access
Semantic Scholar
Two mutations of the Gsα gene in two Japanese patients with sporadic pseudohypoparathyroidism type Ia
Y. Ishikawa, T. Tajima, J. Nakae, T. Nagashima +3 more
2001Journal of Human Genetics24 citations
Semantic Scholar
Constitutive Expression of Insulin Receptor Substrate (IRS)-1 Inhibits Myogenic Differentiation through Nuclear Exclusion of Foxo1 in L6 Myoblasts
F. Hakuno, Y. Yamauchi, G. Kaneko, Y. Yoneyama +6 more
2011PLoS ONE23 citations Open access
Semantic Scholar
Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation
Bo-Yang Zhang, M. Nakata, J. Nakae, W. Ogawa +1 more
2018Scientific Reports22 citations Open access
Semantic Scholar

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D. Accili×18
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D. Accili — researcher profile on SciRah
T. Tajima×13
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T. Tajima — researcher profile on SciRah
K. Fujieda×10
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K. Fujieda — researcher profile on SciRah
T. Kitamura×9
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T. Kitamura — researcher profile on SciRah

×7

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Y. Kido — researcher profile on SciRah

Yong-Heng Cao×7

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Yong-Heng Cao — researcher profile on SciRah

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M. Kasuga — researcher profile on SciRah

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Y. Hayashi — researcher profile on SciRah

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H. Itoh — researcher profile on SciRah

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W. Ogawa — researcher profile on SciRah

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Y. Kitamura — researcher profile on SciRah

Kristy Iskandar×4

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Kristy Iskandar — researcher profile on SciRah