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L. Muskhelishvili · SciRah

Researcher profile · Semantic Scholar

L. Muskhelishvili

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L. Muskhelishvili — researcher profile on SciRah

h-index: 29
Works: 73
Citations: 2,787

Most-cited papers

Evaluation of Cell Proliferation in Rat Tissues with BrdU, PCNA, Ki-67(MIB-5) Immunohistochemistry and In Situ Hybridization for Histone mRNA
L. Muskhelishvili, J. Latendresse, R. Kodell, E. Henderson
2003Journal of Histochemistry and Cytochemistry261 citations Open access
Semantic Scholar
In Situ Hybridization and Immunohistochemical Analysis of Cytochrome P450 1B1 Expression in Human Normal Tissues
L. Muskhelishvili, Patricia A. Thompson, D. Kusewitt, Charles Wang +1 more
2001Journal of Histochemistry and Cytochemistry183 citations Open access
Semantic Scholar
Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 x C3H F1 mice.
S. James, L. Muskhelishvili
1994Cancer Research144 citations
Semantic Scholar
Methyl deficiency, alterations in global histone modifications, and carcinogenesis.
I. Pogribny, V. Tryndyak, L. Muskhelishvili, I. Rusyn +1 more
2007Journal of NutriLife115 citations Open access
Semantic Scholar
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.
T. Uehara, G. Ainslie, K. Kutanzi, I. Pogribny +9 more
2013Toxicological Sciences109 citations Open access
Semantic Scholar
Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice.
L. Muskhelishvili, R. Hart, A. Turturro, S. James
1995American Journal of Pathology95 citations
Semantic Scholar
Early biomarkers of doxorubicin-induced heart injury in a mouse model.
V. Desai, Joshua C. Kwekel, Vikrant Vijay, C. L. Moland +8 more
2014Toxicology and Applied Pharmacology91 citations
Semantic Scholar
Increased distributional variance of mitochondrial DNA content associated with prostate cancer cells as compared with normal prostate cells
T. Mizumachi, L. Muskhelishvili, A. Naito, Jun Furusawa +5 more
2008The Prostate87 citations Open access
Semantic Scholar
Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.
V. Tryndyak, T. Han, L. Muskhelishvili, J. Fuscoe +3 more
2011Molecular Nutrition & Food Research83 citations
Semantic Scholar
Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis.
V. Tryndyak, L. Muskhelishvili, O. Kovalchuk, Rocio Rodriguez-Juarez +5 more
2005Carcinogenesis83 citations
Semantic Scholar
Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR γ agonists on rat primary hepatocytes and human HepG2 cells
Lei Guo, Lu Zhang, Yong-Ming A. Sun, L. Muskhelishvili +5 more
2006Molecular diversity80 citations
Semantic Scholar
Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging.
S. James, L. Muskhelishvili, D. Gaylor, A. Turturro +1 more
1998Environmental Health Perspectives76 citations Open access
Semantic Scholar
Tight junction disruption by cadmium in an in vitro human airway tissue model
Xuefei Cao, Haixia Lin, L. Muskhelishvili, J. Latendresse +2 more
2015Respiratory Research73 citations Open access
Semantic Scholar
Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats
L. Camacho, J. Latendresse, L. Muskhelishvili, R. Patton +3 more
2012Toxicology Letters70 citations
Semantic Scholar
The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation.
I. Pogribny, L. Muskhelishvili, V. Tryndyak, F. A. Beland
2009Toxicology and Applied Pharmacology68 citations
Semantic Scholar
Proliferating Cell Nuclear Antigen—A Marker for Ovarian Follicle Counts
L. Muskhelishvili, Susan K Wingard, J. Latendresse
2005Toxicologic pathology (Print)64 citations Open access
Semantic Scholar
Inter-Strain Differences in Liver Injury and One-Carbon Metabolism in Alcohol-Fed Mice
Masato Tsuchiya, C. Ji, O. Kosyk, Svitlana Shymonyak +7 more
2012Hepatology62 citations Open access
Semantic Scholar
Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.
T. Bagnyukova, V. Tryndyak, Beverly A. Montgomery, M. Churchwell +5 more
2008Carcinogenesis61 citations Open access
Semantic Scholar
In vivo genotoxicity of furan in F344 rats at cancer bioassay doses.
W. Ding, Dayton M. Petibone, J. Latendresse, Mason G. Pearce +12 more
2012Toxicology and Applied Pharmacology55 citations
Semantic Scholar
The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats.
J. F. Bowyer, J. Latendresse, R. Delongchamp, L. Muskhelishvili +5 more
2008Toxicology and Applied Pharmacology54 citations
Semantic Scholar
Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet.
I. Pogribny, S. Shpyleva, L. Muskhelishvili, T. Bagnyukova +2 more
2009Mutation research50 citations
Semantic Scholar
Epigenetic reprogramming of liver cells in tamoxifen‐induced rat hepatocarcinogenesis
V. Tryndyak, O. Kovalchuk, L. Muskhelishvili, Beverly A. Montgomery +5 more
2007Molecular Carcinogenesis46 citations
Semantic Scholar
Effects of intravenous and oral di(2-ethylhexyl) phthalate (DEHP) and 20% Intralipid vehicle on neonatal rat testis, lung, liver, and kidney
L. Camacho, John R. Latendresse, L. Muskhelishvili, C. Law +1 more
2020Food and Chemical Toxicology43 citations Open access
Semantic Scholar
Epigenetic down-regulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats
T. Bagnyukova, V. Tryndyak, L. Muskhelishvili, S. Ross +2 more
2008Cell Cycle43 citations Open access
Semantic Scholar
Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice.
G. R. Jenkins, Taewon Lee, C. L. Moland, Vikrant Vijay +7 more
2016Toxicology and Applied Pharmacology42 citations
Semantic Scholar
Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
Rui Xiong, Qian-Gen Wu, L. Muskhelishvili, K. Davis +5 more
2018Toxicological Sciences36 citations
Semantic Scholar
Disease-related responses induced by cadmium in an in vitro human airway tissue model.
Rui Xiong, Qian-Gen Wu, R. Trbojevich, L. Muskhelishvili +4 more
2019Toxicology Letters35 citations
Semantic Scholar
Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
Yiying Wang, R. Mittelstaedt, R. Wynne, Ying Chen +13 more
2021Environmental and Molecular Mutagenesis34 citations Open access
Semantic Scholar
Cigarette whole smoke solutions disturb mucin homeostasis in a human in vitro airway tissue model.
Xuefei Cao, Yiying Wang, Rui Xiong, L. Muskhelishvili +3 more
2018Toxicology34 citations Open access
Semantic Scholar
MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency.
V. Tryndyak, April K. Marrone, J. Latendresse, L. Muskhelishvili +2 more
2016Journal of Nutritional Biochemistry29 citations
Semantic Scholar
Strain‐dependent dysregulation of one‐carbon metabolism in male mice is associated with choline‐ and folate‐deficient diet‐induced liver injury
I. Pogribny, Kristy R. Kutanzi, S. Melnyk, A. Conti +8 more
2013The FASEB Journal29 citations
Semantic Scholar
The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene.
I. Pogribny, L. Muskhelishvili, V. Tryndyak, F. A. Beland
2011Mutation research29 citations
Semantic Scholar
Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform.
Ji-Eun Seo, Xiaobo He, L. Muskhelishvili, P. Malhi +6 more
2022ALTEX26 citations Open access
Semantic Scholar
Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
Rui Xiong, Yue Wu, Qian-Gen Wu, L. Muskhelishvili +8 more
2021Archives of Toxicology26 citations Open access
Semantic Scholar
Characterization of the variability in the extent of non-alcoholic fatty liver induced by a high-fat diet in the genetically diverse Collaborative Cross mouse model
A. de Conti, V. Tryndyak, Rose A. Willett, Barbara Borowa‐Mazgaj +12 more
2020The FASEB Journal26 citations Open access
Semantic Scholar
Evaluating the Toxicity of Cigarette Whole Smoke Solutions in an Air-Liquid-Interface Human In Vitro Airway Tissue Model
Xuefei Cao, L. Muskhelishvili, J. Latendresse, Patricia Richter +1 more
2017Toxicological Sciences26 citations
Semantic Scholar
Secretory phospholipase A2 mediates progression of acute liver injury in the absence of sufficient cyclooxygenase-2.
V. Bhave, Shashikiran Donthamsetty, J. Latendresse, L. Muskhelishvili +1 more
2008Toxicology and Applied Pharmacology26 citations
Semantic Scholar
Changes in Mouse Liver Protein Glutathionylation after Acetaminophen Exposure
Xi Yang, J. Greenhaw, Akhtar A. Ali, Q. Shi +9 more
2012Journal of Pharmacology and Experimental Therapeutics24 citations Open access
Semantic Scholar
Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis.
I. Pogribny, T. Bagnyukova, V. Tryndyak, L. Muskhelishvili +6 more
2007Toxicology and Applied Pharmacology24 citations
Semantic Scholar
Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism.
S. Shpyleva, M. Pogribna, Christy R Cozart, M. Bryant +5 more
2014Journal of Nutritional Biochemistry22 citations
Semantic Scholar
Mouse Liver Protein Sulfhydryl Depletion after Acetaminophen Exposure
Xi Yang, J. Greenhaw, Q. Shi, D. Roberts +4 more
2013Journal of Pharmacology and Experimental Therapeutics19 citations Open access
Semantic Scholar
Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model
Yiying Wang, Qian-Gen Wu, Baiping Ren, L. Muskhelishvili +4 more
2022International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model
Baiping Ren, Qian-Gen Wu, L. Muskhelishvili, K. Davis +3 more
2022International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
An Immunohistochemical Label to Facilitate Counting of Ovarian Follicles
L. Muskhelishvili, Lisa Freeman, J. Latendresse, T. Bucci
2002Toxicologic pathology (Print)18 citations Open access
Semantic Scholar
Toxicity of Ortho-phthalaldehyde Aerosols in a Human In Vitro Airway Tissue Model.
Yiying Wang, Qian-Gen Wu, L. Muskhelishvili, K. Davis +5 more
2021Chemical Research in Toxicology15 citations
Semantic Scholar
Assessing the respiratory toxicity of dihydroxyacetone using an in vitro human airway epithelial tissue model.
Yiying Wang, Qian-Gen Wu, L. Muskhelishvili, K. Davis +2 more
2019Toxicology in Vitro15 citations
Semantic Scholar
Effects of dietary soy and estrous cycle on adrenal cytochrome p450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague-Dawley rats.
Xin-chun Fu, Betty S. Blaydes, Constance C. Weis, John R. Latendresse +3 more
2003Chemico-Biological Interactions15 citations
Semantic Scholar
Cancer genomics predicts disease relapse and therapeutic response to neoadjuvant chemotherapy of hormone sensitive breast cancers
Jieqiang Zhu, L. Muskhelishvili, W. Tong, J. Borlak +1 more
2020Scientific Reports13 citations Open access
Semantic Scholar
Doxorubicin‐induced delayed‐onset subclinical cardiotoxicity in mice
V. Desai, Vikrant Vijay, T. Han, C. L. Moland +6 more
2021Journal of Applied Toxicology12 citations
Semantic Scholar
Dietary modulation of 7,12-dimethylbenz[a]anthracene (DMBA)-induced adrenal toxicity in female Sprague-Dawley rats.
Xin-chun Fu, J. Latendresse, L. Muskhelishvili, B. Blaydes +1 more
2005Food and Chemical Toxicology12 citations
Semantic Scholar

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