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L. Kleynhans · SciRah

Researcher profile · Semantic Scholar

L. Kleynhans

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L. Kleynhans — researcher profile on SciRah

h-index: 20
Works: 65
Citations: 1,123

Most-cited papers

Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis
C. Eckold, Vinod Kumar, J. Weiner, B. Alisjahbana +126 more
2020Clinical Infectious Diseases62 citations Open access
Semantic Scholar
Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile
F. Vrieling, K. Ronacher, L. Kleynhans, E. B. van den Akker +3 more
2018EBioMedicine61 citations Open access
Semantic Scholar
Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa
J. Shaw, M. Meiring, Tracy Cummins, N. Chegou +16 more
2020PLoS ONE53 citations Open access
Semantic Scholar
Review of Diagnostic Tests for Detection of Mycobacterium bovis Infection in South African Wildlife
Netanya Bernitz, T. Kerr, W. Goosen, Josephine Chileshe +18 more
2021Frontiers in Veterinary Science50 citations Open access
Semantic Scholar
Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study.
C. Ugarte-Gil, B. Alisjahbana, K. Ronacher, A. Riza +19 more
2019Clinical Infectious Diseases49 citations Open access
Semantic Scholar
Diabetes Mellitus Among Pulmonary Tuberculosis Patients From 4 Tuberculosis-endemic Countries: The TANDEM Study
F. Pearson, C. Ugarte-Gil, B. Alisjahbana, K. Ronacher +19 more
202045 citations
Semantic Scholar
GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity
Stacey Bartlett, A. Gemiarto, M. Ngo, H. Sajiir +16 more
2020Frontiers in Immunology44 citations Open access
Semantic Scholar
Comprehensive Characterization of the Attenuated Double Auxotroph Mycobacterium tuberculosisΔleuDΔpanCD as an Alternative to H37Rv
J. Mouton, Tiaan Heunis, A. Dippenaar, J. Gallant +2 more
2019Frontiers in Microbiology44 citations Open access
Semantic Scholar
Acute helminth infection enhances early macrophage mediated control of mycobacterial infection
N. du Plessis, L. Kleynhans, L. Thiart, P. van Helden +3 more
2012Mucosal Immunology41 citations Open access
Semantic Scholar
Clinical immunology and multiplex biomarkers of human tuberculosis.
G. Walzl, M. Haks, S. Joosten, L. Kleynhans +2 more
2015Cold Spring Harbor Perspectives in Medicine39 citations Open access
Semantic Scholar
The Contraceptive Depot Medroxyprogesterone Acetate Impairs Mycobacterial Control and Inhibits Cytokine Secretion in Mice Infected with Mycobacterium tuberculosis
L. Kleynhans, N. du Plessis, N. Allie, M. Jacobs +4 more
2013Infection and Immunity39 citations Open access
Semantic Scholar
Medroxyprogesterone Acetate Alters Mycobacterium Bovis BCG-Induced Cytokine Production in Peripheral Blood Mononuclear Cells of Contraceptive Users
L. Kleynhans, N. du Plessis, G. Black, A. Loxton +4 more
2011PLoS ONE39 citations Open access
Semantic Scholar
Distinct serum biosignatures are associated with different tuberculosis treatment outcomes
K. Ronacher, N. Chegou, L. Kleynhans, J. F. Djoba Siawaya +21 more
2019Tuberculosis31 citations Open access
Semantic Scholar
The Functional Response of B Cells to Antigenic Stimulation: A Preliminary Report of Latent Tuberculosis
W. D. du Plessis, L. Kleynhans, N. du Plessis, K. Stanley +6 more
2016PLoS ONE30 citations Open access
Semantic Scholar
Cell-Mediated Immunological Biomarkers and Their Diagnostic Application in Livestock and Wildlife Infected With Mycobacterium bovis
Katrin Smith, L. Kleynhans, R. Warren, W. Goosen +1 more
2021Frontiers in Immunology28 citations Open access
Semantic Scholar
Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa
N. Soetedjo, S. McAllister, C. Ugarte-Gil, A. Firănescu +20 more
2018Tropical medicine & international health24 citations Open access
Semantic Scholar
Interplay Between the Immune and Endocrine Systems in the Lung: Implications for TB Susceptibility
Tariq Webber, K. Ronacher, Marli Conradie-Smit, L. Kleynhans
2022Frontiers in Immunology22 citations Open access
Semantic Scholar
The Xpert MTB/RIF Ultra assay detects Mycobacterium tuberculosis complex DNA in white rhinoceros (Ceratotherium simum) and African elephants (Loxodonta africana)
W. Goosen, T. Kerr, L. Kleynhans, R. Warren +5 more
2020Scientific Reports22 citations Open access
Semantic Scholar
Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups
B. Restrepo, L. Kleynhans, Alejandra B. Salinas, Bassent Abdelbary +15 more
2018Tuberculosis22 citations Open access
Semantic Scholar
Improved detection of Mycobacterium tuberculosis and M. bovis in African wildlife samples using cationic peptide decontamination and mycobacterial culture supplementation
W. Goosen, L. Kleynhans, T. Kerr, P. van Helden +3 more
2021Journal of Veterinary Diagnostic Investigation20 citations Open access
Semantic Scholar
Changes in Host Immune–Endocrine Relationships during Tuberculosis Treatment in Patients with Cured and Failed Treatment Outcomes
L. Kleynhans, S. Ruzive, L. Ehlers, L. Thiart +9 more
2017Frontiers in Immunology20 citations Open access
Semantic Scholar
B‐cells with a FasL expressing regulatory phenotype are induced following successful anti‐tuberculosis treatment
I. V. van Rensburg, L. Kleynhans, A. Keyser, G. Walzl +1 more
2016Immunity, Inflammation and Disease20 citations Open access
Semantic Scholar
Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis
S. Meier, J. Seddon, E. Maasdorp, L. Kleynhans +15 more
2022bioRxiv16 citations Open access
Semantic Scholar
Transcriptional profiles predict treatment outcome in patients with tuberculosis and diabetes at diagnosis and at two weeks after initiation of anti-tuberculosis treatment
Cassandra L. R. van Doorn, C. Eckold, K. Ronacher, R. Ruslami +19 more
2022medRxiv16 citations Open access
Semantic Scholar
Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability
W. Sadee, Ian H. Cheeseman, A. Papp, Maciej Pietrzak +18 more
2025Communications Biology15 citations Open access
Semantic Scholar
Mycobacterium bovis Infection in Free-Ranging African Elephants
Michele A. Miller, T. Kerr, Candice R. de Waal, W. Goosen +9 more
2021Emerging Infectious Diseases15 citations Open access
Semantic Scholar
Understanding the biology, morbidity and social contexts of adolescent tuberculosis: a prospective observational cohort study protocol (Teen TB)
J. Swanepoel, K. Zimri, M. M. van der Zalm, G. Hoddinott +20 more
2022BMJ Open14 citations Open access
Semantic Scholar
Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa.
B. Alisjahbana, S. McAllister, C. Ugarte-Gil, N. Panduru +16 more
2020Transactions of the Royal Society of Tropical Medicine and Hygiene14 citations Open access
Semantic Scholar
The VetMAX™ M. tuberculosis complex PCR kit detects MTBC DNA in antemortem and postmortem samples from white rhinoceros (Ceratotherium simum), African elephants (Loxodonta africana) and African buffaloes (Syncerus caffer)
W. Goosen, T. Kerr, L. Kleynhans, P. Buss +6 more
2020BMC Veterinary Research13 citations Open access
Semantic Scholar
Optimisation of the tuberculin skin test for detection of Mycobacterium bovis in African buffaloes (Syncerus caffer).
Katrin Smith, Netanya Bernitz, D. Cooper, T. Kerr +13 more
2021Preventive Veterinary Medicine12 citations
Semantic Scholar
The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment
Trust Odia, S. Malherbe, S. Meier, E. Maasdorp +11 more
2021Frontiers in Immunology12 citations Open access
Semantic Scholar
Novel molecular transport medium used in combination with Xpert MTB/RIF ultra provides rapid detection of Mycobacterium bovis in African buffaloes
Charlene Clarke, Katrin Smith, Samantha Goldswain, C. Helm +7 more
2021Scientific Reports12 citations Open access
Semantic Scholar
Mycobacterium bovis BCG infection severely delays Trichuris muris expulsion and co-infection suppresses immune responsiveness to both pathogens
H. Nel, N. du Plessis, L. Kleynhans, A. Loxton +2 more
2014BMC Microbiology12 citations Open access
Semantic Scholar
Culture-Independent PCR Detection and Differentiation of Mycobacteria spp. in Antemortem Respiratory Samples from African Elephants (Loxodonta Africana) and Rhinoceros (Ceratotherium Simum, Diceros Bicornis) in South Africa
W. Goosen, Charlene Clarke, L. Kleynhans, T. Kerr +2 more
2022Pathogens10 citations Open access
Semantic Scholar
Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability
W. Sadee, Ian H. Cheeseman, A. Papp, Maciej Pietrzak +18 more
2022bioRxiv10 citations Open access
Semantic Scholar
African wild dogs (Lycaon pictus) from the Kruger National Park, South Africa are currently not inbred but have low genomic diversity
Christina Meiring, H. Schurz, P. van Helden, E. Hoal +7 more
2022Scientific Reports9 citations Open access
Semantic Scholar
Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity
C. Eckold, Cassandra L. R. van Doorn, R. Ruslami, K. Ronacher +21 more
2022medRxiv7 citations Open access
Semantic Scholar
Diagnosis of Mycobacterium bovis Infection in Free-Ranging Common Hippopotamus (Hippopotamus amphibius).
T. Kerr, W. Goosen, Rachiel Gumbo, L. de Klerk-Lorist +7 more
2021Transboundary and Emerging Diseases7 citations Open access
Semantic Scholar
The potential of imaging tools as correlates of infection and disease for new TB vaccine development.
S. Malherbe, L. Kleynhans, G. Walzl
2018Seminars in Immunology7 citations
Semantic Scholar
Characterizing poorly controlled type 2 diabetes using 1H-NMR metabolomics
Isabella J. Theron, S. Mason, M. van Reenen, Zinandré Stander +3 more
2024Metabolomics6 citations Open access
Semantic Scholar
Prevalence of non-communicable diseases among household contacts of people with tuberculosis: a systematic review and individual participant data meta-analysis
Y. Hamada, Matteo Quartagno, Farihah Malik, K. Ntshamane +31 more
2024Tropical medicine & international health6 citations Open access
Semantic Scholar
DETECTION OF ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS (EEHV) IN FREE-RANGING AFRICAN ELEPHANTS (LOXODONTA AFRICANA) IN THE KRUGER NATIONAL PARK, SOUTH AFRICA
T. Kerr, Jana van Heerden, W. Goosen, L. Kleynhans +3 more
2023Journal of Wildlife Diseases6 citations
Semantic Scholar
Mycobacterium tuberculosis-stimulated whole blood culture to detect host biosignatures for tuberculosis treatment response
K. Cilliers, A. Menezes, Tariq Webber, H. Dockrell +9 more
2021Tuberculosis6 citations Open access
Semantic Scholar
Use of the MILLIPLEX® bovine cytokine/chemokine multiplex assay to identify Mycobacterium bovis-infection biomarkers in African buffaloes (Syncerus caffer).
Katrin Smith, L. Kleynhans, Candice Snyders, Netanya Bernitz +5 more
2020Veterinary Immunology and Immunopathology6 citations
Semantic Scholar
Optimising the yield from bronchoalveolar lavage on human participants in infectious disease immunology research
J. Shaw, M. Meiring, Devon Allies, L. Cruywagen +35 more
2023Scientific Reports5 citations Open access
Semantic Scholar
cis-eQTL mapping of TB-T2D comorbidity elucidates the involvement of African ancestry in TB susceptibility
Yolandi Swart, C. Uren, C. Eckold, J. Cliff +9 more
2022bioRxiv5 citations Open access
Semantic Scholar
SEROLOGICAL EVIDENCE OF COXIELLA BURNETII INFECTION IN THE WHITE RHINOCEROS (CERATOTHERIUM SIMUM) IN SOUTH AFRICA
Kyle A. Donnelly, Michele A. Miller, D. Grobler, P. Buss +4 more
2021Journal of zoo and wildlife medicine5 citations
Semantic Scholar
Immune, metabolic, anatomical, and functional features of people after successful tuberculosis treatment: an exploratory analysis
Tariq Webber, Candice Macdonald, Michèle Tameris, Nicolette Tredoux +17 more
2025Scientific Reports4 citations Open access
Semantic Scholar
Human alveolar macrophage function is impaired in tuberculosis contacts with diabetes
L. Kleynhans, Carine Kunsevi-Kilola, H. Tshivhula, Tariq Webber +16 more
2025EBioMedicine4 citations Open access
Semantic Scholar
Characterizing the tuberculosis and type 2 diabetes mellitus comorbidity in a South African cohort using untargeted GCxGC-TOFMS metabolomics
Karl Reinecke, L. Kleynhans, K. Ronacher, D. Loots
2026Metabolomics3 citations Open access
Semantic Scholar

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