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B. Wienert · SciRah

Researcher profile · Semantic Scholar

B. Wienert

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B. Wienert — researcher profile on SciRah

h-index: 16
Works: 36
Citations: 1,706

Most-cited papers

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq
B. Wienert, S. Wyman, C. Richardson, Charles D. Yeh +10 more
2018Science372 citations Open access
Semantic Scholar
Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding
Gabriella E. Martyn, B. Wienert, Lu Yang, Manan Shah +8 more
2018Nature Genetics265 citations
Semantic Scholar
Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin
B. Wienert, Alister P. W. Funnell, Laura J. Norton, Richard C. M. Pearson +7 more
2015Nature Communications120 citations Open access
Semantic Scholar
In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway
B. Wienert, Jiyung Shin, Elena Zelin, K. Pestal +1 more
2018PLoS Biology114 citations Open access
Semantic Scholar
Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair
B. Wienert, David N. Nguyen, Alexis Guenther, Sharon J. Feng +11 more
2020Nature Communications106 citations Open access
Semantic Scholar
Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies.
B. Wienert, Gabriella E. Martyn, Alister P. W. Funnell, K. Quinlan +1 more
2018Trends in Genetics104 citations
Semantic Scholar
CRISPR off-target detection with DISCOVER-Seq
B. Wienert, S. Wyman, Charles D. Yeh, B. Conklin +1 more
2020Nature Protocols88 citations Open access
Semantic Scholar
KLF1 drives the expression of fetal hemoglobin in British HPFH.
B. Wienert, Gabriella E. Martyn, R. Kurita, Yukio Nakamura +2 more
2017Blood84 citations Open access
Semantic Scholar
A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site.
Gabriella E. Martyn, B. Wienert, R. Kurita, Yukio Nakamura +2 more
2019Blood70 citations Open access
Semantic Scholar
KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells.
Laura J. Norton, Alister P. W. Funnell, J. Burdach, B. Wienert +6 more
2017Blood Advances54 citations Open access
Semantic Scholar
Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin
N. Ravi, B. Wienert, S. Wyman, Henry W. Bell +21 more
2022eLife51 citations Open access
Semantic Scholar
CRISPR nuclease off-target activity and mitigation strategies
B. Wienert, M. Cromer
2022Frontiers in Genome Editing49 citations Open access
Semantic Scholar
Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor
J. Burdach, Alister P. W. Funnell, Ka-Sin Mak, C. Artuz +5 more
2013Nucleic Acids Research48 citations Open access
Semantic Scholar
Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1
Lorna Wilkinson-White, Roland Gamsjaeger, S. Dastmalchi, B. Wienert +4 more
2011Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
Semantic Scholar
METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout*
Joshua J. Hamey, B. Wienert, K. Quinlan, M. Wilkins
2017Molecular & Cellular Proteomics46 citations Open access
Semantic Scholar
Phosphorylation of Krüppel-like Factor 3 (KLF3/BKLF) and C-terminal Binding Protein 2 (CtBP2) by Homeodomain-interacting Protein Kinase 2 (HIPK2) Modulates KLF3 DNA Binding and Activity*
Vitri Dewi, Alister Kwok, S. Lee, Ming-Min Lee +11 more
2015Journal of Biological Chemistry25 citations Open access
Semantic Scholar
Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells
Alister P. W. Funnell, D. Vernimmen, W. F. Lim, Ka-Sin Mak +9 more
2014BMC Molecular Biology14 citations Open access
Semantic Scholar
Dual α-globin-truncated erythropoietin receptor knockin restores hemoglobin production in α-thalassemia-derived erythroid cells
S. N. Chu, Eric Soupene, Devesh Sharma, Roshani Sinha +21 more
2025Cell Reports10 citations Open access
Semantic Scholar
A differentiated β-globin gene replacement strategy uses heterologous introns to restore physiological expression
Kirby A. Wallace, Trevor L. Gerstenberg, Craig L. Ennis, Juan A. Pérez-Bermejo +21 more
2025Molecular Therapy8 citations Open access
Semantic Scholar
Investigating Zeta Globin Gene Expression to Develop a Potential Therapy for Alpha Thalassemia Major
Georgia L. Gregory, B. Wienert, M. Schwab, B. Lianoglou +4 more
20206 citations Open access
Semantic Scholar
Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair
Juan A. Pérez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden +31 more
2024Nature Communications5 citations Open access
Semantic Scholar
Identification of novel HPFH-like mutations by CRISPR base editing that elevates the expression of fetal hemoglobin
N. Ravi, B. Wienert, S. Wyman, J. Vu +11 more
2020bioRxiv5 citations Open access
Semantic Scholar
Proximity determines donor candidacy during DNA double-stranded break homology directed repair
Charles D. Yeh, Lilly van de Venn, Susanne Kreutzer, Xinhe Zheng +9 more
2025bioRxiv3 citations
Semantic Scholar
Corrigendum: CRISPR nuclease off-target activity and mitigation strategies
B. Wienert, M. Cromer
2023Frontiers in Genome Editing3 citations Open access
Semantic Scholar
In vitro transcribed guide RNAs trigger an innate immune response via the RIG-I pathway
B. Wienert, Jiyung Shin, Elena Zelin, K. Pestal +1 more
2018bioRxiv3 citations Open access
Semantic Scholar
In vitro transcription of guide RNAs and 5'-triphosphate removal v12
M. DeWitt, Notter Julia, B. Wienert, M. F
2020protocols.io2 citations Open access
Semantic Scholar
Edinburgh Research Explorer Differential regulation of the alpha-globin locus by Kruppel-like factor 3 in erythroid and non-erythroid cells
Alister P. W. Funnell, D. Vernimmen, Wooi F. Lim, Ka-Sin Mak +9 more
2 citations
Semantic Scholar
Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells
Simon N. Chu, E. Soupene, B. Wienert, Han Yin +10 more
2024bioRxiv1 citations Open access
Semantic Scholar
Functional Screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair
Juan A. Pérez-Bermejo, Oghene Efagene, W. Matern, Jeffrey K. Holden +31 more
2023bioRxiv1 citations Open access
Semantic Scholar
Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair
B. Wienert, Sharon J. Feng, Melissa N. Locke, David N. Nguyen +5 more
2018bioRxiv1 citations Open access
Semantic Scholar
DISCOVER-Seq: MRE11 ChIP Seq v1
B. Wienert
2018protocols.io1 citations Open access
Semantic Scholar
RAD51 proximity mapping reveals spatial constraints on homology search during DNA double-stranded break repair.
Charles D. Yeh, Lilly van de Venn, Susanne Kreutzer, Xinhe Zheng +11 more
2026Cell Reports0 citations Open access
Semantic Scholar
Dual α-Globin and Truncated EPO Receptor Knockin Restores Hemoglobin Production in α-Thalassemia-Derived Hematopoietic Stem and Progenitor Cells
S. N. Chu, Eric Soupene, B. Wienert, Han Yin +8 more
2023Blood0 citations
Semantic Scholar
P1436: DEVELOPMENT OF A BETA-GLOBIN GENE REPLACEMENT STRATEGY AS A THERAPEUTIC APPROACH FOR ΒETA-THALASSEMIA
B. Wienert, K. Wallace, C. Bandoro, A. Churi +5 more
2022HemaSphere0 citations Open access
Semantic Scholar
Development of a β-Globin Gene Replacement Strategy As a β-Thalassemia Therapy
Kirby Wallace, B. Wienert, C. Bandoro, James Partridge +10 more
2022Blood0 citations Open access
Semantic Scholar
haddock model of GATA1NF:Lmo2LIM2-Ldb1LID with FOG
Lorna Wilkinson-White, Roland Gamsjaeger, S. Dastmalchi, B. Wienert +4 more
20110 citations
Semantic Scholar

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