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V. Tryndyak · SciRah

Researcher profile · Semantic Scholar

V. Tryndyak

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V. Tryndyak — researcher profile on SciRah

h-index: 43
Works: 123
Citations: 6,510

Most-cited papers

Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
O. Kovalchuk, J. Filkowski, J. Meservy, Y. Ilnytskyy +3 more
2008Molecular Cancer Therapeutics633 citations Open access
Semantic Scholar
Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
I. Pogribny, J. Filkowski, V. Tryndyak, A. Golubov +2 more
2010International Journal of Cancer329 citations
Semantic Scholar
Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid
S. Zahm, J. P. Bonde, Weihsueh A Chiu, Jane Hoppin +43 more
2023The Lancet Oncology252 citations Open access
Semantic Scholar
E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells
V. Tryndyak, Frederick A. Beland, I. Pogribny
2010International Journal of Cancer235 citations
Semantic Scholar
Role of ferritin alterations in human breast cancer cells
S. Shpyleva, V. Tryndyak, O. Kovalchuk, Athena Starlard-Davenport +3 more
2011Breast Cancer Research and Treatment199 citations
Semantic Scholar
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
I. Pogribny, Athena Starlard-Davenport, V. Tryndyak, T. Han +3 more
2010Laboratory Investigation197 citations Open access
Semantic Scholar
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
I. Pogribny, V. Tryndyak, T. Bagnyukova, S. Melnyk +5 more
2009Journal of Hepatology196 citations Open access
Semantic Scholar
Down‐regulation of the microRNAs miR‐34a, miR‐127, and miR‐200b in rat liver during hepatocarcinogenesis induced by a methyl‐deficient diet
V. Tryndyak, Sharon A. Ross, Frederick A. Beland, I. Pogribny
2009Molecular Carcinogenesis170 citations Open access
Semantic Scholar
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet
V. Tryndyak, J. Latendresse, Beverly A. Montgomery, S. Ross +3 more
2012Toxicology and Applied Pharmacology112 citations Open access
Semantic Scholar
Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.
V. Tryndyak, T. Han, L. Muskhelishvili, J. Fuscoe +3 more
2011Molecular Nutrition & Food Research83 citations
Semantic Scholar
MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
I. Kindrat, V. Tryndyak, A. de Conti, S. Shpyleva +5 more
2015OncoTarget80 citations Open access
Semantic Scholar
Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype
N. Simpson, V. Tryndyak, M. Pogribna, F. A. Beland +1 more
2012Epigenetics77 citations Open access
Semantic Scholar
Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
Svitlana Shpyleva, Samuil Ivanovsky, A. de Conti, S. Melnyk +4 more
2014PLoS ONE76 citations Open access
Semantic Scholar
Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin.
V. Chekhun, N. Lukyanova, Capital A Cyrillicnatoliy P Burlaka, N. Bezdenezhnykh +4 more
2013International Journal of Oncology73 citations Open access
Semantic Scholar
Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.
B. Bradford, E. Lock, O. Kosyk, Sungkyoon Kim +9 more
2011Toxicological Sciences68 citations Open access
Semantic Scholar
The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation.
I. Pogribny, L. Muskhelishvili, V. Tryndyak, F. A. Beland
2009Toxicology and Applied Pharmacology68 citations
Semantic Scholar
An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression
N. Simpson, V. Tryndyak, F. A. Beland, I. Pogribny
2012Breast Cancer Research and Treatment65 citations
Semantic Scholar
Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice.
A. F. Aissa, V. Tryndyak, A. de Conti, S. Melnyk +6 more
2014Molecular Nutrition & Food Research62 citations
Semantic Scholar
Inter-Strain Differences in Liver Injury and One-Carbon Metabolism in Alcohol-Fed Mice
Masato Tsuchiya, C. Ji, O. Kosyk, Svitlana Shymonyak +7 more
2012Hepatology62 citations Open access
Semantic Scholar
Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet.
T. Bagnyukova, Christine L. Powell, O. Pavliv, V. Tryndyak +1 more
2008Brain Research60 citations
Semantic Scholar
MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis
A. de Conti, J. F. Ortega, V. Tryndyak, Kostiantyn Dreval +4 more
2017OncoTarget58 citations Open access
Semantic Scholar
Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver
I. Pogribny, V. Tryndyak, Anna Boureiko, S. Melnyk +3 more
2008Mutation research56 citations Open access
Semantic Scholar
Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
V. Tryndyak, A. Conti, T. Kobets, Kristy R. Kutanzi +11 more
2012The FASEB Journal54 citations Open access
Semantic Scholar
Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.
I. Pogribny, V. Tryndyak, M. Pogribna, S. Shpyleva +3 more
2013International Journal of Oncology53 citations Open access
Semantic Scholar
Epigenetic Alterations in Liver of C57BL/6J Mice after Short-Term Inhalational Exposure to 1,3-Butadiene
Igor Koturbash, Anne Scherhag, J. Sorrentino, K. Sexton +7 more
2010Environmental Health Perspectives49 citations Open access
Semantic Scholar
Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
Dian-Ke Yu, Leihong Wu, Pritmohinder S. Gill, W. Tolleson +28 more
2017Archives of Toxicology48 citations Open access
Semantic Scholar
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice
G. Chappell, Kristy R. Kutanzi, T. Uehara, V. Tryndyak +5 more
2013International Journal of Cancer46 citations Open access
Semantic Scholar
Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
Ji-Eun Seo, V. Tryndyak, Qian-Gen Wu, Kostiantyn Dreval +6 more
2019Archives of Toxicology45 citations
Semantic Scholar
MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells.
April K. Marrone, V. Tryndyak, F. A. Beland, I. Pogribny
2016Toxicological Sciences44 citations Open access
Semantic Scholar
From the Cover: Aloin, a Component of the Aloe Vera Plant Leaf, Induces Pathological Changes and Modulates the Composition of Microbiota in the Large Intestines of F344/N Male Rats
M. Boudreau, G. Olson, V. Tryndyak, M. Bryant +2 more
2017Toxicological Sciences43 citations Open access
Semantic Scholar
Epigenetic down-regulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats
T. Bagnyukova, V. Tryndyak, L. Muskhelishvili, S. Ross +2 more
2008Cell Cycle43 citations Open access
Semantic Scholar
Dose- and time-dependent epigenetic changes in the livers of Fisher 344 rats exposed to furan.
A. de Conti, T. Kobets, C. Escudero-Lourdes, Beverly A. Montgomery +4 more
2014Toxicological Sciences39 citations Open access
Semantic Scholar
The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway.
A. de Conti, V. Tryndyak, Igor Koturbash, R. Heidor +5 more
2013Carcinogenesis38 citations
Semantic Scholar
Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice
E. Jeannot, G. Boorman, O. Kosyk, B. Bradford +7 more
2011International Journal of Cancer38 citations Open access
Semantic Scholar
Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach
Athena Starlard-Davenport, K. Kutanzi, V. Tryndyak, B. Word +1 more
2013Journal of Carcinogenesis37 citations Open access
Semantic Scholar
Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis.
Barbara Borowa‐Mazgaj, A. de Conti, V. Tryndyak, Colleen R Steward +8 more
2019Toxicological Sciences36 citations Open access
Semantic Scholar
Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
A. de Conti, Kostiantyn Dreval, V. Tryndyak, O. Orisakwe +3 more
2017Molecular Cancer Research36 citations Open access
Semantic Scholar
Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment
Xiao-Qing Guo, Ji-Eun Seo, Dayton M. Petibone, V. Tryndyak +4 more
2020Journal of Toxicology and Environmental Health, Part A33 citations Open access
Semantic Scholar
Identification of chromatin‐accessible domains in non‐alcoholic steatohepatitis‐derived hepatocellular carcinoma
M. Dechassa, V. Tryndyak, A. de Conti, W. Xiao +2 more
2018Molecular Carcinogenesis31 citations
Semantic Scholar
Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells.
V. Tryndyak, I. Kindrat, Kostiantyn Dreval, M. Churchwell +2 more
2018Food and Chemical Toxicology31 citations
Semantic Scholar
MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency.
V. Tryndyak, April K. Marrone, J. Latendresse, L. Muskhelishvili +2 more
2016Journal of Nutritional Biochemistry29 citations
Semantic Scholar
Strain‐dependent dysregulation of one‐carbon metabolism in male mice is associated with choline‐ and folate‐deficient diet‐induced liver injury
I. Pogribny, Kristy R. Kutanzi, S. Melnyk, A. Conti +8 more
2013The FASEB Journal29 citations
Semantic Scholar
The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene.
I. Pogribny, L. Muskhelishvili, V. Tryndyak, F. A. Beland
2011Mutation research29 citations
Semantic Scholar
Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats.
Athena Starlard-Davenport, V. Tryndyak, Smitha R. James, A. Karpf +3 more
2010Carcinogenesis29 citations Open access
Semantic Scholar
Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study.
A. de Conti, V. Tryndyak, Linda S. VonTungeln, M. Churchwell +3 more
2019Chemical Research in Toxicology28 citations
Semantic Scholar
Persistence of furan-induced epigenetic aberrations in the livers of F344 rats.
A. de Conti, T. Kobets, V. Tryndyak, Sarah D. Burnett +5 more
2015Toxicological Sciences28 citations Open access
Semantic Scholar
Gene Expression and DNA Methylation Alterations During Non-alcoholic Steatohepatitis-Associated Liver Carcinogenesis
Kostiantyn Dreval, V. Tryndyak, A. de Conti, F. A. Beland +1 more
2019Frontiers in Genetics27 citations Open access
Semantic Scholar
Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice
V. Tryndyak, T. Han, J. Fuscoe, S. Ross +2 more
2016BMC Genomics27 citations Open access
Semantic Scholar
Characterization of the variability in the extent of non-alcoholic fatty liver induced by a high-fat diet in the genetically diverse Collaborative Cross mouse model
A. de Conti, V. Tryndyak, Rose A. Willett, Barbara Borowa‐Mazgaj +12 more
2020The FASEB Journal26 citations Open access
Semantic Scholar
Epigenetically mediated inhibition of S‐adenosylhomocysteine hydrolase and the associated dysregulation of 1‐carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma
I. Pogribny, Kostiantyn Dreval, I. Kindrat, S. Melnyk +8 more
2017The FASEB Journal25 citations Open access
Semantic Scholar

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