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G. Bonuccelli · SciRah

Researcher profile · Semantic Scholar

G. Bonuccelli

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G. Bonuccelli — researcher profile on SciRah

h-index: 42
Works: 74
Citations: 4,619

Most-cited papers

Ketones and lactate “fuel” tumor growth and metastasis
G. Bonuccelli, Aristotelis Tsirigos, D. Whitaker-Menezes, S. Pavlides +8 more
2010Cell Cycle596 citations Open access
Semantic Scholar
The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
G. Bonuccelli, D. Whitaker-Menezes, Remedios Castelló-Cros, S. Pavlides +12 more
2010Cell Cycle233 citations Open access
Semantic Scholar
Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
Claudia Capparelli, Carmela Guido, D. Whitaker-Menezes, G. Bonuccelli +11 more
2012Cell Cycle225 citations Open access
Semantic Scholar
The autophagic tumor stroma model of cancer or “battery-operated tumor growth”
U. Martinez-Outschoorn, D. Whitaker-Menezes, S. Pavlides, Barbara Chiavarina +15 more
2010Cell Cycle172 citations Open access
Semantic Scholar
Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation
I. Mercier, M. Casimiro, Chen-Guang Wang, A. Rosenberg +14 more
2008Cancer Biology & Therapy148 citations Open access
Semantic Scholar
Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
G. Bonuccelli, S. Avnet, G. Grisendi, Manuela Salerno +4 more
2014OncoTarget135 citations Open access
Semantic Scholar
Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins.
G. Bonuccelli, F. Sotgia, W. Schubert, David S. Park +6 more
2003American Journal of Pathology135 citations Open access
Semantic Scholar
Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling
R. Lamb, G. Bonuccelli, B. Ozsvari, Maria Peiris-Pagés +11 more
2015OncoTarget128 citations Open access
Semantic Scholar
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.
F. Sotgia, F. del Galdo, M. Casimiro, G. Bonuccelli +17 more
2009American Journal of Pathology120 citations Open access
Semantic Scholar
TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen.
Kylie A Hotchkiss, Cheryl M Basile, S. C. Spring, G. Bonuccelli +2 more
2005Experimental Cell Research117 citations
Semantic Scholar
ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection.
G. Bonuccelli, F. Sotgia, P. G. Frank, T. Williams +9 more
2005American Journal of Physiology - Cell Physiology107 citations
Semantic Scholar
Caveolin-1-Deficient Mice Show Defects in Innate Immunity and Inflammatory Immune Response during Salmonella enterica Serovar Typhimurium Infection
Freddy A. Medina, Cecília J. de Almeida, Elliott Dew, Jiangwei Li +7 more
2006Infection and Immunity97 citations Open access
Semantic Scholar
Intracellular Retention of Glycosylphosphatidyl Inositol-Linked Proteins in Caveolin-Deficient Cells
F. Sotgia, B. Razani, G. Bonuccelli, W. Schubert +7 more
2002Molecular and Cellular Biology97 citations Open access
Semantic Scholar
Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling
Maria Peiris-Pagés, G. Bonuccelli, F. Sotgia, M. Lisanti
2018OncoTarget96 citations Open access
Semantic Scholar
Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion
M. Cortini, A. Massa, S. Avnet, G. Bonuccelli +1 more
2016PLoS ONE87 citations Open access
Semantic Scholar
Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.
G. Bonuccelli, M. Casimiro, F. Sotgia, Chen-Guang Wang +16 more
2009American Journal of Pathology87 citations Open access
Semantic Scholar
Anthrax Lethal Toxin Kills Macrophages in a Strain-Specific Manner by Apoptosis or Caspase-1-Mediated Necrosis
Stefan M. Muehlbauer, Teresa H. Evering, G. Bonuccelli, Raynal C. Squires +4 more
2007Cell Cycle84 citations Open access
Semantic Scholar
Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells.
T. Williams, F. Sotgia, Hyangkyu Lee, Ghada S. Hassan +7 more
2006American Journal of Pathology83 citations Open access
Semantic Scholar
Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)
E. D. De Francesco, G. Bonuccelli, M. Maggiolini, F. Sotgia +1 more
2017OncoTarget79 citations Open access
Semantic Scholar
Therapeutic potential of proteasome inhibition in Duchenne and Becker muscular dystrophies.
E. Gazzerro, S. Assereto, A. Bonetto, F. Sotgia +8 more
2010American Journal of Pathology79 citations Open access
Semantic Scholar
Localized Treatment with a Novel FDA-Approved Proteasome Inhibitor Blocks the Degradation of Dystrophin and Dystrophin-Associated Proteins in mdx Mice
G. Bonuccelli, F. Sotgia, F. Capozza, E. Gazzerro +2 more
2007Cell Cycle79 citations Open access
Semantic Scholar
Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.
L. Gu, Ayush Dagvadorj, Jacqueline Lutz, B. Leiby +8 more
2010American Journal of Pathology77 citations Open access
Semantic Scholar
Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation.
W. Schubert, F. Sotgia, A. Cohen, F. Capozza +6 more
2007American Journal of Pathology71 citations Open access
Semantic Scholar
Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways
G. Bonuccelli, F. Sotgia, M. Lisanti
2018Aging69 citations Open access
Semantic Scholar
V-ATPase is a candidate therapeutic target for Ewing sarcoma.
S. Avnet, G. Di Pompo, Silvia Lemma, Manuela Salerno +5 more
2013Biochimica et Biophysica Acta68 citations Open access
Semantic Scholar
Cancer esearch cular and Cellular Pathobiology 1 Inhibits Metastatic Potential in Melanomas through R pression of the Integrin / Src / FAK Signaling Pathway
Trimmer, D. Whitaker-Menezes, G. Bonuccelli, Janet N. Milliman +6 more
201068 citations
Semantic Scholar
Pharmacological rescue of the dystrophin-glycoprotein complex in Duchenne and Becker skeletal muscle explants by proteasome inhibitor treatment.
S. Assereto, S. Stringara, F. Sotgia, G. Bonuccelli +8 more
2006American Journal of Physiology - Cell Physiology68 citations
Semantic Scholar
Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions.
I. Mercier, M. Casimiro, Jie Zhou, Chen-Guang Wang +14 more
2009American Journal of Pathology65 citations Open access
Semantic Scholar
Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers.
F. Sotgia, H. Rui, G. Bonuccelli, I. Mercier +2 more
2006Cancer Research65 citations Open access
Semantic Scholar
NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness”
G. Bonuccelli, E. D. De Francesco, R. de Boer, H. Tanowitz +1 more
2017OncoTarget64 citations Open access
Semantic Scholar
Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy
B. Ozsvari, G. Bonuccelli, R. Sánchez‐Alvarez, R. Foster +2 more
2017Aging57 citations Open access
Semantic Scholar
Towards a new “stromal-based” classification system for human breast cancer prognosis and therapy
A. Witkiewicz, M. Casimiro, A. Dasgupta, I. Mercier +8 more
2009Cell Cycle56 citations Open access
Semantic Scholar
Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition
A. Salem, G. Bonuccelli, G. Bevilacqua, H. Arafat +3 more
2011Cell Cycle55 citations Open access
Semantic Scholar
Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity
G. Bonuccelli, Maria Peiris-Pagés, B. Ozsvari, U. Martinez-Outschoorn +2 more
2016OncoTarget53 citations Open access
Semantic Scholar
A mitochondrial based oncology platform for targeting cancer stem cells (CSCs): MITO-ONC-RX
F. Sotgia, B. Ozsvari, M. Fiorillo, E. D. De Francesco +2 more
2018Cell Cycle52 citations Open access
Semantic Scholar
Localization of phospho-beta-dystroglycan (pY892) to an intracellular vesicular compartment in cultured cells and skeletal muscle fibers in vivo.
F. Sotgia, G. Bonuccelli, M. Bedford, A. Brancaccio +6 more
2003Biochemistry49 citations
Semantic Scholar
Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD
Manuela Salerno, S. Avnet, G. Bonuccelli, S. Hosogi +2 more
2014PLoS ONE48 citations Open access
Semantic Scholar
Molecular analysis of 40 Italian patients with mucopolysaccharidosis type II: New mutations in the iduronate‐2‐sulfatase (IDS) gene
M. Filocamo, G. Bonuccelli, F. Corsolini, R. Mazzotti +2 more
2001Human Mutation48 citations
Semantic Scholar
Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells
R. Lamb, B. Ozsvari, G. Bonuccelli, Duncan L. Smith +5 more
2015OncoTarget45 citations Open access
Semantic Scholar
Bortezomib (PS-341) Treatment Decreases Inflammation and Partially Rescues the Expression of the Dystrophin-Glycoprotein Complex in GRMD Dogs
K. P. C. Araújo, G. Bonuccelli, C. N. Duarte, T. P. Gaiad +6 more
2013PLoS ONE45 citations Open access
Semantic Scholar
Phenotypic behavior of caveolin-3 R26Q, a mutant associated with hyperCKemia, distal myopathy, and rippling muscle disease.
F. Sotgia, S. Woodman, G. Bonuccelli, F. Capozza +3 more
2003American Journal of Physiology - Cell Physiology45 citations
Semantic Scholar
Sphere-forming cell subsets with cancer stem cell properties in human musculoskeletal sarcomas.
Manuela Salerno, S. Avnet, G. Bonuccelli, A. Eramo +4 more
2013International Journal of Oncology43 citations Open access
Semantic Scholar
Metabolic remodeling of the tumor microenvironment
Valentina Carito, G. Bonuccelli, U. Martinez-Outschoorn, D. Whitaker-Menezes +6 more
2012Cell Cycle43 citations Open access
Semantic Scholar
The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis
G. Bonuccelli, Remedios Castelló-Cros, F. Capozza, U. Martinez-Outschoorn +7 more
2012Cell Cycle42 citations Open access
Semantic Scholar
Mitoriboscins: Mitochondrial-based therapeutics targeting cancer stem cells (CSCs), bacteria and pathogenic yeast
B. Ozsvari, M. Fiorillo, G. Bonuccelli, A. Cappello +5 more
2017OncoTarget37 citations Open access
Semantic Scholar
Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment
F. Perut, F. Carta, G. Bonuccelli, G. Grisendi +8 more
2015Expert opinion on therapeutic targets37 citations Open access
Semantic Scholar
Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells.
T. Chano, S. Avnet, K. Kusuzaki, G. Bonuccelli +4 more
2016American Journal of Cancer Research34 citations
Semantic Scholar
Antibiotics that target mitochondria extend lifespan in C. elegans
G. Bonuccelli, Darren R. Brooks, Sally Shepherd, F. Sotgia +1 more
2023Aging30 citations Open access
Semantic Scholar
Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation.
F. Sotgia, M. Casimiro, G. Bonuccelli, Man-Ran Liu +17 more
2009American Journal of Pathology29 citations Open access
Semantic Scholar
Acid microenvironment promotes cell survival of human bone sarcoma through the activation of cIAP proteins and NF-κB pathway.
S. Avnet, T. Chano, A. Massa, G. Bonuccelli +5 more
2019American Journal of Cancer Research27 citations
Semantic Scholar

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M. Lisanti — researcher profile on SciRah
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