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R. Riisnaes · SciRah

Researcher profile · Semantic Scholar

R. Riisnaes

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R. Riisnaes — researcher profile on SciRah

h-index: 43
Works: 145
Citations: 10K

Most-cited papers

Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial
J. Mateo, N. Porta, D. Bianchini, U. McGovern +37 more
2019The Lancet Oncology570 citations Open access
Semantic Scholar
Prostate-specific Membrane Antigen Heterogeneity and DNA Repair Defects in Prostate Cancer
A. Paschalis, Beshara Sheehan, R. Riisnaes, D. Rodrigues +17 more
2019European Urology412 citations Open access
Semantic Scholar
Circulating Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition
J. Goodall, J. Mateo, W. Yuan, H. Mossop +30 more
2017Cancer Discovery378 citations Open access
Semantic Scholar
Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer
A. Sharp, I. Coleman, W. Yuan, Cynthia Sprenger +18 more
2018Journal of Clinical Investigation341 citations Open access
Semantic Scholar
Randomized Phase II Study Evaluating Akt Blockade with Ipatasertib, in Combination with Abiraterone, in Patients with Metastatic Prostate Cancer with and without PTEN Loss
J. de Bono, U. de Giorgi, D. Rodrigues, C. Massard +13 more
2018Clinical Cancer Research283 citations Open access
Semantic Scholar
Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer
Daniel Nava Rodrigues, P. Rescigno, David Liu, W. Yuan +48 more
2018Journal of Clinical Investigation195 citations Open access
Semantic Scholar
Targeting p300/CBP in lethal prostate cancer
J. Welti, A. Sharp, N. Brooks, W. Yuan +36 more
2021Cancer Discovery186 citations Open access
Semantic Scholar
Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors
T. Yap, Brent O'Carrigan, M. Penney, J. Lim +19 more
2020Journal of Clinical Oncology181 citations Open access
Semantic Scholar
Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial
S. Carreira, N. Porta, Sara Arce-Gallego, G. Seed +23 more
2021Cancer Discovery129 citations Open access
Semantic Scholar
Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance
Christina Guo, A. Sharp, B. Gurel, M. Crespo +45 more
2023Nature127 citations Open access
Semantic Scholar
SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity
G. Boysen, D. Rodrigues, P. Rescigno, G. Seed +29 more
2018Clinical Cancer Research121 citations Open access
Semantic Scholar
Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer
J. Welti, D. Rodrigues, A. Sharp, Shi-Hua Sun +7 more
2016European Urology117 citations Open access
Semantic Scholar
CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair
T. Shenoy, G. Boysen, M.-Y. Wang, Q.-Z. Xu +22 more
2017Annals of Oncology113 citations Open access
Semantic Scholar
Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors.
A. Neeb, Nicolás Herranz, Sara Arce-Gallego, S. Miranda +38 more
2020European Urology105 citations Open access
Semantic Scholar
B7-H3 as a therapeutic target in advanced prostate cancer
Christina Guo, I. Figueiredo, B. Gurel, A. Neeb +29 more
2022European Urology97 citations Open access
Semantic Scholar
Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis
M. Lambros, G. Seed, S. Sumanasuriya, V. Gil +32 more
2018Clinical Cancer Research96 citations Open access
Semantic Scholar
Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency
Z. Zafeiriou, D. Bianchini, R. Chandler, P. Rescigno +17 more
2019European Urology76 citations Open access
Semantic Scholar
Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer.
A. Sharp, J. Welti, M. Lambros, D. Dolling +31 more
2019European Urology72 citations Open access
Semantic Scholar
Characterizing CDK12-Mutated Prostate Cancers.
P. Rescigno, B. Gurel, Rita Pereira, M. Crespo +23 more
2020Clinical Cancer Research70 citations Open access
Semantic Scholar
A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer
M. Kolinsky, P. Rescigno, D. Bianchini, Z. Zafeiriou +26 more
2020Annals of Oncology68 citations Open access
Semantic Scholar
Phase I trial of the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib and AKT inhibitor capivasertib in patients with BRCA1/2 and non-BRCA1/2 mutant cancers
T. Yap, R. Kristeleit, V. Michalarea, S. Pettitt +32 more
2020Cancer Discovery60 citations Open access
Semantic Scholar
Intermittent schedules of the oral RAF-MEK inhibitor CH5126766/VS-6766 in patients with RAS/RAF-mutant solid tumours and multiple myeloma: a single-centre, open-label, phase 1 dose-escalation and basket dose-expansion study.
Christina Guo, M. Chénard-Poirier, D. Roda, Maria de Miguel +22 more
2020The Lancet Oncology58 citations Open access
Semantic Scholar
Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumors
D. Papadatos-Pastos, W. Yuan, Abhijit Pal, M. Crespo +27 more
2022Journal for ImmunoTherapy of Cancer56 citations Open access
Semantic Scholar
HER3 is an Actionable Target in Advanced Prostate Cancer.
V. Gil, S. Miranda, R. Riisnaes, B. Gurel +41 more
2021Cancer Research55 citations Open access
Semantic Scholar
PTEN loss as a predictive biomarker for the Akt inhibitor ipatasertib combined with abiraterone acetate in patients with metastatic castration-resistant prostate cancer (mCRPC)
J. de Bono, U. de Giorgi, C. Massard, S. Bracarda +14 more
201654 citations Open access
Semantic Scholar
RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer
Daniel Nava Rodrigues, Nicola Casiraghi, A. Romanel, M. Crespo +16 more
2018Clinical Cancer Research52 citations Open access
Semantic Scholar
Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer
Beshara Sheehan, A. Neeb, Lorenzo Buroni, A. Paschalis +14 more
2022Clinical Cancer Research41 citations Open access
Semantic Scholar
Docetaxel Treatment in PTEN- and ERG-aberrant Metastatic Prostate Cancers
P. Rescigno, D. Lorente, D. Dolling, R. Ferraldeschi +14 more
2018European Urology Oncology41 citations Open access
Semantic Scholar
Systematic study of tissue factor expression in solid tumors
J. de Bono, J. Harris, S. Burm, A. Vanderstichele +13 more
2022Cancer Reports40 citations Open access
Semantic Scholar
Pharmacodynamic and clinical results from a phase 1/2 study of the HSP90 inhibitor onalespib in combination with abiraterone acetate in prostate cancer.
S. Slovin, S. Hussain, F. Saad, J. Garcia +10 more
2019Clinical Cancer Research37 citations Open access
Semantic Scholar
Olaparib and Ceralasertib (AZD6738) in Patients with Triple-Negative Advanced Breast Cancer: Results from Cohort E of the plasmaMATCH Trial (CRUK/15/010)
A. Ring, L. Kilburn, A. Pearson, Laura Moretti +20 more
2023Clinical Cancer Research34 citations Open access
Semantic Scholar
JMJD6 is a druggable oxygenase that regulates AR-V7 expression in prostate cancer
A. Paschalis, J. Welti, A. Neeb, W. Yuan +29 more
2021Cancer Research32 citations Open access
Semantic Scholar
Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer
Laura Cato, A. Neeb, A. Sharp, Víctor Buzón +32 more
2017eLife32 citations Open access
Semantic Scholar
Immune Biomarkers in Metastatic Castration-resistant Prostate Cancer
M. D. Fenor de la Maza, K. Chandran, Jan Rekowski, I. Shui +22 more
2022European Urology Oncology31 citations Open access
Semantic Scholar
Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancer
A. Sowalsky, I. Figueiredo, R. Lis, I. Coleman +27 more
2022medRxiv29 citations Open access
Semantic Scholar
Gene Copy Number Estimation from Targeted Next-Generation Sequencing of Prostate Cancer Biopsies: Analytic Validation and Clinical Qualification
G. Seed, W. Yuan, J. Mateo, S. Carreira +17 more
2017Clinical Cancer Research29 citations Open access
Semantic Scholar
Efficacy and Safety of Weekly Paclitaxel Plus Vistusertib vs Paclitaxel Alone in Patients With Platinum-Resistant Ovarian High-Grade Serous Carcinoma: The OCTOPUS Multicenter, Phase 2, Randomized Clinical Trial.
Susana Banerjee, G. Giannone, A. Clamp, D. Ennis +16 more
2023JAMA Oncology25 citations Open access
Semantic Scholar
BCL2 expression is enriched in advanced prostate cancer with features of lineage plasticity
D. Westaby, J. Jiménez-Vacas, I. Figueiredo, Jan Rekowski +37 more
2024Journal of Clinical Investigation23 citations Open access
Semantic Scholar
HER3 expression and MEK activation in non-small-cell lung carcinoma
T. Manickavasagar, W. Yuan, S. Carreira, B. Gurel +12 more
2021Lung Cancer Management20 citations Open access
Semantic Scholar
Capivasertib in combination with enzalutamide for metastatic castration resistant prostate cancer after docetaxel and abiraterone: Results from the randomized phase II RE-AKT trial
P. Rescigno, N. Porta, Laura Finneran, R. Riisnaes +25 more
2024European Journal of Cancer19 citations Open access
Semantic Scholar
SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
M. Llorca-Cardenosa, Lauren I Aronson, D. Krastev, J. Nieminuszczy +19 more
2022Cancer Research16 citations Open access
Semantic Scholar
Abstract CT143: Phase I study of the combination of a RAF-MEK inhibitor CH5126766 and FAK inhibitor defactinib in an intermittent dosing schedule with expansions inKRASmutant cancers
Rajiv Shinde, Angelika Terbuch, M. Little, Reece Caldwell +20 more
2020Tumor Biology16 citations
Semantic Scholar
PD-L1 quantification across tumor types using the reverse phase protein microarray: implications for precision medicine
E. Baldelli, K. A. Hodge, G. Bellezza, Neil J. Shah +24 more
2021Journal for ImmunoTherapy of Cancer13 citations Open access
Semantic Scholar
Myeloid-derived suppressor cells (MDSCs) in metastatic castration-resistant prostate cancer (CRPC) patients (PTS)
N. Mehra, G. Seed, M. Lambros, A. Sharp +15 more
201612 citations Open access
Semantic Scholar
Molecular and immunological features of a prolonged exceptional responder with malignant pleural mesothelioma treated initially and rechallenged with pembrolizumab
A. Minchom, W. Yuan, M. Crespo, B. Gurel +18 more
2020Journal for ImmunoTherapy of Cancer11 citations Open access
Semantic Scholar
An investigator-initiated phase I study of ONX-0801, a first-in-class alpha folate receptor targeted, small molecule thymidylate synthase inhibitor in solid tumors.
U. Banerji, Á. Garces, V. Michalarea, R. Ruddle +16 more
201711 citations
Semantic Scholar
Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer
J. Jiménez-Vacas, D. Westaby, I. Figueiredo, A. K. de Haven Brandon +54 more
2025Nature Communications8 citations Open access
Semantic Scholar
NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth
J. Welti, D. Bogdan, I. Figueiredo, I. Coleman +36 more
2025Clinical Cancer Research7 citations Open access
Semantic Scholar
RNASEH2B loss and PARP inhibition in advanced prostate cancer
J. Carmichael, I. Figueiredo, B. Gurel, Nick Beije +26 more
2024Journal of Clinical Investigation7 citations Open access
Semantic Scholar
Germline ATM Mutations Detected by Somatic DNA Sequencing in Lethal Prostate Cancer
R. Grochot, S. Carreira, S. Miranda, I. Figueiredo +15 more
2023European Urology Open Science7 citations Open access
Semantic Scholar

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