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E. Kranias · SciRah

Researcher profile · Semantic Scholar

E. Kranias

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E. Kranias — researcher profile on SciRah

h-index: 76
Works: 351
Citations: 19K

Most-cited papers

Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome
E. Kranias, R. Hajjar
2012Circulation Research519 citations Open access
Semantic Scholar
Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy
I. Karakikes, F. Stillitano, M. Nonnenmacher, Christos Tzimas +20 more
2015Nature Communications204 citations Open access
Semantic Scholar
Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.
Sanjeewa A. Goonasekera, C. Lam, D. Millay, Michelle A. Sargent +3 more
2011Journal of Clinical Investigation196 citations Open access
Semantic Scholar
The role of CaMKII regulation of phospholamban activity in heart disease
A. Mattiazzi, E. Kranias
2014Frontiers in Pharmacology140 citations Open access
Semantic Scholar
Hsp20 Functions as a Novel Cardiokine in Promoting Angiogenesis via Activation of VEGFR2
Xiao-Wei Zhang, Xiao-Hong Wang, Hong-Yan Zhu, E. Kranias +4 more
2012PLoS ONE127 citations Open access
Semantic Scholar
Phospholamban Interactome in Cardiac Contractility and Survival: A New Vision of an OLD Friend
K. Haghighi, P. Bidwell, E. Kranias
2014Journal of Molecular and Cellular Cardiology103 citations Open access
Semantic Scholar
HNO Enhances SERCA2a Activity and Cardiomyocyte Function by Promoting Redox-Dependent Phospholamban Oligomerization
V. Sivakumaran, Brian A. Stanley, C. Tocchetti, Jeff D. Ballin +14 more
2013Antioxidants and Redox Signaling84 citations Open access
Semantic Scholar
The Small Heat Shock Protein 20 (Hsp20) Interacts with Protein Phosphatase-1 and Enhances Sarcoplasmic Reticulum Ca-Cycling
Jiang Qian, E. Vafiadaki, Stela M. Florea, V. Singh +12 more
2011Circulation Research83 citations Open access
Semantic Scholar
A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia.
Guan-Sheng Liu, A. Morales, E. Vafiadaki, C. Lam +5 more
2015Cardiovascular Research82 citations Open access
Semantic Scholar
S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy
T. Irie, P. Sips, S. Kai, K. Kida +13 more
2015Circulation Research82 citations Open access
Semantic Scholar
Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure.
K. Ishikawa, K. Fish, L. Tilemann, K. Rapti +16 more
2014Molecular Therapy82 citations Open access
Semantic Scholar
Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway.
Sofia-Iris Bibli, I. Andreadou, A. Chatzianastasiou, Christos Tzimas +8 more
2015Cardiovascular Research77 citations Open access
Semantic Scholar
Genomic correction of familial cardiomyopathy in human engineered cardiac tissues.
F. Stillitano, I. Turnbull, I. Karakikes, M. Nonnenmacher +5 more
2016European Heart Journal76 citations Open access
Semantic Scholar
HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart
C. Lam, Wen Zhao, Guan-Sheng Liu, Wen-Feng Cai +3 more
2015Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
Semantic Scholar
AAV9.I-1c Delivered Via Direct Coronary Infusion in a Porcine Model of Heart Failure Improves Contractility and Mitigates Adverse Remodelling
K. Fish, D. Ladage, Y. Kawase, I. Karakikes +9 more
2012Circulation: Heart Failure72 citations Open access
Semantic Scholar
The Human Phospholamban Arg14-Deletion Mutant Localizes to Plasma Membrane and Interacts with the Na/K-ATPase
K. Haghighi, Tracy J. Pritchard, Julie Bossuyt, Jason R. Waggoner +8 more
2011Journal of Molecular and Cellular Cardiology69 citations Open access
Semantic Scholar
Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes
Y. Sassi, A. Abi-Gerges, J. Fauconnier, N. Mougenot +9 more
2012The FASEB Journal66 citations Open access
Semantic Scholar
Triadin/Junctin Double Null Mouse Reveals a Differential Role for Triadin and Junctin in Anchoring CASQ to the jSR and Regulating Ca2+ Homeostasis
S. Boncompagni, Monique Thomas, J. Lopez, P. Allen +4 more
2012PLoS ONE56 citations Open access
Semantic Scholar
Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant
Guan-Sheng Liu, Hong-Yan Zhu, Wen-Feng Cai, Xiao-Hong Wang +13 more
2018Autophagy39 citations Open access
Semantic Scholar
Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia
Adam J. Pollak, K. Haghighi, Swati Kunduri, D. Arvanitis +8 more
2017Proceedings of the National Academy of Sciences of the United States of America38 citations Open access
Semantic Scholar
Long-term Rescue of a Familial Hypertrophic Cardiomyopathy Caused by a Mutation in the Thin Filament Protein, Tropomyosin, via Modulation of a Calcium Cycling Protein
R. Gaffin, James R. Peña, Marco S. L. Alves, Fernando A. L. Dias +6 more
2011Journal of Molecular and Cellular Cardiology37 citations Open access
Semantic Scholar
Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors
C. Valverde, G. Mazzocchi, M. N. Di Carlo, Alejandro Ciocci Pardo +10 more
2018Cardiovascular Research36 citations Open access
Semantic Scholar
Altered regional cardiac wall mechanics are associated with differential cardiomyocyte calcium handling due to nebulette mutations in preclinical inherited dilated cardiomyopathy
K. Maiellaro-Rafferty, J. Wansapura, U. Mendsaikhan, H. Osińska +6 more
2013Journal of Molecular and Cellular Cardiology36 citations Open access
Semantic Scholar
Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca2+ Handling and Arrhythmogenesis
E. Vafiadaki, K. Haghighi, D. Arvanitis, E. Kranias +1 more
2022International Journal of Molecular Sciences33 citations Open access
Semantic Scholar
Targeted ablation of the histidine-rich Ca2+-binding protein (HRC) gene is associated with abnormal SR Ca2+-cycling and severe pathology under pressure-overload stress
Chang-Sik Park, Sha Chen, Ho-Yong Lee, Hyeseon Cha +14 more
2013Basic Research in Cardiology30 citations Open access
Semantic Scholar
HAX-1 Regulates SERCA2a Oxidation and Degradation
P. Bidwell, Guan-Sheng Liu, Narayani Nagarajan, C. Lam +12 more
2017Journal of Molecular and Cellular Cardiology29 citations Open access
Semantic Scholar
Abnormal Calcium Cycling and Cardiac Arrhythmias Associated With the Human Ser96Ala Genetic Variant of Histidine‐Rich Calcium‐Binding Protein
V. Singh, Jack Rubinstein, D. Arvanitis, Xiao-Ping Ren +12 more
2013Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease29 citations Open access
Semantic Scholar
Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging
Stela M. Florea, Ahmad Anjak, Wen-Feng Cai, Jiang Qian +6 more
2012Basic Research in Cardiology28 citations Open access
Semantic Scholar
Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.
Bin Liu, Hsiang‐Ting Ho, L. Brunello, Sathya D. Unudurthi +10 more
2015Cardiovascular Research27 citations Open access
Semantic Scholar
Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy
Kobina Essandoh, Xiao-Hong Wang, Wei Huang, Shan Deng +6 more
2019Journal of Biological Chemistry26 citations Open access
Semantic Scholar
Synergistic Role of Protein Phosphatase Inhibitor 1 and SERCA2a in the Acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells
L. Lipskaia, R. Bobe, Ji-Qiu Chen, I. Turnbull +14 more
2013Circulation25 citations Open access
Semantic Scholar
Phospholamban R14del disease: The past, the present and the future
E. Vafiadaki, P. Glijnis, P. Doevendans, E. Kranias +1 more
2023Frontiers in Cardiovascular Medicine24 citations Open access
Semantic Scholar
Phosphorylation of cardiac myosin–binding protein-C contributes to calcium homeostasis
Mohit Kumar, K. Haghighi, E. Kranias, S. Sadayappan
2020Journal of Biological Chemistry24 citations Open access
Semantic Scholar
Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy due to Phospholamban R14del Mutation
N. Raad, Philip Bittihn, M. Cacheux, Dongtak Jeong +9 more
2021Circulation22 citations Open access
Semantic Scholar
The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart
P. Bidwell, K. Haghighi, E. Kranias
2017Journal of Biological Chemistry22 citations Open access
Semantic Scholar
The Phospholamban Journey Four Decades after Setting out for Ithaka
E. Kranias, R. Hajjar
2017Circulation Research22 citations Open access
Semantic Scholar
Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias
K. Haghighi, G. Gardner, E. Vafiadaki, Mohit Kumar +18 more
2021Journal of Personalized Medicine21 citations Open access
Semantic Scholar
Leducq Transatlantic Network of Excellence to Cure Phospholamban-Induced Cardiomyopathy (CURE-PLaN).
P. Doevendans, P. Glijnis, E. Kranias
2019Circulation Research21 citations Open access
Semantic Scholar
A novel human S10F‐Hsp20 mutation induces lethal peripartum cardiomyopathy
Guan-Sheng Liu, G. Gardner, George Adly, Min Jiang +6 more
2018Journal of Cellular and Molecular Medicine20 citations Open access
Semantic Scholar
Phospholamban Regulates Nuclear Ca2+ Stores and Inositol 1,4,5-Trisphosphate Mediated Nuclear Ca2+ Cycling in Cardiomyocytes
Mu Chen, Dong-Zhu Xu, Adonis Z Wu, E. Kranias +3 more
2018Journal of Molecular and Cellular Cardiology20 citations Open access
Semantic Scholar
Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion.
Wen-Feng Cai, Tracy J. Pritchard, Stela M. Florea, C. Lam +6 more
2012Cardiovascular Research20 citations Open access
Semantic Scholar
Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression.
Peidong Han, Wen-Feng Cai, Yanru Wang, C. Lam +7 more
2011American Journal of Physiology. Heart and Circulatory Physiology20 citations Open access
Semantic Scholar
Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant
Christos Tzimas, Daniel M. Johnson, D. J. Santiago, E. Vafiadaki +13 more
2017Cardiovascular Research18 citations Open access
Semantic Scholar
Active Inhibitor-1 Maintains Protein Hyper-Phosphorylation in Aging Hearts and Halts Remodeling in Failing Hearts
Tracy J. Pritchard, Y. Kawase, K. Haghighi, Ahmad Anjak +9 more
2013PLoS ONE18 citations Open access
Semantic Scholar
Genetic, clinical, molecular, and pathogenic aspects of the South Asian–specific polymorphic MYBPC3Δ25bp variant
M. Arif, Pooneh Nabavizadeh, Taejeong Song, Darshini Desai +9 more
2020Biophysical Reviews17 citations Open access
Semantic Scholar
AAV-Mediated Knock-Down of HRC Exacerbates Transverse Aorta Constriction-Induced Heart Failure
Chang-Sik Park, Hyeseon Cha, E. Kwon, Dongtak Jeong +5 more
2012PLoS ONE17 citations Open access
Semantic Scholar
The Histidine-Rich Calcium Binding Protein in Regulation of Cardiac Rhythmicity
D. Arvanitis, E. Vafiadaki, Daniel M. Johnson, E. Kranias +1 more
2018Frontiers in Physiology16 citations Open access
Semantic Scholar
Identification of a Protein Phosphatase-1/Phospholamban Complex That Is Regulated by cAMP-Dependent Phosphorylation
E. Vafiadaki, D. Arvanitis, D. Sanoudou, E. Kranias
2013PLoS ONE16 citations Open access
Semantic Scholar
Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure
G. Gardner, Joshua G. Travers, Jiang Qian, Guan-Sheng Liu +8 more
2019JACC: Basic to Translational Science15 citations Open access
Semantic Scholar
Hepatic HAX-1 inactivation prevents metabolic diseases by enhancing mitochondrial activity and bile salt export
Fawzi Alogaili, Sivaprakasam Chinnarasu, A. Jaeschke, E. Kranias +1 more
2020Journal of Biological Chemistry14 citations Open access
Semantic Scholar

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K. Haghighi×16
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K. Haghighi — researcher profile on SciRah
R. Hajjar×13
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R. Hajjar — researcher profile on SciRah
D. Sanoudou×12
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D. Sanoudou — researcher profile on SciRah
E. Vafiadaki×11
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Wen-Feng Cai — researcher profile on SciRah

Jack Rubinstein×9

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C. Lam — researcher profile on SciRah

D. Arvanitis×8

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D. Arvanitis — researcher profile on SciRah

Guan-Sheng Liu×7

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Guan-Sheng Liu — researcher profile on SciRah

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I. Karakikes×6

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I. Karakikes — researcher profile on SciRah

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