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S. Eikawa · SciRah

Researcher profile · Semantic Scholar

S. Eikawa

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S. Eikawa — researcher profile on SciRah

h-index: 14
Works: 44
Citations: 1,259

Most-cited papers

Immune-mediated antitumor effect by type 2 diabetes drug, metformin
S. Eikawa, Mikako Nishida, S. Mizukami, C. Yamazaki +2 more
2015Proceedings of the National Academy of Sciences of the United States of America517 citations Open access
Semantic Scholar
Attenuation of CD4+ CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug
Kunisada Yuki, S. Eikawa, Nahoko Tomonobu, Shohei Domae +6 more
2017EBioMedicine142 citations Open access
Semantic Scholar
Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects
T. Uehara, S. Eikawa, Mikako Nishida, Kunisada Yuki +5 more
2018International Immunology105 citations Open access
Semantic Scholar
Berberine improved experimental chronic colitis by regulating interferon-γ- and IL-17A-producing lamina propria CD4+ T cells through AMPK activation
Masahiro Takahara, A. Takaki, S. Hiraoka, T. Adachi +15 more
2019Scientific Reports71 citations Open access
Semantic Scholar
Enrichment of Foxp3+ CD4 Regulatory T Cells in Migrated T Cells to IL-6– and IL-8–Expressing Tumors through Predominant Induction of CXCR1 by IL-6
S. Eikawa, Y. Ohue, Kenta Kitaoka, T. Aji +3 more
2010Journal of Immunology70 citations Open access
Semantic Scholar
Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis
Ichiro Nojima, S. Eikawa, Nahoko Tomonobu, Yoshiko Hada +10 more
2020Scientific Reports51 citations Open access
Semantic Scholar
Increase in Activated Treg in TIL in Lung Cancer and In Vitro Depletion of Treg by ADCC Using an Antihuman CCR4 mAb (KM2760)
K. Kurose, Y. Ohue, E. Sato, A. Yamauchi +6 more
2015Journal of Thoracic Oncology50 citations Open access
Semantic Scholar
Vaccination With NY-ESO-1 Overlapping Peptides Mixed With Picibanil OK-432 and Montanide ISA-51 in Patients With Cancers Expressing the NY-ESO-1 Antigen
H. Wada, Midori Isobe, K. Kakimi, Y. Mizote +18 more
2014Journal of immunotherapy38 citations
Semantic Scholar
Spontaneous antibody, and CD4 and CD8 T‐cell responses against XAGE‐1b (GAGED2a) in non‐small cell lung cancer patients
Y. Ohue, S. Eikawa, Nami Okazaki, Y. Mizote +6 more
2012International Journal of Cancer36 citations Open access
Semantic Scholar
Induction of CD8 T‐cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20‐mer NY‐ESO‐1f (NY‐ESO‐1 91‐110) peptide
S. Eikawa, K. Kakimi, Midori Isobe, K. Kuzushima +8 more
2013International Journal of Cancer30 citations
Semantic Scholar
HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation
Y. Kato, C. Kajiwara, I. Ishige, S. Mizukami +4 more
2012Autoimmune Diseases27 citations Open access
Semantic Scholar
Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient.
Midori Isobe, S. Eikawa, A. Uenaka, Yoichi Nakamura +4 more
2009Cancer Immunity19 citations
Semantic Scholar
[Metabolic Competition in Tumor Microenvironment].
S. Eikawa, H. Udono
2017Gan to kagaku ryoho. Cancer & chemotherapy18 citations
Semantic Scholar
Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade
Edgar Gonzalez-Kozlova, Robert Sweeney, Igor Figueiredo, Kevin Tuballes +58 more
2026Nature Medicine15 citations Open access
Semantic Scholar
Antitumor immunity as the basis for durable disease-free treatment-free survival in patients with metastatic urothelial cancer
J. Anker, S. Pal, S. Kim-Schulze, Huan Wang +13 more
2023Journal for ImmunoTherapy of Cancer12 citations Open access
Semantic Scholar
Monitoring multifunctionality of immune-exhausted CD8 T cells in cancer patients.
S. Eikawa, S. Mizukami, H. Udono
2014Methods in molecular biology12 citations
Semantic Scholar
Tumor-resident regulatory T cells in pancreatic cancer express the αvβ5 integrin as a targetable activation marker
Kodai Suzuki, Kunisada Yuki, N. Miyamura, S. Eikawa +7 more
2023bioRxiv8 citations Open access
Semantic Scholar
AntiTumor and Immunoregulatory Effects of Fermented Papaya Preparation (FPP: SAIDOPS501).
S. Murakami, S. Eikawa, S. Kaya, Mitsuko Imao +1 more
2016Asian Pacific Journal of Cancer Prevention8 citations
Semantic Scholar
Abstract 4732: Depletion of Tregs from PBMCs by treatment with defucosylated anti-CCR4 mAb.
K. Kurose, S. Eikawa, Y. Mizote, Y. Ohue +4 more
20138 citations
Semantic Scholar
The induction of antigen-specific CTL by in situ Ad-REIC gene therapy
Yuichi Ariyoshi, Masami Watanabe, S. Eikawa, C. Yamazaki +7 more
2016Gene Therapy6 citations
Semantic Scholar
Detection and Tracking of NY-ESO-1-Specific CD8+ T Cells by High-Throughput T Cell Receptor β (TCRB) Gene Rearrangements Sequencing in a Peptide-Vaccinated Patient
Manami Miyai, S. Eikawa, A. Hosoi, Tamaki Iino +7 more
2015PLoS ONE5 citations Open access
Semantic Scholar
Abstract 5592: Metformin improves immune function of exhausted peripheral CD8+ T cells derived from cancer patients
Mototsugu Watanabe, S. Eikawa, K. Shien, H. Yamamoto +6 more
20174 citations
Semantic Scholar
Study about the Efficacy of Metformin to Immune Function in Cancer Patients.
Mototsugu Watanabe, H. Yamamoto, S. Eikawa, K. Shien +11 more
2016Acta Medica Okayama3 citations
Semantic Scholar
[Regulation of T-cell immune exhaustion and cancer immunotherapy].
S. Eikawa, H. Udono
2014Gan to kagaku ryoho. Cancer & chemotherapy3 citations
Semantic Scholar
Targeting the αvβ5 Integrin Modifies the TGF-β-Rich Tumor Microenvironment of Pancreatic Cancer
Kodai Suzuki, Kunisada Yuki, Yukihito Kuroda, Hotaka Kawai +10 more
2026Cancer Research2 citations Open access
Semantic Scholar
Abstract B026: αvβ5 Integrin serves as a tumor-specific marker for immunosuppressive regulatory T cells in pancreatic cancer
Kunisada Yuki, Kodai Suzuki, Norio Miyamura, S. Eikawa +7 more
2024Cancer Research0 citations
Semantic Scholar
Abstract 3381: Identifying tumor antigen-specific CD4+ T cell dysfunctional states by single cell transcriptomics in immunotherapy-treated cancer patients
Edgar Kozlova, S. Eikawa, S. Gnjatic, B. Losic
2020Bioinformatics, Convergence Science, and Systems Biology0 citations
Semantic Scholar
Abstract 4558: Mapping tolerized T cell states to exhaustion phenotypes in NSCLC
Edgar Kozlova, S. Eikawa, S. Gnjatic, B. Losic
2019Tumor Biology0 citations Open access
Semantic Scholar
The First International Seminar on Immunology and Cancer in Okayama / 13 th URA International Symposium
H. Udono, Mikako Nishida, S. Eikawa, Kunisada Yuki +1 more
20180 citations
Semantic Scholar
Metformin-dependent metabolic reprogramming contributes to efficient anti-tumor immunity.
Nahoko Tomonobu, S. Eikawa, H. Udono
2017Nihon rinsho. Japanese journal of clinical medicine0 citations
Semantic Scholar
Abstract 4865: Metformin improves multiple cytokine producing ability of exhausted peripheral CD8+ T cells of cancer patients
Mototsugu Watanabe, S. Eikawa, T. Uehara, Kunisada Yuki +3 more
20160 citations
Semantic Scholar
免疫疲弊分子PD-1，CTLA-4
S. Eikawa
20150 citations Open access
Semantic Scholar
The 2014 Incentive Award of the Okayama Medical Association in Cancer Research (2014 Hayashibara Prize and Yamada Prize)
S. Eikawa
20150 citations Open access
Semantic Scholar
The induction of antigen-specific CTL by in situ Ad-REIC gene therapy 2 3
Yuichi Ariyoshi, Masami Watanabe, S. Eikawa, C. Yamazaki +8 more
20150 citations
Semantic Scholar
Abstract 495: Immune response to XAGE-1b (GAGED2a) in NSCLC patients and its clinical relevance.
Y. Ohue, K. Kurose, S. Eikawa, Y. Mizote +6 more
20130 citations
Semantic Scholar
Expressing Tumors through Predominant - and IL-8 - Cells in Migrated T Cells to IL-6 Enrichment of Foxp3+ CD4 Regulatory T
A. Uenaka, M. Oka, E. Nakayama, S. Eikawa +2 more
20130 citations
Semantic Scholar
Abstract 508: Correlation of antibody and T-cell responses against XAGE-1b in NSCLC patients
Y. Ohue, S. Eikawa, Y. Mizote, Hirofumi Matsumoto +5 more
20120 citations
Semantic Scholar
Abstract 518: Immunogenicity of cancer/testis antigenXAGE-1din patients with non-small cell lung cancer (NSCLC)
Hirofumi Matsumoto, Y. Ohue, S. Eikawa, Y. Mizote +6 more
20120 citations
Semantic Scholar
Abstract 2689: XAGE-1b(GAGED2a) immunity in non-small cell lung cancer
Y. Ohue, S. Eikawa, Hirofumi Matsumoto, Y. Mizote +5 more
20110 citations
Semantic Scholar
Abstract 3653: Enrichment of Foxp3+ CD4 Tregs in migrated T-cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6
S. Eikawa, Y. Ohue, Kenta Kitaoka, T. Aji +4 more
20110 citations
Semantic Scholar
This information is current as Induction of CXCR 1 by IL-6 Expressing Tumors through Predominant − and IL-8 − Cells in Migrated T Cells to IL-6 CD 4 Regulatory T + Enrichment of Foxp 3
S. Eikawa, Y. Ohue, Kenta Kitaoka, T. Aji +3 more
20100 citations
Semantic Scholar
Abstract 1915: Enrichment of Tregs in migrated T-cells to IL-6- and IL-8-expressing tumors through induction of CXCR1 by IL-6
S. Eikawa, Y. Ohue, Kenta Kitaoka, T. Aji +3 more
20100 citations
Semantic Scholar
Abstract 2394: Spontaneous immune responses against XAGE-1b in patients with non-small cell lung cancer (NSCLC)
Y. Ohue, S. Eikawa, Y. Mizote, Nami Okazaki +5 more
20100 citations
Semantic Scholar
Tumor immunity and immunosurveillance (PP-093)
J. Abastado, J. Eyles, A. Puaux, J. Wang +496 more
20100 citations
Semantic Scholar

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E. Nakayama×19
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H. Udono×19
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A. Uenaka×17
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Midori Isobe×13

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Kenta Kitaoka×5

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