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V. Christoffels · SciRah

Researcher profile · Semantic Scholar

V. Christoffels

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V. Christoffels — researcher profile on SciRah

h-index: 72
Works: 297
Citations: 17K

Most-cited papers

A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference.
P. Kirchhof, G. Breithardt, J. Bax, G. Benninger +67 more
2016Europace155 citations Open access
Semantic Scholar
Transcriptional regulation of the cardiac conduction system
Vincent W. W. van Eif, H. Devalla, G. J. Boink, V. Christoffels
2018Nature Reviews Cardiology116 citations Open access
Semantic Scholar
52 Genetic Loci Influencing Myocardial Mass
P. van der Harst, J. van Setten, N. Verweij, Georg Vogler +155 more
2017115 citations
Semantic Scholar
Structure and function of the Nppa–Nppb cluster locus during heart development and disease
Joyce C. K. Man, P. Barnett, V. Christoffels
2018Cellular and Molecular Life Sciences112 citations Open access
Semantic Scholar
Development, Proliferation, and Growth of the Mammalian Heart.
Marie Günthel, P. Barnett, V. Christoffels
2018Molecular Therapy108 citations Open access
Semantic Scholar
Conserved NPPB+ Border Zone Switches from MEF2 to AP-1 Driven Gene Program.
K. van Duijvenboden, D. E. D. de Bakker, Joyce C. K. Man, Rob Janssen +11 more
2019Circulation91 citations Open access
Semantic Scholar
Identification of atrial fibrillation associated genes and functional non-coding variants
Antoinette F. van Ouwerkerk, F. Bosada, K. van Duijvenboden, Matthew C. Hill +12 more
2019Nature Communications88 citations Open access
Semantic Scholar
Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program
Vincent W. W. van Eif, Sonia Stefanovic, K. van Duijvenboden, M. Bakker +6 more
2019Development74 citations Open access
Semantic Scholar
Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2.
Sha Chen, Qian Wang, Andriana Christodoulou, Nikolaos Mylonas +9 more
2023Circulation71 citations Open access
Semantic Scholar
Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation
Antoinette F. van Ouwerkerk, A. Hall, Zachary A. Kadow, Sonja Lazarevic +12 more
2020Circulation Research68 citations Open access
Semantic Scholar
An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality
C. Ferrer, M. Alders, A. Postma, Seonmi Park +14 more
2018Genes & Development55 citations Open access
Semantic Scholar
Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells
A. Wiesinger, G. J. Boink, V. Christoffels, H. Devalla
2021Stem Cell Reports54 citations Open access
Semantic Scholar
Excessive trabeculations in noncompaction do not have the embryonic identity.
Bjarke Jensen, A. van der Wal, A. Moorman, V. Christoffels
2017International Journal of Cardiology50 citations Open access
Semantic Scholar
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart.
Joyce C. K. Man, K. van Duijvenboden, Peter H. L. Krijger, Ingeborg B. Hooijkaas +7 more
2020Circulation Research49 citations Open access
Semantic Scholar
On the Evolution of the Cardiac Pacemaker
S. Burkhard, Vincent W. W. van Eif, L. Garric, V. Christoffels +1 more
2017Journal of Cardiovascular Development and Disease44 citations Open access
Semantic Scholar
Cardiac Morphogenesis: Specification of the Four-Chambered Heart.
V. Christoffels, Bjarke Jensen
2020Cold Spring Harbor Perspectives in Biology43 citations Open access
Semantic Scholar
The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes
Pablo Montañés-Agudo, Simona Aufiero, Eva N. Schepers, I. van der Made +7 more
2023Cardiovascular Research42 citations Open access
Semantic Scholar
Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse.
Marina Kaiser, Irina Wojahn, Carsten Rudat, Timo H. Lüdtke +4 more
2021Development42 citations Open access
Semantic Scholar
Specialized impulse conduction pathway in the alligator heart
Bjarke Jensen, B. Boukens, D. Crossley, Justin L. Conner +8 more
2018eLife41 citations Open access
Semantic Scholar
Identification of Functional Variant Enhancers Associated With Atrial Fibrillation
Antoinette F. van Ouwerkerk, F. Bosada, Jia Liu, Juan Zhang +8 more
2020Circulation Research40 citations Open access
Semantic Scholar
Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction
Joyce C. K. Man, F. Bosada, Koen T. Scholman, J. Offerhaus +8 more
2021Circulation38 citations Open access
Semantic Scholar
Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction
Rajiv A. Mohan, M. Mommersteeg, J. Domínguez, C. Choquet +7 more
2018Development37 citations Open access
Semantic Scholar
TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti
Marina Kaiser, Timo H. Lüdtke, Lena Deuper, Carsten Rudat +3 more
2022Nature Communications36 citations Open access
Semantic Scholar
Quantified growth of the human embryonic heart
Jaeike W. Faber, J. Hagoort, A. Moorman, V. Christoffels +1 more
2021Biology Open36 citations Open access
Semantic Scholar
Loss-of-function variants in myocardin cause congenital megabladder in humans and mice
A. Houweling, G. Beaman, A. Postma, T. B. Gainous +21 more
2019Journal of Clinical Investigation36 citations Open access
Semantic Scholar
TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme
N. Aydoğdu, Carsten Rudat, Mark-Oliver Trowe, Marina Kaiser +5 more
2018Development35 citations Open access
Semantic Scholar
Lack of morphometric evidence for ventricular compaction in humans.
Jaeike W. Faber, A. D’Silva, V. Christoffels, Bjarke Jensen
2021Journal of Cardiology34 citations Open access
Semantic Scholar
A single cell transcriptional roadmap of human pacemaker cell differentiation
A. Wiesinger, Jiuru Li, L. Fokkert, Priscilla Bakker +4 more
2022eLife32 citations Open access
Semantic Scholar
Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction
Antoinette F. van Ouwerkerk, F. Bosada, K. van Duijvenboden, A. Houweling +11 more
2022Circulation31 citations Open access
Semantic Scholar
T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system
Rajiv A. Mohan, F. Bosada, J. H. van Weerd, K. van Duijvenboden +11 more
2020Proceedings of the National Academy of Sciences of the United States of America31 citations Open access
Semantic Scholar
Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.
Vincent W. W. van Eif, S. Protze, F. Bosada, Xuefei Yuan +14 more
2020Circulation Research31 citations Open access
Semantic Scholar
Morpho-functional characterization of the systemic venous pole of the reptile heart
Bjarke Jensen, Signe Vesterskov, B. Boukens, J. M. Nielsen +3 more
2017Scientific Reports30 citations Open access
Semantic Scholar
The Impact of Natriuretic Peptides on Heart Development, Homeostasis, and Disease
Alexandra E. Giovou, M. Gladka, V. Christoffels
2024Cells28 citations Open access
Semantic Scholar
An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
Joyce C. K. Man, Rajiv A. Mohan, M. van den Boogaard, Catharina R. E. Hilvering +7 more
2019Nature Communications26 citations Open access
Semantic Scholar
Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing
Rajiv A. Mohan, B. Boukens, V. Christoffels
2018Pediatric Cardiology26 citations Open access
Semantic Scholar
Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries
Doris Škorić-Milosavljević, R. Tadros, F. Bosada, F. Tessadori +76 more
2021Circulation Research25 citations Open access
Semantic Scholar
TAD boundary deletion causes PITX2-related cardiac electrical and structural defects
M. Baudic, H. Murata, F. Bosada, U. S. Melo +40 more
2024Nature Communications24 citations Open access
Semantic Scholar
Hippo-Yap signaling maintains sinoatrial node homeostasis
Ming-Jie Zheng, Rich Gang Li, Jia Song, Xiaolei Zhao +11 more
2022Circulation24 citations Open access
Semantic Scholar
Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process
F. Tessadori, E. Tsingos, E. Colizzi, Fabian Kruse +5 more
2021eLife23 citations Open access
Semantic Scholar
Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiomyocytes
L. Medzikovic, Hylja Heese, P. V. van Loenen, C. van Roomen +5 more
2021International Journal of Molecular Sciences23 citations Open access
Semantic Scholar
Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression.
Vincent W. W. van Eif, Sonia Stefanovic, Rajiv A. Mohan, V. Christoffels
2020Biochimica et biophysica acta. Molecular cell research23 citations Open access
Semantic Scholar
Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function
Joshua W. Vincentz, B. Firulli, Kevin P. Toolan, D. Arking +7 more
2019Circulation Research22 citations Open access
Semantic Scholar
Cardiomyocyte and endothelial cells play distinct roles in the tumor necrosis factor (TNF)-dependent atrial responses and increased atrial fibrillation vulnerability induced by endurance exercise training in mice.
R. Lakin, N. Polidovitch, Si-Bao Yang, Mihir A. Parikh +13 more
2023Cardiovascular Research20 citations Open access
Semantic Scholar
Identification of the building blocks of ventricular septation in monitor lizards (Varanidae)
J. Hanemaaijer, M. Gregorovičová, J. M. Nielsen, A. Moorman +5 more
2019Development19 citations Open access
Semantic Scholar
Genetics of sinoatrial node function and heart rate disorders
Lieve E. van der Maarel, A. Postma, V. Christoffels
2023Disease Models & Mechanisms18 citations Open access
Semantic Scholar
Sinus venosus incorporation: contentious issues and operational criteria for developmental and evolutionary studies
Jaeike W. Faber, B. Boukens, R. Oostra, A. Moorman +2 more
2019Journal of Anatomy18 citations Open access
Semantic Scholar
Comparative analysis of avian hearts provides little evidence for variation among species with acquired endothermy
Jelle G. H. Kroneman, Jaeike W. Faber, J. Schouten, C. Wolschrijn +2 more
2019Journal of morphology17 citations Open access
Semantic Scholar
Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models
Jiuru Li, A. Wiesinger, L. Fokkert, B. Boukens +4 more
2022Journal of Tissue Engineering16 citations Open access
Semantic Scholar
Reptiles as a Model System to Study Heart Development.
Bjarke Jensen, V. Christoffels
2019Cold Spring Harbor Perspectives in Biology16 citations Open access
Semantic Scholar
Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung
Timo H. Lüdtke, Irina Wojahn, M. Kleppa, Jasper Schierstaedt +3 more
2021Respiratory Research15 citations Open access
Semantic Scholar

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