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A. Krachler · SciRah

Researcher profile · Semantic Scholar

A. Krachler

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A. Krachler — researcher profile on SciRah

h-index: 28
Works: 90
Citations: 2,785

Most-cited papers

Mechanisms of outer membrane vesicle entry into host cells
Eloise J O'Donoghue, A. Krachler
2016Cellular Microbiology338 citations Open access
Semantic Scholar
Targeting the bacteria–host interface
A. Krachler, K. Orth
2013Virulence185 citations Open access
Semantic Scholar
Outer Membrane Vesicle—Host Cell Interactions
Jessica D. Cecil, Natalie Sirisaengtaksin, Neil M. O'Brien-Simpson, A. Krachler
2019Microbiology spectrum167 citations Open access
Semantic Scholar
Outer membrane adhesion factor multivalent adhesion molecule 7 initiates host cell binding during infection by Gram-negative pathogens
A. Krachler, Hyeilin Ham, K. Orth
2011Proceedings of the National Academy of Sciences of the United States of America146 citations Open access
Semantic Scholar
Manipulation of kinase signaling by bacterial pathogens
A. Krachler, Andrew R. Woolery, K. Orth
2011Journal of Cell Biology143 citations Open access
Semantic Scholar
Type III effector VopC mediates invasion for Vibrio species
Ling-Ling Zhang, A. Krachler, Christopher A. Broberg, Yan Li +3 more
2012Cell Reports123 citations Open access
Semantic Scholar
Against the tide: the role of bacterial adhesion in host colonization
D. H. Stones, A. Krachler
2016Biochemical Society Transactions111 citations Open access
Semantic Scholar
The Zebrafish as a Model for Gastrointestinal Tract - Microbe Interactions
Erika M. Flores, A. T. Nguyen, M. Odem, G. T. Eisenhoffer +1 more
2019Cellular Microbiology109 citations Open access
Semantic Scholar
Host attachment and fluid shear are integrated into a mechanical signal regulating virulence in Escherichia coli O157:H7
Ghadah S Alsharif, Sadia Ahmad, M. Islam, Riddhi Shah +2 more
2015Proceedings of the National Academy of Sciences of the United States of America107 citations Open access
Semantic Scholar
Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells
Eloise J O'Donoghue, Natalie Sirisaengtaksin, Douglas F. Browning, E. Bielska +5 more
2017PLoS Pathogens94 citations Open access
Semantic Scholar
Allosteric β‐propeller signalling in TolB and its manipulation by translocating colicins
D. Bonsor, Oliver Hecht, M. Vankemmelbeke, Amit Sharma +6 more
2009EMBO Journal88 citations Open access
Semantic Scholar
Functional Characterization of the Interaction between Bacterial Adhesin Multivalent Adhesion Molecule 7 (MAM7) Protein and Its Host Cell Ligands*
A. Krachler, K. Orth
2011Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Bacterial fitness shapes the population dynamics of antibiotic-resistant and -susceptible bacteria in a model of combined antibiotic and anti-virulence treatment
L. Ternent, R. Dyson, A. Krachler, S. Jabbari
2014Journal of Theoretical Biology73 citations Open access
Semantic Scholar
The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells
Melissa A. Altura, Elizabeth A. C. Heath-Heckman, A. Gillette, N. Kremer +5 more
2013Environmental Microbiology69 citations Open access
Semantic Scholar
Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents.
R. Vargha, M. Endemann, Klaus Kratochwill, A. Riesenhuber +4 more
2006Nephrology, Dialysis and Transplantation69 citations Open access
Semantic Scholar
Fatal Attraction: How Bacterial Adhesins Affect Host Signaling and What We Can Learn from Them
D. H. Stones, A. Krachler
2015International Journal of Molecular Sciences61 citations Open access
Semantic Scholar
cAMP Receptor Protein Controls Vibrio cholerae Gene Expression in Response to Host Colonization
Jainaba Manneh-Roussel, James R. J. Haycocks, Andrés Magán, Nicolas Perez-Soto +4 more
2018mBio57 citations Open access
Semantic Scholar
Self‐association of TPR domains: Lessons learned from a designed, consensus‐based TPR oligomer
A. Krachler, Amit Sharma, C. Kleanthous
2010Proteins: Structure, Function, and Bioinformatics50 citations Open access
Semantic Scholar
TolA modulates the oligomeric status of YbgF in the bacterial periplasm.
A. Krachler, Amit Sharma, A. Cauldwell, G. Papadakos +1 more
2010Journal of Molecular Biology46 citations
Semantic Scholar
Preparation and antimicrobial evaluation of polyion complex (PIC) nanoparticles loaded with polymyxin B
Ignacio Insua, S. Majok, Anna F. A. Peacock, A. Krachler +1 more
2017European Polymer Journal38 citations Open access
Semantic Scholar
Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury
R. Huebinger, D. H. Stones, M. de Souza Santos, D. Carlson +6 more
2016Scientific Reports37 citations Open access
Semantic Scholar
Zebrafish (Danio rerio) as a Vertebrate Model Host To Study Colonization, Pathogenesis, and Transmission of Foodborne Escherichia coli O157
D. H. Stones, Alexander G. J. Fehr, L. Thompson, J. Rocha +4 more
2017Msphere34 citations Open access
Semantic Scholar
Polymyxin B containing polyion complex (PIC) nanoparticles: Improving the antimicrobial activity by tailoring the degree of polymerisation of the inert component
Ignacio Insua, L. Zizmare, Anna F. A. Peacock, A. Krachler +1 more
2017Scientific Reports33 citations Open access
Semantic Scholar
In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel
A. Krachler, Katrin Mende, Clinton K. Murray, K. Orth
2012Virulence32 citations Open access
Semantic Scholar
The Multivalent Adhesion Molecule SSO1327 plays a key role in Shigella sonnei pathogenesis
Rasha Y. Mahmoud, D. H. Stones, Wenqin Li, Mohamed Emara +5 more
2016Molecular Microbiology31 citations Open access
Semantic Scholar
Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers
Ignacio Insua, Evangelos Liamas, Z. Zhang, Anna F. A. Peacock +2 more
2016Polymer Chemistry29 citations Open access
Semantic Scholar
Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence
Thomas Calder, M. de Souza Santos, V. Attah, John A Klimko +4 more
2014FEMS Microbiology Letters29 citations Open access
Semantic Scholar
Optimal translational fidelity is critical for Salmonella virulence and host interactions
Yongqiang Fan, L. Thompson, Zhihui Lyu, T. A. Cameron +3 more
2019Nucleic Acids Research28 citations Open access
Semantic Scholar
Multivalent Adhesion Molecule 7 Clusters Act as Signaling Platform for Host Cellular GTPase Activation and Facilitate Epithelial Barrier Dysfunction
J. Lim, D. H. Stones, C. Hawley, C. Watson +1 more
2014PLoS Pathogens28 citations Open access
Semantic Scholar
A MAM7 Peptide-Based Inhibitor of Staphylococcus aureus Adhesion Does Not Interfere with In Vitro Host Cell Function
C. Hawley, C. Watson, K. Orth, A. Krachler
2013PLoS ONE27 citations Open access
Semantic Scholar
Using the Protozoan Paramecium Caudatum as a Vehicle for Food-Borne Infections in Zebrafish Larvae
Erika M. Flores, L. Thompson, Natalie Sirisaengtaksin, A. T. Nguyen +2 more
2019Journal of Visualized Experiments26 citations Open access
Semantic Scholar
The E. coli transcription factor GrlA is regulated by subcellular compartmentalization and activated in response to mechanical stimuli
Natalie Sirisaengtaksin, M. Odem, Rachel E. Bosserman, Erika M. Flores +1 more
2020Proceedings of the National Academy of Sciences of the United States of America24 citations Open access
Semantic Scholar
Turnabout is fair play
A. Krachler, Hyeilin Ham, K. Orth
2012Virulence24 citations Open access
Semantic Scholar
University of Birmingham Mathematical modelling of the antibiotic-induced morphological transition of Pseudomonas aeruginosa
C. Spalding, E. Keen, David J. Smith, A. Krachler +1 more
24 citations
Semantic Scholar
3-Sulfogalactosyl-dependent adhesion of Escherichia coli HS multivalent adhesion molecule is attenuated by sulfatase activity
Fitua Al-Saedi, D. Vaz, D. H. Stones, A. Krachler
2017Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Made to stick: Anti-adhesion therapy for bacterial infections
A. Krachler, K. Orth
201318 citations Open access
Semantic Scholar
Mathematical model predicts anti-adhesion–antibiotic–debridement combination therapies can clear an antibiotic resistant infection
P. A. Roberts, R. Huebinger, E. Keen, A. Krachler +1 more
2019PLoS Comput. Biol.15 citations Open access
Semantic Scholar
Aggregation of Vibrio cholerae by Cationic Polymers Enhances Quorum Sensing but Overrides Biofilm Dissipation in Response to Autoinduction
Nicolas Perez-Soto, Oliver Creese, F. Fernandez-Trillo, A. Krachler
2018bioRxiv15 citations Open access
Semantic Scholar
Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds
P. A. Roberts, R. Huebinger, E. Keen, A. Krachler +1 more
2017PLoS Comput. Biol.14 citations Open access
Semantic Scholar
Vibrio parahaemolyticus virulence determinants
M. de Souza Santos, D. Salomon, Peng Li, A. Krachler +1 more
201514 citations
Semantic Scholar
Defective phagocyte association during infection of Galleria mellonella with Yersinia pseudotuberculosis is detrimental to both insect host and microbe
A. Krachler, Natalie Sirisaengtaksin, P. Monteith, C. E. Timothy Paine +2 more
2021Virulence13 citations Open access
Semantic Scholar
2012 Landes Bioscience. Do not distribute. Turnabout is fair play Use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent
A. Krachler, Hyeilin Ham, K. Orth
201213 citations
Semantic Scholar
Bacterial outer membrane vesicles provide an alternative pathway for trafficking of Escherichia coli O157 type III secreted effectors to epithelial cells
Natalie Sirisaengtaksin, Eloise J O'Donoghue, S. Jabbari, A. Roe +1 more
2023Msphere12 citations Open access
Semantic Scholar
Colonization of larval zebrafish (Danio rerio) with adherent-invasive Escherichia coli prevents recovery of the intestinal mucosa from drug-induced enterocolitis
Erika M. Flores, S. Dutta, R. Bosserman, A. van Hoof +1 more
2023Msphere12 citations Open access
Semantic Scholar
Mechanosensing regulates virulence in Escherichia coli O157:H7
M. Islam, A. Krachler
2016Gut microbes12 citations Open access
Semantic Scholar
Structural Determinants of the Stability of Enzyme‐Responsive Polyion Complex Nanoparticles Targeting Pseudomonas aeruginosa’s Elastase
Ignacio Insua, M. Petit, Lewis D. Blackman, R. Keogh +5 more
2018ChemNanoMat10 citations Open access
Semantic Scholar
Displacement of Pathogens by an Engineered Bacterium Is a Multifactorial Process That Depends on Attachment Competition and Interspecific Antagonism
Fitua Al-Saedi, D. H. Stones, D. Vaz, A. Krachler
2016Infection and Immunity10 citations Open access
Semantic Scholar
Dual function of a bacterial protein as an adhesin and extracellular effector of host GTPase signaling
D. H. Stones, A. Krachler
2015Small GTPases8 citations Open access
Semantic Scholar
Frequency-independent biological signal identification (FIBSI): A free program that simplifies intensive analysis of non-stationary time series data
R. Cassidy, A. Bavencoffe, E. R. Lopez, S. Cheruvu +4 more
2020bioRxiv7 citations Open access
Semantic Scholar
Correction: Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in Vibrio cholerae and downregulate the expression of virulence genes
Nicolas Perez-Soto, Lauren Moule, D. Crisan, Ignacio Insua +4 more
2018Chemical Science7 citations Open access
Semantic Scholar

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