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David Karnak · SciRah

Researcher profile · Semantic Scholar

David Karnak

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David Karnak — researcher profile on SciRah

h-index: 22
Works: 44
Citations: 2,189

Most-cited papers

Identification of an Evolutionarily Conserved Heterotrimeric Protein Complex Involved in Protein Targeting*
J. Borg, S. Straight, S. Kaech, M. de Taddéo-Borg +5 more
1998Journal of Biological Chemistry201 citations Open access
Semantic Scholar
A natural BH3-mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2—Beclin1 interaction at endoplasmic reticulum
J. Lian, Xiao-Qing Wu, F. He, David Karnak +6 more
2010Cell Death and Differentiation184 citations Open access
Semantic Scholar
Molecular Cloning and Characterization of Pals, Proteins Associated with mLin-7*
E. Kamberov, O. Makarova, M. Roh, Albert Liu +3 more
2000Journal of Biological Chemistry184 citations Open access
Semantic Scholar
Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer
David Karnak, Carl G. Engelke, L. Parsels, T. Kausar +8 more
2014Clinical Cancer Research152 citations Open access
Semantic Scholar
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells
I. Chefetz, E. Grimley, Kun Yang, Linda J Hong +22 more
2019Cell Reports135 citations Open access
Semantic Scholar
FBXW7 facilitates non-homologous end-joining via K63-linked polyubiquitylation of XRCC4
Qiang Zhang, David Karnak, M. Tan, T. Lawrence +2 more
2016Molecules and Cells131 citations Open access
Semantic Scholar
PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors
L. Parsels, David Karnak, Joshua D Parsels, Qiang Zhang +7 more
2017Molecular Cancer Research113 citations Open access
Semantic Scholar
Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor, MK8776
Carl G. Engelke, L. Parsels, Y. Qian, Qiang Zhang +11 more
2013Clinical Cancer Research105 citations Open access
Semantic Scholar
Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair
Dong-Ping Wei, L. Parsels, David Karnak, M. Davis +7 more
2013Clinical Cancer Research98 citations Open access
Semantic Scholar
Chemosensitization of Prostate Cancer by Modulating Bcl-2 Family Proteins
David Karnak, Liang Xu
2010Current Drug Targets89 citations Open access
Semantic Scholar
The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells
J. Lian, David Karnak, Liang Xu
201085 citations Open access
Semantic Scholar
Poor concordance among nine immunohistochemistry classifiers of cell-of-origin for diffuse large B-cell lymphoma: implications for therapeutic strategies.
B. Rini, P. Kluetz, Yang-min Ning, V. Maher +82 more
2013Clinical Cancer Research84 citations Open access
Semantic Scholar
Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair
T. Kausar, Jason S. Schreiber, David Karnak, L. Parsels +6 more
2015Neoplasia74 citations Open access
Semantic Scholar
HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s ,
Ling Li, Wenhua Tang, Xiao-Qing Wu, David Karnak +11 more
2013Clinical Cancer Research72 citations Open access
Semantic Scholar
Co-Targeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer
T. Williams, A. Flecha, P. Keller, A. Ram +7 more
2012Molecular Cancer Therapeutics70 citations Open access
Semantic Scholar
Identification of Multiple Binding Partners for the Amino-terminal Domain of Synapse-associated Protein 97*
David Karnak, Seonok Lee, B. Margolis
2002Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Irrespective of TP53 Mutational Status through the Induction of Replication Stress
K. Cuneo, M. Morgan, M. Davis, Leslie A. Parcels +6 more
2016International Journal of Radiation Oncology, Biology, Physics56 citations Open access
Semantic Scholar
mLin-7 is localized to the basolateral surface of renal epithelia via its NH(2) terminus.
S. Straight, David Karnak, J. Borg, E. Kamberov +3 more
2000AJP - Renal Physiology53 citations
Semantic Scholar
Interaction with mLin-7 alters the targeting of endocytosed transmembrane proteins in mammalian epithelial cells.
S. Straight, Li-Guang Chen, David Karnak, Ben Margolis
2001Molecular Biology of the Cell50 citations Open access
Semantic Scholar
Structural basis for L27 domain‐mediated assembly of signaling and cell polarity complexes
Yuanhe Li, David Karnak, B. Demeler, B. Margolis +1 more
2004EMBO Journal43 citations Open access
Semantic Scholar
Cervical Mucins Carry α(1,2)Fucosylated Glycans that Partly Protect from Experimental Vaginal Candidiasis
S. Domino, Elizabeth A. Hurd, K. Thomsson, David Karnak +4 more
2009Glycoconjugate Journal36 citations Open access
Semantic Scholar
DNA-PK inhibition and radiation promote anti-tumoral immunity through RNA Polymerase III in pancreatic cancer
Wei-Wei Wang, M. McMillan, Xinyi Zhao, Zhuwen Wang +10 more
2022Molecular Cancer Research23 citations Open access
Semantic Scholar
The Potential for Midtreatment Albumin-Bilirubin (ALBI) Score to Individualize Liver Stereotactic Body Radiation Therapy
W. Jackson, H. Hartman, L. Gharzai, C. Maurino +8 more
2021International Journal of Radiation Oncology, Biology, Physics17 citations Open access
Semantic Scholar
Serum Levels of Hepatocyte Growth Factor and CD40 Ligand Predict Radiation-Induced Liver Injury
K. Cuneo, T. Devasia, Yilun Sun, M. Schipper +8 more
2019Translational Oncology17 citations Open access
Semantic Scholar
TNFR1 and the TNFα axis as a targetable mediator of liver injury from stereotactic body radiation therapy
M. Cousins, E. Morris, C. Maurino, T. Devasia +8 more
2020Translational Oncology12 citations Open access
Semantic Scholar
No small matter: microRNAs - key regulators of cancer stem cells.
Qing Ji, David Karnak, P. Hao, Rongquan Wang +1 more
2010International Journal of Clinical and Experimental Medicine12 citations
Semantic Scholar
Cell Surface Fucosylation Does Not Affect Development of Colon Tumors in Mice with Germline Smad3 Mutation
S. Domino, David Karnak, Elizabeth A. Hurd
2007Tumor Biology9 citations Open access
Semantic Scholar
Improved prediction of radiation pneumonitis by combining biological and radiobiological parameters using a data-driven Bayesian network analysis
T. Hinton, David Karnak, Ming Tang, R. Jiang +18 more
2022Translational Oncology6 citations Open access
Semantic Scholar
Translation of DNA damage response inhibitors as chemoradiation sensitizers from the laboratory to the clinic
L. Parsels, Qiang Zhang, David Karnak, Joshua D Parsels +6 more
2021International Journal of Radiation Oncology, Biology, Physics6 citations Open access
Semantic Scholar
Olaparib and radiotherapy induce type I interferon and CD8+ T cell-dependent sensitization to immunotherapy in pancreatic cancer
V. Valvo, Qiang Zhang, Long Jiang, Erin A. Holcomb +20 more
2024Molecular Cancer Therapeutics3 citations
Semantic Scholar
Abstract 1459: Combined inhibition of Wee1 and PARP1 sensitizes pancreatic cancer cells to radiation
David Karnak, L. Parsels, J. Maybaum, T. Lawrence +1 more
20123 citations
Semantic Scholar
Abstract 862: Sensitization of pancreatic cancer to chemoradiation by the Wee1 inhibitor AZD1775
T. Kausar, L. Parsels, Joshua D Parsels, David Karnak +4 more
20142 citations
Semantic Scholar
Medical Hypothesis No small matter: microRNAs -- key regulators of cancer stem cells
Qing Ji, David Karnak, P. Hao, Rongquan Wang +1 more
20102 citations
Semantic Scholar
Murine Functional Lung Imaging Using X-Ray Velocimetry for Longitudinal Noninvasive Quantitative Spatial Assessment of Pulmonary Airflow
K. Heist, Christopher A Bonham, Youngsoon Jang, Ingrid L. Bergin +8 more
2025Tomography1 citations Open access
Semantic Scholar
Predicting Radiation Pneumonitis Using Plasma Biomarkers Related to TNFα-NFκB Pathway
Dipankar Ray, S. Jolly, T. Hinton, David Karnak +14 more
2020International Journal of Radiation Oncology, Biology, Physics1 citations
Semantic Scholar
A Mid-Treatment Increase in Albi Score Is Strongly Associated with Treatment Related Toxicity Following Liver Radiation Therapy
W. Jackson, H. Hartman, L. Gharzai, C. Maurino +9 more
2019International Journal of Radiation Oncology, Biology, Physics1 citations Open access
Semantic Scholar
Roles for STYX in MAPK signaling and nuclear transport during germ cell maturation
David Karnak, Balin Carter, K. M. Torgersen, M. J. Wishart
20081 citations
Semantic Scholar
Tumor Necrosis Factor Receptor 1 Levels Predict Radiation Induced Liver Injury
K. Cuneo, T. Devasia, David Karnak, D. Ray +4 more
2019International Journal of Radiation Oncology, Biology, Physics0 citations Open access
Semantic Scholar
Abstract 519: Combined inhibition of WEE1 and PARP1 radiosensitizes KRAS mutant non-small cell lung cancers via inhibition of DSB repair
L. Parsels, David Karnak, Joshua D Parsels, Z. Reichert +3 more
20160 citations
Semantic Scholar
Cancer Therapy : Preclinical Sensitization of Pancreatic Cancer to Chemoradiation by the Chk 1 Inhibitor MK 8776
Carl G. Engelke, L. Parsels, Y. Qian, Qiang Zhang +11 more
20130 citations
Semantic Scholar
Abstract B43: Co-targeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer.
T. Williams, A. Flecha, P. Keller, A. Ram +5 more
20120 citations
Semantic Scholar
Abstract 1394: Pro-apoptotic and anti-tumorigenic effects of a naturally occurring proteasome inhibitor on hormone-refractory prostate cancer
David Karnak, Yao Dai, Jeffrey Desano, Wenhua Tang +3 more
20100 citations
Semantic Scholar
Abstract 4851: BH-3 mimetics radiosensitizes human prostate cancer via modulating autophagy
J. Lian, Xiao-Qing Wu, Wenhua Tang, David Karnak +4 more
20100 citations
Semantic Scholar
Biochemical and structural studies of the LIN-2 and 7 (L27) dimerization domain: Linking proteins important to cell polarity.
David Karnak
20040 citations
Semantic Scholar

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Joshua D Parsels

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Wenhua Tang — researcher profile on SciRah

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