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M. Freudenberg · SciRah

Researcher profile · Semantic Scholar

M. Freudenberg

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M. Freudenberg — researcher profile on SciRah

h-index: 66
Works: 201
Citations: 27K

Most-cited papers

CD14 is required for MyD88-independent LPS signaling
Zheng-Fan Jiang, P. Georgel, Xin Du, L. Shamel +8 more
2005Nature Immunology742 citations
Semantic Scholar
Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel
Marc Schmidt, B. Raghavan, V. Müller, T. Vogl +11 more
2010Nature Immunology585 citations
Semantic Scholar
Human and mouse granzyme A induce a proinflammatory cytokine response.
S. Metkar, C. Menaa, J. Pardo, Baikun Wang +7 more
2008Immunity314 citations Open access
Semantic Scholar
Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage
Lukas Schwab, Luise Goroncy, Senthilnathan Palaniyandi, S. Gautam +25 more
2014Nature Medicine275 citations
Semantic Scholar
Mechanisms of chemical‐induced innate immunity in allergic contact dermatitis
S. F. Martin, P. Esser, F. C. Weber, T. Jakob +3 more
2011Allergy. European Journal of Allergy and Clinical Immunology273 citations Open access
Semantic Scholar
Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan Parasite Leishmania major
P. Kropf, M. Freudenberg, M. Modolell, Helen P. Price +5 more
2004Infection and Immunity266 citations Open access
Semantic Scholar
Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC
H. Lauterbach, B. Bathke, S. Gilles, C. Traidl-Hoffmann +12 more
2010Journal of Experimental Medicine246 citations Open access
Semantic Scholar
Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists
T. Yamazaki, D. Hannani, V. Poirier-Colame, S. Ladoire +10 more
2013Cell Death and Differentiation245 citations Open access
Semantic Scholar
Shift Towards Pro-inflammatory Intestinal Bacteria Aggravates Acute Murine Colitis via Toll-like Receptors 2 and 4
M. Heimesaat, André Fischer, B. Siegmund, Andreas Kupz +12 more
2007PLoS ONE223 citations Open access
Semantic Scholar
MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease
M. Heimesaat, A. Nogai, S. Bereswill, Rita Plickert +8 more
2010Gut215 citations
Semantic Scholar
Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity
Stefan F. Martin, Jan C. Dudda, E. Bachtanian, A. Lembo +12 more
2008Journal of Experimental Medicine208 citations Open access
Semantic Scholar
Bacterial Sensing, Cell Signaling, and Modulation of the Immune Response During Sepsis
R. Salomão, M. C. Brunialti, M. Rapozo, G. L. Baggio-Zappia +2 more
2012Shock206 citations Open access
Semantic Scholar
R‐form LPS, the master key to the activation ofTLR4/MD‐2‐positive cells
M. Huber, C. Kalis, S. Keck, Zheng-Fan Jiang +8 more
2006European Journal of Immunology190 citations Open access
Semantic Scholar
Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli
M. Heimesaat, André Fischer, Hannah-Katharina Jahn, Julia Niebergall +6 more
2007Gut174 citations Open access
Semantic Scholar
Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, ‐4 and ‐9
C. Hölscher, N. Reiling, U. Schaible, Alexandra Hölscher +11 more
2008European Journal of Immunology172 citations
Semantic Scholar
Contact Sensitizers Induce Skin Inflammation via ROS Production and Hyaluronic Acid Degradation
P. Esser, U. Wölfle, C. Dürr, F. V. von Loewenich +4 more
2012PLoS ONE170 citations Open access
Semantic Scholar
Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity.
M. Freudenberg, Sandrine Y. Tchaptchet, S. Keck, György Fejer +4 more
2008Immunobiology152 citations Open access
Semantic Scholar
TLR4 Up-Regulation at Protein or Gene Level Is Pathogenic for Lupus-Like Autoimmune Disease1
Bei Liu, Yi Yang, Jie Dai, R. Medzhitov +3 more
2006Journal of Immunology139 citations Open access
Semantic Scholar
Cutting Edge: A Murine, IL-12-Independent Pathway of IFN-γ Induction by Gram-Negative Bacteria Based on STAT4 Activation by Type I IFN and IL-18 Signaling1
M. Freudenberg, T. Merlin, C. Kalis, Y. Chvatchko +2 more
2002Journal of Immunology134 citations Open access
Semantic Scholar
TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
Stephan Spiller, G. Elson, Ruth Ferstl, Stefan Dreher +5 more
2008Journal of Experimental Medicine133 citations Open access
Semantic Scholar
Key Role of Splenic Myeloid DCs in the IFN-αβ Response to Adenoviruses In Vivo
György Fejer, Lisa Drechsel, J. Liese, U. Schleicher +8 more
2008PLoS Pathogens132 citations Open access
Semantic Scholar
Requirement for TLR9 in the Immunomodulatory Activity of Propionibacterium acnes1
C. Kalis, M. Gumenscheimer, N. Freudenberg, Sandrine Y. Tchaptchet +5 more
2005Journal of Immunology126 citations Open access
Semantic Scholar
IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages.
N. Schuetze, S. Schoeneberger, U. Mueller, M. Freudenberg +2 more
2005International Immunology125 citations Open access
Semantic Scholar
Pepsin Digest of Wheat Gliadin Fraction Increases Production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB Signaling Pathway and an NLRP3 Inflammasome Activation
L. Palová-Jelínková, K. Dáňová, Hana Drašarová, M. Dvořák +8 more
2013PLoS ONE117 citations Open access
Semantic Scholar
Toll‐like receptor 4 expression levels determine the degree of LPS‐susceptibility in mice
C. Kalis, B. Kanzler, A. Lembo, A. Poltorak +2 more
2003European Journal of Immunology116 citations Open access
Semantic Scholar
Nontransformed, GM-CSF–dependent macrophage lines are a unique model to study tissue macrophage functions
György Fejer, M. Wegner, I. Győry, Idan Cohen +13 more
2013Proceedings of the National Academy of Sciences of the United States of America114 citations Open access
Semantic Scholar
The role of Toll‐like receptor 4 versus interleukin‐12 in immunity to respiratory syncytial virus
S. Ehl, R. Bischoff, T. Ostler, S. Vallbracht +3 more
2004European Journal of Immunology112 citations Open access
Semantic Scholar
Infection of C57BL/10ScCr and C57BL/10ScNCr mice with Leishmania major reveals a role for Toll‐like receptor 4 in the control of parasite replication
P. Kropf, N. Freudenberg, C. Kalis, M. Modolell +4 more
2004Journal of Leukocyte Biology92 citations
Semantic Scholar
Enhanced B‐cell activation mediated by TLR4 and BCR crosstalk
S. Minguet, E. Dopfer, C. Pollmer, M. Freudenberg +4 more
2008European Journal of Immunology85 citations
Semantic Scholar
Activation of Murine Macrophages via TLR2 and TLR4 Is Negatively Regulated by a Lyn/PI3K Module and Promoted by SHIP1
S. Keck, M. Freudenberg, M. Huber
2010Journal of Immunology83 citations Open access
Semantic Scholar
Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages
M. Maler, P. Nielsen, Nicole Stichling, Idan Cohen +15 more
2017mBio80 citations Open access
Semantic Scholar
Macrophages recognize streptococci through bacterial single‐stranded RNA
S. Deshmukh, Bernhard Kremer, M. Freudenberg, S. Bauer +2 more
2011EMBO Reports80 citations Open access
Semantic Scholar
Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response to Salmonella enterica Serovar Typhimurium and Staphylococcus aureus in Mice
A. Lembo, C. Kalis, C. Kirschning, V. Mitolo +4 more
2003Infection and Immunity80 citations Open access
Semantic Scholar
Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor
Nicole Stichling, M. Suomalainen, J. Flatt, Markus Schmid +10 more
2018PLoS Pathogens75 citations Open access
Semantic Scholar
Lipopolysaccharide-induced expression of cell surface receptors and cell activation of neutrophils and monocytes in whole human blood.
Natália E. Gomes, M. C. Brunialti, M. Mendes, M. Freudenberg +2 more
2010Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas71 citations Open access
Semantic Scholar
Year : 2008 Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo
György Fejer, Lisa Drechsel, J. Liese, U. Schleicher +9 more
200966 citations
Semantic Scholar
Toll-Like Receptor 4 Deficiency Accelerates the Development of Insulin-Deficient Diabetes in Non-Obese Diabetic Mice
E. Gülden, M. Ihira, Atsushi Ohashi, Anna Lena Reinbeck +3 more
2013PLoS ONE61 citations Open access
Semantic Scholar
Sulfatides are endogenous ligands for the TLR4–MD-2 complex
L. Su, M. Athamna, Ying Wang, Jun-Mei Wang +7 more
2021Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
Semantic Scholar
Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis.
Sabine Siegemund, Nicole Schütze, M. Freudenberg, M. Lutz +2 more
2008Immunobiology57 citations Open access
Semantic Scholar
Chemokine Gene Expression in Toll-Like Receptor-Competent and -Deficient Mice Infected with Leishmania major
S. Antoniazi, Helen P. Price, P. Kropf, M. Freudenberg +3 more
2004Infection and Immunity56 citations Open access
Semantic Scholar
Immunotherapy of patients with hormone‐refractory prostate carcinoma pre‐treated with interferon‐gamma and vaccinated with autologous PSA‐peptide loaded dendritic cells—A pilot study
B. Hildenbrand, B. Sauer, O. Kalis, C. Stoll +9 more
2007The Prostate54 citations
Semantic Scholar
Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro
J. Schupp, Sandrine Y. Tchaptchet, N. Lützen, Peggy Engelhard +3 more
2015BMC Pulmonary Medicine53 citations Open access
Semantic Scholar
Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells.
Carolin N. Zorn, S. Keck, R. Hendriks, M. Leitges +2 more
2009Cellular Signalling45 citations
Semantic Scholar
Adenovirus-triggered innate signalling pathways.
G. Fejer, M. Freudenberg, Urs F. Greber, I. Győry
2011European Journal of Microbiology & Immunology41 citations Open access
Semantic Scholar
Innate and adaptive immune responses in contact dermatitis: analogy with infections.
M. Freudenberg, Philipp R. Esser, Thilo Jakob, Chris Galanos +1 more
2009Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia41 citations
Semantic Scholar
Absence of TRIF Signaling in Lipopolysaccharide-Stimulated Murine Mast Cells
S. Keck, Ines Müller, György Fejer, I. Savić +5 more
2011Journal of Immunology39 citations Open access
Semantic Scholar
Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice
Jisen Huai, E. Firat, A. Nil, D. Million +9 more
2008Proceedings of the National Academy of Sciences of the United States of America39 citations Open access
Semantic Scholar
Stimulation of mast cells via FcεR1 and TLR2: The type of ligand determines the outcome
Kerstin Fehrenbach, F. Port, Gordon Grochowy, C. Kalis +5 more
200739 citations
Semantic Scholar
Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLR3, -7, -9 and Trif but dependent on Unc93B
T. Eigenbrod, L. Franchi, Raúl Muñoz-Planillo, C. Kirschning +3 more
2012Journal of Immunology36 citations Open access
Semantic Scholar
Tumour Biology: tumour-associated inflammation versus antitumor immunity.
Boris Müller-Hübenthal, M. Azemar, D. Lorenzen, M. Huber +4 more
2009Anticancer Research35 citations
Semantic Scholar

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C. Galanos×19
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M. Huber×11
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György Fejer×10
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György Fejer — researcher profile on SciRah
C. Kalis×9
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C. Kalis — researcher profile on SciRah

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