Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

T. Smithgall · SciRah

Researcher profile · Semantic Scholar

T. Smithgall

Share profile

T. Smithgall — researcher profile on SciRah

h-index: 57
Works: 223
Citations: 9,563

Most-cited papers

Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways
Judong Lee, E. Su, Chen Zhu, S. Hainline +5 more
2011Molecular and Cellular Biology246 citations Open access
Semantic Scholar
A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter
R. Perrone, M. Nadai, I. Frasson, Jerrod A. Poe +5 more
2013Journal of Medicinal Chemistry172 citations Open access
Semantic Scholar
MCPIP1 endoribonuclease activity negatively regulates interleukin-17-mediated signaling and inflammation
A. Garg, Nilesh Amatya, Kong Chen, J. Cruz +12 more
2015Immunity141 citations Open access
Semantic Scholar
Structure and Dynamic Regulation of Abl Kinases*
Shoghag Panjarian, Roxana E. Iacob, Shu-Gui Chen, J. Engen +1 more
2013Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Inhibition of histone deacetylase expands the renal progenitor cell population.
Eric D. de Groh, Lisa M. Swanhart, C. Cosentino, R. Jackson +5 more
2010Journal of the American Society of Nephrology108 citations Open access
Semantic Scholar
Human trophoblasts confer resistance to viruses implicated in perinatal infection
Avraham N Bayer, Elizabeth Delorme-Axford, Christie Sleigher, T. Frey +10 more
2014American Journal of Obstetrics and Gynecology104 citations Open access
Semantic Scholar
Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity
R. Perrone, M. Nadai, Jerrod A. Poe, I. Frasson +4 more
2013PLoS ONE102 citations Open access
Semantic Scholar
Behavioural immune landscapes of Inflammation
G. Crainiciuc, Miguel Palomino-Segura, M. Molina-Moreno, Jon Sicilia +24 more
2022Nature96 citations Open access
Semantic Scholar
HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System
Jing Shi, Ran Xiong, Tao Zhou, Peiyi Su +9 more
2018Journal of Virology88 citations Open access
Semantic Scholar
Expression of a Src Family Kinase in Chronic Myelogenous Leukemia Cells Induces Resistance to Imatinib in a Kinase-dependent Manner*
T. Pene-Dumitrescu, T. Smithgall
2010Journal of Biological Chemistry70 citations Open access
Semantic Scholar
DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target
Z. Qu, P. Yan, Jing Fu, Jing Jiang +3 more
2010Cancer Research65 citations Open access
Semantic Scholar
Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1
Rong Tan, S. Nakajima, Qun Wang, Hongxiang Sun +11 more
2017Molecules and Cells57 citations Open access
Semantic Scholar
Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Anti-retroviral Activity
Lori A. Emert-Sedlak, P. Narute, S. Shu, Jerrod A. Poe +7 more
2013Chemistry and Biology49 citations Open access
Semantic Scholar
Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes
Ryan P. Staudt, J. Alvarado, Lori A. Emert-Sedlak, Haibin Shi +4 more
2020Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Differential Sensitivity of Src-Family Kinases to Activation by SH3 Domain Displacement
Jamie A. Moroco, J. Craigo, Roxana E. Iacob, T. Wales +2 more
2014PLoS ONE48 citations Open access
Semantic Scholar
Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo
Mark C. Weir, S. Shu, Ravi K. Patel, S. Hellwig +4 more
2018ACS Chemical Biology45 citations Open access
Semantic Scholar
Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment*
J. Alvarado, Sreya Tarafdar, Joanne I. Yeh, T. Smithgall
2014Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Small Molecule Inhibitors of the c-Fes Protein-tyrosine Kinase
S. Hellwig, Chandrasekhar V. Miduturu, S. Kanda, Jian-Ming Zhang +9 more
2012Chemistry and Biology38 citations Open access
Semantic Scholar
Src-family Tyrosine Kinase Activities are Essential for Differentiation of Human Embryonic Stem Cells
Xiong Zhang, C. Simerly, Carrie Hartnett, G. Schatten +1 more
2014Stem Cell Research37 citations Open access
Semantic Scholar
Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry
J. Engen, T. Wales, Shu-Gui Chen, Elaine M. Marzluff +3 more
2012International reviews in physical chemistry (Print)36 citations Open access
Semantic Scholar
Nef Alleles from All Major HIV-1 Clades Activate Src-Family Kinases and Enhance HIV-1 Replication in an Inhibitor-Sensitive Manner
P. Narute, T. Smithgall
2012PLoS ONE36 citations Open access
Semantic Scholar
Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance
Ravi K. Patel, Mark C. Weir, Ke-Xin Shen, Daniel J. Snyder +2 more
2019PLoS ONE35 citations Open access
Semantic Scholar
Small molecule inhibitors of the HIV-1 virulence factor, Nef
T. Smithgall, G. Thomas
2013Drug Discovery Today : Technologies34 citations Open access
Semantic Scholar
The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation
Ke-Xin Shen, Jamie A. Moroco, Ravi K. Patel, Haibin Shi +3 more
2018Science Signaling33 citations Open access
Semantic Scholar
On the solution conformation and dynamics of the HIV-1 Viral Infectivity Factor
S. Marcsisin, P. Narute, Lori A. Emert-Sedlak, M. Kloczewiak +2 more
2011Journal of Molecular Biology33 citations Open access
Semantic Scholar
Pharmacologic HIV-1 Nef blockade promotes CD8 T cell-mediated elimination of latently HIV-1-infected cells in vitro.
S. Mujib, A. Saiyed, S. Fadel, Ardalan Bozorgzad +7 more
2017JCI Insight32 citations Open access
Semantic Scholar
The Accessory Factor Nef Links HIV-1 to Tec/Btk Kinases in an Src Homology 3 Domain-dependent Manner*♦
Sreya Tarafdar, Jerrod A. Poe, T. Smithgall
2014Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Enhanced SH3/Linker Interaction Overcomes Abl Kinase Activation by Gatekeeper and Myristic Acid Binding Pocket Mutations and Increases Sensitivity to Small Molecule Inhibitors*
Shoghag Panjarian, Roxana E. Iacob, Shu-Gui Chen, T. Wales +2 more
2013Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Tight-binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-mediated MHC-I downregulation
Haibin Shi, C. Tice, Lori A. Emert-Sedlak, Li Chen +5 more
2019ACS Infectious Diseases26 citations Open access
Semantic Scholar
Nef homodimers down-regulate SERINC5 by AP-2–mediated endocytosis to promote HIV-1 infectivity
Ryan P. Staudt, T. Smithgall
2020Journal of Biological Chemistry24 citations Open access
Semantic Scholar
Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen
R. Trible, P. Narute, Lori A. Emert-Sedlak, J. Alvarado +8 more
2013Retrovirology23 citations Open access
Semantic Scholar
An Unexpected Role for the Clock Protein Timeless in Developmental Apoptosis
Linda P. O'Reilly, Simon C Watkins, T. Smithgall
2011PLoS ONE23 citations Open access
Semantic Scholar
HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck
T. Pene-Dumitrescu, S. Shu, T. Wales, J. Alvarado +6 more
2012BMC Chemical Biology22 citations Open access
Semantic Scholar
Development and Validation of a High-Content Bimolecular Fluorescence Complementation Assay for Small Molecule Inhibitors of HIV-1 Nef Dimerization
Jerrod A. Poe, L. Vollmer, A. Vogt, T. Smithgall
2013Journal of biomolecular screening21 citations Open access
Semantic Scholar
Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation*
S. Shu, Lori A. Emert-Sedlak, T. Smithgall
2016Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding
Jamie A. Moroco, J. Alvarado, Ryan P. Staudt, Haibin Shi +3 more
2017Journal of Molecular Biology19 citations Open access
Semantic Scholar
The membrane-associated conformation of HIV-1 Nef investigated with hydrogen exchange mass spectrometry at a Langmuir monolayer
Gregory F. Pirrone, Lori A. Emert-Sedlak, T. Wales, T. Smithgall +2 more
2015Analytical Chemistry19 citations Open access
Semantic Scholar
The c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src
Xiong Zhang, Malcolm A. Meyn, T. Smithgall
2013ACS Chemical Biology18 citations Open access
Semantic Scholar
Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth
Mark C. Weir, S. Hellwig, L. Tan, Yao Liu +2 more
2017PLoS ONE17 citations Open access
Semantic Scholar
C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.
Y. Chong, Andrew S. Chan, Khai-Chew Chan, N. Williamson +8 more
2015Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Synthesis and Structure-activity Analysis of Diphenylpyrazolodiazene Inhibitors of the HIV-1 Nef Virulence Factor
Prema c. Iyer, Jielu Zhao, Lori A. Emert-Sedlak, Kerry K Moore +2 more
2014Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor
T. Wales, J. Hochrein, Christopher R. Morgan, Lori A. Emert-Sedlak +2 more
2015Biochemistry16 citations Open access
Semantic Scholar
ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr
Shou-Cheng Du, J. Alvarado, T. Wales, Jamie A. Moroco +2 more
2022Structure15 citations Open access
Semantic Scholar
Inhibitors of HIV-1 Nef-mediated activation of the myeloid Src-family kinase Hck block HIV-1 replication in macrophages and disrupt MHC-I downregulation
Lori A. Emert-Sedlak, O. Moukha-Chafiq, Haibin Shi, Shou-Cheng Du +15 more
2022ACS Infectious Diseases15 citations Open access
Semantic Scholar
Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine
Gahana Advani, Ya C. Lim, B. Catimel, D. S. Lio +11 more
2017Cell Communication and Signaling15 citations Open access
Semantic Scholar
Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function
Prerna Grover, Haibin Shi, Matthew P. Baumgartner, C. Camacho +1 more
2015PLoS ONE12 citations Open access
Semantic Scholar
Hydrogen exchange mass spectrometry of related proteins with divergent sequences: A comparative study of HIV-1 Nef allelic variants
T. Wales, Jerrod A. Poe, Lori A. Emert-Sedlak, Christopher R. Morgan +2 more
2016Journal of the American Society for Mass Spectrometry11 citations Open access
Semantic Scholar
Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor
Lori A. Emert-Sedlak, Haibin Shi, C. Tice, Li Chen +7 more
2022Viruses10 citations Open access
Semantic Scholar
The contrasting oncogenic and tumor suppressor roles of FES.
P. Greer, S. Kanda, T. Smithgall
2012Frontiers in Bioscience10 citations
Semantic Scholar
Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation
Linda P. O'Reilly, Xiong Zhang, T. Smithgall
2012Cellular Signalling10 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Lori A. Emert-Sedlak×14
Invite
Lori A. Emert-Sedlak — researcher profile on SciRah
J. Engen×13
Invite
J. Engen — researcher profile on SciRah
T. Wales×10
Invite
T. Wales — researcher profile on SciRah
Haibin Shi×9
Invite
Haibin Shi — researcher profile on SciRah

×9

Invite

J. Alvarado — researcher profile on SciRah

Jamie A. Moroco×6

Invite

Jamie A. Moroco — researcher profile on SciRah

Jerrod A. Poe×6

Invite

Jerrod A. Poe — researcher profile on SciRah

Invite

S. Shu — researcher profile on SciRah

Invite

P. Narute — researcher profile on SciRah

Invite

S. Hellwig — researcher profile on SciRah

Invite

Li Chen — researcher profile on SciRah

Roxana E. Iacob×3

Invite

Roxana E. Iacob — researcher profile on SciRah