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I. Luescher · SciRah

Researcher profile · Semantic Scholar

I. Luescher

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I. Luescher — researcher profile on SciRah

h-index: 47
Works: 189
Citations: 9,354

Most-cited papers

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients
J. Fourcade, Zhao-Jun Sun, M. Benallaoua, P. Guillaume +5 more
2010Journal of Experimental Medicine1,316 citations Open access
Semantic Scholar
CD8+ T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1
J. Fourcade, Zhao-Jun Sun, Ornella Pagliano, P. Guillaume +6 more
2011Cancer Research353 citations Open access
Semantic Scholar
T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion
Daniel T. Utzschneider, Amandine Legat, Silvia A. Fuertes Marraco, L. Carrié +3 more
2013Nature Immunology280 citations
Semantic Scholar
Full activation of the T cell receptor requires both clustering and conformational changes at CD3.
S. Minguet, M. Swamy, B. Alarcón, I. Luescher +1 more
2007Immunity270 citations Open access
Semantic Scholar
PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8+ T cells induced by melanoma vaccines
J. Fourcade, Zhao-Jun Sun, Ornella Pagliano, Joe-Marc Chauvin +13 more
2013Cancer Research205 citations Open access
Semantic Scholar
Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes.
N. Demotte, V. Stroobant, P. Courtoy, P. van der Smissen +9 more
2008Immunity195 citations Open access
Semantic Scholar
PD-1 Is a Regulator of NY-ESO-1-Specific CD8+ T Cell Expansion in Melanoma Patients
J. Fourcade, P. Kudela, Zhao-Jun Sun, Hong-Mei Shen +8 more
2009Journal of Immunology167 citations Open access
Semantic Scholar
Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering*
E. Molnár, M. Swamy, Martin Holzer, Katharina Beck-García +8 more
2012Journal of Biological Chemistry163 citations Open access
Semantic Scholar
Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+ T Cell Responsiveness*
M. Irving, V. Zoete, Michael Hebeisen, D. Schmid +7 more
2012Journal of Biological Chemistry139 citations Open access
Semantic Scholar
Melan-A–specific Cytotoxic T Cells Are Associated with Tumor Regression and Autoimmunity Following Treatment with Anti-CTLA-4
O. Klein, Lisa M. Ebert, T. Nicholaou, J. Browning +10 more
2009Clinical Cancer Research102 citations
Semantic Scholar
A constant affinity threshold for T cell tolerance
D. Naeher, M. Daniels, B. Hausmann, P. Guillaume +2 more
2007Journal of Experimental Medicine89 citations Open access
Semantic Scholar
Vaccination with LAG-3Ig (IMP321) and Peptides Induces Specific CD4 and CD8 T-Cell Responses in Metastatic Melanoma Patients—Report of a Phase I/IIa Clinical Trial
Amandine Legat, Hélène Maby-El Hajjami, P. Baumgaertner, Laurene Cagnon +14 more
2015Clinical Cancer Research86 citations Open access
Semantic Scholar
Direct tumor recognition by a human CD4+ T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses
Junko Matsuzaki, Takemasa Tsuji, I. Luescher, H. Shiku +6 more
2015Scientific Reports82 citations Open access
Semantic Scholar
CD8 kinetically promotes ligand binding to the T-cell antigen receptor.
Dmitry M. Gakamsky, I. Luescher, A. Pramanik, R. Kopito +4 more
2005Biophysical Journal75 citations Open access
Semantic Scholar
A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: implications for cancer vaccine design.
Lisa M. Ebert, Yu-Chih Liu, C. Clements, N. Robson +10 more
2009Cancer Research56 citations Open access
Semantic Scholar
CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire
J. Verhagen, R. Genolet, G. Britton, Brian J. Stevenson +4 more
2012Proceedings of the National Academy of Sciences of the United States of America54 citations Open access
Semantic Scholar
KAP1 Regulates Gene Networks Controlling T cell Development and Responsiveness
F. R. Santoni de Sio, Isabelle Barde, Sandra Offner, Adamandia Kapopoulou +8 more
2012The FASEB Journal53 citations Open access
Semantic Scholar
Vaccination‐induced functional competence of circulating human tumor‐specific CD8 T‐cells
P. Baumgaertner, C. Jandus, J. Rivals, L. Derré +9 more
2012International Journal of Cancer53 citations Open access
Semantic Scholar
Current tools for predicting cancer-specific T cell immunity
D. Gfeller, M. Bassani-Sternberg, J. Schmidt, I. Luescher
2016Oncoimmunology49 citations Open access
Semantic Scholar
Peptide Vaccine Induces Enhanced Tumor Growth Associated with Apoptosis Induction in CD8+ T Cells
D. Muraoka, Takuma Kato, Linan Wang, Y. Maeda +9 more
2010Journal of Immunology47 citations Open access
Semantic Scholar
Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR-Ligand Off-Rates Measurements on Living Cells.
Michael Hebeisen, J. Schmidt, P. Guillaume, P. Baumgaertner +3 more
2015Cancer Research46 citations Open access
Semantic Scholar
Striking Immunodominance Hierarchy of Naturally Occurring CD8+ and CD4+ T Cell Responses to Tumor Antigen NY-ESO-11
H. Jackson, Nektaria Dimopoulos, N. Mifsud, T. Tai +9 more
2006Journal of Immunology46 citations
Semantic Scholar
Non-classical antigen processing pathways are required for MHC class II-restricted direct tumor recognition by NY-ESO-1-specific CD4+ T cells
Junko Matsuzaki, Takemasa Tsuji, I. Luescher, L. Old +3 more
2013Cancer immunology research45 citations Open access
Semantic Scholar
Tumor antigen-specific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts.
C. Jandus, Gilles Bioley, D. Dojcinovic, L. Derré +8 more
2009Cancer Research44 citations Open access
Semantic Scholar
TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function
Koshika Yadava, Anke Sichelstiel, I. Luescher, L. Nicod +2 more
2012Mucosal Immunology43 citations Open access
Semantic Scholar
Monitoring of NY-ESO-1 specific CD4+ T cells using molecularly defined MHC class II/His-tag-peptide tetramers
M. Ayyoub, D. Dojcinovic, P. Pignon, Isabelle Raimbaud +3 more
2010Proceedings of the National Academy of Sciences of the United States of America42 citations Open access
Semantic Scholar
Highly diverse TCRα chain repertoire of pre‐immune CD8+ T cells reveals new insights in gene recombination
R. Genolet, Brian J. Stevenson, L. Farinelli, M. Østerås +1 more
2012EMBO Journal41 citations Open access
Semantic Scholar
A peptide encoded by the human MAGE3 gene and presented by HLA-1344 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE3
J. Herman, P. van der Bruggen, I. Luescher, S. Mandruzzato +5 more
2005Immunogenetics41 citations
Semantic Scholar
Analysis, Isolation, and Activation of Antigen-Specific CD4+ and CD8+ T Cells by Soluble MHC-Peptide Complexes
J. Schmidt, D. Dojcinovic, P. Guillaume, I. Luescher
2013Frontiers in Immunology40 citations Open access
Semantic Scholar
Reversible Major Histocompatibility Complex I-Peptide Multimers Containing Ni2+-Nitrilotriacetic Acid Peptides and Histidine Tags Improve Analysis and Sorting of CD8+ T Cells*
J. Schmidt, P. Guillaume, M. Irving, P. Baumgaertner +2 more
2011Journal of Biological Chemistry38 citations Open access
Semantic Scholar
The T-cell receptor is not hardwired to engage MHC ligands
S. Holland, I. Bartok, Meriem Attaf, R. Genolet +9 more
2012Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
In silico and cell-based analyses reveal strong divergence between prediction and observation of T-cell–recognized tumor antigen T-cell epitopes
J. Schmidt, P. Guillaume, D. Dojcinovic, J. Karbach +2 more
2017Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Induction of CD8 T‐cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20‐mer NY‐ESO‐1f (NY‐ESO‐1 91‐110) peptide
S. Eikawa, K. Kakimi, Midori Isobe, K. Kuzushima +8 more
2013International Journal of Cancer30 citations
Semantic Scholar
Basal and Antigen-Induced Exposure of the Proline-Rich Sequence in CD3ε
J. de la Cruz, Travis Kruger, Christopher A. Parks, Robert L. Silge +4 more
2011Journal of Immunology30 citations Open access
Semantic Scholar
The T Cell Receptor’s α-Chain Connecting Peptide Motif Promotes Close Approximation of the CD8 Coreceptor Allowing Efficient Signal Initiation1
M. Mallaun, D. Naeher, M. Daniels, P. Yachi +4 more
2008Journal of Immunology30 citations Open access
Semantic Scholar
Highly diverse TCRα chain repertoire of pre‐immune CD8+ T cells reveals new insights in gene recombination
R. Genolet, Brian J. Stevenson, L. Farinelli, M. Østerås +1 more
2012EMBO Journal28 citations Open access
Semantic Scholar
Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose
T. Lövgren, P. Baumgaertner, Sébastien Wieckowski, Estelle F. Devêvre +4 more
2012Cancer Immunology and Immunotherapy28 citations Open access
Semantic Scholar
Vaccination With a Recombinant Protein Encoding the Tumor-specific Antigen NY-ESO-1 Elicits an A2/157-165-specific CTL Repertoire Structurally Distinct and of Reduced Tumor Reactivity Than That Elicited by Spontaneous Immune Responses to NY-ESO-1-expressing Tumors
Gilles Bioley, P. Guillaume, I. Luescher, N. Bhardwaj +4 more
2009Journal of immunotherapy28 citations
Semantic Scholar
Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition*
J. Segura, P. Guillaume, S. Mark, D. Dojcinovic +6 more
2008Journal of Biological Chemistry25 citations Open access
Semantic Scholar
Recognition of naturally processed and ovarian cancer reactive CD8+ T cell epitopes within a promiscuous HLA class II T-helper region of NY-ESO-1
Junko Matsuzaki, F. Qian, I. Luescher, S. Lele +5 more
2008Cancer Immunology and Immunotherapy25 citations Open access
Semantic Scholar
HLA Class I–Associated Immunodominance Affects CTL Responsiveness to an ESO Recombinant Protein Tumor Antigen Vaccine
Gilles Bioley, P. Guillaume, I. Luescher, Alice Yeh +6 more
2009Clinical Cancer Research22 citations Open access
Semantic Scholar
IL-12 Controls Cytotoxicity of a Novel Subset of Self-Antigen-Specific Human CD28+ Cytolytic T Cells1
C. Barbey, P. Baumgaertner, Estelle F. Devêvre, V. Rubio‐Godoy +9 more
2007Journal of Immunology21 citations Open access
Semantic Scholar
Soluble MHC-peptide complexes: tools for the monitoring of T cell responses in clinical trials and basic research.
P. Guillaume, D. Dojcinovic, I. Luescher
2009Cancer Immunity20 citations
Semantic Scholar
Soluble MHC-Peptide Complexes Containing Long Rigid Linkers Abolish CTL-Mediated Cytotoxicity1
Georgi S. Angelov, P. Guillaume, M. Cebecauer, G. Bosshard +3 more
2006Journal of Immunology20 citations Open access
Semantic Scholar
Combining MHC tetramer and intracellular cytokine staining for CD8(+) T cells to reveal antigenic epitopes naturally presented on tumor cells.
Nektaria Dimopoulos, H. Jackson, Lisa M. Ebert, P. Guillaume +3 more
2009JIM - Journal of Immunological Methods17 citations
Semantic Scholar
NY-ESO-1-Specific Circulating CD4+ T Cells in Ovarian Cancer Patients Are Prevalently TH1 Type Cells Undetectable in the CD25+FOXP3+Treg Compartment
N. Redjimi, Karine Duperrier-Amouriaux, Isabelle Raimbaud, I. Luescher +7 more
2011PLoS ONE16 citations Open access
Semantic Scholar
Recent advances in tumour antigen‐specific therapy: In vivo veritas
Yolanda D. Mahnke, D. Speiser, I. Luescher, J. Cerottini +1 more
2005International Journal of Cancer16 citations
Semantic Scholar
CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity
P. Baumgaertner, J. Schmidt, Carla Costa-Nunes, N. Bordry +5 more
2022Frontiers in Immunology15 citations Open access
Semantic Scholar
Active Antiviral T-Lymphocyte Response Can Be Redirected against Tumor Cells by Antitumor Antibody × MHC/Viral Peptide Conjugates
V. Cesson, K. Stirnemann, B. Robert, I. Luescher +4 more
2006Clinical Cancer Research15 citations Open access
Semantic Scholar
An optimized method for establishing high purity murine CD8+ T cell cultures.
D. Zanker, Kun Xiao, S. Oveissi, P. Guillaume +2 more
2013JIM - Journal of Immunological Methods14 citations
Semantic Scholar

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