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T. Turbyville · SciRah

Researcher profile · Semantic Scholar

T. Turbyville

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T. Turbyville — researcher profile on SciRah

h-index: 20
Works: 73
Citations: 1,268

Most-cited papers

Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.
T. Turbyville, E. M. Kithsiri Wijeratne, Man-Ping X. Liu, Anna M. Burns +6 more
2006Journal of Natural Products154 citations Open access
Semantic Scholar
A Rhizosphere Fungus Enhances Arabidopsis Thermotolerance through Production of an HSP90 Inhibitor1
C. Mclellan, T. Turbyville, E. Wijeratne, A. Kerschen +4 more
2007Plant Physiology137 citations Open access
Semantic Scholar
Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice.
Xiang-Dang Liu, T. Turbyville, A. Fritz, L. Whitesell
1998Cancer Research89 citations
Semantic Scholar
Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins
H. Ingólfsson, Chris Neale, T. Carpenter, R. Shrestha +38 more
2020Proceedings of the National Academy of Sciences of the United States of America84 citations Open access
Semantic Scholar
Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran Desert.
E. M. Kithsiri Wijeratne, T. Turbyville, Z. Zhang, D. Bigelow +5 more
2003Journal of Natural Products70 citations
Semantic Scholar
A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity.
E. M. Kithsiri Wijeratne, T. Turbyville, A. Fritz, L. Whitesell +1 more
2006Bioorganic & Medicinal Chemistry62 citations
Semantic Scholar
Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells
Snider Desir, P. Wong, T. Turbyville, De Chen +10 more
2019Cancers58 citations Open access
Semantic Scholar
Synthesis of a 35-Member Stereoisomer Library of Bistramide A: Evaluation of Effects on Actin State, Cell Cycle and Tumor Cell Growth
I. Wrona, Jason T. Lowe, T. Turbyville, Tanya R. Johnson +3 more
2009Journal of Organic Chemistry54 citations Open access
Semantic Scholar
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors
Tadahiro Nagaoka, H. Karasawa, T. Turbyville, M. Rangel +9 more
2012Cellular Signalling50 citations Open access
Semantic Scholar
Machine Learning-Driven Multiscale Modeling: Bridging the Scales with a Next-Generation Simulation Infrastructure
H. Ingólfsson, H. Bhatia, Fikret Aydin, T. Oppelstrup +27 more
2023Journal of Chemical Theory and Computation44 citations Open access
Semantic Scholar
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties
M. Whitley, Timothy H. Tran, Megan Rigby, Ming Yi +13 more
2024Science Advances38 citations Open access
Semantic Scholar
Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis type 1 Tumor Cells in an NF1-GRD Dependent Manner
T. Turbyville, Demirkan B. Gursel, R. Tuskan, Jessica C. Walrath +5 more
2010Molecular Cancer Therapeutics36 citations Open access
Semantic Scholar
RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention
Que N. Van, P. Prakash, R. Shrestha, Trent E. Balius +2 more
2021Biomolecules32 citations Open access
Semantic Scholar
Virtual screening for small molecule pathway regulators by image profile matching
M. Rohban, Ashley M. Fuller, Ceryl Tan, Jonathan T. Goldstein +26 more
2021bioRxiv31 citations Open access
Semantic Scholar
The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways
T. Turbyville, E. M. Kithsiri Wijeratne, L. Whitesell, A. A. Leslie Gunatilaka
2005Molecular Cancer Therapeutics31 citations Open access
Semantic Scholar
Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma Cells*
Vittorio Caropreso, Emad Darvishi, T. Turbyville, Ranjala Ratnayake +3 more
2016Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A.
G. Woldemichael, T. Turbyville, J. Vasselli, W. Linehan +1 more
2012Neoplasia25 citations Open access
Semantic Scholar
Exploring CRD mobility during RAS/RAF engagement at the membrane.
Kien Nguyen, C. López, Chris Neale, Que N. Van +26 more
2022Biophysical Journal23 citations Open access
Semantic Scholar
RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy
Antonio Cuevas-Navarro, Morgan Wagner, Richard A. Van, M. Swain +11 more
2023Science Advances22 citations Open access
Semantic Scholar
Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior
D. Goswami, De Chen, Yue Yang, Prabhakar R. Gudla +14 more
2020eLife20 citations Open access
Semantic Scholar
Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane
R. Shrestha, T. Carpenter, Que N. Van, Constance Agamasu +16 more
2024Communications Biology19 citations Open access
Semantic Scholar
Direct Modulators of K-Ras–Membrane Interactions
Johannes Morstein, R. Shrestha, Que N. Van, C. López +9 more
2023ACS Chemical Biology19 citations Open access
Semantic Scholar
Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells
G. Woldemichael, T. Turbyville, W. Linehan, J. Mcmahon
2011Cancer Research19 citations Open access
Semantic Scholar
Asynchronous Reciprocal Coupling of Martini 2.2 Coarse-Grained and CHARMM36 All-Atom Simulations in an Automated Multiscale Framework.
C. López, Xiaohua Zhang, Fikret Aydin, R. Shrestha +22 more
2022Journal of Chemical Theory and Computation18 citations Open access
Semantic Scholar
Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptata.
E. M. Kithsiri Wijeratne, C. Carbonezi, J. Takahashi, Christopher J. Seliga +7 more
2004Journal of antibiotics (Tokyo. 1968)18 citations Open access
Semantic Scholar
New weapons to penetrate the armor: novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics
Dominic Esposito, A. Stephen, T. Turbyville, M. Holderfield
2018Seminars in Cancer Biology14 citations Open access
Semantic Scholar
Recapitulation of cell-like KRAS4b membrane dynamics on complex biomimetic membranes
R. Shrestha, De Chen, Peter H. Frank, D. Nissley +1 more
2021iScience13 citations Open access
Semantic Scholar
Quantitative Analysis of F-Actin Redistribution in Astrocytoma Cells Treated with Candidate Pharmaceuticals
S. Lockett, C. Verma, A. Brafman, Prabhakar R. Gudla +7 more
2014Cytometry Part A13 citations Open access
Semantic Scholar
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling
A. Nelson, T. Turbyville, S. Dharmaiah, Megan Rigby +12 more
2020Journal of Biological Chemistry9 citations Open access
Semantic Scholar
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine
A. Maciag, Yue Yang, Alok K. Sharma, David M. Turner +30 more
2025Proceedings of the National Academy of Sciences of the United States of America8 citations Open access
Semantic Scholar
An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving Disassembly of the Autoinhibited BRAF State
Daniel A. Ritt, David E. Durrant, Matthew R. Drew, S. Sandin +22 more
2025bioRxiv7 citations
Semantic Scholar
Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations
T. Carpenter, Fikret Aydin, Chris Neale, Que N. Van +36 more
2025Biophysical Journal5 citations Open access
Semantic Scholar
Quantifying the astrocytoma cell response to candidate pharmaceutical from F-ACTIN image analysis
Chi Cui, J. Jaja, T. Turbyville, J. Beutler +3 more
2009Annual International Conference of the IEEE Engineering in Medicine and Biology Society5 citations
Semantic Scholar
Natural Product Graveoline Modulates Kirsten Rat Sarcoma Viral Oncogene Homologue (KRAS) Membrane Association: Insights from Advanced Spectroscopic Studies.
Gabriel Cornilescu, L. Bindu, Louise M. Sternicki, Fa-an Chao +14 more
2024ACS Pharmacology & Translational Science4 citations Open access
Semantic Scholar
Author Correction: Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane
R. Shrestha, T. Carpenter, Que N. Van, Constance Agamasu +16 more
2024Communications Biology3 citations Open access
Semantic Scholar
Discovery of small molecule bioactive agents from endophytic fungi of the Sonoran Desert
Bharat P. Bashyal, Anna M. Burns, Mao-Qiang Liu, P. Paranagama +9 more
2007NZGA: Research and Practice Series3 citations Open access
Semantic Scholar
KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics
Konstantia Georgouli, Jeremy O. B. Tempkin, Liam G. Stanton, T. Oppelstrup +30 more
2026Journal of Biological Chemistry2 citations Open access
Semantic Scholar
Studying RAS Interactions in Live Cells with BRET.
John Columbus, T. Turbyville
2024Methods in molecular biology2 citations
Semantic Scholar
A New Dihydroxanthenone from a Plant‐Associated Strain of the Fungus Chaetomium globosum Demonstrates Anticancer Activity.
E. M. Kithsiri Wijeratne, T. Turbyville, A. Fritz, L. Whitesell +1 more
20072 citations
Semantic Scholar
Leveraging Topological Events in Tracking Graphs for Understanding Particle Diffusion
T. McDonald, R. Shrestha, X. Yi, H. Bhatia +5 more
2021Computer graphics forum (Print)1 citations
Semantic Scholar
Progress in targeting RAF kinases for cancer therapy.
T. Turbyville, M. Holderfield
2015Personalized Medicine1 citations
Semantic Scholar
Tumors in Mice Neuroblastoma Cells Induces the Regression of Established Inhibition of Insulin-like Growth Factor I Receptor Expression in Updated
Xiang-Dang Liu, T. Turbyville, A. Fritz, L. Whitesell
19981 citations
Semantic Scholar
Abstract B001: eIF2B Selectively Anchors and Activates Mutant KRAS4B
Hyungdong Kim, Shi-Qi Diao, Kwang-jin Cho, Hyun-Ro Lee +27 more
2026Cancer Research0 citations
Semantic Scholar
Abstract 5976: Spatiotemporal control of RAS-RAF signaling at the single-molecule level
Rodrigo E Cáceres-Gutiérrez, Rebika Shreshta, Jean A Castillo-Badillo, Vanessa E. Wall +8 more
2026Cancer Research0 citations
Semantic Scholar
eIF2B Selectively Anchors and Activates Mutant KRAS
Hyungdong Kim, Shi-Qi Diao, Kwang-jin Cho, Hyun-Ro Lee +28 more
2025bioRxiv0 citations
Semantic Scholar
Abstract B027: Bioluminescence resonance energy transfer (BRET) as a tool for assessing mutant KRAS-effector affinity and drug efficacy
Megan Rigby, J. Columbus, Vanessa E. Wall, Dominic Esposito +5 more
2023Molecular Cancer Research0 citations
Semantic Scholar
Single particle tracking with compressive sensing using progressive refinement method on sparse recovery (spt-PRIS)
Xiyu Yi, R. Shrestha, T. McDonald, De Chen +4 more
2022bioRxiv0 citations Open access
Semantic Scholar
Leveraging Topological Events in Tracking Graphs
T. McDonald, R. Shrestha, X. Yi, H. Bhatia +5 more
20210 citations
Semantic Scholar
Discovery of small molecule pathway regulators by image 2 profile matching
M. Rohban, Ashley M. Fuller, Ceryl Tan, Jonathan T. Goldstein +23 more
20210 citations
Semantic Scholar
Abstract 2272: Interrogating RAS isoform and mutational specificity for effectors with bioluminescence resonance energy transfer (BRET)
Megan Rigby, J. Columbus, Vanessa E. Wall, Dominic Esposito +1 more
2021Molecular and Cellular Biology/Genetics0 citations
Semantic Scholar

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