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Walter A. Korfmacher · SciRah

Researcher profile · Semantic Scholar

Walter A. Korfmacher

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Walter A. Korfmacher — researcher profile on SciRah

h-index: 39
Works: 186
Citations: 5,862

Most-cited papers

Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery.
H. Mei, Y. Hsieh, C. Nardo, Xiao-Ying Xu +3 more
2003Rapid Communications in Mass Spectrometry356 citations
Semantic Scholar
Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry.
Michelle L. Reyzer, Y. Hsieh, K. Ng, Walter A. Korfmacher +1 more
2003Journal of Mass Spectrometry340 citations
Semantic Scholar
Foundation review: Principles and applications of LC-MS in new drug discovery
Walter A. Korfmacher
2005252 citations
Semantic Scholar
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor:
S. Venkatraman, Stéphane L. Bogen, A. Arasappan, F. Bennett +48 more
2006Journal of Medicinal Chemistry238 citations Open access
Semantic Scholar
It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS.
R. Ramanathan, M. Jemal, S. Ramagiri, Yuan-Qing Xia +3 more
2011Journal of Mass Spectrometry179 citations
Semantic Scholar
Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue.
Y. Hsieh, R. Casale, E. Fukuda, Jiwen Chen +4 more
2006Rapid Communications in Mass Spectrometry171 citations
Semantic Scholar
Liquid extraction surface analysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example.
D. Eikel, M. Vavrek, S. Smith, Carol Bason +3 more
2011Rapid Communications in Mass Spectrometry167 citations
Semantic Scholar
Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery.
Walter A. Korfmacher, K. Cox, K. Ng, J. Veals +6 more
2001Rapid Communications in Mass Spectrometry141 citations
Semantic Scholar
Mapping pharmaceuticals in tissues using MALDI imaging mass spectrometry.
Y. Hsieh, Jiwen Chen, Walter A. Korfmacher
2007Journal of pharmacological and toxicological methods130 citations
Semantic Scholar
Systematic LC/MS metabolite identification in drug discovery.
N. J. Clarke, D. Rindgen, Walter A. Korfmacher, K. Cox
2001Analytical Chemistry130 citations
Semantic Scholar
Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry.
Y. Hsieh, M. Chintala, H. Mei, J. Agans +3 more
2001Rapid Communications in Mass Spectrometry125 citations
Semantic Scholar
Increasing speed and throughput when using HPLC-MS/MS systems for drug metabolism and pharmacokinetic screening.
Y. Hsieh, Walter A. Korfmacher
2006Current drug metabolism108 citations
Semantic Scholar
Using Mass Spectrometry for Drug Metabolism Studies
Walter A. Korfmacher
200792 citations
Semantic Scholar
Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species
Geoffrey B. Varty, L. Hyde, R. Hodgson, Sherry X. Lu +11 more
2005Psychopharmacology82 citations
Semantic Scholar
Chiral liquid chromatography-tandem mass spectrometric methods for stereoisomeric pharmaceutical determinations.
Jiwen Chen, Walter A. Korfmacher, Y. Hsieh
2005Journal of chromatography. B, Analytical technologies in the biomedical and life sciences80 citations
Semantic Scholar
High-performance liquid chromatography-atmospheric pressure photoionization/tandem mass spectrometric analysis for small molecules in plasma.
Y. Hsieh, K. Merkle, Ganfeng Wang, J. Brisson +1 more
2003Analytical Chemistry80 citations
Semantic Scholar
Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column high-performance liquid chromatography/tandem mass spectrometry.
Y. Hsieh, Gangfeng Wang, Y. Wang, S. Chackalamannil +3 more
2002Rapid Communications in Mass Spectrometry70 citations
Semantic Scholar
A fully automated nanoelectrospray tandem mass spectrometric method for analysis of Caco-2 samples.
Colleen K. Van Pelt, Sheng Zhang, Eliza N. Fung, Inhou Chu +4 more
2003Rapid Communications in Mass Spectrometry69 citations
Semantic Scholar
A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in high-performance liquid chromatography tandem mass spectrometry assays.
Xiao-Ying Xu, H. Mei, Shi-Yong Wang, Qiao Zhou +4 more
2005Rapid Communications in Mass Spectrometry60 citations
Semantic Scholar
High-resolution mass spectrometry will dramatically change our drug-discovery bioanalysis procedures.
Walter A. Korfmacher
2011Bioanalysis55 citations
Semantic Scholar
Direct plasma analysis of drug compounds using monolithic column liquid chromatography and tandem mass spectrometry.
Y. Hsieh, Ganfeng Wang, Y. Wang, S. Chackalamannil +1 more
2003Analytical Chemistry52 citations
Semantic Scholar
Direct cocktail analysis of drug discovery compounds in pooled plasma samples using liquid chromatography-tandem mass spectrometry.
Y. Hsieh, M. Bryant, J. Brisson, K. Ng +1 more
2002Journal of chromatography. B, Analytical technologies in the biomedical and life sciences52 citations
Semantic Scholar
Comparison of atmospheric pressure chemical ionization, electrospray ionization, and atmospheric pressure photoionization for the determination of cyclosporin A in rat plasma.
Ganfeng Wang, Y. Hsieh, Walter A. Korfmacher
2004Analytical Chemistry51 citations
Semantic Scholar
Ultra-performance liquid chromatography/tandem mass spectrometric determination of testosterone and its metabolites in in vitro samples.
Ganfeng Wang, Y. Hsieh, Xiaoming Cui, K. Cheng +1 more
2006Rapid Communications in Mass Spectrometry50 citations
Semantic Scholar
Supercritical fluid chromatography-tandem mass spectrometry for the enantioselective determination of propranolol and pindolol in mouse blood by serial sampling.
Jiwen Chen, Y. Hsieh, J. Cook, R. Morrison +1 more
2006Analytical Chemistry48 citations
Semantic Scholar
Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry.
Y. Hsieh, M. Bryant, G. Gruela, J. Brisson +1 more
2000Rapid Communications in Mass Spectrometry47 citations
Semantic Scholar
Investigation of the profiling depth in matrix-assisted laser desorption/ionization imaging mass spectrometry.
Lee Crossman, N. McHugh, Y. Hsieh, Walter A. Korfmacher +1 more
2006Rapid Communications in Mass Spectrometry44 citations
Semantic Scholar
Rapid determination of pharmacokinetic properties of new chemical entities: in vivo approaches.
K. Cox, R. White, Walter A. Korfmacher
2002Combinatorial chemistry & high throughput screening40 citations
Semantic Scholar
Visualization of first-pass drug metabolism of terfenadine by MALDI-imaging mass spectrometry.
Y. Hsieh, Jiwen Chen, Ian Knemeyer, Lee Crossman +1 more
2008Drug Metabolism Letters38 citations
Semantic Scholar
The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena.
R. Ramanathan, Walter A. Korfmacher
2012Bioanalysis33 citations
Semantic Scholar
Pharmacological Characterization of the Novel Histamine H3-Receptor Antagonist N-(3,5-Dichlorophenyl)-N′-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687)
R. Mcleod, C. Rizzo, R. West, R. Aslanian +10 more
2003Journal of Pharmacology and Experimental Therapeutics33 citations Open access
Semantic Scholar
Advances in the integration of drug metabolism into the lead optimization paradigm.
Walter A. Korfmacher
2009Mini-Reviews in Medical Chemistry32 citations
Semantic Scholar
Rapid in vivo oral screening in rats: Reliability, acceptance criteria, and filtering efficiency
H. Mei, Walter A. Korfmacher, R. Morrison
2006AAPS Journal32 citations Open access
Semantic Scholar
Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models
R. Mcleod, D. Tulshian, D. Bolser, Geoffrey B. Varty +17 more
2009European Journal of Pharmacology28 citations Open access
Semantic Scholar
Fast mass spectrometry-based methodologies for pharmaceutical analyses.
Y. Hsieh, E. Fukuda, Julia Wingate Wight, Walter A. Korfmacher
2006Combinatorial chemistry & high throughput screening27 citations
Semantic Scholar
Rapid LC/MS/MS method development for drug discovery.
Xiao-Ying Xu, Jing Lan, Walter A. Korfmacher
2005Analytical Chemistry26 citations
Semantic Scholar
Comparison of conventional and enhanced mass resolution triple-quadrupole mass spectrometers for discovery bioanalytical applications.
Xiao-Ying Xu, J. Veals, Walter A. Korfmacher
2003Rapid Communications in Mass Spectrometry26 citations
Semantic Scholar
Lead optimization strategies as part of a drug metabolism environment.
Walter A. Korfmacher
2003Current opinion in drug discovery & development26 citations
Semantic Scholar
Evaluation of two blood microsampling approaches for drug discovery PK studies in rats.
Yongyi Luo, Walter A. Korfmacher, S. Ho, Liduo Shen +5 more
2015Bioanalysis25 citations
Semantic Scholar
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
G. Ho, J. Anthes, A. Bercovici, J. Caldwell +16 more
2009Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Optimizing an ultrafast generic high-performance liquid chromatography/tandem mass spectrometry method for faster discovery pharmacokinetic sample throughput.
K. Dunn-Meynell, Samuel B. Wainhaus, Walter A. Korfmacher
2005Rapid Communications in Mass Spectrometry25 citations
Semantic Scholar
Utility of capillary microsampling for rat pharmacokinetic studies: Comparison of tail-vein bleed to jugular vein cannula sampling.
Walter A. Korfmacher, Yongyi Luo, S. Ho, Wei Sun +6 more
2015Journal of pharmacological and toxicological methods22 citations
Semantic Scholar
Lead Optimization in Discovery Drug Metabolism and Pharmacokinetics/Case study: The Hepatitis C Virus (HCV) Protease Inhibitor SCH 503034
K. Cheng, Walter A. Korfmacher, R. White, F. Njoroge
2007Perspectives in Medicinal Chemistry22 citations Open access
Semantic Scholar
Simultaneous fast HPLC-MS/MS analysis of drug candidates and hydroxyl metabolites in plasma.
Y. Hsieh, J. Brisson, Ganfeng Wang, K. Ng +1 more
2003Journal of Pharmaceutical and Biomedical Analysis22 citations
Semantic Scholar
MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolite in rat brain sections.
Fangbiao Li, Yunsheng Hsieh, Ling Kang, Christopher Sondey +2 more
2009Bioanalysis21 citations
Semantic Scholar
Ultra-performance liquid chromatography/tandem mass spectrometric determination of diastereomers of SCH 503034 in monkey plasma.
Ganfeng Wang, Y. Hsieh, K. Cheng, R. Morrison +4 more
2007Journal of chromatography. B, Analytical technologies in the biomedical and life sciences21 citations
Semantic Scholar
Estimation of the extent of oral absorption in animals from oral and intravenous pharmacokinetic data in drug discovery.
A. Nomeir, R. Morrison, D. Prelusky, Walter A. Korfmacher +4 more
2009Journal of Pharmacy and Science20 citations
Semantic Scholar
Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048).
A. Nomeir, B. Pramanik, L. Heimark, F. Bennett +19 more
2008Journal of Mass Spectrometry20 citations
Semantic Scholar
Direct simultaneous determination of drug discovery compounds in monkey plasma using mixed-function column liquid chromatography/tandem mass spectrometry.
Y. Hsieh, J. Brisson, K. Ng, Walter A. Korfmacher
2002Journal of Pharmaceutical and Biomedical Analysis20 citations
Semantic Scholar
Mass spectrometry for drug discovery and drug development
Walter A. Korfmacher
201318 citations
Semantic Scholar

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Y. Hsieh×21
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K. Ng×8
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J. Brisson×8
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Ganfeng Wang×7
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Xiao-Ying Xu×5

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