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L. Karnitz · SciRah

Researcher profile · Semantic Scholar

L. Karnitz

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L. Karnitz — researcher profile on SciRah

h-index: 51
Works: 113
Citations: 9,682

Most-cited papers

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.
J. Sarkaria, Ericka C. Busby, Randal S. Tibbetts, Pia M. K. Roos +3 more
1999Cancer Research1,157 citations
Semantic Scholar
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.
A. Sekulic, Christine C. Hudson, J. Homme, Peng Yin +3 more
2000Cancer Research789 citations
Semantic Scholar
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.
S. Delacroix, J. Wagner, Masahiko Kobayashi, Ken-Ichi Yamamoto +1 more
2007Genes & Development521 citations Open access
Semantic Scholar
An acetylation site in the middle domain of Hsp90 regulates chaperone function.
B. Scroggins, Kenneth Robzyk, Dongxia Wang, M. Marcu +8 more
2007Molecules and Cells436 citations Open access
Semantic Scholar
Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex.
Edgardo R. Parrilla-Castellar, Sonnet J. H. Arlander, L. Karnitz
2004DNA Repair358 citations
Semantic Scholar
The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.
Ericka C. Busby, Dru F. Leistritz, Robert T. Abraham, L. Karnitz +1 more
2000Cancer Research356 citations
Semantic Scholar
Molecular Pathways: Targeting ATR in Cancer Therapy
L. Karnitz, L. Zou
2015Clinical Cancer Research247 citations Open access
Semantic Scholar
Human Homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 Form a DNA Damage-responsive Protein Complex*
E. Volkmer, L. Karnitz
1999Journal of Biological Chemistry221 citations Open access
Semantic Scholar
The Bile Acid Taurochenodeoxycholate Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade*
C. Rust, L. Karnitz, C. Paya, J. Moscat +2 more
2000Journal of Biological Chemistry200 citations Open access
Semantic Scholar
ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status
C. Huntoon, K. Flatten, A. Wahner Hendrickson, A. Huehls +3 more
2013Cancer Research190 citations Open access
Semantic Scholar
Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors*
Poorval Joshi, S. Sutor, C. Huntoon, L. Karnitz
2014Journal of Biological Chemistry188 citations Open access
Semantic Scholar
Hsp90 Inhibition Depletes Chk1 and Sensitizes Tumor Cells to Replication Stress*
Sonnet J. H. Arlander, A. Eapen, B. Vroman, R. McDonald +2 more
2003Journal of Biological Chemistry174 citations Open access
Semantic Scholar
Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity
Kiran Kurmi, Sadae Hitosugi, Elizabeth K. Wiese, F. Boakye-Agyeman +5 more
2018Cell Reports162 citations Open access
Semantic Scholar
Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway
L. Karnitz, L. A. Burns, S. Sutor, J. Blenis +1 more
1995Molecular and Cellular Biology151 citations Open access
Semantic Scholar
Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex*
M. Burtelow, Pia Roos-Mattjus, M. Rauen, J. Babendure +1 more
2001Journal of Biological Chemistry147 citations Open access
Semantic Scholar
Cisplatin-Induced DNA Damage Activates Replication Checkpoint Signaling Components that Differentially Affect Tumor Cell Survival
J. Wagner, L. Karnitz
2009Molecular Pharmacology144 citations Open access
Semantic Scholar
Pharmacological Abrogation of S-Phase Checkpoint Enhances the Anti-Tumor Activity of Gemcitabine In Vivo
D. J. Matthews, Michael Yakes, Jason J. Chen, M. Tadano +9 more
2007Cell Cycle141 citations Open access
Semantic Scholar
Gemcitabine-Induced Activation of Checkpoint Signaling Pathways That Affect Tumor Cell Survival
L. Karnitz, K. Flatten, J. Wagner, D. Loegering +10 more
2005Molecular Pharmacology141 citations
Semantic Scholar
Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling*
Pia Roos-Mattjus, K. M. Hopkins, Andrea J. Oestreich, B. Vroman +4 more
2003Journal of Biological Chemistry128 citations Open access
Semantic Scholar
Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine.
R. Mesa, D. Loegering, Heather L. Powell, K. Flatten +10 more
2005Blood123 citations Open access
Semantic Scholar
The Human Checkpoint Protein hRad17 Interacts with the PCNA-like Proteins hRad1, hHus1, and hRad9*
M. Rauen, M. Burtelow, Vanessa Dufault, L. Karnitz
2000Journal of Biological Chemistry120 citations Open access
Semantic Scholar
Retention of the Human Rad9 Checkpoint Complex in Extraction-resistant Nuclear Complexes after DNA Damage*
M. Burtelow, S. Kaufmann, L. Karnitz
2000Journal of Biological Chemistry117 citations Open access
Semantic Scholar
Interaction between lck and syk Family Tyrosine Kinases in Fcγ Receptor-initiated Activation of Natural Killer Cells (*)
A. Ting, C. Dick, R. Schoon, L. Karnitz +2 more
1995Journal of Biological Chemistry113 citations Open access
Semantic Scholar
The Role of Checkpoint Kinase 1 in Sensitivity to Topoisomerase I Poisons*
K. Flatten, Nga T. Dai, B. Vroman, D. Loegering +3 more
2005Journal of Biological Chemistry109 citations Open access
Semantic Scholar
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network
Liyi Geng, C. Huntoon, L. Karnitz
2010Journal of Cell Biology104 citations Open access
Semantic Scholar
Chaperoning Checkpoint Kinase 1 (Chk1), an Hsp90 Client, with Purified Chaperones*
Sonnet J. H. Arlander, S. Felts, J. Wagner, B. Stensgard +2 more
2006Journal of Biological Chemistry102 citations Open access
Semantic Scholar
Dependence of insulin-stimulated glucose transporter 4 translocation on 3-phosphoinositide-dependent protein kinase-1 and its target threonine-410 in the activation loop of protein kinase C-zeta.
G. Bandyopadhyay, M. Standaert, M. Sajan, L. Karnitz +3 more
1999Molecular Endocrinology96 citations Open access
Semantic Scholar
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) Chromatin Association Is an Early Checkpoint Signaling Event*
Pia Roos-Mattjus, B. Vroman, M. Burtelow, M. Rauen +2 more
2002Journal of Biological Chemistry86 citations Open access
Semantic Scholar
A Phosphatidylinositol 3-Kinase-dependent Pathway That Differentially Regulates c-Raf and A-Raf*
S. Sutor, B. Vroman, E. Armstrong, R. Abraham +1 more
1999Journal of Biological Chemistry78 citations Open access
Semantic Scholar
Heat Shock Protein 90 (HSP90) Inhibition Depletes LATS1 and LATS2, Two Regulators of the Mammalian Hippo Tumor Suppressor Pathway
C. Huntoon, M. Nye, Liyi Geng, Kevin L. Peterson +4 more
2010Cancer Research75 citations Open access
Semantic Scholar
Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway
Kiran Kurmi, Sadae Hitosugi, Jia Yu, F. Boakye-Agyeman +11 more
2018Cell Metabolism65 citations Open access
Semantic Scholar
Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin*
Edgardo R. Parrilla-Castellar, L. Karnitz
2003Journal of Biological Chemistry65 citations Open access
Semantic Scholar
Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability
J. Leonard, H. Ye, C. Wetmore, L. Karnitz
2008Journal of Cell Biology64 citations Open access
Semantic Scholar
BRCA1 Deficiency Upregulates NNMT Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents
Arun Kanakkanthara, Kiran Kurmi, Thomas L. Ekstrom, X. Hou +13 more
2019Cancer Research63 citations Open access
Semantic Scholar
A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia
I. Gojo, J. H. Beumer, K. Pratz, Michael A. Mcdevitt +21 more
2016Clinical Cancer Research62 citations Open access
Semantic Scholar
Enzymatic Activation of Pyruvate Kinase Increases Cytosolic Oxaloacetate to Inhibit the Warburg Effect
Elizabeth K. Wiese, Sadae Hitosugi, S. Loa, Annapoorna Sreedhar +6 more
2021Nature Metabolism61 citations Open access
Semantic Scholar
Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer
Dongqing Huang, Shrabanti Chowdhury, Hong Wang, Sara R. Savage +26 more
2021Cell Reports Medicine59 citations Open access
Semantic Scholar
Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells in Vitro
E. Schenk, Brian D. Koh, K. Flatten, Kevin L. Peterson +6 more
2012Clinical Cancer Research58 citations Open access
Semantic Scholar
Gi Proteins Use a Novel βγ- and Ras-independent Pathway to Activate Extracellular Signal-regulated Kinase and Mobilize AP-1 Transcription Factors in Jurkat T Lymphocytes*
K. Hedin, M. Bell, C. Huntoon, L. Karnitz +1 more
1999Journal of Biological Chemistry56 citations Open access
Semantic Scholar
Interleukin-2 receptor signaling mechanisms.
L. Karnitz, R. Abraham
1996Advances in Immunology56 citations
Semantic Scholar
Cytokine receptor signaling mechanisms.
L. Karnitz, R. Abraham
1995Current Opinion in Immunology56 citations
Semantic Scholar
Randomized Phase II Trial of Cytosine Arabinoside with and without the CHK1 inhibitor MK-8776 in Relapsed and Refractory Acute Myeloid Leukemia
Jonathan A. Webster, R. Tibes, L. Morris, Amanda L. Blackford +12 more
2017Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis54 citations Open access
Semantic Scholar
Cdc37 Regulation of the Kinome: When to Hold ‘Em and When to Fold ‘Em
L. Karnitz, S. Felts
2007Science's STKE52 citations
Semantic Scholar
Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination
A. Huehls, C. Huntoon, Poorval Joshi, C. Baehr +4 more
2016Molecular Pharmacology51 citations Open access
Semantic Scholar
Rad9 Protects Cells from Topoisomerase Poison-induced Cell Death*
D. Loegering, Sonnet J. H. Arlander, Jennifer S. Hackbarth, B. Vroman +5 more
2004Journal of Biological Chemistry49 citations Open access
Semantic Scholar
S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells.
Jennifer S. Hackbarth, Sun-Hee Lee, Xue W. Meng, B. Vroman +2 more
2004BioTechniques48 citations
Semantic Scholar
Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells
A. Huehls, J. Wagner, C. Huntoon, Liyi Geng +4 more
2011Cancer Research47 citations Open access
Semantic Scholar
Cloning and Characterization of hCTF18, hCTF8, and hDCC1
C. J. Merkle, L. Karnitz, John T. Henry-Sánchez, Jun-Jie Chen
2003Journal of Biological Chemistry47 citations Open access
Semantic Scholar
A Phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms and chronic myelomonocytic leukemia
K. Pratz, M. Rudek, I. Gojo, M. Litzow +16 more
2016Clinical Cancer Research39 citations Open access
Semantic Scholar
Identification of DNA Repair Pathways That Affect the Survival of Ovarian Cancer Cells Treated with a Poly(ADP-Ribose) Polymerase Inhibitor in a Novel Drug Combination
A. Huehls, J. Wagner, C. Huntoon, L. Karnitz
2012Molecular Pharmacology39 citations Open access
Semantic Scholar

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S. Kaufmann — researcher profile on SciRah
C. Huntoon×11
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J. Wagner×8
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R. Abraham — researcher profile on SciRah

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S. Sutor — researcher profile on SciRah

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Kiran Kurmi — researcher profile on SciRah

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T. Hitosugi — researcher profile on SciRah

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M. Burtelow — researcher profile on SciRah